A biologically stable DNAzyme that efficiently silences gene expression in cells

Patient-Customized Oligonucleotide Therapy for a Rare Genetic Disease

(2019) Jinkuk Kim et al.   NEW ENGLAND JOURNAL OF MEDICINE

Orthogonal Genetic Systems

(2019) John C. Chaput et al.   CHEMBIOCHEM

A densely modified M2+-independent DNAzyme that cleaves RNA efficiently with multiple catalytic turnover

(2018) Yajun Wang et al.   Chemical Science

Absence of Unspecific Innate Immune Cell Activation by GATA-3-Specific DNAzymes

(2018) Tanja Dicke et al.   Nucleic Acid Therapeutics

The chemical evolution of oligonucleotide therapies of clinical utility

(2017) Anastasia Khvorova et al.   NATURE BIOTECHNOLOGY

Evaluating TNA stability under simulated physiological conditions

(2016) Michelle C. Culbertson et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Delivery of therapeutic RNA-cleaving oligodeoxyribonucleotides (deoxyribozymes): from cell culture studies to clinical trials

(2016) Alesya A. Fokina et al.   Expert Opinion on Drug Delivery

Catalytic DNA: Scope, Applications, and Biochemistry of Deoxyribozymes

(2016) Scott K. Silverman   TRENDS IN BIOCHEMICAL SCIENCES

Enzymatic Synthesis of Nucleic Acids with Defined Regioisomeric 2′-5′ Linkages

(2015) Christopher Cozens et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

KRAS as a Therapeutic Target

(2015) F. McCormick   CLINICAL CANCER RESEARCH

DNA enzymes as potential therapeutics: towards clinical application of 10-23 DNAzymes

(2015) Alesya A Fokina et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

The structural diversity of artificial genetic polymers

(2015) Irina Anosova et al.   NUCLEIC ACIDS RESEARCH

An in vivo evaluation of amphiphilic, biodegradable peptide copolymers as siRNA delivery agents

(2014) Stephanie E. Barrett et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Safety and tolerability of an intratumorally injected DNAzyme, Dz13, in patients with nodular basal-cell carcinoma: a phase 1 first-in-human trial (DISCOVER)

(2013) Eun-Ae Cho et al.   LANCET

KRAS mutant allele-specific imbalance is associated with worse prognosis in pancreatic cancer and progression to undifferentiated carcinoma of the pancreas

(2013) Alyssa M Krasinskas et al.   MODERN PATHOLOGY

Therapeutic Evaluation of Epstein-Barr Virus-encoded Latent Membrane Protein-1 Targeted DNAzyme for Treating of Nasopharyngeal Carcinomas

(2013) Ya Cao et al.   MOLECULAR THERAPY

Toward the Combinatorial Selection of Chemically Modified DNAzyme RNase A Mimics Active Against all-RNA Substrates

(2013) Marcel Hollenstein et al.   ACS Combinatorial Science

Targeting Insulin-like Growth Factor I with 10–23 DNAzymes: 2′-O-Methyl Modifications in the Catalytic Core Enhance mRNA Cleavage

(2012) Alesya A. Fokina et al.   BIOCHEMISTRY

Synthetic polymers and their potential as genetic materials

(2012) Vitor B. Pinheiro et al.   BIOESSAYS

The Emerging World of Synthetic Genetics

(2012) John C. Chaput et al.   CHEMISTRY & BIOLOGY

Mutant allele-specific imbalance modulates prognostic impact of KRAS mutations in colorectal adenocarcinoma and is associated with worse overall survival

(2012) D. J. Hartman et al.   INTERNATIONAL JOURNAL OF CANCER

An Overview of Sugar-Modified Oligonucleotides for Antisense Therapeutics

(2011) Thazha P. Prakash   CHEMISTRY & BIODIVERSITY

KRAS mutant allele-specific imbalance in lung adenocarcinoma

(2011) Simion I Chiosea et al.   MODERN PATHOLOGY

Development of Allele-Specific Therapeutic siRNA in Meesmann Epithelial Corneal Dystrophy

(2011) Haihui Liao et al.   PLoS One

Activation and Deactivation of DNAzyme and Antisense Function with Light for the Photochemical Regulation of Gene Expression in Mammalian Cells

(2010) Douglas D. Young et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY