Allele-Specific RNA Knockdown with a Biologically Stable and Catalytically Efficient XNAzyme

A biologically stable DNAzyme that efficiently silences gene expression in cells

(2021) Yajun Wang et al.   Nature Chemistry

Targeting Cavity-Creating p53 Cancer Mutations with Small-Molecule Stabilizers: the Y220X Paradigm

(2020) Matthias R. Bauer et al.   ACS Chemical Biology

Targeting Aberrant RAS/RAF/MEK/ERK Signaling for Cancer Therapy

(2020) Ufuk Degirmenci et al.   Cells

Follow the Mutations: Toward Class-Specific, Small-Molecule Reactivation of p53

(2020) Stewart N. Loh   Biomolecules

KRAS G12V Mutation in Acquired Resistance to Combined BRAF and MEK Inhibition in Papillary Thyroid Cancer

(2019) Dwight H. Owen et al.   Journal of the National Comprehensive Cancer Network

Antisense oligonucleotides: the next frontier for treatment of neurological disorders

(2017) Carlo Rinaldi et al.   Nature Reviews Neurology

Chemistry, mechanism and clinical status of antisense oligonucleotides and duplex RNAs

(2017) Xiulong Shen et al.   NUCLEIC ACIDS RESEARCH

Theranostic DNAzymes

(2017) Wenhu Zhou et al.   Theranostics

Towards personalised allele-specific CRISPR gene editing to treat autosomal dominant disorders

(2017) Kathleen A. Christie et al.   Scientific Reports

Antisense molecules: A new class of drugs

(2016) Daniel P. Potaczek et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Prognostic value of the KRAS G12V mutation in 841 surgically resected Caucasian lung adenocarcinoma cases

(2015) Stéphane Renaud et al.   BRITISH JOURNAL OF CANCER

Application of modified antisense oligonucleotides and siRNAs as antiviral drugs

(2015) Anke Wagner et al.   Future Medicinal Chemistry

Knockdown of Oncogenic KRAS in Non-Small Cell Lung Cancers Suppresses Tumor Growth and Sensitizes Tumor Cells to Targeted Therapy

(2011) N. Sunaga et al.   MOLECULAR CANCER THERAPEUTICS

Development of Allele-Specific Therapeutic siRNA in Meesmann Epithelial Corneal Dystrophy

(2011) Haihui Liao et al.   PLoS One

Targeting the Undruggable Proteome: The Small Molecules of My Dreams

(2010) Craig M. Crews   CHEMISTRY & BIOLOGY