Emerging Concepts Promising New Horizons for Marine Biodiscovery and Synthetic Biology

ApnI, a Transmembrane Protein Responsible for Subtilomycin Immunity, Unveils a Novel Model for Lantibiotic Immunity

(2014) Yun Deng et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Peptidomimetics via modifications of amino acids and peptide bonds

(2014) Ilker Avan et al.   CHEMICAL SOCIETY REVIEWS

Screening of marine bacteria with bacteriocin-like activities and probiotic potential for ornate spiny lobster (Panulirus ornatus) juveniles

(2014) Van Duy Nguyen et al.   FISH & SHELLFISH IMMUNOLOGY

Marine Microbial Metagenomics: From Individual to the Environment

(2014) Ching-Hung Tseng et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Marine Algae-Derived Bioactive Peptides for Human Nutrition and Health

(2014) Xiaodan Fan et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Baulamycins A and B, Broad-Spectrum Antibiotics Identified as Inhibitors of Siderophore Biosynthesis in Staphylococcus aureus and Bacillus anthracis

(2014) Ashootosh Tripathi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Emerging Strategies and Integrated Systems Microbiology Technologies for Biodiscovery of Marine Bioactive Compounds

(2014) Javier Rocha-Martin et al.   Marine Drugs

Marketed Marine Natural Products in the Pharmaceutical and Cosmeceutical Industries: Tips for Success

(2014) Ana Martins et al.   Marine Drugs

Marine biotechnologies and synthetic biology, new issues for a fair and equitable profit-sharing commercial use

(2014) Jean-François Bloch et al.   Marine Genomics

An environmental bacterial taxon with a large and distinct metabolic repertoire

(2014) Micheal C. Wilson et al.   NATURE

Semi-synthetic artemisinin: a model for the use of synthetic biology in pharmaceutical development

(2014) Chris J. Paddon et al.   NATURE REVIEWS MICROBIOLOGY

Solonamide B Inhibits Quorum Sensing and Reduces Staphylococcus aureus Mediated Killing of Human Neutrophils

(2014) Anita Nielsen et al.   PLoS One

Novel LanT Associated Lantibiotic Clusters Identified by Genome Database Mining

(2014) Mangal Singh et al.   PLoS One

High-throughput platform for the discovery of elicitors of silent bacterial gene clusters

(2014) M. R. Seyedsayamdost   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tle distribution and diversity in metagenomic datasets reveal niche specialization

(2014) Frank Egan et al.   Environmental Microbiology Reports

QseC Inhibitors as an Antivirulence Approach for Gram-Negative Pathogens

(2014) Meredith M. Curtis et al.   mBio

Prediction-driven matched molecular pairs to interpret QSARs and aid the molecular optimization process

(2014) Yurii Sushko et al.   Journal of Cheminformatics

Single cell genome analysis of an uncultured heterotrophic stramenopile

(2014) Rajat S. Roy et al.   Scientific Reports

Machine learning methods in chemoinformatics

(2014) John B. O. Mitchell   Wiley Interdisciplinary Reviews-Computational Molecular Science

Pep2Path: Automated Mass Spectrometry-Guided Genome Mining of Peptidic Natural Products

(2014) Marnix H. Medema et al.   PLoS Computational Biology

Single Cell Genomics: Advances and Future Perspectives

(2014) Iain C. Macaulay et al.   PLoS Genetics

Antibiofilm Activity of the Marine Bacterium Pseudoalteromonas sp. 3J6 Against Vibrio tapetis, the Causative Agent of Brown Ring Disease

(2014) Sophie Rodrigues et al.   Probiotics and Antimicrobial Proteins

Functional Analysis of Environmental DNA-Derived Microviridins Provides New Insights into the Diversity of the Tricyclic Peptide Family

(2013) Douglas Gatte-Picchi et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Metagenomic Approaches for Exploiting Uncultivated Bacteria as a Resource for Novel Biosynthetic Enzymology

(2013) Micheal C. Wilson et al.   CHEMISTRY & BIOLOGY

The phenomenon of microbial uncultivability

(2013) SS Epstein   CURRENT OPINION IN MICROBIOLOGY

Peptide nucleic acids inhibit growth of Brucella suis in pure culture and in infected murine macrophages

(2013) Parthiban Rajasekaran et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Single-cell genomics shedding light on marine Thaumarchaeota diversification

