Bidirectional cargo transport: moving beyond tug of war

UV Irradiation Accelerates Amyloid Precursor Protein (APP) Processing and Disrupts APP Axonal Transport

(2014) A. Almenar-Queralt et al.   JOURNAL OF NEUROSCIENCE

Molecular Adaptations Allow Dynein to Generate Large Collective Forces inside Cells

(2013) Arpan K. Rai et al.   CELL

Local Cytoskeletal and Organelle Interactions Impact Molecular-Motor-Driven Early Endosomal Trafficking

(2013) Allison L. Zajac et al.   CURRENT BIOLOGY

Motor Domain Phosphorylation Modulates Kinesin-1 Transport

(2013) Hannah A. DeBerg et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

JIP1 regulates the directionality of APP axonal transport by coordinating kinesin and dynein motors

(2013) Meng-meng Fu et al.   JOURNAL OF CELL BIOLOGY

TRAK/Milton Motor-Adaptor Proteins Steer Mitochondrial Trafficking to Axons and Dendrites

(2013) Myrrhe van Spronsen et al.   NEURON

In vivo optical trapping indicates kinesin’s stall force is reduced by dynein during intracellular transport

(2013) Benjamin H. Blehm et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Teamwork in microtubule motors

(2013) Roop Mallik et al.   TRENDS IN CELL BIOLOGY

Mitochondrial Trafficking in Neurons

(2013) T. L. Schwarz   Cold Spring Harbor Perspectives in Biology

Force-Dependent Detachment of Kinesin-2 Biases Track Switching at Cytoskeletal Filament Intersections

(2012) Harry W. Schroeder et al.   BIOPHYSICAL JOURNAL

Lis1 Acts as a “Clutch” between the ATPase and Microtubule-Binding Domains of the Dynein Motor

(2012) Julie Huang et al.   CELL

She1-Mediated Inhibition of Dynein Motility along Astral Microtubules Promotes Polarized Spindle Movements

(2012) Steven M. Markus et al.   CURRENT BIOLOGY

Autophagosomes initiate distally and mature during transport toward the cell soma in primary neurons

(2012) Sandra Maday et al.   JOURNAL OF CELL BIOLOGY

Lis1 is an initiation factor for dynein-driven organelle transport

(2012) Martin J. Egan et al.   JOURNAL OF CELL BIOLOGY

The axonal transport of mitochondria

(2012) W. M. Saxton et al.   JOURNAL OF CELL SCIENCE

Molecular motor function in axonal transport in vivo probed by genetic and computational analysis in Drosophila

(2012) Gerald F. Reis et al.   MOLECULAR BIOLOGY OF THE CELL

Quantitative optical trapping on single organelles in cell extract

(2012) Pradeep Barak et al.   NATURE METHODS

Dynactin Is Required for Transport Initiation from the Distal Axon

(2012) Armen J. Moughamian et al.   NEURON

Axon injury and stress trigger a microtubule-based neuroprotective pathway

(2012) L. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tug-of-War in Motor Protein Ensembles Revealed with a Programmable DNA Origami Scaffold

(2012) N. D. Derr et al.   SCIENCE

Ndel1-derived peptides modulate bidirectional transport of injected beads in the squid giant axon

(2012) M. Segal et al.   Biology Open

Productive Cooperation among Processive Motors Depends Inversely on Their Mechanochemical Efficiency

(2011) Jonathan W. Driver et al.   BIOPHYSICAL JOURNAL

Stable Kinesin and Dynein Assemblies Drive the Axonal Transport of Mammalian Prion Protein Vesicles

(2011) Sandra E. Encalada et al.   CELL

Arl8 and SKIP Act Together to Link Lysosomes to Kinesin-1

(2011) Cláudia Rosa-Ferreira et al.   DEVELOPMENTAL CELL

Cooperative Responses of Multiple Kinesins to Variable and Constant Loads

(2011) D. Kenneth Jamison et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

