An Updated Review on Marine Anticancer Compounds: The Use of Virtual Screening for the Discovery of Small-Molecule Cancer Drugs

Nanoassemblies from amphiphilic cytarabine prodrug for leukemia targeted therapy

(2017) Jing Liu et al.   JOURNAL OF COLLOID AND INTERFACE SCIENCE

Potential of marine natural products against drug-resistant fungal, viral, and parasitic infections

(2017) Usama Ramadan Abdelmohsen et al.   LANCET INFECTIOUS DISEASES

NPCARE: database of natural products and fractional extracts for cancer regulation

(2017) Hwanho Choi et al.   Journal of Cheminformatics

A phase 2 study of glembatumumab vedotin (GV), an antibody-drug conjugate (ADC) targeting gpNMB, in advanced melanoma

(2016) P.A. Ott et al.   ANNALS OF ONCOLOGY

Cancer statistics, 2016

(2016) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Phase I Study of the Anti-CD22 Antibody–Drug Conjugate Pinatuzumab Vedotin with/without Rituximab in Patients with Relapsed/Refractory B-cell Non-Hodgkin Lymphoma

(2016) Ranjana H. Advani et al.   CLINICAL CANCER RESEARCH

Immunotherapy and Hormone-therapy in Metastatic Breast Cancer: A Review and an Update

(2016) Andrea Nicolini et al.   CURRENT DRUG TARGETS

New developments for antibody-drug conjugate-based therapeutic approaches

(2016) Bart ECG de Goeij et al.   CURRENT OPINION IN IMMUNOLOGY

Cancer control potential of marine natural product scaffolds through inhibition of tumor cell migration and invasion

(2016) Mudit Mudit et al.   DRUG DISCOVERY TODAY

A novel hybrid drug between two potent anti-tubulin agents as a potential prolonged anticancer approach

(2016) Paolo Marchetti et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Ancistectorine D, a naphthylisoquinoline alkaloid with antiprotozoal and antileukemic activities, and further 5,8'- and 7,1'-linked metabolites from the Chinese liana Ancistrocladus tectorius

(2016) Gerhard Bringmann et al.   FITOTERAPIA

Bioactivities, isolation and purification methods of polysaccharides from natural products: A review

(2016) Lei Shi   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

The marine triterpene glycoside frondoside A exhibits activity in vitro and in vivo in prostate cancer

(2016) Sergey A. Dyshlovoy et al.   INTERNATIONAL JOURNAL OF CANCER

Single-cell profiling approaches to probing tumor heterogeneity

(2016) Bee Luan Khoo et al.   INTERNATIONAL JOURNAL OF CANCER

Pseudopterosin A: Protection of Synaptic Function and Potential as a Neuromodulatory Agent

(2016) Stacee Caplan et al.   Marine Drugs

Chemical contaminants entering the marine environment from sea-based sources: A review with a focus on European seas

(2016) Victoria Tornero et al.   MARINE POLLUTION BULLETIN

Developing natural product drugs: Supply problems and how they have been overcome

(2016) David J. Newman   PHARMACOLOGY & THERAPEUTICS

Looking for inhibitors of the dengue virus NS5 RNA-dependent RNA-polymerase using a molecular docking approach

(2016) Vicente Galiano et al.   Drug Design Development and Therapy

Stellettin B Induces G1 Arrest, Apoptosis and Autophagy in Human Non-small Cell Lung Cancer A549 Cells via Blocking PI3K/Akt/mTOR Pathway

(2016) Ran Wang et al.   Scientific Reports

Development of gelatin nanoparticles conjugated with phytohemagglutinin erythroagglutinating loaded with gemcitabine for inducing apoptosis in non-small cell lung cancer cells

(2016) Wei-Ting Kuo et al.   Journal of Materials Chemistry B

The Pharmacological Potential of Non-ribosomal Peptides from Marine Sponge and Tunicates

(2016) Shivankar Agrawal et al.   Frontiers in Pharmacology

The Contribution of Angiogenesis to the Process of Metastasis

(2015) Diane R. Bielenberg et al.   CANCER JOURNAL

The Effects of Marine Carbohydrates and Glycosylated Compounds on Human Health

(2015) Hee-Kyoung Kang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Targeting cancer with kinase inhibitors

(2015) Stefan Gross et al.   JOURNAL OF CLINICAL INVESTIGATION

Marine Snails and Slugs: a Great Place To Look for Antiviral Drugs: TABLE 1

(2015) Vinh T. Dang et al.   JOURNAL OF VIROLOGY

Synthesis and Antiproliferative Activity of Thiazolyl-bis-pyrrolo[2,3-b]pyridines and Indolyl-thiazolyl-pyrrolo[2,3-c]pyridines, Nortopsentin Analogues

(2015) Anna Carbone et al.   Marine Drugs

Activation of p53 with Ilimaquinone and Ethylsmenoquinone, Marine Sponge Metabolites, Induces Apoptosis and Autophagy in Colon Cancer Cells

(2015) Hyun-Young Lee et al.   Marine Drugs

Marine Peptides: Bioactivities and Applications

(2015) Randy Cheung et al.   Marine Drugs

Apoptosis, autophagy, necroptosis, and cancer metastasis

(2015) Zhenyi Su et al.   Molecular Cancer

Marine natural products

(2015) John W. Blunt et al.   NATURAL PRODUCT REPORTS

Mode of action and pharmacogenomic biomarkers for exceptional responders to didemnin B

(2015) Malia B Potts et al.   Nature Chemical Biology

FDA approves first immunotherapy combo

(2015) Asher Mullard   NATURE REVIEWS DRUG DISCOVERY

Elisidepsin Interacts Directly with Glycosylceramides in the Plasma Membrane of Tumor Cells to Induce Necrotic Cell Death

(2015) José Manuel Molina-Guijarro et al.   PLoS One

Stalked sea squirt (Styela clava) tunic waste as a valuable bioresource: Cosmetic and antioxidant activities

(2015) Sang-Mee Lee et al.   PROCESS BIOCHEMISTRY

Marine steroids as potential anticancer drug candidates: In silico investigation in search of inhibitors of Bcl-2 and CDK-4/Cyclin D1

(2015) Surovi Saikia et al.   STEROIDS

Analogues of the marine alkaloids oroidin, clathrodin, and hymenidin induce apoptosis in human HepG2 and THP-1 cancer cells

(2015) Tihomir Tomašič et al.   MedChemComm

In silico approach for the discovery of new PPARγ modulators among plant-derived polyphenols

(2015) Jose Antonio Encinar et al.   Drug Design Development and Therapy

Marine alkaloid Monanchocidin a overcomes drug resistance by induction of autophagy and lysosomal membrane permeabilization

(2015) Sergey A. Dyshlovoy et al.   Oncotarget

Bryostatin activates HIV-1 latent expression in human astrocytes through a PKC and NF-ĸB-dependent mechanism

(2015) Laura Díaz et al.   Scientific Reports

Translating Genomics for Precision Cancer Medicine

(2014) Roychowdhury Sameek et al.   Annual Review of Genomics and Human Genetics

Durable remissions in a pivotal phase 2 study of brentuximab vedotin in relapsed or refractory Hodgkin lymphoma

(2014) A. K. Gopal et al.   BLOOD

Trabectedin, a drug acting on both cancer cells and the tumour microenvironment

(2014) M D’Incalci et al.   BRITISH JOURNAL OF CANCER

Anticancer effects of gemcitabine are enhanced by co-administered iRGD peptide in murine pancreatic cancer models that overexpressed neuropilin-1

(2014) Y Akashi et al.   BRITISH JOURNAL OF CANCER

The role of PI3K/AKT/mTOR pathway in the modulation of autophagy and the clearance of protein aggregates in neurodegeneration

(2014) David Heras-Sandoval et al.   CELLULAR SIGNALLING

The Unique Binding Mode of Laulimalide to Two Tubulin Protofilaments

(2014) Cassandra D. M. Churchill et al.   Chemical Biology & Drug Design

Synthesis and Antiproliferative Activity of Substituted 3[2-(1H-indol-3-yl)- 1,3-thiazol-4-yl]-1H-pyrrolo[3,2-b]pyridines, Marine Alkaloid Nortopsentin Analogues

(2014) A. Carbone et al.   CURRENT MEDICINAL CHEMISTRY

Tumor–stroma crosstalk

(2014) Carmen Criscitiello et al.   CURRENT OPINION IN ONCOLOGY

Recent developments in tubulin polymerization inhibitors: An overview

(2014) Ramandeep Kaur et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Marine Invertebrate Natural Products for Anti-Inflammatory and Chronic Diseases

(2014) Kalimuthu Senthilkumar et al.   Evidence-based Complementary and Alternative Medicine

Ilimaquinone induces death receptor expression and sensitizes human colon cancer cells to TRAIL-induced apoptosis through activation of ROS-ERK/p38 MAPK–CHOP signaling pathways

(2014) Minh Truong Do et al.   FOOD AND CHEMICAL TOXICOLOGY

Phase I/II Study of the Antibody-Drug Conjugate Glembatumumab Vedotin in Patients With Locally Advanced or Metastatic Breast Cancer

(2014) Johanna Bendell et al.   JOURNAL OF CLINICAL ONCOLOGY

Hydroxamic Acid-Based Histone Deacetylase (HDAC) Inhibitors Can Mediate Neuroprotection Independent of HDAC Inhibition

(2014) S. F. Sleiman et al.   JOURNAL OF NEUROSCIENCE

Marine-Sourced Anti-Cancer and Cancer Pain Control Agents in Clinical and Late Preclinical Development

(2014) David Newman et al.   Marine Drugs

Marine Sponge Derived Natural Products between 2001 and 2010: Trends and Opportunities for Discovery of Bioactives

(2014) Mohammad Mehbub et al.   Marine Drugs

Synergistic combination of marine oligosaccharides and azithromycin against Pseudomonas aeruginosa

(2014) Xiaojia He et al.   MICROBIOLOGICAL RESEARCH

Targeting Microtubules by Natural Agents for Cancer Therapy

(2014) E. Mukhtar et al.   MOLECULAR CANCER THERAPEUTICS

PM00104 (Zalypsis®): A Marine Derived Alkylating Agent

(2014) Bradley Petek et al.   MOLECULES

Zampanolide and dactylolide: cytotoxic tubulin-assembly agents and promising anticancer leads

(2014) Qiao-Hong Chen et al.   NATURAL PRODUCT REPORTS

Emerging Targets in Pituitary Adenomas: Role of the CXCL12/CXCR4-R7 System

(2014) Federica Barbieri et al.   International Journal of Endocrinology

In vitro characterisation of the anti-intravasative properties of the marine product heteronemin

(2013) Sabine Kopf et al.   ARCHIVES OF TOXICOLOGY

Dolastatin, along with Celecoxib, stimulates apoptosis by a mechanism involving oxidative stress, membrane potential change and PI3-K/AKT pathway down regulation

(2013) Honit Piplani et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Prospective randomized double-blind multicentre phase II study comparing gemcitabine and cisplatin plus sorafenib chemotherapy with gemcitabine and cisplatin plus placebo in locally advanced and/or metastasized urothelial cancer: SUSE (AUO-AB 31/05)

(2013) Susanne Krege et al.   BJU INTERNATIONAL

Optimization of Marine Triterpene Sipholenols as Inhibitors of Breast Cancer Migration and Invasion

(2013) Ahmed I. Foudah et al.   ChemMedChem

Matrix metalloproteinases (MMPs) inhibitory effects of an octameric oligopeptide isolated from abalone Haliotis discus hannai

(2013) Van-Tinh Nguyen et al.   FOOD CHEMISTRY

Bioactive compounds from marine mussels and their effects on human health

(2013) Ulrike Grienke et al.   FOOD CHEMISTRY

Oral delivery of anticancer drugs: Challenges and opportunities

(2013) Kaushik Thanki et al.   JOURNAL OF CONTROLLED RELEASE

Novel 1H-Pyrrolo[2,3-b]pyridine Derivative Nortopsentin Analogues: Synthesis and Antitumor Activity in Peritoneal Mesothelioma Experimental Models

(2013) Anna Carbone et al.   JOURNAL OF MEDICINAL CHEMISTRY

Inducers of Hypoxic Response: Marine Sesquiterpene Quinones Activate HIF-1

(2013) Lin Du et al.   JOURNAL OF NATURAL PRODUCTS

Marine Pharmacology in 2009–2011: Marine Compounds with Antibacterial, Antidiabetic, Antifungal, Anti-Inflammatory, Antiprotozoal, Antituberculosis, and Antiviral Activities; Affecting the Immune and Nervous Systems, and other Miscellaneous Mechanisms of Action

(2013) Alejandro Mayer et al.   Marine Drugs

Cyclic versus Hemi-Bastadins. Pleiotropic Anti-Cancer Effects: from Apoptosis to Anti-Angiogenic and Anti-Migratory Effects

(2013) Véronique Mathieu et al.   MOLECULES

An improved and efficient synthesis for IPL576,092 and its analogues

(2013) Jin Liu et al.   MONATSHEFTE FUR CHEMIE

Brentuximab Vedotin: A CD30-Directed Antibody-Cytotoxic Drug Conjugate

(2013) Ashley M. Newland et al.   PHARMACOTHERAPY

Tanshinone IIA inhibits human prostate cancer cells growth by induction of endoplasmic reticulum stress in vitro and in vivo

(2013) S C Chiu et al.   PROSTATE CANCER AND PROSTATIC DISEASES

A diverse induction of apoptosis by trabectedin in MCF-7 (HER2−/ER+) and MDA-MB-453 (HER2+/ER−) breast cancer cells

(2013) Harika Atmaca et al.   TOXICOLOGY LETTERS

Coral aquaculture to support drug discovery

(2013) Miguel C. Leal et al.   TRENDS IN BIOTECHNOLOGY

MT-Stabilizer, Dictyostatin, Exhibits Prolonged Brain Retention and Activity: Potential Therapeutic Implications

(2013) Kurt R. Brunden et al.   ACS Medicinal Chemistry Letters

Zampanolide, a Potent New Microtubule-Stabilizing Agent, Covalently Reacts with the Taxane Luminal Site in Tubulin α,β-Heterodimers and Microtubules

(2012) Jessica J. Field et al.   CHEMISTRY & BIOLOGY

Lessons from the Past and Charting the Future of Marine Natural Products Drug Discovery and Chemical Biology

(2012) William H. Gerwick et al.   CHEMISTRY & BIOLOGY

The PI3K/AKT/mTOR Pathway as a Therapeutic Target in Endometrial Cancer

(2012) B. M. Slomovitz et al.   CLINICAL CANCER RESEARCH

A Novel Polypeptide Extracted From Ciona savignyi Induces Apoptosis Through a Mitochondrial-Mediated Pathway in Human Colorectal Carcinoma Cells

(2012) Linyou Cheng et al.   Clinical Colorectal Cancer

Eribulin Mesylate (E7389): Review of Efficacy and Tolerability in Breast, Pancreatic, Head and Neck, and Non–Small Cell Lung Cancer

(2012) Sarah L. Scarpace   CLINICAL THERAPEUTICS

Apoptosis and Autophagy Induction As Mechanism of Cancer Prevention by Naturally Occurring Dietary Agents

(2012) Eiman Mukhtar et al.   CURRENT DRUG TARGETS

Screening bacterial metabolites for inhibitory effects against Batrachochytrium dendrobatidis using a spectrophotometric assay

(2012) SC Bell et al.   DISEASES OF AQUATIC ORGANISMS

A novel polypeptide from Meretrix meretrix Linnaeus inhibits the growth of human lung adenocarcinoma

(2012) Cuicui Wang et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Subereamolline A as a Potent Breast Cancer Migration, Invasion and Proliferation Inhibitor and Bioactive Dibrominated Alkaloids from the Red Sea Sponge Pseudoceratina arabica

(2012) Lamiaa Shaala et al.   Marine Drugs

Marine Compounds Selectively Induce Apoptosis in Female Reproductive Cancer Cells but Not in Primary-Derived Human Reproductive Granulosa Cells

(2012) Vicki Edwards et al.   Marine Drugs

Bioprospecting of Marine Invertebrates for New Natural Products — A Chemical and Zoogeographical Perspective

(2012) Miguel Costa Leal et al.   MOLECULES

Semisynthetic analogues of the marine cembranoid sarcophine as prostate and breast cancer migration inhibitors

(2011) Hossam M. Hassan et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Stylissamide X, a new proline-rich cyclic octapeptide as an inhibitor of cell migration, from an Indonesian marine sponge of Stylissa sp.

(2011) Masayoshi Arai et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and Antitumor Activity of 3-(2-Phenyl-1,3-thiazol-4-yl)-1H-indoles and 3-(2-Phenyl-1,3-thiazol-4-yl)-1H-7-azaindoles

(2011) Patrizia Diana et al.   ChemMedChem

SKLB1002, a Novel Potent Inhibitor of VEGF Receptor 2 Signaling, Inhibits Angiogenesis and Tumor Growth In Vivo

(2011) S. Zhang et al.   CLINICAL CANCER RESEARCH

PM02734 (Elisidepsin) Induces Caspase-Independent Cell Death Associated with Features of Autophagy, Inhibition of the Akt/mTOR Signaling Pathway, and Activation of Death-Associated Protein Kinase

(2011) Yi-He Ling et al.   CLINICAL CANCER RESEARCH

Frondoside A inhibits human breast cancer cell survival, migration, invasion and the growth of breast tumor xenografts

(2011) Nadia Al Marzouqi et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Marine natural products: a new wave of drugs?

(2011) Rana Montaser et al.   Future Medicinal Chemistry

The cytotoxic activity of Aplidin in chronic lymphocytic leukemia (CLL) is mediated by a direct effect on leukemic cells and an indirect effect on monocyte-derived cells

(2011) Pablo E. Morande et al.   INVESTIGATIONAL NEW DRUGS

Mitochondrial c-Jun N-terminal Kinase (JNK) Signaling Initiates Physiological Changes Resulting in Amplification of Reactive Oxygen Species Generation

(2011) Jeremy W. Chambers et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chemical Constituents of a Marine Fungus,Arthrinium sacchari

(2011) Mariko Tsukada et al.   JOURNAL OF NATURAL PRODUCTS

In vitro and in vivo anti-tumour activities of echinoside A and ds-echinoside A from Pearsonothuria graeffei

(2011) Qin Zhao et al.   JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE

Ds-echinoside A, a new triterpene glycoside derived from sea cucumber, exhibits antimetastatic activity via the inhibition of NF-κB-dependent MMP-9 and VEGF expressions

(2011) Qin Zhao et al.   Journal of Zhejiang University-SCIENCE B

Statistical Research on Marine Natural Products Based on Data Obtained between 1985 and 2008

(2011) Gu-Ping Hu et al.   Marine Drugs

Antiproliferative and Antiangiogenic Activities of Smenospongine, a Marine Sponge Sesquiterpene Aminoquinone

(2011) Dexin Kong et al.   Marine Drugs

Kinase Inhibitors from Marine Sponges

(2011) Danielle Skropeta et al.   Marine Drugs

A Simplified Synthesis of Novel Dictyostatin Analogues with In Vitro Activity against Epothilone B-Resistant Cells and Antiangiogenic Activity in Zebrafish Embryos

(2011) L. L. Vollmer et al.   MOLECULAR CANCER THERAPEUTICS

Experimental Therapy of Ovarian Cancer with Synthetic Makaluvamine Analog: In Vitro and In Vivo Anticancer Activity and Molecular Mechanisms of Action

(2011) Tao Chen et al.   PLoS One

Mechanisms and functions of p38 MAPK signalling

(2010) Ana Cuadrado et al.   BIOCHEMICAL JOURNAL

Neopetrosiamine A, biologically active bis-piperidine alkaloid from the Caribbean sea sponge Neopetrosia proxima

(2010) Xiaomei Wei et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Enhanced acute apoptotic response to azoxymethane-induced DNA damage in the rodent colonic epithelium by Tyrian purple precursors: A potential colorectal cancer chemopreventative

(2010) Chantel B. Westley et al.   CANCER BIOLOGY & THERAPY

Marine natural products as sources of novel scaffolds: achievement and concern

(2010) De-Xin Kong et al.   DRUG DISCOVERY TODAY

A neuroprotective sulfone of marine origin and the in vivo anti-inflammatory activity of an analogue

(2010) Zhi-Hong Wen et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Polyacetylenediols regulate the function of human monocyte-derived dendritic cells

(2010) Masao Takei et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Peloruside A inhibits microtubule dynamics in a breast cancer cell line MCF7

(2010) Ariane Chan et al.   INVESTIGATIONAL NEW DRUGS

Differential Effects of Sulfated Triterpene Glycosides, Holothurin A1, and 24-Dehydroechinoside A, on Antimetastasic Activity via Regulation of the MMP-9 Signal Pathway

(2010) Qin Zhao et al.   JOURNAL OF FOOD SCIENCE

New Structures and Bioactivity Properties of Jasplakinolide (Jaspamide) Analogues from Marine Sponges

(2010) Sarah J. Robinson et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of Phosphatidylinositol 3-Kinase (PI3K) Inhibitory Analogues of the Sponge Meroterpenoid Liphagal

(2010) Alban R. Pereira et al.   JOURNAL OF MEDICINAL CHEMISTRY

Terpenes from Marine-Derived Fungi

(2010) Rainer Ebel   Marine Drugs

Marine Polysaccharides in Pharmaceutical Applications: An Overview

(2010) Paola Laurienzo   Marine Drugs

Marine Antitumor Drugs: Status, Shortfalls and Strategies

(2010) Ira Bhatnagar et al.   Marine Drugs

Enantioselective Total Synthesis of the Selective PI3 Kinase Inhibitor Liphagal

(2010) Enrique Alvarez-Manzaneda et al.   ORGANIC LETTERS

Monanchocidin: A New Apoptosis-Inducing Polycyclic Guanidine Alkaloid from the Marine SpongeMonanchora pulchra

(2010) Alla G. Guzii et al.   ORGANIC LETTERS

The odyssey of marine pharmaceuticals: a current pipeline perspective

(2010) Alejandro M.S. Mayer et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Development and biological activities of marine-derived bioactive peptides: A review

(2010) Se-Kwon Kim et al.   Journal of Functional Foods

Sceptrin, a Marine Natural Compound, Inhibits Cell Motility in a Variety of Cancer Cell Lines

(2009) Angel Cipres et al.   ACS Chemical Biology

From anti-fouling to biofilm inhibition: New cytotoxic secondary metabolites from two Indonesian Agelas sponges

(2009) Triana Hertiani et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Impact of Natural Products on Developing New Anti-Cancer Agents†

(2009) Gordon M. Cragg et al.   CHEMICAL REVIEWS

Bioactivity of theMurexHomeopathic Remedy and of Extracts from an Australian Muricid Mollusc against Human Cancer Cells

(2009) Kirsten Benkendorff et al.   Evidence-based Complementary and Alternative Medicine

Apoptosis signaling in cancer stem cells

(2009) Simone Fulda et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Microtubule-Stabilizing Activity of Zampanolide, a Potent Macrolide Isolated from the Tongan Marine SpongeCacospongia mycofijiensis

(2009) Jessica J. Field et al.   JOURNAL OF MEDICINAL CHEMISTRY

Early Effects of Lasonolide A on Pancreatic Cancer Cells

(2009) R. A. Isbrucker et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Two New Jaspamide Derivatives from the Marine Sponge Jaspis splendens

(2009) Sherif Ebada et al.   Marine Drugs

A genetic approach for finding small RNAs regulators of genes of interest identifies RybC as regulating the DpiA/DpiB two-component system

