The origins and formation of bone-resorbing osteoclasts

The origins and roles of osteoclasts in bone development, homeostasis and repair

(2022) Yasuhito Yahara et al.   DEVELOPMENT

Discovery of the RANKL/RANK/OPG system

(2021) Hisataka Yasuda   JOURNAL OF BONE AND MINERAL METABOLISM

Syncytins expressed in human placental trophoblast

(2021) R. Michael Roberts et al.   PLACENTA

Osteoclasts recycle via osteomorphs during RANKL-stimulated bone resorption

(2021) Michelle M. McDonald et al.   CELL

PTPRJ promotes osteoclast maturation and activity by inhibiting Cbl‐mediated ubiquitination of NFATc1 in late osteoclastogenesis

(2021) Moran Shalev et al.   FEBS Journal

Flagging fusion: Phosphatidylserine signaling in cell-cell fusion

(2021) Jarred M. Whitlock et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sexual Dimorphism in Differentiating Osteoclast Precursors Demonstrates Enhanced Inflammatory Pathway Activation in Female Cells

(2021) Se Hwan Mun et al.   JOURNAL OF BONE AND MINERAL RESEARCH

An SNX10-dependent mechanism downregulates fusion between mature osteoclasts

(2021) Maayan Barnea-Zohar et al.   JOURNAL OF CELL SCIENCE

Role of OSCAR Signaling in Osteoclastogenesis and Bone Disease

(2021) Iva R. Nedeva et al.   Frontiers in Cell and Developmental Biology

Sorting Nexin 10 as a Key Regulator of Membrane Trafficking in Bone-Resorbing Osteoclasts: Lessons Learned From Osteopetrosis

(2021) Ari Elson et al.   Frontiers in Cell and Developmental Biology

CX3CL1/fractalkine regulates the differentiation of human peripheral blood monocytes and monocyte-derived dendritic cells into osteoclasts

(2021) Sei Muraoka et al.   CYTOKINE

Comprehensive Transcriptomic Profiling of Murine Osteoclast Differentiation Reveals Novel Differentially Expressed Genes and LncRNAs

(2021) Salman M. Toor et al.   Frontiers in Genetics

The Osteocyte: New Insights

(2020) Alexander G. Robling et al.   Annual Review of Physiology

Erythromyeloid progenitors give rise to a population of osteoclasts that contribute to bone homeostasis and repair

(2020) Yasuhito Yahara et al.   NATURE CELL BIOLOGY

Management of Osteogenesis Imperfecta

(2020) Stuart H. Ralston et al.   Frontiers in Endocrinology

Ostm1 from Mouse to Human: Insights into Osteoclast Maturation

(2020) Jean Vacher et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Osteoclast Multinucleation: Review of Current Literature

(2020) Joe Kodama et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Re-thinking the bone remodeling cycle mechanism and the origin of bone loss

(2020) Jean-Marie Delaisse et al.   BONE

Osteoclast Fusion: Physiological Regulation of Multinucleation through Heterogeneity—Potential Implications for Drug Sensitivity

(2020) Kent Søe   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mechanisms of RANKL delivery to the osteoclast precursor cell surface

(2020) Masashi Honma et al.   JOURNAL OF BONE AND MINERAL METABOLISM

One Disease, Many Genes: Implications for the Treatment of Osteopetroses

(2019) Sara Penna et al.   Frontiers in Endocrinology

Osteoporosis

(2019) Juliet E Compston et al.   LANCET

Interaction between the integrin Mac-1 and signal regulatory protein α (SIRPα) mediates fusion in heterologous cells

(2019) Nataly P. Podolnikova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Membrane trafficking in osteoclasts and implications for osteoporosis

(2019) Pei Ying Ng et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

The macrophage-specific V-ATPase subunit ATP6V0D2 restricts inflammasome activation and bacterial infection by facilitating autophagosome-lysosome fusion

(2019) Yu Xia et al.   Autophagy

An Overview of the Derivation and Function of Multinucleated Giant Cells and Their Role in Pathological Processes

