标题
Structures of the ADGRG2–Gs complex in apo and ligand-bound forms
作者
关键词
-
出版物
Nature Chemical Biology
Volume 18, Issue 11, Pages 1196-1203
出版商
Springer Science and Business Media LLC
发表日期
2022-08-19
DOI
10.1038/s41589-022-01084-6
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Autonomous sensing of the insulin peptide by an olfactory G protein-coupled receptor modulates glucose metabolism
- (2022) Jie Cheng et al. Cell Metabolism
- CD97 promotes spleen dendritic cell homeostasis through the mechanosensing of red blood cells
- (2022) Dan Liu et al. SCIENCE
- The tethered peptide activation mechanism of adhesion GPCRs
- (2022) Ximena Barros-Álvarez et al. NATURE
- Structural basis of tethered agonism of the adhesion GPCRs ADGRD1 and ADGRF1
- (2022) Xiangli Qu et al. NATURE
- Tethered peptide activation mechanism of the adhesion GPCRs ADGRG2 and ADGRG4
- (2022) Peng Xiao et al. NATURE
- Structural basis for the tethered peptide activation of adhesion GPCRs
- (2022) Yu-Qi Ping et al. NATURE
- Progesterone activates GPR126 to promote breast cancer development via the Gi pathway
- (2022) Wentao An et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Structures of the glucocorticoid-bound adhesion receptor GPR97–Go complex
- (2021) Yu-Qi Ping et al. NATURE
- Cryo-EM structure of the AVP–vasopressin receptor 2–Gs signaling complex
- (2021) Lei Wang et al. CELL RESEARCH
- Molecular basis of ligand recognition and activation of human V2 vasopressin receptor
- (2021) Fulai Zhou et al. CELL RESEARCH
- RTN4/NoGo-receptor binding to BAI adhesion-GPCRs regulates neuronal development
- (2021) Jie Wang et al. CELL
- Structure, function and pharmacology of human itch receptor complexes
- (2021) Fan Yang et al. NATURE
- Opportunities and challenges for drug discovery in modulating Adhesion G protein-coupled receptor (GPCR) functions
- (2020) Andrey D. Bondarev et al. Expert Opinion on Drug Discovery
- Structural basis of GPBAR activation and bile acid recognition
- (2020) Fan Yang et al. NATURE
- Structural insights into differences in G protein activation by family A and family B GPCRs
- (2020) Daniel Hilger et al. SCIENCE
- Function and therapeutic potential of GPCRs in epididymis
- (2020) Daolai Zhang et al. BRITISH JOURNAL OF PHARMACOLOGY
- Activation of GPR56, a novel adhesion GPCR, is necessary for nuclear androgen receptor signaling in prostate cells
- (2020) Julie Pratibha Singh et al. PLoS One
- Optimization of a peptide ligand for the adhesion GPCR ADGRG2 provides a potent tool to explore receptor biology
- (2020) Yujing Sun et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Spatial regulation of GPR64/ADGRG2 signaling by β‐arrestins and GPCR kinases
- (2019) Pedram Azimzadeh et al. Annals of the New York Academy of Sciences
- Adhesion G protein-coupled receptors: opportunities for drug discovery
- (2019) Frederic Bassilana et al. NATURE REVIEWS DRUG DISCOVERY
- Adhesion G Protein–Coupled Receptors as Drug Targets
- (2018) Ryan H. Purcell et al. Annual Review of Pharmacology and Toxicology
- Gedunin- and Khivorin-Derivatives Are Small-Molecule Partial Agonists for Adhesion G Protein-Coupled Receptors GPR56/ADGRG1 and GPR114/ADGRG5
- (2018) Hannah M. Stoveken et al. MOLECULAR PHARMACOLOGY
- A molecular mechanism for Wnt ligand-specific signaling
- (2018) Marie Eubelen et al. SCIENCE
- Homocysteine directly interacts and activates the angiotensin II type I receptor to aggravate vascular injury
- (2018) Tuoyi Li et al. Nature Communications
- Gq activity- and β-arrestin-1 scaffolding-mediated ADGRG2/CFTR coupling are required for male fertility
- (2018) Dao-Lai Zhang et al. eLife
- Phase-plate cryo-EM structure of a biased agonist-bound human GLP-1 receptor–Gs complex
- (2018) Yi-Lynn Liang et al. NATURE
- New tools for automated high-resolution cryo-EM structure determination in RELION-3
- (2018) Jasenko Zivanov et al. eLife
- Activation of Adhesion G Protein-coupled Receptors
- (2017) Lilian M. Demberg et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy
- (2017) Shawn Q Zheng et al. NATURE METHODS
- Truncating Mutations in the Adhesion G Protein-Coupled Receptor G2 Gene ADGRG2 Cause an X-Linked Congenital Bilateral Absence of Vas Deferens
- (2016) Olivier Patat et al. AMERICAN JOURNAL OF HUMAN GENETICS
- GPCR Dynamics: Structures in Motion
- (2016) Naomi R. Latorraca et al. CHEMICAL REVIEWS
- The prion protein is an agonistic ligand of the G protein-coupled receptor Adgrg6
- (2016) Alexander Küffer et al. NATURE
- The conformational signature of β-arrestin2 predicts its trafficking and signalling functions
- (2016) Mi-Hye Lee et al. NATURE
- Vibratory Urticaria Associated with a Missense Variant in ADGRE2
- (2016) Steven E. Boyden et al. NEW ENGLAND JOURNAL OF MEDICINE
- Identification of the tethered peptide agonist of the adhesion G protein-coupled receptor GPR64/ADGRG2
- (2015) Lilian M. Demberg et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- The Phyre2 web portal for protein modeling, prediction and analysis
- (2015) Lawrence A Kelley et al. Nature Protocols
- CHARMM36 all-atom additive protein force field: Validation based on comparison to NMR data
- (2013) Jing Huang et al. JOURNAL OF COMPUTATIONAL CHEMISTRY
- Genetic variants in GPR126 are associated with adolescent idiopathic scoliosis
- (2013) Ikuyo Kou et al. NATURE GENETICS
- Quantifying the local resolution of cryo-EM density maps
- (2013) Alp Kucukelbir et al. NATURE METHODS
- Polar transmembrane interactions drive formation of ligand-specific and signal pathway-biased family B G protein-coupled receptor conformations
- (2013) D. Wootten et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Signaling property study of adhesion G-protein-coupled receptors
- (2012) Jamila Gupte et al. FEBS LETTERS
- RELION: Implementation of a Bayesian approach to cryo-EM structure determination
- (2012) Sjors H.W. Scheres JOURNAL OF STRUCTURAL BIOLOGY
- The GPS Motif Is a Molecular Switch for Bimodal Activities of Adhesion Class G Protein-Coupled Receptors
- (2012) Simone Prömel et al. Cell Reports
- Crystal structure of the β2 adrenergic receptor–Gs protein complex
- (2011) Søren G. F. Rasmussen et al. NATURE
- PHENIX: a comprehensive Python-based system for macromolecular structure solution
- (2010) Paul D. Adams et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- A common variant of the latrophilin 3 gene, LPHN3, confers susceptibility to ADHD and predicts effectiveness of stimulant medication
- (2010) M Arcos-Burgos et al. MOLECULAR PSYCHIATRY
- Ligand-specific regulation of the extracellular surface of a G-protein-coupled receptor
- (2010) Michael P. Bokoch et al. NATURE
- CHARMM-GUI: A web-based graphical user interface for CHARMM
- (2008) Sunhwan Jo et al. JOURNAL OF COMPUTATIONAL CHEMISTRY
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