Article
Critical Care Medicine
Ryan C. Murphy, Ying Lai, Matthew Liu, Taha Al-Shaikhly, Matthew C. Altman, William A. Altemeier, Charles W. Frevert, Jason S. Debley, Adrian M. Piliponsky, Steven F. Ziegler, Sina A. Gharib, Teal S. Hallstrand
Summary: This study identified differentially expressed genes associated with exercise-induced bronchoconstriction in individuals with asthma using RNA-sequencing analysis. Experiments suggested that the interactions between airway epithelial cells, mast cells, and eosinophils are closely associated with indirect airway hyperresponsiveness and play a critical role in modulating airway inflammation.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Cell Biology
Neeraj Dholia, Gurupreet S. Sethi, Amarjit S. Naura, Umesh C. S. Yadav
Summary: The study found that LTD4 can induce inflammatory response in human airway epithelial cells by activating the NALP3 inflammasome, and further promote airway epithelial cells' remodeling through the TGF-beta/smad2/3-mediated pathway. Additionally, obese mice challenged with OVA showed asthma-like lung inflammation and remodeling phenotypes.
INFLAMMATION RESEARCH
(2021)
Review
Microbiology
Bianca C. S. C. Barros, Bruna R. Almeida, Debora T. L. Barros, Marcos S. Toledo, Erika Suzuki
Summary: The response of respiratory epithelial cells to fungal pathogens involves complex cellular interactions, including cell signaling, adhesion, invasion, and cytokine secretion.
Review
Immunology
Richard J. Hewitt, Clare M. Lloyd
Summary: The community of cells lining our airways collaborates in maintaining immune homeostasis in the lung and protecting against pathogens and pollutants in the air. Single-cell RNA-sequencing reveals cellular heterogeneity in the airway wall and identifies novel cell populations with unique molecular signatures and functions in health and disease. This review discusses the evolving understanding of the airway epithelial landscape with a focus on interactions with the local neuronal and immune systems.
NATURE REVIEWS IMMUNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Natsumi Saito, Akiko Kikuchi, Mutsuo Yamaya, Xue Deng, Mitsuru Sugawara, Shin Takayama, Ryoichi Nagatomi, Tadashi Ishii
Summary: Kakkonto extract can reduce the production of specific pro-inflammatory cytokines in response to rhinovirus (RV) infection, suggesting its potential as an effective therapy to inhibit inflammation caused by RV and subsequent airway inflammation.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Plant Sciences
Kanako Yoshida, Tetsuji Takabayashi, Atsushi Kaneko, Mikina Takiyama, Masafumi Sakashita, Yoshimasa Imoto, Yukinori Kato, Norihiko Narita, Shigeharu Fujieda
Summary: The traditional Japanese herbal medicine Shin'iseihaito, specifically its bioactive compound baicalin, has been found to have a direct effect on type 2 immune responses in human airway epithelial cells and mast cells. By inhibiting IL-33-dependent gene expression and downregulating IL-5 and IL-13 levels, baicalin shows potential as an effective alternative therapeutic option for type 2 inflammatory diseases like ECRS and asthma.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Cell Biology
Onofrio Laselva, Caterina Allegretta, Sante Di Gioia, Carlo Avolio, Massimo Conese
Summary: DMF demonstrates anti-inflammatory and antioxidant effects in CF treatment, reducing inflammatory responses, restoring CFTR function, and potentially serving as a novel drug to ameliorate lung inflammation in CF patients and enhance drug efficacy.
Review
Biochemistry & Molecular Biology
Guadalupe Cumplido-Laso, Dixan A. Benitez, Sonia Mulero-Navarro, Jose Maria Carvajal-Gonzalez
Summary: The airway epithelium is a crucial component of the respiratory system, serving as a barrier against inhaled pathogens and toxins. Chronic respiratory diseases can disrupt the cellular composition of the airway epithelium, leading to a decrease in multiciliated cells and an increase in secretory cells. Basal cells are identified as the primary stem cells in the airway epithelium, capable of differentiating into multiciliated cells and secretory cells. Recent advancements in single-cell RNA sequencing techniques have provided insights into the cellular composition of the airway epithelium, highlighting the importance of understanding cellular composition and differentiation processes for targeted therapies for respiratory diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Respiratory System
James P. Bridges, Eszter K. Vladar, Hua Huang, Robert J. Mason
Summary: COVID-19 infection in the lungs progresses through different stages with distinct characteristics, and effective therapy relies on the specific location and extent of infection. The virus targets different cell types in the conducting airways and gas exchange portions of the lung, requiring tailored therapeutic approaches. Alveolar infection can lead to acute respiratory distress syndrome and a hyperinflammatory state, necessitating specific therapies in severe cases.
