Beyond DNA and RNA: The Expanding Toolbox of Synthetic Genetics

Aptamer chemistry

(2018) Pascal Röthlisberger et al.   ADVANCED DRUG DELIVERY REVIEWS

Genetic alphabet expansion biotechnology by creating unnatural base pairs

(2018) Kyung Hyun Lee et al.   CURRENT OPINION IN BIOTECHNOLOGY

Reprograming the Replisome of a Semisynthetic Organism for the Expansion of the Genetic Alphabet

(2018) Michael P. Ledbetter et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Evolution of sequence-defined highly functionalized nucleic acid polymers

(2018) Zhen Chen et al.   Nature Chemistry

Identification and characterization of nucleobase-modified aptamers by click-SELEX

(2018) Franziska Pfeiffer et al.   Nature Protocols

A densely modified M2+-independent DNAzyme that cleaves RNA efficiently with multiple catalytic turnover

(2018) Yajun Wang et al.   Chemical Science

Current Advances in Aptamers for Cancer Diagnosis and Therapy

(2018) Shin-ichiro Hori et al.   Cancers

Selection of 2′-Fluoro-Modified Aptamers with Optimized Properties

(2017) Deepak Thirunavukarasu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Chemical modifications and reactions in DNA nanostructures

(2017) Kurt V. Gothelf   MRS BULLETIN

The chemical evolution of oligonucleotide therapies of clinical utility

(2017) Anastasia Khvorova et al.   NATURE BIOTECHNOLOGY

Building membrane nanopores

(2017) Stefan Howorka   Nature Nanotechnology

The emerging complexity of the tRNA world: mammalian tRNAs beyond protein synthesis

(2017) Paul Schimmel   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Synthesis and polymerase activity of a fluorescent cytidine TNA triphosphate analogue

(2017) Hui Mei et al.   NUCLEIC ACIDS RESEARCH

Nucleic acids: function and potential for abiogenesis

(2017) Falk Wachowius et al.   QUARTERLY REVIEWS OF BIOPHYSICS

Evolved polymerases facilitate selection of fully 2′-OMe-modified aptamers

(2017) Zhixia Liu et al.   Chemical Science

Structural basis for TNA synthesis by an engineered TNA polymerase

(2017) Nicholas Chim et al.   Nature Communications

Analysis of aptamer discovery and technology

(2017) Matthew R. Dunn et al.   Nature Reviews Chemistry

Nanostructures from Synthetic Genetic Polymers

(2016) Alexander I. Taylor et al.   CHEMBIOCHEM

Biosynthesis and Function of Modified Bases in Bacteria and Their Viruses

(2016) Peter Weigele et al.   CHEMICAL REVIEWS

The expanding world of DNA and RNA

(2016) Tingjian Chen et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Embracing proteins: structural themes in aptamer–protein complexes

(2016) Amy D Gelinas et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Self-assembled mirror DNA nanostructures for tumor-specific delivery of anticancer drugs

(2016) Kyoung-Ran Kim et al.   JOURNAL OF CONTROLLED RELEASE

DNA-Catalyzed Amide Hydrolysis

(2016) Cong Zhou et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

High-Affinity DNA Aptamer Generation Targeting von Willebrand Factor A1-Domain by Genetic Alphabet Expansion for Systematic Evolution of Ligands by Exponential Enrichment Using Two Types of Libraries Composed of Five Different Bases

(2016) Ken-ichiro Matsunaga et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A synthetic molecular system capable of mirror-image genetic replication and transcription

(2016) Zimou Wang et al.   Nature Chemistry

Evolution of thermophilic DNA polymerases for the recognition and amplification of C2ʹ-modified DNA

(2016) Tingjian Chen et al.   Nature Chemistry

Aptamers as targeted therapeutics: current potential and challenges

(2016) Jiehua Zhou et al.   NATURE REVIEWS DRUG DISCOVERY

An integrated, structure- and energy-based view of the genetic code

(2016) Henri Grosjean et al.   NUCLEIC ACIDS RESEARCH

Amplification of RNA by an RNA polymerase ribozyme

(2016) David P. Horning et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In vitro evolution of chemically-modified nucleic acid aptamers: Pros and cons, and comprehensive selection strategies