(2019) Patricia Joyce Brooks et al.   AMERICAN JOURNAL OF PATHOLOGY

How cells fuse

(2019) Nicolas G. Brukman et al.   JOURNAL OF CELL BIOLOGY

Developmental origin, functional maintenance and genetic rescue of osteoclasts

(2019) Christian E. Jacome-Galarza et al.   NATURE

The fusogenic synapse at a glance

(2019) Ji Hoon Kim et al.   JOURNAL OF CELL SCIENCE

Fusogens

(2018) Nadav Segev et al.   CURRENT BIOLOGY

The hematopoietic stem cell niche: from embryo to adult

(2018) Xin Gao et al.   DEVELOPMENT

OC-STAMP promotes osteoclast fusion for pathogenic bone resorption in periodontitis via up-regulation of permissive fusogen CD9

(2018) Takenobu Ishii et al.   FASEB JOURNAL

Ostm1 Bifunctional Roles in Osteoclast Maturation: Insights From a Mouse Model Mimicking a Human OSTM1 Mutation

(2018) Monica Pata et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Soluble RANKL contributes to osteoclast formation in adult mice but not ovariectomy-induced bone loss

(2018) Jinhu Xiong et al.   Nature Communications

Vacuolar ATPase as a potential therapeutic target and mediator of treatment resistance in cancer

(2018) Bradleigh Whitton et al.   Cancer Medicine

Genetics of Osteopetrosis

(2018) Eleonora Palagano et al.   Current Osteoporosis Reports

The Osteoclast in Bone Metastasis: Player and Target

(2018) Antonio Maurizi et al.   Cancers

The contribution of cross-talk between the cell-surface proteins CD36 and CD47–TSP-1 in osteoclast formation and function

(2018) Srinivas V. Koduru et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cell-surface phosphatidylserine regulates osteoclast precursor fusion

(2017) Santosh K. Verma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Surface microtopography modulates sealing zone development in osteoclasts cultured on bone

(2017) Michal Shemesh et al.   Journal of the Royal Society Interface

Phosphatidylethanolamine dynamics are required for osteoclast fusion

(2017) Atsushi Irie et al.   Scientific Reports

Dendritic-cell-derived osteoclasts: a new game changer in bone-resorption-associated diseases

(2016) Olivier Lapérine et al.   DRUG DISCOVERY TODAY

Feel the force: Podosomes in mechanosensing

(2016) Stefan Linder et al.   EXPERIMENTAL CELL RESEARCH

DC-STAMP: A Key Regulator in Osteoclast Differentiation

(2016) Ya-Hui Chiu et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Osteoclast Fusion: Time-Lapse Reveals Involvement of CD47 and Syncytin-1 at Different Stages of Nuclearity

(2016) Anaïs Marie Julie Møller et al.   JOURNAL OF CELLULAR PHYSIOLOGY

RAB-5- and DYNAMIN-1-Mediated Endocytosis of EFF-1 Fusogen Controls Cell-Cell Fusion

(2016) Ksenia Smurova et al.   Cell Reports

Osteoclast fusion is initiated by a small subset of RANKL-stimulated monocyte progenitors, which can fuse to RANKL-unstimulated progenitors

(2015) Noam Levaot et al.   BONE

The elementary fusion modalities of osteoclasts

(2015) Kent Søe et al.   BONE

Membrane tension and membrane fusion

(2015) Michael M Kozlov et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

The RANKL-RANK Story

(2015) Vanja Nagy et al.   GERONTOLOGY

Oxysterols and EBI2 promote osteoclast precursor migration to bone surfaces and regulate bone mass homeostasis

(2015) Erin Nevius et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Discovery of CLC transport proteins: cloning, structure, function and pathophysiology

(2015) Thomas J. Jentsch   JOURNAL OF PHYSIOLOGY-LONDON

Circulating monocytes: an appropriate model for bone-related study

(2015) Y. Zhou et al.   OSTEOPOROSIS INTERNATIONAL

RANKL/OPG; Critical role in bone physiology

(2015) T. John Martin et al.   REVIEWS IN ENDOCRINE & METABOLIC DISORDERS

Studies of OC-STAMP in Osteoclast Fusion: A New Knockout Mouse Model, Rescue of Cell Fusion, and Transmembrane Topology

(2015) Hanna Witwicka et al.   PLoS One

Late stages of the synchronized macrophage fusion in osteoclast formation depend on dynamin

(2014) Santosh K. Verma et al.   BIOCHEMICAL JOURNAL

Osteoclast Fusion is Based on Heterogeneity Between Fusion Partners

(2014) Anne-Sofie Hobolt-Pedersen et al.   CALCIFIED TISSUE INTERNATIONAL

Novel techniques in the development of osteoporosis drug therapy: the osteoclast ruffled-border vacuolar H+-ATPase as an emerging target

