CD4+ T cells indirectly kill tumor cells via induction of cytotoxic macrophages in mouse models

CD4+ T cell-mediated rejection of MHC class II-positive tumor cells is dependent on antigen secretion and indirect presentation on host APCs

(2018) Ole Audun Werner Haabeth et al.   CANCER RESEARCH

Tumor Killing by CD4+ T Cells Is Mediated via Induction of Inducible Nitric Oxide Synthase-Dependent Macrophage Cytotoxicity

(2018) Marte Fauskanger et al.   Frontiers in Immunology

Evolutionary Pressure against MHC Class II Binding Cancer Mutations

(2018) Rachel Marty Pyke et al.   CELL

Adoptive Transfer of Tumor-Specific Th2 Cells Eradicates Tumors by Triggering an In Situ Inflammatory Immune Response

(2016) Kristina Berg Lorvik et al.   CANCER RESEARCH

Tumour-specific CD4 T cells eradicate melanoma via indirect recognition of tumour-derived antigen

(2016) Elena Shklovskaya et al.   IMMUNOLOGY AND CELL BIOLOGY

Tumor-specific CD4+ T cells eradicate myeloma cells genetically deficient in MHC class II display

(2016) Anders Tveita et al.   Oncotarget

Tumors Escape CD4+ T-cell-Mediated Immunosurveillance by Impairing the Ability of Infiltrating Macrophages to Indirectly Present Tumor Antigens

(2015) A. A. Tveita et al.   CANCER RESEARCH

Idiotype-specific CD4+ T cells eradicate disseminated myeloma

(2015) O A Haabeth et al.   LEUKEMIA

Indirect CD4+T-cell-mediated elimination of MHC IINEGtumor cells is spatially restricted and fails to prevent escape of antigen-negative cells

(2014) Anders A. Tveita et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

High-throughput epitope discovery reveals frequent recognition of neo-antigens by CD4+ T cells in human melanoma

(2014) Carsten Linnemann et al.   NATURE MEDICINE

Cancer Immunotherapy Based on Mutation-Specific CD4+ T Cells in a Patient with Epithelial Cancer

(2014) E. Tran et al.   SCIENCE

T-helper-1-cell cytokines drive cancer into senescence

(2013) Heidi Braumüller et al.   NATURE

Molecular profiling of tumor-specific TH1 cells activated in vivo

(2013) Kristina Berg Lorvik et al.   OncoImmunology

Fingolimod blocks immunosurveillance of myeloma and B-cell lymphoma resulting in cancer development in mice

(2012) K. B. Lorvik et al.   BLOOD

A Novel Mouse Model for Multiple Myeloma (MOPC315.BM) That Allows Noninvasive Spatiotemporal Detection of Osteolytic Disease

(2012) Peter O. Hofgaard et al.   PLoS One

Inflammation driven by tumour-specific Th1 cells protects against B-cell cancer

(2011) Ole Audun Werner Haabeth et al.   Nature Communications

Naive tumor-specific CD4+T cells differentiated in vivo eradicate established melanoma

(2010) Ying Xie et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Tumor-reactive CD4+T cells develop cytotoxic activity and eradicate large established melanoma after transfer into lymphopenic hosts

(2010) Sergio A. Quezada et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Secretion of Tumor-Specific Antigen by Myeloma Cells Is Required for Cancer Immunosurveillance by CD4+ T Cells

(2009) A. Corthay et al.   CANCER RESEARCH

Tumor-specific Th17-polarized cells eradicate large established melanoma

(2008) P. Muranski et al.   BLOOD

Treatment of Metastatic Melanoma with Autologous CD4+ T Cells against NY-ESO-1

(2008) Naomi N. Hunder et al.   NEW ENGLAND JOURNAL OF MEDICINE