Autonomous sensing of the insulin peptide by an olfactory G protein-coupled receptor modulates glucose metabolism

Immune dysfunction in developmental programming of type 2 diabetes mellitus

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TRUPATH, an open-source biosensor platform for interrogating the GPCR transducerome

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The MHC-II peptidome of pancreatic islets identifies key features of autoimmune peptides

(2020) Xiaoxiao Wan et al.   NATURE IMMUNOLOGY

Structural basis of GPBAR activation and bile acid recognition

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Cell-type-specific 3D epigenomes in the developing human cortex

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Interference with pancreatic sympathetic signaling halts the onset of diabetes in mice

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GPR35 promotes glycolysis, proliferation, and oncogenic signaling by engaging with the sodium potassium pump

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OLFR734 Mediates Glucose Metabolism as a Receptor of Asprosin

(2019) Erwei Li et al.   Cell Metabolism

Glucose-Dependent Insulinotropic Polypeptide Receptor-Expressing Cells in the Hypothalamus Regulate Food Intake

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Extracellular transglutaminase 2 induces myotube hypertrophy through G protein-coupled receptor 56

(2019) Tomoya Kitakaze et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Adipsin preserves beta cells in diabetic mice and associates with protection from type 2 diabetes in humans

(2019) Nicolás Gómez-Banoy et al.   NATURE MEDICINE

The role of macrophages in obesity-associated islet inflammation and β-cell abnormalities

(2019) Wei Ying et al.   Nature Reviews Endocrinology

Differential mobility spectrometry followed by tandem mass spectrometry with multiple ion monitoring for bioanalysis of eptifibatide in rat plasma

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Biased signalling: from simple switches to allosteric microprocessors

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Gq activity- and β-arrestin-1 scaffolding-mediated ADGRG2/CFTR coupling are required for male fertility

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Pancreatic islets communicate with lymphoid tissues via exocytosis of insulin peptides

(2018) Xiaoxiao Wan et al.   NATURE

Peptide secretion triggers diabetes

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Allosteric mechanisms underlie GPCR signaling to SH3-domain proteins through arrestin

(2018) Fan Yang et al.   Nature Chemical Biology

Expansion of Islet-Resident Macrophages Leads to Inflammation Affecting β Cell Proliferation and Function in Obesity

(2018) Wei Ying et al.   Cell Metabolism

Therapeutic potential of ectopic olfactory and taste receptors

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Folding mutations suppress early beta-cell proliferation

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Inhibition of mTORC1 by ER stress impairs neonatal β-cell expansion and predisposes to diabetes in the Akita mouse

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A cullin 4B-RING E3 ligase complex fine-tunes pancreatic δ cell paracrine interactions

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Olfactory receptor 544 reduces adiposity by steering fuel preference toward fats

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Islet inflammation in type 2 diabetes and physiology

(2017) Kosei Eguchi et al.   JOURNAL OF CLINICAL INVESTIGATION

Autoimmunity against a defective ribosomal insulin gene product in type 1 diabetes

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Arrestin-biased AT1R agonism induces acute catecholamine secretion through TRPC3 coupling

(2017) Chun-Hua Liu et al.   Nature Communications

The pancreas anatomy conditions the origin and properties of resident macrophages

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PRL-3 Mediates the Protein Maturation of ULBP2 by Regulating the Tyrosine Phosphorylation of HSP60

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TCF1 links GIPR signaling to the control of beta cell function and survival

(2015) Jonathan E Campbell et al.   NATURE MEDICINE

Application of BRET to monitor ligand binding to GPCRs

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The IL-1 Pathway in Type 2 Diabetes and Cardiovascular Complications

(2015) Christian Herder et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Generic GPCR residue numbers – aligning topology maps while minding the gaps

(2015) Vignir Isberg et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Constitutive GαiCoupling Activity of Very Large G Protein-coupled Receptor 1 (VLGR1) and Its Regulation by PDZD7 Protein

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Divergent Transducer-specific Molecular Efficacies Generate Biased Agonism at a G Protein-coupled Receptor (GPCR)

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Regulation of astrocyte activation by glycolipids drives chronic CNS inflammation

(2014) Lior Mayo et al.   NATURE MEDICINE

Pancreas-Specific Cre Driver Lines and Considerations for Their Prudent Use

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Molecular mechanism of ERK dephosphorylation by striatal-enriched protein tyrosine phosphatase

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Adaptive immunity in obesity and insulin resistance

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RNAscope

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Conditional Gene Targeting in Mouse Pancreatic  -Cells: Analysis of Ectopic Cre Transgene Expression in the Brain

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Unique autoreactive T cells recognize insulin peptides generated within the islets of Langerhans in autoimmune diabetes

(2010) James F Mohan et al.   NATURE IMMUNOLOGY

Diabetogenic T cells recognize insulin bound to IAg7 in an unexpected, weakly binding register

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Src-dependent STAT-3-mediated Expression of Monocyte Chemoattractant Protein-1 Is Required for 15(S)-Hydroxyeicosatetraenoic Acid-induced Vascular Smooth Muscle Cell Migration

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