(2016) Farhana Lipi et al.   RNA Biology

Synthetic evolutionary origin of a proofreading reverse transcriptase

(2016) J. W. Ellefson et al.   SCIENCE

Catalytic DNA: Scope, Applications, and Biochemistry of Deoxyribozymes

(2016) Scott K. Silverman   TRENDS IN BIOCHEMICAL SCIENCES

Alternative Watson–Crick Synthetic Genetic Systems

(2016) Steven A. Benner et al.   Cold Spring Harbor Perspectives in Biology

A general strategy for expanding polymerase function by droplet microfluidics

(2016) Andrew C. Larsen et al.   Nature Communications

Enzymatic Synthesis of Nucleic Acids with Defined Regioisomeric 2′-5′ Linkages

(2015) Christopher Cozens et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Highly stable aptamers selected from a 2′-fully modified fGmH RNA library for targeting biomaterials

(2015) Adam D. Friedman et al.   BIOMATERIALS

Current approaches in SELEX: An update to aptamer selection technology

(2015) Mariia Darmostuk et al.   BIOTECHNOLOGY ADVANCES

Turning mirror-image oligonucleotides into drugs: the evolution of Spiegelmer® therapeutics

(2015) Axel Vater et al.   DRUG DISCOVERY TODAY

DNA enzymes as potential therapeutics: towards clinical application of 10-23 DNAzymes

(2015) Alesya A Fokina et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Specific Inhibition of MicroRNA Processing Using l-RNA Aptamers

(2015) Jonathan T. Sczepanski et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Directed evolution of artificial enzymes (XNAzymes) from diverse repertoires of synthetic genetic polymers

(2015) Alexander I Taylor et al.   Nature Protocols

Knocking down disease: a progress report on siRNA therapeutics

(2015) Anders Wittrup et al.   NATURE REVIEWS GENETICS

The structural diversity of artificial genetic polymers

(2015) Irina Anosova et al.   NUCLEIC ACIDS RESEARCH

Catalysts from synthetic genetic polymers

(2014) Alexander I. Taylor et al.   NATURE

A cross-chiral RNA polymerase ribozyme

(2014) Jonathan T. Sczepanski et al.   NATURE

Capillary Electrophoresis–Systematic Evolution of Ligands by Exponential Enrichment Selection of Base- and Sugar-Modified DNA Aptamers: Target Binding Dominated by 2′-O,4′-C-Methylene-Bridged/Locked Nucleic Acid Primer

(2013) Yuuya Kasahara et al.   ANALYTICAL CHEMISTRY

Sequence-Controlled Polymers

(2013) J.-F. Lutz et al.   SCIENCE

Chemical fidelity of an RNA polymerase ribozyme

(2013) James Attwater et al.   Chemical Science

An open-label, phase 2 trial of RPI.4610 (angiozyme) in the treatment of metastatic breast cancer

(2012) Phuong Khanh Morrow et al.   CANCER

The Emerging World of Synthetic Genetics

(2012) John C. Chaput et al.   CHEMISTRY & BIOLOGY

Darwinian evolution of an alternative genetic system provides support for TNA as an RNA progenitor

(2012) Hanyang Yu et al.   Nature Chemistry

A short adaptive path from DNA to RNA polymerases

(2012) C. Cozens et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synthetic Genetic Polymers Capable of Heredity and Evolution

(2012) V. B. Pinheiro et al.   SCIENCE

Aptamer-Based Multiplexed Proteomic Technology for Biomarker Discovery

(2011) Larry Gold et al.   PLoS One

Ribozyme-Catalyzed Transcription of an Active Ribozyme

(2011) A. Wochner et al.   SCIENCE

Fabrication of Stable and RNase-Resistant RNA Nanoparticles Active in Gearing the Nanomotors for Viral DNA Packaging

(2010) Jing Liu et al.   ACS Nano

Activation and Deactivation of DNAzyme and Antisense Function with Light for the Photochemical Regulation of Gene Expression in Mammalian Cells

(2010) Douglas D. Young et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The Importance of Being Tyrosine: Lessons in Molecular Recognition from Minimalist Synthetic Binding Proteins

(2009) Shohei Koide et al.   ACS Chemical Biology

Toward Safe Genetically Modified Organisms through the Chemical Diversification of Nucleic Acids

(2009) Piet Herdewijn et al.   CHEMISTRY & BIODIVERSITY

In vivo selection of tumor-targeting RNA motifs

(2009) Jing Mi et al.   Nature Chemical Biology