Article
Immunology
Charu Rajput, Mingyuan Han, Tomoko Ishikawa, Jing Lei, Adam M. Goldsmith, Seyedehzarifeh Jazaeri, Claudia C. Stroupe, J. Kelley Bentley, Marc B. Hershenson
Summary: The study developed a mouse model showing that RV-C15 infection induces type 2 airway inflammation, leading to exacerbated eosinophilic inflammation compared to RV-A1B.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Elizabeth F. Maughan, Robert E. Hynds, Adam Pennycuick, Ersilia Nigro, Kate H. C. Gowers, Celine Denais, Sandra Gomez-Lopez, Kyren A. Lazarus, Jessica C. Orr, David R. Pearce, Sarah E. Clarke, Dani Do Hyang Lee, Maximillian N. J. Woodall, Tereza Masonou, Katie-Marie Case, Vitor H. Teixeira, Benjamin E. Hartley, Richard J. Hewitt, Chadwan Al Yaghchi, Gurpreet S. Sandhu, Martin A. Birchall, Christopher O'Callaghan, Claire M. Smith, Paolo De Coppi, Colin R. Butler, Sam M. Janes
Summary: This study found cell-intrinsic differences between airway epithelial cells from children and adults in both homeostatic and proliferative states, with pediatric cells showing higher colony formation ability and outcompeting adult cells in cell culture.
Article
Physiology
Katja Koeppen, Amanda Nymon, Roxanna Barnaby, Zhongyou Li, Thomas H. Hampton, Alix Ashare, Bruce A. Stanton
Summary: Mutations in CFTR affect macrophage responses to bacteria, while EVs secreted by AEC play a regulatory role in macrophages, especially in the presence of Pseudomonas aeruginosa, with attenuated effects in CF macrophages.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2021)
Review
Cell Biology
Christiane E. Whetstone, Maral Ranjbar, Hafsa Omer, Ruth P. Cusack, Gail M. Gauvreau
Summary: The airway epithelium is the first line of defense for the lungs, detecting environmental threats and releasing alarmin cytokines that play important roles in inflammation. Blockade of TSLP and IL-33 is beneficial for asthma treatment, but further research is needed to determine which subsets of asthma patients will benefit the most from anti-alarmin therapy.
Article
Biochemistry & Molecular Biology
Luke R. Bonser, Kyung Duk Koh, Kristina Johansson, Semil P. Choksi, Dan Cheng, Leqian Liu, Dingyuan Sun, Lorna T. Zlock, Walter L. Eckalbar, Walter E. Finkbeiner, David J. Erle
Summary: Researchers have developed a new method to characterize and isolate different subsets of airway epithelial cells in human bronchial epithelial-cell cultures, which will help to further understand airway epithelial biology.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Mengjun Zhang, Huiyang Jiang, Lan Wu, Haoyu Lu, Hriday Bera, Xing Zhao, Xiong Guo, Xulu Liu, Dongmei Cun, Mingshi Yang
Summary: This study demonstrates the successful delivery of siRNA to AECs using inhaled lipid nanoparticles (LNPs) targeting ICAM-1 receptors, resulting in reduced expression of proinflammatory cytokines in AECs and effective alleviation of symptoms in asthmatic mice.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Chemistry, Medicinal
Melody Dutot, Elodie Olivier, Sophie Fouyet, Romain Magny, Karim Hammad, Emmanuel Roulland, Patrice Rat, Roxane Fagon
Summary: The study evaluated the effects of phlorotannins on the response of human lung cells to benzo[a]pyrene (B[a]P), showing that the brown algae extract had a protective effect against B[a]P-induced cytotoxicity. It was observed that the brown algae extract inhibited CYP1 activity, reduced P2X7 receptor activation, and lowered reactive oxygen species production during exposure to B[a]P.
Article
Chemistry, Analytical
Elodie Lamy, Lea Pilyser, Claire Paquet, Elodie Bouaziz-Amar, Stanislas Grassin-Delyle
Summary: A hydrophilic interaction liquid chromatography - mass spectrometry method was developed for the quantification of acetylcholine and choline in human cerebrospinal fluid, demonstrating high sensitivity and selectivity. The method showed excellent precision and accuracy, making it suitable for the analysis of cholinergic neurotransmission in human pathologies and drug effects study.
Review
Pharmacology & Pharmacy
Mehwish Jabeen, Melody Dutot, Roxane Fagon, Bernard Verrier, Claire Monge
Summary: Natural marine sulfated polysaccharides with promising antiviral activity could be a safe alternative to synthetic broad-spectrum antiviral drugs.
Article
Pharmacology & Pharmacy
Zoe Kane, Roberto Picetti, Alison Wilby, Joseph F. Standing, Stanislas Grassin-Delyle, Ian Roberts, Haleema Shakur-Still
Summary: The study suggests that intramuscular administration of TXA may achieve targeted exposure and capture variability in pharmacokinetics. Well-designed clinical trials are recommended to validate these findings.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Letter
Critical Care Medicine
Djillali Annane, Martin Rottman, Nicholas Heming, Veronique Godot, Jerome Fleuriet, Jean Sebastien Blanchet, Pierre Moine, Lamiae Grimaldi, Sylvie Chevret
INTENSIVE CARE MEDICINE
(2021)
Article
Biochemical Research Methods
Camille Roquencourt, Stanislas Grassin-Delyle, Etienne A. Thevenot
Summary: Motivation analysis of VOCs in exhaled breath using PTR-TOF-MS is gaining interest for real-time, non-invasive diagnosis and drug monitoring. However, there is a lack of methods and software tools for processing PTR-TOF-MS data. In this study, we developed algorithms and software for accurate estimation and quantification of VOCs.
Article
Anesthesiology
Stanislas Grassin-Delyle, Michaela Semeraro, Elodie Lamy, Saik Urien, Ileana Runge, Frantz Foissac, Naim Bouazza, Jean-Marc Treluyer, Monica Arribas, Ian Roberts, Haleema Shakur-Still
Summary: The study showed significant differences in pharmacokinetics between intramuscular and oral administration of TXA in healthy volunteers, with intramuscular absorption being rapid and complete, making it a potentially effective alternative to intravenous TXA. Adverse events were mild and transient, mainly consisting of local reactions and low-intensity pain.
BRITISH JOURNAL OF ANAESTHESIA
(2022)
Article
Pharmacology & Pharmacy
Stanislas Grassin-Delyle, Elodie Lamy, Michaela Semeraro, Ileana Runge, Jean-Marc Treluyer, Raoul Mansukhani, Monica Arribas, Ian Roberts, Haleema Shakur-Still
Summary: The study assessed the accuracy of measuring TXA concentrations in capillary whole blood using VAMS devices, finding them to be sufficiently accurate for pharmacokinetic studies of TXA treatment within the relevant plasma concentration range for assessing fibrinolysis inhibition.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Cell Biology
Sophie Fouyet, Elodie Olivier, Pascale Leproux, Melody Dutot, Patrice Rat
Summary: This study investigates the toxicity mechanisms of endocrine-disrupting chemicals (EDCs) in pregnant women by focusing on the activation of the P2X7 receptor in different cell types. The results show that EDCs can activate the P2X7 receptor in skin and placenta cells, but not in lung non-endocrine cells. The activation of the P2X7 receptor and induction of apoptosis are shared pathways among all tested EDCs in placental cells.
Review
Obstetrics & Gynecology
Haleema Shakur-Still, Stanislas Grassin-Delyle, Kopalasuntharam Muhunthan, Homa K. Ahmadzia, David Faraoni, Monica Arribas, Ian Roberts
Summary: This review examines the plasma concentration of tranexamic acid (TXA) needed to inhibit fibrinolysis and the time required to reach this concentration when administered through different routes. The study found that intramuscular TXA rapidly achieves therapeutic concentration, while oral TXA tablets take longer to reach the minimum therapeutic concentration.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2022)
Article
Environmental Sciences
Sophie Fouyet, Elodie Olivier, Pascale Leproux, Sabrina Boutefnouchet, Melody Dutot, Patrice Rat
Summary: Chlorpyrifos, a banned pesticide, can still be found in soil, posing a risk to pregnant women through drinking water and herbal products. This study evaluated the endocrine disrupting effects of chlorpyrifos in lavender essential oil (EO) compared to its free form. The results showed that free chlorpyrifos disrupted placental hormones and activated the P2X7 receptor, while chlorpyrifos in lavender EO only disrupted placental hormones. This study confirms that chlorpyrifos is an endocrine disrupting chemical (EDC) for pregnant women and highlights the potential protective effects of lavender EO.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Chemistry, Analytical
Waqar Ahmed, Emmanuelle Bardin, Michael D. Davis, Isabelle Sermet-Gaudelus, Stanislas Grassin Delyle, Stephen J. Fowler
Summary: Early detection of lung infection is crucial, and measuring VOCs in exhaled breath has shown potential as a rapid and accurate method. This study investigated VOCs in ALI cultures and identified potential biomarkers for S. aureus lung infection. By analyzing VOCs, we found significant changes in infected cells compared to uninfected cells, suggesting VOC analysis as a highly sensitive and specific test for S. aureus infection.
