Membrane trafficking in osteoclasts and implications for osteoporosis

SNX10 mediates alcohol-induced liver injury and steatosis by regulating the activation of chaperone-mediated autophagy

(2018) Yan You et al.   JOURNAL OF HEPATOLOGY

Essential Role of the a3 Isoform of V-ATPase in Secretory Lysosome Trafficking via Rab7 Recruitment

(2018) Naomi Matsumoto et al.   Scientific Reports

Genetics of Osteopetrosis

(2018) Eleonora Palagano et al.   Current Osteoporosis Reports

Why do we need to regulate autophagy (and how can we do it)? A cartoon depiction

(2018) Daniel J. Klionsky   Autophagy

Rab GTPases in Osteoclastic Endomembrane Systems

(2018) Michèle Roy et al.   Biomed Research International

Time-lapse reveals that osteoclasts can move across the bone surface while resorbing

(2017) Kent Søe et al.   JOURNAL OF CELL SCIENCE

SNX10 Plays a Critical Role in MMP9 Secretion via JNK-p38-ERK Signaling Pathway

(2017) Chun Zhou et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Rab GTPases: master regulators that establish the secretory and endocytic pathways

(2017) Suzanne R. Pfeffer   MOLECULAR BIOLOGY OF THE CELL

SNX10 gene mutation leading to osteopetrosis with dysfunctional osteoclasts

(2017) Eva-Lena Stattin et al.   Scientific Reports

Osteoporosis treatment: a missed opportunity

(2016) Frances Milat et al.   MEDICAL JOURNAL OF AUSTRALIA

Therapeutic implications of suppressing osteoclast formation versus function

(2016) Steven L. Teitelbaum   RHEUMATOLOGY

PLEKHM1: Adapting to life at the lysosome

(2015) David G McEwan et al.   Autophagy

Fluorescent Bisphosphonate and Carboxyphosphonate Probes: A Versatile Imaging Toolkit for Applications in Bone Biology and Biomedicine

(2015) Shuting Sun et al.   BIOCONJUGATE CHEMISTRY

Molecular Basis for SMC Rod Formation and Its Dissolution upon DNA Binding

(2015) Young-Min Soh et al.   MOLECULAR CELL

Rab27A Regulates Transport of Cell Surface Receptors Modulating Multinucleation and Lysosome-Related Organelles in Osteoclasts

(2015) Megumi Shimada-Sugawara et al.   Scientific Reports

Osteopetrorickets due to Snx10 Deficiency in Mice Results from Both Failed Osteoclast Activity and Loss of Gastric Acid-Dependent Calcium Absorption

(2015) Liang Ye et al.   PLoS Genetics

The Biogenesis of Lysosomes and Lysosome-Related Organelles

(2014) J. P. Luzio et al.   Cold Spring Harbor Perspectives in Biology

Osteoclast-Derived Coupling Factors in Bone Remodeling

(2013) Kim Henriksen et al.   CALCIFIED TISSUE INTERNATIONAL

The TBC/RabGAP Armus Coordinates Rac1 and Rab7 Functions during Autophagy

(2013) Bernadette Carroll et al.   DEVELOPMENTAL CELL

Osteopetrosis: genetics, treatment and new insights into osteoclast function

(2013) Cristina Sobacchi et al.   Nature Reviews Endocrinology

Novel interaction of Rab13 and Rab8 with endospanins

(2013) Mirkka J. Hirvonen et al.   FEBS Open Bio

The collection of NFATc1-dependent transcripts in the osteoclast includes numerous genes non-essential to physiologic bone resorption

(2012) Julia F. Charles et al.   BONE

Homozygous stop mutation in the SNX10 gene in a consanguineous Iraqi boy with osteopetrosis and corpus callosum hypoplasia

(2012) André Mégarbané et al.   European Journal of Medical Genetics

V-ATPases in osteoclasts: Structure, function and potential inhibitors of bone resorption

(2012) A. Qin et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Autophagy: A new player in skeletal maintenance?

(2012) Lynne J Hocking et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Disruption of the dynein-dynactin complex unveils motor-specific functions in osteoclast formation and bone resorption

(2012) Pei Ying Ng et al.   JOURNAL OF BONE AND MINERAL RESEARCH

SNX10mutations define a subgroup of human autosomal recessive osteopetrosis with variable clinical severity

(2012) Alessandra Pangrazio et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Rab13 Is Upregulated During Osteoclast Differentiation and Associates with Small Vesicles Revealing Polarized Distribution in Resorbing Cells

(2012) Mirkka J. Hirvonen et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

AnSNX10mutation causes malignant osteopetrosis of infancy

(2012) Memet Aker et al.   JOURNAL OF MEDICAL GENETICS

Membrane Trafficking in Osteoblasts and Osteoclasts: New Avenues for Understanding and Treating Skeletal Diseases

(2012) Haibo Zhao   TRAFFIC

Insights into the PX (phox-homology) domain and SNX (sorting nexin) protein families: structures, functions and roles in disease

(2011) Rohan D. Teasdale et al.   BIOCHEMICAL JOURNAL

A SNX10/V-ATPase pathway regulates ciliogenesis in vitro and in vivo

(2011) Yanqun Chen et al.   CELL RESEARCH

Autophagic Factors Cut to the Bone

(2011) Amir Gelman et al.   DEVELOPMENTAL CELL

Autophagy Proteins Regulate the Secretory Component of Osteoclastic Bone Resorption

(2011) Carl J. DeSelm et al.   DEVELOPMENTAL CELL

Bone remodelling at a glance

(2011) J. C. Crockett et al.   JOURNAL OF CELL SCIENCE

Rac deletion in osteoclasts causes severe osteopetrosis

(2011) M. Croke et al.   JOURNAL OF CELL SCIENCE

SNX10 is required for osteoclast formation and resorption activity

(2011) C. H. Zhu et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Tctex-1, a Novel Interaction Partner of Rab3D, Is Required for Osteoclastic Bone Resorption

(2011) N. J. Pavlos et al.   MOLECULAR AND CELLULAR BIOLOGY

LIS1 Regulates Osteoclast Formation and Function through Its Interactions with Dynein/Dynactin and Plekhm1

(2011) Shiqiao Ye et al.   PLoS One

Disruption of the Man-6-P Targeting Pathway in Mice Impairs Osteoclast Secretory Lysosome Biogenesis

(2011) Eline van Meel et al.   TRAFFIC

Armus Is a Rac1 Effector that Inactivates Rab7 and Regulates E-Cadherin Degradation

(2010) Marieke A.M. Frasa et al.   CURRENT BIOLOGY

Rubicon and PLEKHM1 Negatively Regulate the Endocytic/Autophagic Pathway via a Novel Rab7-binding Domain

(2010) Keisuke Tabata et al.   MOLECULAR BIOLOGY OF THE CELL

Rab GTPases as coordinators of vesicle traffic

(2009) Harald Stenmark   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Osteoclast: Friend or Foe?

(2008) Deborah V. Novack et al.   Annual Review of Pathology-Mechanisms of Disease

Synaptotagmin VII Regulates Bone Remodeling by Modulating Osteoclast and Osteoblast Secretion

(2008) Haibo Zhao et al.   DEVELOPMENTAL CELL

Vesicular trafficking in osteoclasts

(2008) Fraser P. Coxon et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY