A modular XNAzyme cleaves long, structured RNAs under physiological conditions and enables allele-specific gene silencing

On gene silencing by the X10-23 DNAzyme

(2022) Alexander I. Taylor et al.   Nature Chemistry

Allele-Specific RNA Knockdown with a Biologically Stable and Catalytically Efficient XNAzyme

(2021) Kim Nguyen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A biologically stable DNAzyme that efficiently silences gene expression in cells

(2021) Yajun Wang et al.   Nature Chemistry

RNA-Cleaving NAzymes: The Next Big Thing in Biosensing?

(2020) Saba Safdar et al.   TRENDS IN BIOTECHNOLOGY

Influence of monovalent metal ions on metal binding and catalytic activity of the 10–23 DNAzyme

(2020) Hannah Rosenbach et al.   BIOLOGICAL CHEMISTRY

Deoxyribozymes as Catalytic Nanotherapeutic Agents

(2019) Levon M. Khachigian   CANCER RESEARCH

An Ontology for Facilitating Discussion of Catalytic Strategies of RNA-Cleaving Enzymes

(2019) Philip C. Bevilacqua et al.   ACS Chemical Biology

DNA sensing by the cGAS–STING pathway in health and disease

(2019) Mona Motwani et al.   NATURE REVIEWS GENETICS

Beyond DNA and RNA: The Expanding Toolbox of Synthetic Genetics

(2019) Alexander I. Taylor et al.   Cold Spring Harbor Perspectives in Biology

Dual Mechanisms of Action of Self-Delivering, Anti-HIV-1 FANA Oligonucleotides as a Potential New Approach to HIV Therapy

(2019) Mayumi Takahashi et al.   Molecular Therapy-Nucleic Acids

Nucleic acid enzymes based on functionalized nucleosides

(2019) Marcel Hollenstein   CURRENT OPINION IN CHEMICAL BIOLOGY

Comprehensive Characterization of Cancer Driver Genes and Mutations

(2018) Matthew H. Bailey et al.   CELL

Specificity of RNAi, LNA and CRISPRi as loss-of-function methods in transcriptional analysis

(2018) Lovorka Stojic et al.   NUCLEIC ACIDS RESEARCH

The Galaxy platform for accessible, reproducible and collaborative biomedical analyses: 2018 update

(2018) Enis Afgan et al.   NUCLEIC ACIDS RESEARCH

A densely modified M2+-independent DNAzyme that cleaves RNA efficiently with multiple catalytic turnover

(2018) Yajun Wang et al.   Chemical Science

Cellular conditions of weakly chelated magnesium ions strongly promote RNA stability and catalysis

(2018) Ryota Yamagami et al.   Nature Communications

Detection of Microbial Infections Through Innate Immune Sensing of Nucleic Acids

(2018) Xiaojun Tan et al.   Annual Review of Microbiology

Tetrahedral DNAzymes for enhanced intracellular gene-silencing activity

(2018) Hien Bao Dieu Thai et al.   CHEMICAL COMMUNICATIONS

Evolution of a General RNA-Cleaving FANA Enzyme

(2018) Yajun Wang et al.   Nature Communications

RNA-Cleaving DNAzymes: Old Catalysts with New Tricks for Intracellular and In Vivo Applications

(2018) JingJing Zhang   Catalysts

Inability of DNAzymes to cleave RNA in vivo is due to limited Mg $$^{2+}$$ 2 + concentration in cells

(2017) Julian Victor et al.   EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

Biological applications of xeno nucleic acids

(2017) Kunihiko Morihiro et al.   Molecular BioSystems

The chemical evolution of oligonucleotide therapies of clinical utility

(2017) Anastasia Khvorova et al.   NATURE BIOTECHNOLOGY

ClinVar: improving access to variant interpretations and supporting evidence

(2017) Melissa J Landrum et al.   NUCLEIC ACIDS RESEARCH

A microRNA-initiated DNAzyme motor operating in living cells

(2017) Hanyong Peng et al.   Nature Communications

Novel Chemically-modified DNAzyme targeting Integrin alpha-4 RNA transcript as a potential molecule to reduce inflammation in multiple sclerosis

(2017) Madhuri Chakravarthy et al.   Scientific Reports

Nanostructures from Synthetic Genetic Polymers

(2016) Alexander I. Taylor et al.   CHEMBIOCHEM

Delivery of therapeutic RNA-cleaving oligodeoxyribonucleotides (deoxyribozymes): from cell culture studies to clinical trials

(2016) Alesya A. Fokina et al.   Expert Opinion on Drug Delivery

Efficacy of T-cell transcription factor–specific DNAzymes in murine skin inflammation models

(2016) Ulrich Purath et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

DNA enzymes as potential therapeutics: towards clinical application of 10-23 DNAzymes

(2015) Alesya A Fokina et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Ribozyme–Spherical Nucleic Acids

(2015) Jessica L. Rouge et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Directed evolution of artificial enzymes (XNAzymes) from diverse repertoires of synthetic genetic polymers

(2015) Alexander I Taylor et al.   Nature Protocols

The structural diversity of artificial genetic polymers

(2015) Irina Anosova et al.   NUCLEIC ACIDS RESEARCH

Visual Displays that Directly Interface and Provide Read-Outs of Molecular States via Molecular Graphics Processing Units

(2014) Julia E. Poje et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Catalysts from synthetic genetic polymers

(2014) Alexander I. Taylor et al.   NATURE

NCBI Viral Genomes Resource

(2014) J. Rodney Brister et al.   NUCLEIC ACIDS RESEARCH

Smart-seq2 for sensitive full-length transcriptome profiling in single cells

(2013) Simone Picelli et al.   NATURE METHODS

A library of programmable DNAzymes that operate in a cellular environment

(2013) Maya Kahan-Hanum et al.   Scientific Reports

Targeting Insulin-like Growth Factor I with 10–23 DNAzymes: 2′-O-Methyl Modifications in the Catalytic Core Enhance mRNA Cleavage

(2012) Alesya A. Fokina et al.   BIOCHEMISTRY

An open-label, phase 2 trial of RPI.4610 (angiozyme) in the treatment of metastatic breast cancer

(2012) Phuong Khanh Morrow et al.   CANCER

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

The solution structure of double helical arabino nucleic acids (ANA and 2′F-ANA): effect of arabinoses in duplex-hairpin interconversion

(2012) Nerea Martín-Pintado et al.   NUCLEIC ACIDS RESEARCH

Synthetic Genetic Polymers Capable of Heredity and Evolution

(2012) V. B. Pinheiro et al.   SCIENCE

Resurrecting DNAzymes as Sequence-Specific Therapeutics

(2012) J. J. Rossi   Science Translational Medicine

ViennaRNA Package 2.0

(2011) Ronny Lorenz et al.   Algorithms for Molecular Biology

“Locked onto the Target”: Increasing the Efficiency of Antagomirzymes Using Locked Nucleic Acid Modifications

(2010) Harleen Kaur et al.   BIOCHEMISTRY

Activation and Deactivation of DNAzyme and Antisense Function with Light for the Photochemical Regulation of Gene Expression in Mammalian Cells

(2010) Douglas D. Young et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Sequence-Related Off-Target Effect of Dz13 Against Human Tumor Cells and Safety in Adult and Fetal Mice Following Systemic Administration

(2010) Crispin R. Dass et al.   OLIGONUCLEOTIDES

A self-cleaving DNA enzyme modified with amines, guanidines and imidazoles operates independently of divalent metal cations (M 2+ )

(2009) Marcel Hollenstein et al.   NUCLEIC ACIDS RESEARCH