(2014) Norbert Kartner et al.   Expert Opinion on Drug Discovery

The CD47-SIRP  signalling system: its physiological roles and therapeutic application

(2014) Y. Murata et al.   JOURNAL OF BIOCHEMISTRY

Thrombospondin-1 Regulates Bone Homeostasis Through Effects on Bone Matrix Integrity and Nitric Oxide Signaling in Osteoclasts

(2014) Sarah R Amend et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Dynamin and endocytosis are required for the fusion of osteoclasts and myoblasts

(2014) Nah-Young Shin et al.   JOURNAL OF CELL BIOLOGY

Absence of Dap12 and the αvβ3 integrin causes severe osteopetrosis

(2014) Wei Zou et al.   JOURNAL OF CELL BIOLOGY

Pin1 Regulates Osteoclast Fusion Through Suppression of the Master Regulator of Cell Fusion DC-STAMP

(2014) Rabia Islam et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Integrating Phosphoproteome and Transcriptome Reveals New Determinants of Macrophage Multinucleation

(2014) Maxime Rotival et al.   MOLECULAR & CELLULAR PROTEOMICS

CSF-1 Receptor Signaling in Myeloid Cells

(2014) E. R. Stanley et al.   Cold Spring Harbor Perspectives in Biology

Podosome organization drives osteoclast-mediated bone resorption

(2014) Dan Georgess et al.   Cell Adhesion & Migration

Comprehensive profiling analysis of actively resorbing osteoclasts identifies critical signaling pathways regulated by bone substrate

(2014) P. Edward Purdue et al.   Scientific Reports

The Interaction Between Signal Regulatory Protein Alpha (SIRPα) and CD47: Structure, Function, and Therapeutic Target

(2013) A. Neil Barclay et al.   Annual Review of Immunology

Immature dendritic cells in multiple myeloma are prone to osteoclast-like differentiation through interleukin-17A stimulation

(2013) Marco Tucci et al.   BRITISH JOURNAL OF HAEMATOLOGY

Lack of CD47 Impairs Bone Cell Differentiation and Results in an Osteopenic Phenotypein Vivodue to Impaired Signal Regulatory Protein α (SIRPα) Signaling

(2013) Cecilia Koskinen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Extracellular annexins and dynamin are important for sequential steps in myoblast fusion

(2013) Evgenia Leikina et al.   JOURNAL OF CELL BIOLOGY

Osteopetrosis: genetics, treatment and new insights into osteoclast function

(2013) Cristina Sobacchi et al.   Nature Reviews Endocrinology

A novel human endogenous retroviral protein inhibits cell-cell fusion

(2013) Jun Sugimoto et al.   Scientific Reports

Osteoclasts: New Insights

(2013) Feng Xu et al.   Bone Research

Osteoclast Fusion and Fission

(2012) Ineke D. C. Jansen et al.   CALCIFIED TISSUE INTERNATIONAL

Bone Modeling and Remodeling

(2012) Ego Seeman   CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION

Osteoclasts Have Multiple Roles in Bone in Addition to Bone Resorption

(2012) Brendan Boyce et al.   CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION

Stroma-Derived Interleukin-34 Controls the Development and Maintenance of Langerhans Cells and the Maintenance of Microglia

(2012) Melanie Greter et al.   IMMUNITY

Osteoclast stimulatory transmembrane protein and dendritic cell-specific transmembrane protein cooperatively modulate cell-cell fusion to form osteoclasts and foreign body giant cells

(2012) Hiroya Miyamoto et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Osteoprotection by semaphorin 3A

(2012) Mikihito Hayashi et al.   NATURE

IL-34 is a tissue-restricted ligand of CSF1R required for the development of Langerhans cells and microglia

(2012) Yaming Wang et al.   NATURE IMMUNOLOGY

The osteoclast and its unique cytoskeleton

(2011) Steven L. Teitelbaum   Annals of the New York Academy of Sciences

Regulation of human osteoclast development by dendritic cell-specific transmembrane protein (DC-STAMP)

(2011) Ya-Hui Chiu et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Lineage-committed osteoclast precursors circulate in blood and settle down into bone

