Astragalus polysaccharides (PG2) Enhances the M1 Polarization of Macrophages, Functional Maturation of Dendritic Cells, and T Cell-Mediated Anticancer Immune Responses in Patients with Lung Cancer

Karnofsky Performance Status as A Predictive Factor for Cancer-Related Fatigue Treatment with Astragalus Polysaccharides (PG2) Injection—A Double Blind, Multi-Center, Randomized Phase IV Study

(2019) Cheng-Hsu Wang et al.   Cancers

Astragalus polysaccharide (PG2) Ameliorates Cancer Symptom Clusters, as well as Improves Quality of Life in Patients with Metastatic Disease, through Modulation of the Inflammatory Cascade

(2019) Wen-Chien Huang et al.   Cancers

Targeting LAG-3 and PD-1 to Enhance T Cell Activation by Antigen-Presenting Cells

(2018) Felix S. Lichtenegger et al.   Frontiers in Immunology

Integrin CD11b activation drives anti-tumor innate immunity

(2018) Michael C. Schmid et al.   Nature Communications

BST2 confers cisplatin resistance via NF-κB signaling in nasopharyngeal cancer

(2017) Chun-mei Kuang et al.   Cell Death & Disease

Cisplatin in the modern era: The backbone of first-line chemotherapy for non-small cell lung cancer

(2016) D.A. Fennell et al.   CANCER TREATMENT REVIEWS

Polysaccharopeptide exerts immunoregulatory effects via MyD88-dependent signaling pathway

(2016) Zifang Feng et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Cancer Stem Cells and Macrophages: Implications in Tumor Biology and Therapeutic Strategies

(2016) Bruno Sainz et al.   MEDIATORS OF INFLAMMATION

Pembrolizumab versus Chemotherapy for PD-L1–Positive Non–Small-Cell Lung Cancer

(2016) Martin Reck et al.   NEW ENGLAND JOURNAL OF MEDICINE

PLD4 promotes M1 macrophages to perform antitumor effects in colon cancer cells

(2016) Long Gao et al.   ONCOLOGY REPORTS

Role of tumor-associated macrophages in human malignancies: friend or foe?

(2016) Motohiro Takeya et al.   PATHOLOGY INTERNATIONAL

Macrophage subtype predicts lymph node metastasis in oesophageal adenocarcinoma and promotes cancer cell invasion in vitro

(2015) Wenqing Cao et al.   BRITISH JOURNAL OF CANCER

Interleukin-6 Prevents the Initiation but Enhances the Progression of Lung Cancer

(2015) Z. Qu et al.   CANCER RESEARCH

Modulatory Effects ofAstragalusPolysaccharides on T-Cell Polarization in Mice with Polymicrobial Sepsis

(2015) Yu-Chen Hou et al.   MEDIATORS OF INFLAMMATION

Nivolumab versus Docetaxel in Advanced Squamous-Cell Non–Small-Cell Lung Cancer

(2015) Julie Brahmer et al.   NEW ENGLAND JOURNAL OF MEDICINE

Nivolumab versus Docetaxel in Advanced Nonsquamous Non–Small-Cell Lung Cancer

(2015) Hossein Borghaei et al.   NEW ENGLAND JOURNAL OF MEDICINE

Macrophages and cancer: from mechanisms to therapeutic implications

(2015) Renato Ostuni et al.   TRENDS IN IMMUNOLOGY

Opposite Effects of M1 and M2 Macrophage Subtypes on Lung Cancer Progression

(2015) Ang Yuan et al.   Scientific Reports

Tumor-associated macrophages promote cancer stem cell-like properties via transforming growth factor-beta1-induced epithelial–mesenchymal transition in hepatocellular carcinoma

(2014) Qing-Min Fan et al.   CANCER LETTERS

PECAM-1: regulator of endothelial junctional integrity

(2014) Jamie R. Privratsky et al.   CELL AND TISSUE RESEARCH

Inflammation and cancer stem cells

(2013) Sarah Shigdar et al.   CANCER LETTERS

A study on the immunomodulation of polysaccharopeptide through the TLR4-TIRAP/MAL-MyD88 signaling pathway in PBMCs from breast cancer patients

(2013) Jing Wang et al.   IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

Astragalus polysaccharide induces anti-inflammatory effects dependent on AMPK activity in palmitate-treated RAW264.7 cells

(2013) JINZHI LU et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Treating Patients With EGFR-Sensitizing Mutations: First Line or Second Line—Is There a Difference?

(2013) Tony Mok et al.   JOURNAL OF CLINICAL ONCOLOGY

Management of non-small-cell lung cancer: recent developments

(2013) Martin Reck et al.   LANCET

Tissue-resident macrophages

(2013) Luke C Davies et al.   NATURE IMMUNOLOGY

Innate and adaptive immune cells in the tumor microenvironment

(2013) Thomas F Gajewski et al.   NATURE IMMUNOLOGY

Immuno-oncology: understanding the function and dysfunction of the immune system in cancer

(2012) O. J. Finn   ANNALS OF ONCOLOGY

Macrophage plasticity and polarization: in vivo veritas

(2012) Antonio Sica et al.   JOURNAL OF CLINICAL INVESTIGATION

Macrophage plasticity and polarization in tissue repair and remodelling

(2012) Alberto Mantovani et al.   JOURNAL OF PATHOLOGY

HRG Inhibits Tumor Growth and Metastasis by Inducing Macrophage Polarization and Vessel Normalization through Downregulation of PlGF

(2011) Charlotte Rolny et al.   CANCER CELL

Characterization of polysaccharide from Astragalus radix as the macrophage stimulator

(2011) Lu-Hang Zhao et al.   CELLULAR IMMUNOLOGY

IL-4 induces cathepsin protease activity in tumor-associated macrophages to promote cancer growth and invasion

(2010) V. Gocheva et al.   GENES & DEVELOPMENT

Astragalus polysaccharides regulate T cell-mediated immunity via CD11chighCD45RBlow DCs in vitro

(2010) Qing-yang Liu et al.   JOURNAL OF ETHNOPHARMACOLOGY

The Anti-Inflammatory Actions of Platelet Endothelial Cell Adhesion Molecule-1 Do Not Involve Regulation of Endothelial Cell NF- B

(2010) J. R. Privratsky et al.   JOURNAL OF IMMUNOLOGY

Stromal Macrophage Expressing CD204 is Associated with Tumor Aggressiveness in Lung Adenocarcinoma

(2010) Yoichi Ohtaki et al.   Journal of Thoracic Oncology

Regulation of macrophage function in tumors: the multifaceted role of NF- B

(2009) T. Hagemann et al.   BLOOD

GM-CSF and IL-4 induce dendritic cell differentiation and disrupt osteoclastogenesis through M-CSF receptor shedding by up-regulation of TNF-  converting enzyme (TACE)

(2009) M. Hiasa et al.   BLOOD

CD4+ T Cells Regulate Pulmonary Metastasis of Mammary Carcinomas by Enhancing Protumor Properties of Macrophages

(2009) David G. DeNardo et al.   CANCER CELL

Activated monocytes in peritumoral stroma of hepatocellular carcinoma foster immune privilege and disease progression through PD-L1

(2009) Dong-Ming Kuang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Evaluation of 3 Clinical Dendritic Cell Maturation Protocols Containing Lipopolysaccharide and Interferon-γ

(2009) Tae Hee Han et al.   JOURNAL OF IMMUNOTHERAPY