Seaweeds in the Oncology Arena: Anti-Cancer Potential of Fucoidan as a Drug—A Review

Metabolite profiling of a Sargassum micracanthum methanol extract with in vitro efficacy against human head and neck squamous cell carcinoma aggressiveness

(2022) Min-Hye Ahn et al.   ARCHIVES OF ORAL BIOLOGY

Comparison of human peripheral blood dendritic cell activation by four fucoidans

(2021) Wei Zhang et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

The Therapeutic Potential of the Anticancer Activity of Fucoidan: Current Advances and Hurdles

(2021) Jun-O. Jin et al.   Marine Drugs

Therapeutic Potential of Algal Nanoparticles: A brief review

(2021) Pallavi Singh Chauhan et al.   COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING

Ecklonia cava fucoidan has potential to stimulate natural killer cells in vivo

(2021) Wei Zhang et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Cytotoxicity and growth-inhibiting activity of Astragalus polysaccharides against breast cancer via the regulation of EGFR and ANXA1

(2021) Wenfang Li et al.   Journal of Natural Medicines

The anti-cancer effects of fucoidan: a review of both in vivo and in vitro investigations

(2020) Yuan Lin et al.   Cancer Cell International

Dendritic cell-mediated cancer immunotherapy with Ecklonia cava fucoidan

(2020) Hae-Bin Park et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Algae-Derived Bioactive Compounds with Anti-Lung Cancer Potential

(2020) Imen Saadaoui et al.   Marine Drugs

Fucoidan Induces Apoptosis and Inhibits Proliferation of Hepatocellular Carcinoma via the p38 MAPK/ERK and PI3K/Akt Signal Pathways

(2020) Yifei Duan et al.   Cancer Management and Research

Protective effects of sulfated polysaccharides isolated from the enzymatic digest of Codium fragile against hydrogen peroxide-induced oxidative stress in in vitro and in vivo models

(2020) Lei Wang et al.   Algal Research-Biomass Biofuels and Bioproducts

Fucoidan from Fucus vesiculosus attenuates doxorubicin-induced acute cardiotoxicity by regulating JAK2/STAT3-mediated apoptosis and autophagy

(2020) Jie Zhang et al.   BIOMEDICINE & PHARMACOTHERAPY

Heparanase and the hallmarks of cancer

(2020) Krishnath M. Jayatilleke et al.   Journal of Translational Medicine

Polysaccharide from Codium fragile Induces Anti-Cancer Immunity by Activating Natural Killer Cells

(2020) Hae-Bin Park et al.   Marine Drugs

Marine Anticancer Agents: An Overview with a Particular Focus on Their Chemical Classes

(2020) Marilia Barreca et al.   Marine Drugs

Activation of Human Dendritic Cells by Ascophyllan Purified from Ascophyllum nodosum

(2019) Wei Zhang et al.   Marine Drugs

Ascophyllan Induces Activation of Natural Killer Cells in Mice In Vivo and In Vitro

(2019) Wei Zhang et al.   Marine Drugs

Dietary Supplementation with Low-Molecular-Weight Fucoidan Enhances Innate and Adaptive Immune Responses and Protects against Mycoplasma pneumoniae Antigen Stimulation

(2019) Pai-An Hwang et al.   Marine Drugs

A convergent total synthesis of the kedarcidin chromophore: 20-years in the making

(2019) Martin J. Lear et al.   JOURNAL OF ANTIBIOTICS

Anti-tumor potential of astragalus polysaccharides on breast cancer cell line mediated by macrophage activation

(2019) Wenfang Li et al.   Materials Science & Engineering C-Materials for Biological Applications

A marine-sourced fucoidan solution inhibits Toll-like-receptor-3-induced cytokine release by human bronchial epithelial cells

(2019) M. Dutot et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Comparison of the Effects of Fucoidans on the Cell Viability of Tumor and Non-Tumor Cell Lines

(2019) Bittkau et al.   Marine Drugs

Prebiotics from Seaweeds: An Ocean of Opportunity?

(2019) Paul Cherry et al.   Marine Drugs

CD4+ T cells indirectly kill tumor cells via induction of cytotoxic macrophages in mouse models

(2019) Bjarne Bogen et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Therapeutic Effects of Fucoidan: A Review on Recent Studies

(2019) Sibusiso Luthuli et al.   Marine Drugs

Characterization and anti-tumor bioactivity of astragalus polysaccharides by immunomodulation

(2019) Wenfang Li et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

In vitro anticancer activity of fucoidan extracted from Sargassum cinereum against Caco-2 cells

(2019) S. Sivasankara Narayani et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

“Fucoidan, a natural biopolymer in cancer combating: From edible algae to nanocarrier tailoring”

(2019) Samar M. Etman et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Therapies from Fucoidan: New Developments

(2019) Fitton et al.   Marine Drugs

Astragalus polysaccharides (PG2) Enhances the M1 Polarization of Macrophages, Functional Maturation of Dendritic Cells, and T Cell-Mediated Anticancer Immune Responses in Patients with Lung Cancer

(2019) Oluwaseun Adebayo Bamodu et al.   Nutrients

Enriching cancer pharmacology with drugs of marine origin

(2019) Paula C. Jimenez et al.   BRITISH JOURNAL OF PHARMACOLOGY

Marine Pharmacology in 2014–2015: Marine Compounds with Antibacterial, Antidiabetic, Antifungal, Anti-Inflammatory, Antiprotozoal, Antituberculosis, Antiviral, and Anthelmintic Activities; Affecting the Immune and Nervous Systems, and Other Miscellaneous Mechanisms of Action

(2019) Alejandro M. S. Mayer et al.   Marine Drugs

The Pharmacokinetics of Fucoidan after Topical Application to Rats

(2019) Olga N. Pozharitskaya et al.   Marine Drugs

Marine Seaweed Polysaccharides-Based Engineered Cues for the Modern Biomedical Sector

(2019) Bilal et al.   Marine Drugs

Astragalus polysaccharide enhanced antitumor effects of Apatinib in gastric cancer AGS cells by inhibiting AKT signalling pathway

(2018) Jun Wu et al.   BIOMEDICINE & PHARMACOTHERAPY

Fucoidan upregulates TLR4/CHOP-mediated caspase-3 and PARP activation to enhance cisplatin-induced cytotoxicity in human lung cancer cells

(2018) Hsien-Yeh Hsu et al.   CANCER LETTERS

Pharmacokinetic and Tissue Distribution of Fucoidan from Fucus vesiculosus after Oral Administration to Rats

(2018) Olga Pozharitskaya et al.   Marine Drugs

Marine natural products

(2018) John W. Blunt et al.   NATURAL PRODUCT REPORTS

Animal Toxins as Therapeutic Tools to Treat Neurodegenerative Diseases

(2018) Jessica M. de Souza et al.   Frontiers in Pharmacology

Improved chemotherapy against breast cancer through immunotherapeutic activity of fucoidan decorated electrostatically assembled nanoparticles bearing doxorubicin

(2018) Vivek K. Pawar et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Radiosensitizing effect of the fucoidan from brown alga Fucus evanescens and its derivative in human cancer cells

(2018) O.S. Malyarenko et al.   CARBOHYDRATE POLYMERS

Evaluation Fucoidan Extracts From Undaria pinnatifida and Fucus vesiculosus in Combination With Anticancer Drugs in Human Cancer Orthotopic Mouse Models

(2017) Maryam Burney et al.   INTEGRATIVE CANCER THERAPIES

Characterization and Potential Antitumor Activity of Polysaccharide from Gracilariopsis lemaneiformis

(2017) Yani Kang et al.   Marine Drugs

Tuberatolide B Suppresses Cancer Progression by Promoting ROS-Mediated Inhibition of STAT3 Signaling

(2017) Youn Choi et al.   Marine Drugs

Efficacy of Low-Molecular-Weight Fucoidan as a Supplemental Therapy in Metastatic Colorectal Cancer Patients: A Double-Blind Randomized Controlled Trial

(2017) Hsiang-Lin Tsai et al.   Marine Drugs

Current Status and Future Prospects of Marine Natural Products (MNPs) as Antimicrobials

(2017) Alka Choudhary et al.   Marine Drugs

Extraction of a Novel Cold-Water-Soluble Polysaccharide from Astragalus membranaceus and Its Antitumor and Immunological Activities