High-resolution imaging reveals indirect coordination of opposite motors and a role for LIS1 in high-load axonal transport

(2011) Julie Y. Yi et al.   JOURNAL OF CELL BIOLOGY

Mechanical stochastic tug-of-war models cannot explain bidirectional lipid-droplet transport

(2011) A. Kunwar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Structure of the Kinesin-1 Motor-Tail Complex Reveals the Mechanism of Autoinhibition

(2011) H. Y. K. Kaan et al.   SCIENCE

Bidirectional Transport by Molecular Motors: Enhanced Processivity and Response to External Forces

(2010) Melanie J.I. Müller et al.   BIOPHYSICAL JOURNAL

Two Kinesins Transport Cargo Primarily via the Action of One Motor: Implications for Intracellular Transport

(2010) D. Kenneth Jamison et al.   BIOPHYSICAL JOURNAL

Probing Intracellular Motor Protein Activity Using an Inducible Cargo Trafficking Assay

(2010) Lukas C. Kapitein et al.   BIOPHYSICAL JOURNAL

LIS1 and NudE Induce a Persistent Dynein Force-Producing State

(2010) Richard J. McKenney et al.   CELL

Neck Linker Length Determines the Degree of Processivity in Kinesin-1 and Kinesin-2 Motors

(2010) Shankar Shastry et al.   CURRENT BIOLOGY

Motor Coordination via a Tug-of-War Mechanism Drives Bidirectional Vesicle Transport

(2010) Adam G. Hendricks et al.   CURRENT BIOLOGY

Autoinhibition of the kinesin-2 motor KIF17 via dual intramolecular mechanisms

(2010) Jennetta W. Hammond et al.   JOURNAL OF CELL BIOLOGY

Functional interplay between LIS1, NDE1 and NDEL1 in dynein-dependent organelle positioning

(2010) C. Lam et al.   JOURNAL OF CELL SCIENCE

Global Up-Regulation of Microtubule Dynamics and Polarity Reversal during Regeneration of an Axon from a Dendrite

(2010) Michelle C. Stone et al.   MOLECULAR BIOLOGY OF THE CELL

Huntingtin coordinates the dynein-mediated dynamic positioning of endosomes and lysosomes

(2010) Juliane P. Caviston et al.   MOLECULAR BIOLOGY OF THE CELL

Molecular Motors in Neurons: Transport Mechanisms and Roles in Brain Function, Development, and Disease

(2010) Nobutaka Hirokawa et al.   NEURON

Coupling between motor proteins determines dynamic behaviors of motor protein assemblies

(2010) Jonathan W. Driver et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Deficits in axonal transport precede ALS symptoms in vivo

(2010) L. G. Bilsland et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fat on the move: intracellular motion of lipid droplets: Figure 1

(2009) Michael A. Welte   BIOCHEMICAL SOCIETY TRANSACTIONS

An end to 40 years of mistakes in DNA–protein association kinetics?

(2009) Stephen E. Halford   BIOCHEMICAL SOCIETY TRANSACTIONS

The Mechanism of Ca2+-Dependent Regulation of Kinesin-Mediated Mitochondrial Motility

(2009) Xinnan Wang et al.   CELL

The diffusive interaction of microtubule binding proteins

(2009) Jeremy R Cooper et al.   CURRENT OPINION IN CELL BIOLOGY

Kinesin-1 Regulates Microtubule Dynamics via a c-Jun N-terminal Kinase-dependent Mechanism

(2009) Vanessa Daire et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The mechanochemistry of integrated motor protein complexes

(2009) Pamela E. Constantinou et al.   JOURNAL OF BIOMECHANICS

Opposite-polarity motors activate one another to trigger cargo transport in live cells

(2009) Shabeen Ally et al.   JOURNAL OF CELL BIOLOGY

A Switch in Retrograde Signaling from Survival to Stress in Rapid-Onset Neurodegeneration