(2011) Akinori Muto et al.   JOURNAL OF BONE AND MINERAL RESEARCH

An essential role for the association of CD47 to SHPS-1 in skeletal remodeling

(2011) Laura A Maile et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Effects of surface microtopography on the assembly of the osteoclast resorption apparatus

(2011) D. Geblinger et al.   Journal of the Royal Society Interface

Suppression of bone formation by osteoclastic expression of semaphorin 4D

(2011) Takako Negishi-Koga et al.   NATURE MEDICINE

RANKL and RANK in sex hormone-induced breast cancer and breast cancer metastasis

(2011) Daniel Schramek et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Involvement of human endogenous retroviral syncytin-1 in human osteoclast fusion

(2010) Kent Søe et al.   BONE

Evolution of programmed cell fusion: Common mechanisms and distinct functions

(2010) Meital Oren-Suissa et al.   DEVELOPMENTAL DYNAMICS

A CSF-1 Receptor Phosphotyrosine 559 Signaling Pathway Regulates Receptor Ubiquitination and Tyrosine Phosphorylation

(2010) Ying Xiong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CCN family 2/connective tissue growth factor (CCN2/CTGF) promotes osteoclastogenesis via induction of and interaction with dendritic cell-specific transmembrane protein (DC-STAMP)

(2010) Takashi Nishida et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Functional overlap but differential expression of CSF-1 and IL-34 in their CSF-1 receptor-mediated regulation of myeloid cells

(2010) Suwen Wei et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Protein-driven membrane stresses in fusion and fission

(2010) Michael M. Kozlov et al.   TRENDS IN BIOCHEMICAL SCIENCES

Adrm1 interacts with Atp6v0d2 and regulates osteoclast differentiation

(2009) Taesoo Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Dominant role of CD47-thrombospondin-1 interactions in myeloma-induced fusion of human dendritic cells: implications for bone disease

(2009) A. Kukreja et al.   BLOOD

CD47 Regulates Bone Mass and Tumor Metastasis to Bone

(2009) O. Uluckan et al.   CANCER RESEARCH

Negative Feedback Control of Osteoclast Formation through Ubiquitin-mediated Down-regulation of NFATc1

(2009) Jung Ha Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of cell cycle–arrested quiescent osteoclast precursors in vivo

(2009) Toshihide Mizoguchi et al.   JOURNAL OF CELL BIOLOGY

Molecular mediators of macrophage fusion

(2009) Laura Helming et al.   TRENDS IN CELL BIOLOGY

The Osteoclast: Friend or Foe?

(2008) Deborah V. Novack et al.   Annual Review of Pathology-Mechanisms of Disease

Cell fusion in osteoclasts plays a critical role in controlling bone mass and osteoblastic activity

(2008) Ryotaro Iwasaki et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Characterization of the Bone Phenotype in ClC-7-Deficient Mice

(2008) Anita Vibsig Neutzsky-Wulff et al.   CALCIFIED TISSUE INTERNATIONAL

Cardiotrophin-1 Is an Osteoclast-Derived Stimulus of Bone Formation Required for Normal Bone Remodeling

(2008) Emma C Walker et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Atp6v0d2 Is an Essential Component of the Osteoclast-Specific Proton Pump That Mediates Extracellular Acidification in Bone Resorption

(2008) Haiping Wu et al.   JOURNAL OF BONE AND MINERAL RESEARCH

NFATc1 in mice represses osteoprotegerin during osteoclastogenesis and dissociates systemic osteopenia from inflammation in cherubism

(2008) Antonios O. Aliprantis et al.   JOURNAL OF CLINICAL INVESTIGATION

Mechanisms of membrane fusion: disparate players and common principles

(2008) Sascha Martens et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mechanics of membrane fusion

(2008) Leonid V Chernomordik et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Regulation of bone formation by osteoclasts involves Wnt/BMP signaling and the chemokine sphingosine-1-phosphate

(2008) L. Pederson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Discovery of a Cytokine and Its Receptor by Functional Screening of the Extracellular Proteome

(2008) H. Lin et al.   SCIENCE

Osteoclast stimulatory transmembrane protein (OC-STAMP), a novel protein induced by RANKL that promotes osteoclast differentiation

(2007) Meiheng Yang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

NFATc1 Induces Osteoclast Fusion Via Up-Regulation of Atp6v0d2 and the Dendritic Cell-Specific Transmembrane Protein (DC-STAMP)

(2007) Kabsun Kim et al.   MOLECULAR ENDOCRINOLOGY