(2013) Haiwei Luo et al.   ISME Journal

Antimicrobial activity of a UV-stable bacteriocin-like inhibitory substance (BLIS) produced by Enterococcus faecium strain DSH20 against vancomycin-resistant Enterococcus (VRE) strains

(2013) Dariush Shokri et al.   JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION

Chemical and genetic characterization of bacteriocins: antimicrobial peptides for food safety

(2013) Abigail B Snyder et al.   JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE

Interactions of protamine with the marine bacterium,Pseudoalteromonassp. NCIMB 2021

(2013) A. Pustam et al.   LETTERS IN APPLIED MICROBIOLOGY

Delivery of Nucleic Acids, Proteins, and Nanoparticles by Arginine-Rich Cell-Penetrating Peptides in Rotifers

(2013) Betty Revon Liu et al.   MARINE BIOTECHNOLOGY

Antimicrobial Peptides from Marine Proteobacteria

(2013) Florie Desriac et al.   Marine Drugs

Strategies for the Development of Conotoxins as New Therapeutic Leads

(2013) Ryan Brady et al.   Marine Drugs

Subtilomycin: A New Lantibiotic from Bacillus subtilis Strain MMA7 Isolated from the Marine Sponge Haliclona simulans

(2013) Robert Phelan et al.   Marine Drugs

Identification of Four New agr Quorum Sensing-Interfering Cyclodepsipeptides from a Marine Photobacterium

(2013) Louise Kjaerulff et al.   Marine Drugs

BH3 Mimetics: Status of the Field and New Developments

(2013) C. Billard   MOLECULAR CANCER THERAPEUTICS

antiSMASH 2.0—a versatile platform for genome mining of secondary metabolite producers

(2013) Kai Blin et al.   NUCLEIC ACIDS RESEARCH

Anti-biofilm activity of the Antarctic marine bacterium Pseudoalteromonas haloplanktis TAC125

(2013) Rosanna Papa et al.   RESEARCH IN MICROBIOLOGY

Activation and characterization of a cryptic polycyclic tetramate macrolactam biosynthetic gene cluster

(2013) Yunzi Luo et al.   Nature Communications

Hydroxyapatite/gold/arginine: designing the structure to create antibacterial activity

(2013) M. Vukomanović et al.   Journal of Materials Chemistry B

Inhibition of Growth and Gene Expression by PNA-peptide Conjugates in Streptococcus pyogenes

(2013) Nadja Patenge et al.   Molecular Therapy-Nucleic Acids

Discovery, Biosynthesis, and Engineering of Lantipeptides

(2012) Patrick J. Knerr et al.   Annual Review of Biochemistry

Functional assignment of metagenomic data: challenges and applications

(2012) T. Prakash et al.   BRIEFINGS IN BIOINFORMATICS

Current opportunities and challenges in microbial metagenome analysis--a bioinformatic perspective

(2012) H. Teeling et al.   BRIEFINGS IN BIOINFORMATICS

Identification of Synthetic Host Defense Peptide Mimics That Exert Dual Antimicrobial and Anti-Inflammatory Activities

(2012) Abhigyan Som et al.   Clinical and Vaccine Immunology

A review on biosynthesis of nanoparticles by marine organisms

(2012) N. Asmathunisha et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Competition, Not Cooperation, Dominates Interactions among Culturable Microbial Species

(2012) Kevin R. Foster et al.   CURRENT BIOLOGY

Biocatalysts and small molecule products from metagenomic studies

(2012) Hala A Iqbal et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Biological activities and potential health benefits of bioactive peptides derived from marine organisms

(2012) Dai-Hung Ngo et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Discovery of Marinopyrrole A (Maritoclax) as a Selective Mcl-1 Antagonist that Overcomes ABT-737 Resistance by Binding to and Targeting Mcl-1 for Proteasomal Degradation

(2012) Kenichiro Doi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Malleilactone, a Polyketide Synthase-Derived Virulence Factor Encoded by the Cryptic Secondary Metabolome of Burkholderia pseudomallei Group Pathogens

(2012) John B. Biggins et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Attenuation ofPseudomonas aeruginosavirulence by marine invertebrate-derivedStreptomycessp.