Article
Biochemical Research Methods
Christelle Ghazaly, Krystyna Biletska, Etienne A. Thevenot, Philippe Devillier, Emmanuel Naline, Stanislas Grassin-Delyle, Emmanuel Scorsone
Summary: Early, rapid and non-invasive diagnosis of SARS-CoV-2 infection is crucial for the prevention and control of COVID-19. This study optimized an experimental protocol using an electronic-nose to identify respiratory imprint in COVID-19 patients. The commercial e-nose device (Cyranose(R)) showed promising analytical performance under various controlled conditions.
JOURNAL OF BREATH RESEARCH
(2023)
Article
Respiratory System
Camille Roquencourt, Helene Salvator, Emmanuelle Bardin, Elodie Lamy, Eric Farfour, Emmanuel Naline, Philippe Devillier, Stanislas Grassin-Delyle
Summary: This study developed a reliable, rapid, noninvasive method for screening COVID-19 using real-time mass spectrometry breath analysis and artificial intelligence. The method was able to differentiate between COVID-19-positive and -negative participants with high accuracy, regardless of symptoms or vaccination status.
Article
Biochemistry & Molecular Biology
Sophie Fouyet, Elodie Olivier, Pascale Leproux, Melody Dutot, Patrice Rat
Summary: This study aimed to explore and compare the placental toxicity and endocrine disrupting effects of various essential oils (EOs) and their key compounds. The results showed that the EOs and their key components disrupted at least one of the studied hormones in placental cells, but did not activate the cell death receptor. Therefore, these tested EOs appear to act as hormonal modulators rather than endocrine disrupting compounds in human placental cells.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Wei-Han Hui, Yen-Lin Chen, Shu-Wei Chang
Summary: Crosslinking affects the mechanical behavior and tissue metabolism of collagen-based tissues. Aging and diabetes alter the crosslinking type and density, thus changing tissue properties. High-connectivity enzymatic crosslinking and advanced-glycation end-products result in uniform deformation under daily activity, while low-connectivity enzymatic crosslinking does not. High-connectivity model displays more sliding, while AGEs induce instability in structures near the binding sites.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yao-Bin Ma, Xiao-Qiu Zhou, Wei-Dan Jiang, Pei Wu, Yang Liu, Shu-Wei Li, Ling Tang, Lu Zhang, Hai-Feng Mi, Lin Feng
Summary: Tea polyphenols (TPs) are an inexpensive feed additive that can protect the gill function of fish against Flavobacterium columnare (F. columnare) through various mechanisms, including suppression of oxidative stress, apoptosis, and inflammation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yan-Jia Guo, Jing-Ru Pang, Yu Zhang, Zhong-Rui Li, Xiao-Lin Zi, Hong-Min Liu, Ning Wang, Li-Juan Zhao, Ya Gao, Bo Wang, Piet Herdewijn, Cheng-Yun Jin, Ying Liu, Yi-Chao Zheng
Summary: This study identifies the conjugation of NEDD8 to LSD1 and its impact on GC cells, revealing the significance of LSD1 neddylation in GC.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Geum-Jae Jeong, Fazlurrahman Khan, Nazia Tabassum, Young-Mog Kim
Summary: Vibrio species are motile gram-negative bacteria commonly found in aquatic environments. They can adapt to environmental fluctuations and develop protective mechanisms against host immune systems. Different types of sigma and anti-sigma factors play important roles in regulating gene expression and virulence in Vibrio species.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Zahra Mohammadbagheri, Behrooz Movahedi, Shaghayegh Saeedi, Abbas Rahmati
Summary: In this study, a reusable biobased composite hydrogel was successfully synthesized and used for the removal of Tl(I) from aqueous solutions. The hydrogel exhibited high adsorption capacity and thermal stability, and the adsorption process was found to be thermodynamically spontaneous. The results demonstrated that the hydrogel can be reused multiple times without significant loss of its adsorption capacity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Iqra Batool, Muhammad Imran, Ayesha Anwar, Farhan Ahmed Khan, Afrah E. Mohammed, Ashwag Shami, Hafiz Iqbal
Summary: Enzyme immobilization on ZnO/SnO2 and ZnO/SnO2/SA nanocomposites was studied, and the catalytic and biochemical characteristics of the immobilized enzyme were investigated. The results showed that ZnO/SnO2 and ZnO/SnO2/SA nanostructures are suitable carriers for enzyme immobilization.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Elias Mosaffa, Dhruvi Patel, Nasim Amiri Ramsheh, Rishikumar Indravadan Patel, Atanu Banerjee, Hossein Ghafuri