(2017) An-jun Liu et al.   MOLECULES

An Updated Review on Marine Anticancer Compounds: The Use of Virtual Screening for the Discovery of Small-Molecule Cancer Drugs

(2017) Verónica Ruiz-Torres et al.   MOLECULES

Laminarin promotes anti-cancer immunity by the maturation of dendritic cells

(2017) Kyeongeun Song et al.   Oncotarget

Marine-Derived Pharmaceuticals - Challenges and Opportunities

(2016) Ulrike Lindequist   Biomolecules & Therapeutics

Marine Sponges as a Drug Treasure

(2016) Komal Anjum et al.   Biomolecules & Therapeutics

Heparanase: a rainbow pharmacological target associated to multiple pathologies including rare diseases

(2016) Silvia Rivara et al.   Future Medicinal Chemistry

The Effect of Undaria pinnatifida Fucoidan on the Pharmacokinetics of Letrozole and Tamoxifen in Patients With Breast Cancer

(2016) Shreya Tocaciu et al.   INTEGRATIVE CANCER THERAPIES

Preclinical Evaluation of Safety of Fucoidan Extracts From Undaria pinnatifida and Fucus vesiculosus for Use in Cancer Treatment

(2016) Lata Mathew et al.   INTEGRATIVE CANCER THERAPIES

Cytotoxic effect of fucoidan extracted from Sargassum cinereum on colon cancer cell line HCT-15

(2016) Sivasankara Narayani Somasundaram et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Enhanced anti-inflammatory activity of brown seaweed Laminaria japonica by fermentation using Bacillus subtilis

(2016) Hong-Ting Victor Lin et al.   PROCESS BIOCHEMISTRY

Ascophyllan functions as an adjuvant to promote anti-cancer effect by dendritic cell activation

(2016) Wei Zhang et al.   Oncotarget

Anti-metastatic effects of the sulfated polysaccharide ascophyllan isolated from Ascophyllum nodosum on B16 melanoma

(2015) Ryogo Abu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

MicroRNA-29c Correlates with Neuroprotection Induced by FNS by Targeting Both Birc2 and Bak1 in Rat Brain after Stroke

(2015) Li-Gang Huang et al.   CNS Neuroscience & Therapeutics

Prophylactic Administration of Fucoidan Represses Cancer Metastasis by Inhibiting Vascular Endothelial Growth Factor (VEGF) and Matrix Metalloproteinases (MMPs) in Lewis Tumor-Bearing Mice

(2015) Tse-Hung Huang et al.   Marine Drugs

Molecular Mechanisms by Which a Fucus vesiculosus Extract Mediates Cell Cycle Inhibition and Cell Death in Pancreatic Cancer Cells

(2015) Ulf Geisen et al.   Marine Drugs

Seaweed Polysaccharides (Laminarin and Fucoidan) as Functional Ingredients in Pork Meat: An Evaluation of Anti-Oxidative Potential, Thermal Stability and Bioaccessibility

(2015) Natasha Moroney et al.   Marine Drugs

Emerging Concepts Promising New Horizons for Marine Biodiscovery and Synthetic Biology

(2015) F. Reen et al.   Marine Drugs

Fucoidan Suppresses Hypoxia-Induced Lymphangiogenesis and Lymphatic Metastasis in Mouse Hepatocarcinoma

(2015) Hongming Teng et al.   Marine Drugs

Fucoidan Elevates MicroRNA-29b to Regulate DNMT3B-MTSS1 Axis and Inhibit EMT in Human Hepatocellular Carcinoma Cells

(2015) Ming-De Yan et al.   Marine Drugs

Fucoidan and Cancer: A Multifunctional Molecule with Anti-Tumor Potential

(2015) Farzaneh Atashrazm et al.   Marine Drugs

Recent Advances and Applications of Experimental Technologies in Marine Natural Product Research

(2015) Ke Li et al.   Marine Drugs

Cross-talk between signaling pathways: The link between plant secondary metabolite production and wounding stress response

(2015) Daniel A. Jacobo-Velázquez et al.   Scientific Reports

Corals and Their Potential Applications to Integrative Medicine

(2014) Edwin L. Cooper et al.   Evidence-based Complementary and Alternative Medicine

Fucoidans: Pro- or antiangiogenic agents?

(2014) N. E. Ustyuzhanina et al.   GLYCOBIOLOGY

Maturation of mouse bone marrow dendritic cells (BMDCs) induced by Laminaria japonica polysaccharides (LJP)

(2014) Jingjuan Meng et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Dieckol, isolated from the edible brown algae Ecklonia cava, induces apoptosis of ovarian cancer cells and inhibits tumor xenograft growth

(2014) Ji-Hye Ahn et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Fucoidan, a major component of brown seaweed, prohibits the growth of human cancer cell lines in vitro

(2014) Suguru Fukahori et al.   Molecular Medicine Reports

Anti-proliferative and angio-suppressive effect ofStoechospermum marginatum(C. Agardh) Kutzing extract using various experimental models

(2014) Rashmi Vinayak et al.   Nutrition Research and Practice

AstragalusPolysaccharide Suppresses Doxorubicin-Induced Cardiotoxicity by Regulating the PI3k/Akt and p38MAPK Pathways

(2014) Yuan Cao et al.   Oxidative Medicine and Cellular Longevity

Exploring Marine Resources for Bioactive Compounds

(2014) Paula Kiuru et al.   PLANTA MEDICA

Toxins and drug discovery

(2014) Alan L. Harvey   TOXICON

Dendritic Cell-Targeted Vaccines

(2014) Lillian Cohn et al.   Frontiers in Immunology

The Role of Heparanase and Sulfatases in the Modification of Heparan Sulfate Proteoglycans within the Tumor Microenvironment and Opportunities for Novel Cancer Therapeutics

(2014) Edward Hammond et al.   Frontiers in Oncology

Clinical Application of Drug Delivery Systems in Cancer Chemotherapy: Review of the Efficacy and Side Effects of Approved Drugs

(2013) Takuya Iwamoto   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Doxorubicin loading fucoidan acetate nanoparticles for immune and chemotherapy in cancer treatment

(2013) Kun Woo Lee et al.   CARBOHYDRATE POLYMERS

Structure, enzymatic transformation and anticancer activity of branched high molecular weight laminaran from brown alga Eisenia bicyclis

(2013) Roza V. Menshova et al.   CARBOHYDRATE POLYMERS

Antitumor and immunomodulatory activity of Astragalus membranaceus polysaccharides in H22 tumor-bearing mice

(2013) Bin Yang et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Fucoidan induces G1 phase arrest and apoptosis through caspases-dependent pathway and ROS induction in human breast cancer MCF-7 cells

(2013) Amal M. Banafa et al.   Journal of Huazhong University of Science and Technology-Medical Sciences

Anticancer and Cancer Preventive Properties of Marine Polysaccharides: Some Results and Prospects

(2013) Sergey Fedorov et al.   Marine Drugs

Fucoidan Derived from Undaria pinnatifida Induces Apoptosis in Human Hepatocellular Carcinoma SMMC-7721 Cells via the ROS-Mediated Mitochondrial Pathway

(2013) Lili Yang et al.   Marine Drugs

Structural Characteristics and Anticancer Activity of Fucoidan from the Brown Alga Sargassum mcclurei

(2013) Pham Thinh et al.   Marine Drugs

Marine-Derived Angiogenesis Inhibitors for Cancer Therapy

(2013) Ying-Qing Wang et al.   Marine Drugs

Fucoxanthin: A Marine Carotenoid Exerting Anti-Cancer Effects by Affecting Multiple Mechanisms

(2013) Sangeetha Kumar et al.   Marine Drugs

Boundary lines in symbiosis forms

(2013) Eric Parmentier et al.   SYMBIOSIS

Fucoidans from brown seaweeds: an update on structures, extraction techniques and use of enzymes as tools for structural elucidation

(2013) Marcel Tutor Ale et al.   RSC Advances

Antioxidant, Antiproliferative, and Antiangiogenesis Effects of Polyphenol-Rich Seaweed (Sargassum muticum)

(2013) Farideh Namvar et al.   Biomed Research International

Immunostimulatory Activities of the Sulfated Polysaccharide Ascophyllan fromAscophyllum nodosuminin Vivoandin VitroSystems

(2012) Kiyoaki NAKANO et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Anticancer polysaccharides from natural resources: A review of recent research

(2012) Aizhen Zong et al.   CARBOHYDRATE POLYMERS

Stabilization of mitochondrial and microsomal function of fucoidan from Sargassum plagiophyllum in diethylnitrosamine induced hepatocarcinogenesis

(2012) Veeraperumal Suresh et al.   CARBOHYDRATE POLYMERS

Fucoidan induces changes in the epithelial to mesenchymal transition and decreases metastasis by enhancing ubiquitin-dependent TGF  receptor degradation in breast cancer

(2012) H.-Y. Hsu et al.   CARCINOGENESIS

Lessons from the Past and Charting the Future of Marine Natural Products Drug Discovery and Chemical Biology

(2012) William H. Gerwick et al.   CHEMISTRY & BIOLOGY

In vitro antioxidant properties of crude extracts and compounds from brown algae

(2012) Elena M. Balboa et al.   FOOD CHEMISTRY

Effects of Oral Administration of Fucoidan Extracted from Cladosiphon okamuranus on Tumor Growth and Survival Time in a Tumor-Bearing Mouse Model

(2012) Kazuo Azuma et al.   Marine Drugs

Polysaccharides composition from tropical brown seaweeds

(2012) Virginia García-Ríos et al.   PHYCOLOGICAL RESEARCH

Fucoidan extract derived from Undaria pinnatifida inhibits angiogenesis by human umbilical vein endothelial cells

(2012) Fang Liu et al.   PHYTOMEDICINE

Fucoidan from Seaweed Fucus vesiculosus Inhibits Migration and Invasion of Human Lung Cancer Cell via PI3K-Akt-mTOR Pathways

(2012) Hyunkyoung Lee et al.   PLoS One

Cancer as Multifaceted Disease

(2012) A. Friedman   Mathematical Modelling of Natural Phenomena

Water-soluble polysaccharides from the brown alga Eisenia bicyclis: Structural characteristics and antitumor activity

(2012) Svetlana Ermakova et al.   Algal Research-Biomass Biofuels and Bioproducts

Antitumor and immunomodulatory activity of polysaccharides from Sargassum fusiforme

(2011) Xiaoming Chen et al.   FOOD AND CHEMICAL TOXICOLOGY

Antioxidant effects of fermented sea tangle (Laminaria japonica) by Lactobacillus brevis BJ20 in individuals with high level of γ-GT: A randomized, double-blind, and placebo-controlled clinical study

(2011) Young Mi Kang et al.   FOOD AND CHEMICAL TOXICOLOGY

Marine natural products: a new wave of drugs?

(2011) Rana Montaser et al.   Future Medicinal Chemistry

Fucoidan from Sargassum sp. and Fucus vesiculosus reduces cell viability of lung carcinoma and melanoma cells in vitro and activates natural killer cells in mice in vivo

(2011) Marcel Tutor Ale et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Antiproliferative Activity of Fucoidan Was Associated with the Induction of Apoptosis and Autophagy in AGS Human Gastric Cancer Cells

(2011) Hyun Soo Park et al.   JOURNAL OF FOOD SCIENCE

Radiolabeled Fucoidan as a P-Selectin Targeting Agent for In Vivo Imaging of Platelet-Rich Thrombus and Endothelial Activation

(2011) F. Rouzet et al.   JOURNAL OF NUCLEAR MEDICINE

Heterofucan from Sargassum filipendula Induces Apoptosis in HeLa Cells

(2011) Leandro Silva Costa et al.   Marine Drugs

Fucose-Containing Sulfated Polysaccharides from Brown Seaweeds Inhibit Proliferation of Melanoma Cells and Induce Apoptosis by Activation of Caspase-3 in Vitro

(2011) Marcel Tutor Ale et al.   Marine Drugs

Fucoxanthin, a Marine Carotenoid Present in Brown Seaweeds and Diatoms: Metabolism and Bioactivities Relevant to Human Health

(2011) Juan Peng et al.   Marine Drugs

Chemical Structures and Bioactivities of Sulfated Polysaccharides from Marine Algae

(2011) Guangling Jiao et al.   Marine Drugs

Fucoidan from Undaria pinnatifida Induces Apoptosis in A549 Human Lung Carcinoma Cells