(2009) Pierre Mandin et al.   MOLECULAR MICROBIOLOGY

Development of Yondelis® (trabectedin, ET-743). A semisynthetic process solves the supply problem

(2009) Carmen Cuevas et al.   NATURAL PRODUCT REPORTS

Polyketide synthases of bacterial symbionts in sponges – Evolution-based applications in natural products research

(2009) Thomas Hochmuth et al.   PHYTOCHEMISTRY

Programmed cell death and cancer

(2009) Y Sun et al.   POSTGRADUATE MEDICAL JOURNAL

Antibiotics for Emerging Pathogens

(2009) M. A. Fischbach et al.   SCIENCE

Synthesis of BC-ring model of globostellatic acid X methyl ester, an anti-angiogenic substance from marine sponge

(2008) Naoyuki Kotoku et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Aplidin, a Marine Organism-Derived Compound with Potent Antimyeloma Activity In vitro and In vivo

(2008) C. S. Mitsiades et al.   CANCER RESEARCH

Xenohormesis: Sensing the Chemical Cues of Other Species

(2008) Konrad T. Howitz et al.   CELL

Protein scaffolds in MAP kinase signalling

(2008) Matthew D. Brown et al.   CELLULAR SIGNALLING

The Structure of Glycosaminoglycans and their Interactions with Proteins

(2008) Neha S. Gandhi et al.   Chemical Biology & Drug Design

Phase I Pharmacokinetic and Pharmacodynamic Study of LAQ824, a Hydroxamate Histone Deacetylase Inhibitor with a Heat Shock Protein-90 Inhibitory Profile, in Patients with Advanced Solid Tumors

(2008) J. S. de Bono et al.   CLINICAL CANCER RESEARCH

Identification of the Smallest Structure Capable of Evoking Opsonophagocytic Antibodies against Streptococcus pneumoniae Type 14

(2008) D. Safari et al.   INFECTION AND IMMUNITY

Agelasines J, K, and L from the Solomon Islands Marine SpongeAgelascf.mauritiana

(2008) Jérôme Appenzeller et al.   JOURNAL OF NATURAL PRODUCTS

Sinulodurins A and B, Antiproliferative and Anti-invasive Diterpenes from the Soft CoralSinularia dura

(2008) Mohamed M. Radwan et al.   JOURNAL OF NATURAL PRODUCTS

Latrunculin A and Its C-17-O-Carbamates Inhibit Prostate Tumor Cell Invasion and HIF-1 Activation in Breast Tumor Cells⊥

(2008) Khalid A. El Sayed et al.   JOURNAL OF NATURAL PRODUCTS

Arenamides A−C, Cytotoxic NFκB Inhibitors from the Marine ActinomyceteSalinispora arenicola⊥

(2008) Ratnakar N. Asolkar et al.   JOURNAL OF NATURAL PRODUCTS

Celebesides A−C and Theopapuamides B−D, Depsipeptides from an Indonesian Sponge That Inhibit HIV-1 Entry

(2008) Alberto Plaza et al.   JOURNAL OF ORGANIC CHEMISTRY

A Fatty Acid from the Diatom Phaeodactylum tricornutum is Antibacterial Against Diverse Bacteria Including Multi-resistant Staphylococcus aureus (MRSA)

(2008) Andrew P. Desbois et al.   MARINE BIOTECHNOLOGY

The Structure Activity Relationship of Discodermolide Analogues

(2008) Simon Shaw   MINI-REVIEWS IN MEDICINAL CHEMISTRY

The synthetic challenge of diazonamide A, a macrocyclic indole bis-oxazole marine natural product

(2008) Mathilde Lachia et al.   NATURAL PRODUCT REPORTS

High-throughput kinase profiling as a platform for drug discovery

(2008) David M. Goldstein et al.   NATURE REVIEWS DRUG DISCOVERY

Drug development from marine natural products

(2008) Tadeusz F. Molinski et al.   NATURE REVIEWS DRUG DISCOVERY

Panning for chemical gold: marine bacteria as a source of new therapeutics

(2008) Philip G. Williams   TRENDS IN BIOTECHNOLOGY