Summary: In this study, a unique 3D bead structure of adsorbent, composed of bacterial cellulose microfilaments reinforced chitosan adorned with melamine 2D plates, was synthesized for anionic dye removal. The adsorbent showed high specific surface area and abundant functional groups, resulting in exceptional adsorption capacity. The characteristics and optimal conditions of the adsorbent were assessed and analyzed.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Carolina Gismene, Jorge Enrique Hernandez Gonzalez, Marilia de Freitas Calmon, Andrey Fabricio Ziem Nascimento, Angela Rocio Nino Santisteban, Felipe Antunes Calil, Alana Della Torre da Silva, Paula Rahal, Rejane Maira Goes, Raghuvir Krishnaswamy Arni, Ricardo Barros Mariutti
Summary: Mammaliicoccus sciuri, a bacterium of clinical and veterinary relevance, expresses the virulence factor Exfoliative Toxin C (ExhC), which binds specifically to desmoglein-1 (Dsg1) and plays a role in tissue integrity. This study investigates the necrotic activity of ExhC and identifies a variant lacking necrotic potential but retaining enzymatic activity through mutagenesis experiments and crystal structure determination.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Bibhas K. Bhunia, Ashutosh Bandyopadhyay, Souradeep Dey, Biman B. Mandal
Summary: Intervertebral disc degeneration is a major cause of chronic low back pain and disability. Researchers have developed a bioactive silk-based hybrid hydrogel system functionalized with decellularized human Wharton's jelly extracellular matrix as bioactive cues. The hydrogels mimic the rheological and mechanical properties of the native nucleus pulposus tissue and support cell viability, proliferation, and tissue maturation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Qun Zhang, Yonggan Yan, Zhao Li, Jing Du, Kai Zhang, Liguo Zhang, Ting Wang, Alberto Bianco, Shaohua Ge, Baojin Ma
Summary: A new crosslinking strategy has been devised to construct injectable sodium alginate hydrogels, which can be regulated for injectability and have great potential in biomedical applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Seong Eun Hong, Ji-Soo Lee, Hyeon Gyu Lee
Summary: The potential of multi-layer nanoemulsions for improving the cellular uptake, antioxidant activity, and in vitro bioaccessibility of alpha-tocopherol was examined. The results showed that the multi-layer nanoemulsions significantly enhanced the cellular uptake and antioxidant activity of alpha-tocopherol compared to free coumarin 6. Furthermore, the use of chitosan and dextran sulfate as wall materials in the multi-layer nanoemulsions led to even higher cellular uptake, in vitro bioaccessibility, and antioxidant activity of alpha-tocopherol.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jingjing Yu, Yanhui Zhang, Ruoning Zhang, Yanxiang Gao, Like Mao
Summary: High internal phase emulsions (HIPEs) based on beeswax (BW) oleogels and octenyl succinic acid starch (OSA starch) were prepared by a simple one-step method. The results showed that oleogelation improved the stability and encapsulation capability of the HIPEs, which is significant for the development of novel healthy food.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Bi-Feng Yao, Xiu-Ju Luo, Jun Peng
Summary: The balanced and continuous fission and fusion of mitochondria, regulated by OPA1, are important for maintaining mitochondrial dynamics in cardiovascular disorders. Understanding the role of OPA1 in mitochondrial fusion can provide insights into the pathogenesis of cardiovascular diseases.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Gokul Paramasivam, Anandhavelu Sanmugam, Vishnu Vardhan Palem, Murugan Sevanan, Ananda Babu Sairam, Nachiappan Nachiappan, Buhyun Youn, Jung Sub Lee, Muthuchamy Nallal, Kang Hyun Park
Summary: Nanomaterials are being used to deliver therapeutic agents in living systems. Different nanotechnological applications such as immunosensors, immune assays, and drug delivery are being implemented using nanotechnology. Genomics plays a crucial role in selecting appropriate drugs for personalized cancer therapy. It helps in analyzing gene and protein expression, disease classification, and designing disease models. Delivering drugs to specific areas using nanoparticles is a challenging issue.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jing Li, Wei Wang, Han Wu, Feng Peng, Hui Gao, Ying Guan
Summary: In this study, CMH-based CPF films were prepared and their thermal and barrier properties were successfully regulated. The tensile strength and water vapor barrier property of CPF films were significantly improved, making them promising for food packaging applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)