(2012) D.N. Naik et al.   LETTERS IN APPLIED MICROBIOLOGY

Bioactive Peptides and Depsipeptides with Anticancer Potential: Sources from Marine Animals

(2012) Guadalupe-Miroslava Suarez-Jimenez et al.   Marine Drugs

Are Uncultivated Bacteria Really Uncultivable?

(2012) Indun Dewi Puspita et al.   MICROBES AND ENVIRONMENTS

Pathogen espionage: multiple bacterial adrenergic sensors eavesdrop on host communication systems

(2012) Michail H. Karavolos et al.   MOLECULAR MICROBIOLOGY

Unlocking the potential of metagenomics through replicated experimental design

(2012) Rob Knight et al.   NATURE BIOTECHNOLOGY

Computational tools for the synthetic design of biochemical pathways

(2012) Marnix H. Medema et al.   NATURE REVIEWS MICROBIOLOGY

Bacteriocins — a viable alternative to antibiotics?

(2012) Paul D. Cotter et al.   NATURE REVIEWS MICROBIOLOGY

Quorumpeps database: chemical space, microbial origin and functionality of quorum sensing peptides

(2012) Evelien Wynendaele et al.   NUCLEIC ACIDS RESEARCH

Bioactive Peptides from Marine Organisms: A Short Overview

(2012) Fernando Lazcano-Perez et al.   PROTEIN AND PEPTIDE LETTERS

Cultivation of unculturable soil bacteria

(2012) Van H.T. Pham et al.   TRENDS IN BIOTECHNOLOGY

Anti-biofilm potential of a glycolipid surfactant produced by a tropical marine strain ofSerratia marcescens

(2011) Devendra H. Dusane et al.   BIOFOULING

Antisense inhibition of gene expression and growth in gram-negative bacteria by cell-penetrating peptide conjugates of peptide nucleic acids targeted to rpoD gene

(2011) Hui Bai et al.   BIOMATERIALS

Next generation sequencing and bioinformatic bottlenecks: the current state of metagenomic data analysis

(2011) Matthew B. Scholz et al.   CURRENT OPINION IN BIOTECHNOLOGY

Targeted metagenomics: a high-resolution metagenomics approach for specific gene clusters in complex microbial communities

(2011) Hikaru Suenaga   ENVIRONMENTAL MICROBIOLOGY

Evaluating the feasibility of lantibiotics as an alternative therapy against bacterial infections in humans

(2011) Auke Johan van Heel et al.   Expert Opinion on Drug Metabolism & Toxicology

Biological Systems Discovery In Silico: Radical S-Adenosylmethionine Protein Families and Their Target Peptides for Posttranslational Modification

(2011) D. H. Haft et al.   JOURNAL OF BACTERIOLOGY

“Nanoantibiotics”: A new paradigm for treating infectious diseases using nanomaterials in the antibiotics resistant era

(2011) Ae Jung Huh et al.   JOURNAL OF CONTROLLED RELEASE

Inhibition of Virulence Gene Expression in Staphylococcus aureus by Novel Depsipeptides from a Marine Photobacterium

(2011) Maria Mansson et al.   Marine Drugs

Antitumor Peptides from Marine Organisms

(2011) Lan-Hong Zheng et al.   Marine Drugs

Production of Bioactive Secondary Metabolites by Marine Vibrionaceae

(2011) Maria Mansson et al.   Marine Drugs

Anti-biofilm activity of an exopolysaccharide from a sponge-associated strain of Bacillus licheniformis

(2011) SM Sayem et al.   Microbial Cell Factories

In vivobiodistribution of nanoparticles

(2011) Joao Paulo Mattos Almeida et al.   Nanomedicine

A mass spectrometry–guided genome mining approach for natural product peptidogenomics

(2011) Roland D Kersten et al.   Nature Chemical Biology

Single Cell Genome Amplification Accelerates Identification of the Apratoxin Biosynthetic Pathway from a Complex Microbial Assemblage

(2011) Rashel V. Grindberg et al.   PLoS One

Genome Mining for Radical SAM Protein Determinants Reveals Multiple Sactibiotic-Like Gene Clusters

(2011) Kiera Murphy et al.   PLoS One

Single-Cell Genomics Reveals Organismal Interactions in Uncultivated Marine Protists

(2011) H. S. Yoon et al.   SCIENCE

Bioactive peptides from marine processing waste and shellfish: A review

(2011) Pádraigín A. Harnedy et al.   Journal of Functional Foods

Antibiofilm Activity of the Marine Bacterium Pseudoalteromonas sp. Strain 3J6

(2010) A. Dheilly et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Synthetic biology approaches in drug discovery and pharmaceutical biotechnology

