Cargo adaptors regulate stepping and force generation of mammalian dynein–dynactin

Directionality of dynein is controlled by the angle and length of its stalk

(2019) Sinan Can et al.   NATURE

The cytoplasmic dynein transport machinery and its many cargoes

(2018) Samara L. Reck-Peterson et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cryo-electron tomography reveals that dynactin recruits a team of dyneins for processive motility

(2018) Danielle A. Grotjahn et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Cryo-electron tomography reveals that dynactin recruits a team of dyneins for processive motility

(2018) Danielle A. Grotjahn et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Cryo-EM shows how dynactin recruits two dyneins for faster movement

(2018) Linas Urnavicius et al.   NATURE

Intraflagellar transport dynein is autoinhibited by trapping of its mechanical and track-binding elements

(2017) Katerina Toropova et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Intraflagellar transport dynein is autoinhibited by trapping of its mechanical and track-binding elements

(2017) Katerina Toropova et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Dynein Clusters into Lipid Microdomains on Phagosomes to Drive Rapid Transport toward Lysosomes

(2016) Ashim Rai et al.   CELL

Cargo rigidity affects the sensitivity of dynein ensembles to individual motor pausing

(2016) Amalia R. Driller-Colangelo et al.   Cytoskeleton

The mammalian dynein–dynactin complex is a strong opponent to kinesin in a tug-of-war competition

(2016) Vladislav Belyy et al.   NATURE CELL BIOLOGY

Structural organization of the dynein–dynactin complex bound to microtubules

(2015) Saikat Chowdhury et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Cytoplasmic dynein regulates its attachment to microtubules via nucleotide state-switched mechanosensing at multiple AAA domains

(2015) Matthew P. Nicholas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The structure of the dynactin complex and its interaction with dynein

(2015) L. Urnavicius et al.   SCIENCE

Control of cytoplasmic dynein force production and processivity by its C-terminal domain

(2015) Matthew P. Nicholas et al.   Nature Communications

Structural organization of the dynein–dynactin complex bound to microtubules

(2015) Saikat Chowdhury et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Kinesin’s Front Head Is Gated by the Backward Orientation of Its Neck Linker

(2015) Merve Yusra Dogan et al.   Cell Reports

Impact-Free Measurement of Microtubule Rotations on Kinesin and Cytoplasmic-Dynein Coated Surfaces

(2015) Aniruddha Mitra et al.   PLoS One

In vitroreconstitution of a highly processive recombinant human dynein complex

(2014) Max A Schlager et al.   EMBO JOURNAL

Autoinhibition and cooperative activation mechanisms of cytoplasmic dynein

(2014) Takayuki Torisawa et al.   NATURE CELL BIOLOGY

Reconstitution of a hierarchical +TIP interaction network controlling microtubule end tracking of dynein

(2014) Christian Duellberg et al.   NATURE CELL BIOLOGY

The AAA3 domain of cytoplasmic dynein acts as a switch to facilitate microtubule release

(2014) Mark A DeWitt et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Activation of cytoplasmic dynein motility by dynactin-cargo adapter complexes

(2014) R. J. McKenney et al.   SCIENCE

Cytoplasmic dynein transports cargos via load-sharing between the heads

(2014) Vladislav Belyy et al.   Nature Communications

Tension on the linker gates the ATP-dependent release of dynein from microtubules

(2014) Frank B. Cleary et al.   Nature Communications

Bicaudal D Family Adaptor Proteins Control the Velocity of Dynein-Based Movements

(2014) Max A. Schlager et al.   Cell Reports

Bidirectional helical motility of cytoplasmic dynein around microtubules

(2014) Sinan Can et al.   eLife

Molecular Adaptations Allow Dynein to Generate Large Collective Forces inside Cells

(2013) Arpan K. Rai et al.   CELL

Functions and mechanics of dynein motor proteins

(2013) Anthony J. Roberts et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Collective Dynamics of Elastically Coupled Myosin V Motors

(2012) Hailong Lu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

BICD2, dynactin, and LIS1 cooperate in regulating dynein recruitment to cellular structures

(2012) Daniël Splinter et al.   MOLECULAR BIOLOGY OF THE CELL

The 2.8 Å crystal structure of the dynein motor domain

(2012) Takahide Kon et al.   NATURE

Insights into dynein motor domain function from a 3.3-Å crystal structure

(2012) Helgo Schmidt et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Dynactin Is Required for Transport Initiation from the Distal Axon

(2012) Armen J. Moughamian et al.   NEURON

Measuring collective transport by defined numbers of processive and nonprocessive kinesin motors

(2012) K. Furuta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reconstitution of the human cytoplasmic dynein complex

(2012) M. Trokter et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tug-of-War in Motor Protein Ensembles Revealed with a Programmable DNA Origami Scaffold

(2012) N. D. Derr et al.   SCIENCE

Cooperative Responses of Multiple Kinesins to Variable and Constant Loads

(2011) D. Kenneth Jamison et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal Structure of the Dynein Motor Domain

(2011) A. P. Carter et al.   SCIENCE

Cytoplasmic Dynein Moves Through Uncoordinated Stepping of the AAA+ Ring Domains

(2011) M. A. DeWitt et al.   SCIENCE

LIS1 and NudE Induce a Persistent Dynein Force-Producing State

(2010) Richard J. McKenney et al.   CELL

Tug-of-war between dissimilar teams of microtubule motors regulates transport and fission of endosomes

(2009) V. Soppina et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Consequences of Motor Copy Number on the Intracellular Transport of Kinesin-1-Driven Lipid Droplets

(2008) George T. Shubeita et al.   CELL