(2009) E. Perlson et al.   JOURNAL OF NEUROSCIENCE

Tight Functional Coupling of Kinesin-1A and Dynein Motors in the Bidirectional Transport of Neurofilaments

(2009) Atsuko Uchida et al.   MOLECULAR BIOLOGY OF THE CELL

Pathogenic huntingtin inhibits fast axonal transport by activating JNK3 and phosphorylating kinesin

(2009) Gerardo A Morfini et al.   NATURE NEUROSCIENCE

Kinesin superfamily motor proteins and intracellular transport

(2009) Nobutaka Hirokawa et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Regulators of the cytoplasmic dynein motor

(2009) Julia R. Kardon et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Catalysis of the microtubule on-rate is the major parameter regulating the depolymerase activity of MCAK

(2009) Jeremy R Cooper et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Miro1 Is a Calcium Sensor for Glutamate Receptor-Dependent Localization of Mitochondria at Synapses

(2009) Andrew F. MacAskill et al.   NEURON

Negative interference dominates collective transport of kinesin motors in the absence of load

(2009) Arthur R. Rogers et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Tug-of-war between dissimilar teams of microtubule motors regulates transport and fission of endosomes

(2009) V. Soppina et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Diffusive Movement of Processive Kinesin-1 on Microtubules

(2009) Hailong Lu et al.   TRAFFIC

Huntingtin as an essential integrator of intracellular vesicular trafficking

(2009) Juliane P. Caviston et al.   TRENDS IN CELL BIOLOGY

Mammalian Kinesin-3 Motors Are Dimeric In Vivo and Move by Processive Motility upon Release of Autoinhibition

(2009) Jennetta W Hammond et al.   PLOS BIOLOGY

Single Molecule Imaging Reveals Differences in Microtubule Track Selection Between Kinesin Motors

(2009) Dawen Cai et al.   PLOS BIOLOGY

Strong Inference for Systems Biology

(2009) Daniel A. Beard et al.   PLoS Computational Biology

Role of Axonal Transport in Neurodegenerative Diseases

(2008) Kurt J. De Vos et al.   Annual Review of Neuroscience

Consequences of Motor Copy Number on the Intracellular Transport of Kinesin-1-Driven Lipid Droplets

(2008) George T. Shubeita et al.   CELL

Stepping, Strain Gating, and an Unexpected Force-Velocity Curve for Multiple-Motor-Based Transport

(2008) Ambarish Kunwar et al.   CURRENT BIOLOGY

Cargo transport: molecular motors navigate a complex cytoskeleton

(2008) Jennifer L Ross et al.   CURRENT OPINION IN CELL BIOLOGY

Huntingtin phosphorylation acts as a molecular switch for anterograde/retrograde transport in neurons

(2008) Emilie Colin et al.   EMBO JOURNAL

Regulatory ATPase Sites of Cytoplasmic Dynein Affect Processivity and Force Generation

(2008) Carol Cho et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Microtubule cross-linking triggers the directional motility of kinesin-5

(2008) Lukas C. Kapitein et al.   JOURNAL OF CELL BIOLOGY

Retrograde axonal transport and motor neuron disease

(2008) Anna-Lena Strm et al.   JOURNAL OF NEUROCHEMISTRY

Phosphorylation Relieves Autoinhibition of the Kinetochore Motor Cenp-E

(2008) Julien Espeut et al.   MOLECULAR CELL

Myosin V and Kinesin act as tethers to enhance each others' processivity

(2008) M. Y. Ali et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tug-of-war as a cooperative mechanism for bidirectional cargo transport by molecular motors

(2008) M. J. I. Muller et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differential Regulation of Dynein and Kinesin Motor Proteins by Tau

(2008) R. Dixit et al.   SCIENCE

Identification of an Axonal Kinesin-3 Motor for Fast Anterograde Vesicle Transport that Facilitates Retrograde Transport of Neuropeptides

(2007) Rosemarie V. Barkus et al.   MOLECULAR BIOLOGY OF THE CELL