(2010) Heinz Neumann et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Peptide nucleic acids (PNAs) antisense effect to bacterial growth and their application potentiality in biotechnology

(2010) Masashi Hatamoto et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Approaches for novel enzyme discovery from marine environments

(2010) Hyun Sook Lee et al.   CURRENT OPINION IN BIOTECHNOLOGY

Metagenomics: Facts and Artifacts, and Computational Challenges

(2010) John C. Wooley et al.   JOURNAL OF COMPUTER SCIENCE AND TECHNOLOGY

A heparin mimetic isolated from a marine shrimp suppresses neovascularization

(2010) J. L. DREYFUSS et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Gram-Positive Marine Bacteria as a Potential Resource for the Discovery of Quorum Sensing Inhibitors

(2010) Margaret E. Teasdale et al.   MARINE BIOTECHNOLOGY

Marine Metagenomics: New Tools for the Study and Exploitation of Marine Microbial Metabolism

(2010) Jonathan Kennedy et al.   Marine Drugs

Production of Metabolites as Bacterial Responses to the Marine Environment

(2010) Carla C. C. R. De Carvalho et al.   Marine Drugs

Anti-virulence strategies to combat bacteria-mediated disease

(2010) David A. Rasko et al.   NATURE REVIEWS DRUG DISCOVERY

Synthetic biology: applications come of age

(2010) Ahmad S. Khalil et al.   NATURE REVIEWS GENETICS

Peptidomimetic Antibiotics Target Outer-Membrane Biogenesis in Pseudomonas aeruginosa

(2010) N. Srinivas et al.   SCIENCE

Development and biological activities of marine-derived bioactive peptides: A review

(2010) Se-Kwon Kim et al.   Journal of Functional Foods

A Primer on Metagenomics

(2010) John C. Wooley et al.   PLoS Computational Biology

Mini-review: quorum sensing in the marine environment and its relationship to biofouling

(2009) Sergey Dobretsov et al.   BIOFOULING

Antiadhesive action of a marine microbial surfactant

(2009) Palashpriya Das et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Non-genetic heterogeneity of cells in development: more than just noise

(2009) S. Huang   DEVELOPMENT

Antibiofilm activity of coral-associated bacteria against different clinical M serotypes ofStreptococcus pyogenes

(2009) Ramalingam Thenmozhi et al.   FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY

Resuscitation-promoting factors as lytic enzymes for bacterial growth and signaling

(2009) Bavesh Davandra Kana et al.   FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY

Identification of Novel Antibacterial Peptides by Chemoinformatics and Machine Learning†

(2009) Christopher D. Fjell et al.   JOURNAL OF MEDICINAL CHEMISTRY

Subinhibitory concentrations of the cationic antimicrobial peptide colistin induce the pseudomonas quinolone signal in Pseudomonas aeruginosa

(2009) J. Cummins et al.   MICROBIOLOGY-SGM

CAMP: a useful resource for research on antimicrobial peptides

(2009) Shaini Thomas et al.   NUCLEIC ACIDS RESEARCH

Perspectives and Challenges of Emerging Single-Molecule DNA Sequencing Technologies

(2009) Mingsheng Xu et al.   Small

Short Peptide Induces an "Uncultivable" Microorganism To Grow In Vitro

(2008) D. Nichols et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Apolipoprotein B Is an Innate Barrier against Invasive Staphylococcus aureus Infection

(2008) M. Michal Peterson et al.   Cell Host & Microbe

Peptidomimetics, a synthetic tool of drug discovery

(2008) Josef Vagner et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Diversity and expression of nitrogen fixation genes in bacterial symbionts of marine sponges

(2008) Naglaa M. Mohamed et al.   ENVIRONMENTAL MICROBIOLOGY

Isolation and Analysis of Bacteria with Antimicrobial Activities from the Marine Sponge Haliclona simulans Collected from Irish Waters

(2008) Jonathan Kennedy et al.   MARINE BIOTECHNOLOGY

Discovery of a Quorum-Sensing Inhibitor of Drug-Resistant Staphylococcal Infections by Structure-Based Virtual Screening

(2008) M. D. Kiran et al.   MOLECULAR PHARMACOLOGY