Inability of DNAzymes to cleave RNA in vivo is due to limited Mg $$^{2+}$$ 2 + concentration in cells

Dual MicroRNA to Cellular Prion Protein Inhibits Propagation of Pathogenic Prion Protein in Cultured Cells

(2017) Sang-Gyun Kang et al.   MOLECULAR NEUROBIOLOGY

The prion protein is an agonistic ligand of the G protein-coupled receptor Adgrg6

(2016) Alexander Küffer et al.   NATURE

Catalytic DNA: Scope, Applications, and Biochemistry of Deoxyribozymes

(2016) Scott K. Silverman   TRENDS IN BIOCHEMICAL SCIENCES

Delivery of Therapeutic siRNA to the CNS Using Cationic and Anionic Liposomes

(2016) Heather R. Bender et al.   Jove-Journal of Visualized Experiments

Allergen-Induced Asthmatic Responses Modified by a GATA3-Specific DNAzyme

(2015) Norbert Krug et al.   NEW ENGLAND JOURNAL OF MEDICINE

Systemic Delivery of siRNA Down Regulates Brain Prion Protein and Ameliorates Neuropathology in Prion Disorder

(2014) Sylvain Lehmann et al.   PLoS One

Safety and tolerability of an intratumorally injected DNAzyme, Dz13, in patients with nodular basal-cell carcinoma: a phase 1 first-in-human trial (DISCOVER)

(2013) Eun-Ae Cho et al.   LANCET

Alzheimer amyloid-β oligomer bound to postsynaptic prion protein activates Fyn to impair neurons

(2012) Ji Won Um et al.   NATURE NEUROSCIENCE

Intracerebral Infusion of Antisense Oligonucleotides Into Prion-infected Mice

(2012) Karah Nazor Friberg et al.   Molecular Therapy-Nucleic Acids

Cellular magnesium homeostasis

(2011) Andrea M.P. Romani   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Activation and Deactivation of DNAzyme and Antisense Function with Light for the Photochemical Regulation of Gene Expression in Mammalian Cells

(2010) Douglas D. Young et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Axonal prion protein is required for peripheral myelin maintenance

(2010) Juliane Bremer et al.   NATURE NEUROSCIENCE

Liposome-siRNA-Peptide Complexes Cross the Blood-Brain Barrier and Significantly Decrease PrPC on Neuronal Cells and PrPRES in Infected Cell Cultures

(2010) Bruce Pulford et al.   PLoS One

Cellular prion protein mediates impairment of synaptic plasticity by amyloid-β oligomers

(2009) Juha Laurén et al.   NATURE

The impact of target site accessibility on the design of effective siRNAs

(2008) Hakim Tafer et al.   NATURE BIOTECHNOLOGY