(2011) Hye-Jin Boo et al.   PHYTOTHERAPY RESEARCH

Fucoidan reduces the toxicities of chemotherapy for patients with unresectable advanced or recurrent colorectal cancer

(2011) MASAHIDE IKEGUCHI et al.   Oncology Letters

Development of a Fucoidan-Specific Antibody and Measurement of Fucoidan in Serum and Urine by Sandwich ELISA

(2010) Yoshiharu TOKITA et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Fucoidan present in brown algae induces apoptosis of human colon cancer cells

(2010) Eun Ji Kim et al.   BMC GASTROENTEROLOGY

A potent antitumor polysaccharide from the edible brown seaweed Hydroclathrus clathratus

(2010) Hui Wang et al.   BOTANICA MARINA

Pharmaceuticals from marine natural products: surge or ebb?

(2010) Russell T Hill et al.   CURRENT OPINION IN BIOTECHNOLOGY

Structural characterization of laminaran and galactofucan extracted from the brown seaweed Saccharina longicruris

(2010) Laurie-Eve Rioux et al.   PHYTOCHEMISTRY

Bioactive Compounds from Marine Bacteria and Fungi

(2010) Abdessamad Debbab et al.   Microbial Biotechnology

Apoptosis in cancer: Key molecular signaling pathways and therapy targets

(2009) Claudia Burz et al.   ACTA ONCOLOGICA

Apoptosis Inducing Activity of Fucoidan in HCT-15 Colon Carcinoma Cells

(2009) Jae-Hee Hyun et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Biological Activities of Fucose-Containing Polysaccharide Ascophyllan Isolated from the Brown AlgaAscophyllum nodosum

(2009) Seiichirou NAKAYASU et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

mTOR mediates human trophoblast invasion through regulation of matrix-remodeling enzymes and is associated with serine phosphorylation of STAT3

(2009) Susann Busch et al.   EXPERIMENTAL CELL RESEARCH

In vitro cancer chemopreventive properties of polysaccharide extract from the brown alga, Sargassum latifolium

(2009) Amira M. Gamal-Eldeen et al.   FOOD AND CHEMICAL TOXICOLOGY

Fucoidan Induces Apoptosis through Activation of Caspase-8 on Human Breast Cancer MCF-7 Cells

(2009) Yumi Yamasaki-Miyamoto et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Effects of Astragalus polysaccharide on the erythroid lineage and microarray analysis in K562 cells

(2009) Min Yang et al.   JOURNAL OF ETHNOPHARMACOLOGY

Inhibitory Effect of Fucoidan on Huh7 Hepatoma Cells Through Downregulation of CXCL12

(2009) Takeaki Nagamine et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

A 4-week repeated oral dose toxicity study of fucoidan from the Sporophyll of Undaria pinnatifida in Sprague–Dawley rats

(2009) Kui-Jin Kim et al.   TOXICOLOGY

Affinity of low molecular weight fucoidan for P-selectin triggers its binding to activated human platelets

(2008) Laure Bachelet et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Structure, biological activity, and enzymatic transformation of fucoidans from the brown seaweeds

(2008) Mikhail Kusaykin et al.   Biotechnology Journal

Signal cross talks for sustained MAPK activation and cell migration: the potential role of reactive oxygen species

(2008) Wen-Sheng Wu et al.   CANCER AND METASTASIS REVIEWS

Purification, antitumor and antioxidant activities in vitro of polysaccharides from the brown seaweed Sargassum pallidum

(2008) Hong Ye et al.   FOOD CHEMISTRY

Antiproliferative activity of sulfated polysaccharide isolated from an enzymatic digest of Ecklonia cava on the U-937 cell line

(2008) Yasantha Athukorala et al.   JOURNAL OF APPLIED PHYCOLOGY

Fucoidan fromLaminaria cichorioidesinhibits AP‐1 transactivation and cell transformation in the mouse epidermal JB6 cells

(2008) Na Yeon Lee et al.   MOLECULAR CARCINOGENESIS

Fucoidan: Structure and Bioactivity

(2008) Bo Li et al.   MOLECULES

Drug development from marine natural products

(2008) Tadeusz F. Molinski et al.   NATURE REVIEWS DRUG DISCOVERY