The origins and roles of osteoclasts in bone development, homeostasis and repair

Biology of resident tissue macrophages

(2022) Christopher Zhe Wei Lee et al.   DEVELOPMENT

Osteoclasts recycle via osteomorphs during RANKL-stimulated bone resorption

(2021) Michelle M. McDonald et al.   CELL

Monocyte/Macrophage Lineage Cells From Fetal Erythromyeloid Progenitors Orchestrate Bone Remodeling and Repair

(2021) Yasuhito Yahara et al.   Frontiers in Cell and Developmental Biology

Aged skeletal stem cells generate an inflammatory degenerative niche

(2021) Thomas H. Ambrosi et al.   NATURE

Osteoclasts Derive Predominantly from Bone Marrow–Resident CX3CR1+ Precursor Cells in Homeostasis, whereas Circulating CX3CR1+ Cells Contribute to Osteoclast Development during Fracture Repair

(2020) Sanja Novak et al.   JOURNAL OF IMMUNOLOGY

Erythromyeloid progenitors give rise to a population of osteoclasts that contribute to bone homeostasis and repair

(2020) Yasuhito Yahara et al.   NATURE CELL BIOLOGY

Dissecting the phenotypic and functional heterogeneity of mouse inflammatory osteoclasts by the expression of Cx3cr1

(2020) Maria-Bernadette Madel et al.   eLife

Combinatorial Single-Cell Analyses of Granulocyte-Monocyte Progenitor Heterogeneity Reveals an Early Uni-potent Neutrophil Progenitor

(2020) Immanuel Kwok et al.   IMMUNITY

Osteoclast Fusion: Physiological Regulation of Multinucleation through Heterogeneity—Potential Implications for Drug Sensitivity

(2020) Kent Søe   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mechanisms of bone development and repair

(2020) Ankit Salhotra et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

OPG Production Matters Where It Happened

(2020) Masayuki Tsukasaki et al.   Cell Reports

Local Production of Osteoprotegerin by Osteoblasts Suppresses Bone Resorption

(2020) Keisha M. Cawley et al.   Cell Reports

Osteoblast-Osteoclast Communication and Bone Homeostasis

(2020) Jung-Min Kim et al.   Cells

Autoregulation of Osteocyte Sema3A Orchestrates Estrogen Action and Counteracts Bone Aging

(2019) Mikihito Hayashi et al.   Cell Metabolism

A radical switch in clonality reveals a stem cell niche in the epiphyseal growth plate

(2019) Phillip T. Newton et al.   NATURE

Lkb1 deletion in periosteal mesenchymal progenitors induces osteogenic tumors through mTORC1 activation

(2019) Yujiao Han et al.   JOURNAL OF CLINICAL INVESTIGATION

Epigenetic control of early dendritic cell lineage specification by the transcription factor IRF8 in mice

(2019) Daisuke Kurotaki et al.   BLOOD

Developmental origin, functional maintenance and genetic rescue of osteoclasts

(2019) Christian E. Jacome-Galarza et al.   NATURE

New paradigms on hematopoietic stem cell differentiation

(2019) Hui Cheng et al.   Protein & Cell

Osteoclasts Provide Coupling Signals to Osteoblast Lineage Cells Through Multiple Mechanisms

(2019) Natalie A. Sims et al.   Annual Review of Physiology

Tissue-Specific Macrophage Responses to Remote Injury Impact the Outcome of Subsequent Local Immune Challenge

(2019) Friedrich Felix Hoyer et al.   IMMUNITY

Identification of a novel arthritis-associated osteoclast precursor macrophage regulated by FoxM1

(2019) Tetsuo Hasegawa et al.   NATURE IMMUNOLOGY

Identification of Functionally Distinct Mx1+αSMA+ Periosteal Skeletal Stem Cells

(2019) Laura C. Ortinau et al.   Cell Stem Cell

In Vivo Labeling by CD73 Marks Multipotent Stromal Cells and Highlights Endothelial Heterogeneity in the Bone Marrow Niche

(2018) Martin Breitbach et al.   Cell Stem Cell

Fetal monocytes and the origins of tissue-resident macrophages

(2018) Guillaume Hoeffel et al.   CELLULAR IMMUNOLOGY

Direct cell–cell contact between mature osteoblasts and osteoclasts dynamically controls their functions in vivo

(2018) Masayuki Furuya et al.   Nature Communications

Periosteum contains skeletal stem cells with high bone regenerative potential controlled by Periostin

(2018) Oriane Duchamp de Lageneste et al.   Nature Communications

Coupling of bone resorption and formation by RANKL reverse signalling

(2018) Yuki Ikebuchi et al.   NATURE

Discovery of a periosteal stem cell mediating intramembranous bone formation

(2018) Shawon Debnath et al.   NATURE

Resting zone of the growth plate houses a unique class of skeletal stem cells

(2018) Koji Mizuhashi et al.   NATURE

Coupling of Bone Resorption and Formation in Real Time: New Knowledge Gained From Human Haversian BMUs

(2017) Nicolai Ernlund Lassen et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Three-dimensional map of nonhematopoietic bone and bone-marrow cells and molecules

(2017) Daniel L Coutu et al.   NATURE BIOTECHNOLOGY

Human haematopoietic stem cell lineage commitment is a continuous process

(2017) Lars Velten et al.   NATURE CELL BIOLOGY

The Origins and Functions of Tissue-Resident Macrophages in Kidney Development

(2017) David A. D. Munro et al.   Frontiers in Physiology

Osteoimmunology in Bone Fracture Healing

(2017) Takehito Ono et al.   Current Osteoporosis Reports

Inflammation, fracture and bone repair

(2016) Florence Loi et al.   BONE

De Novo Prediction of Stem Cell Identity using Single-Cell Transcriptome Data

(2016) Dominic Grün et al.   Cell Stem Cell

Leptin Receptor Promotes Adipogenesis and Reduces Osteogenesis by Regulating Mesenchymal Stromal Cells in Adult Bone Marrow

(2016) Rui Yue et al.   Cell Stem Cell

Osteocyte Apoptosis Caused by Hindlimb Unloading is Required to Trigger Osteocyte RANKL Production and Subsequent Resorption of Cortical and Trabecular Bone in Mice Femurs

(2016) Pamela Cabahug-Zuckerman et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Inflammatory Osteoclasts Prime TNFα-Producing CD4+T Cells and Express CX3CR1

(2016) Lidia Ibáñez et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Osteoclast Fusion: Time-Lapse Reveals Involvement of CD47 and Syncytin-1 at Different Stages of Nuclearity

(2016) Anaïs Marie Julie Møller et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Osteoclast depletion with clodronate liposomes delays fracture healing in mice

(2016) Hsuan-Ni Lin et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Specification of tissue-resident macrophages during organogenesis

(2016) E. Mass et al.   SCIENCE

IL-17-producing γδ T cells enhance bone regeneration

(2016) Takehito Ono et al.   Nature Communications

Osteoclast-derived exosomal miR-214-3p inhibits osteoblastic bone formation

(2016) Defang Li et al.   Nature Communications

Wnt16 regulates osteoclast differentiation in conjunction with Wnt5a

(2015) Yasuhiro Kobayashi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The elementary fusion modalities of osteoclasts

(2015) Kent Søe et al.   BONE

Bone development

(2015) Agnes D. Berendsen et al.   BONE

Osteoblast-derived microvesicles: A novel mechanism for communication between osteoblasts and osteoclasts

(2015) Lili Deng et al.   BONE

Transcriptional Heterogeneity and Lineage Commitment in Myeloid Progenitors

(2015) Franziska Paul et al.   CELL

Most Tissue-Resident Macrophages Except Microglia Are Derived from Fetal Hematopoietic Stem Cells

(2015) Jianpeng Sheng et al.   IMMUNITY

C-Myb+ Erythro-Myeloid Progenitor-Derived Fetal Monocytes Give Rise to Adult Tissue-Resident Macrophages

(2015) Guillaume Hoeffel et al.   IMMUNITY

Macrophages Promote Osteoblastic Differentiation In Vivo: Implications in Fracture Repair and Bone Homeostasis

(2015) Linda Vi et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Distinct routes of lineage development reshape the human blood hierarchy across ontogeny

(2015) F. Notta et al.   SCIENCE

Distinct Sources of Hematopoietic Progenitors Emerge before HSCs and Provide Functional Blood Cells in the Mammalian Embryo

(2015) Kathleen E. McGrath et al.   Cell Reports

Identification of the Common Origins of Osteoclasts, Macrophages, and Dendritic Cells in Human Hematopoiesis

(2015) Yanling Xiao et al.   Stem Cell Reports

CD271 as a marker to identify mesenchymal stem cells from diverse sources before culture

(2015) María Álvarez-Viejo   World Journal of Stem Cells

Osteoclast Fusion is Based on Heterogeneity Between Fusion Partners

(2014) Anne-Sofie Hobolt-Pedersen et al.   CALCIFIED TISSUE INTERNATIONAL

Osteogenic fate of hypertrophic chondrocytes

(2014) Guan Yang et al.   CELL RESEARCH

Leptin-Receptor-Expressing Mesenchymal Stromal Cells Represent the Main Source of Bone Formed by Adult Bone Marrow

(2014) Bo O. Zhou et al.   Cell Stem Cell

In-vivo imaging of the fracture healing in medaka revealed two types of osteoclasts before and after the callus formation by osteoblasts

(2014) Kazuhiro Takeyama et al.   DEVELOPMENTAL BIOLOGY

Embryonic and Adult-Derived Resident Cardiac Macrophages Are Maintained through Distinct Mechanisms at Steady State and during Inflammation

(2014) Slava Epelman et al.   IMMUNITY

Pin1 Regulates Osteoclast Fusion Through Suppression of the Master Regulator of Cell Fusion DC-STAMP

(2014) Rabia Islam et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors

(2014) Elisa Gomez Perdiguero et al.   NATURE

A subset of chondrogenic cells provides early mesenchymal progenitors in growing bones

(2014) Noriaki Ono et al.   NATURE CELL BIOLOGY

MCP/CCR2 Signaling Is Essential for Recruitment of Mesenchymal Progenitor Cells during the Early Phase of Fracture Healing

(2014) Masahiro Ishikawa et al.   PLoS One

Development of the Fetal Bone Marrow Niche and Regulation of HSC Quiescence and Homing Ability by Emerging Osteolineage Cells

(2014) Süleyman Coşkun et al.   Cell Reports

Chondrocytes Transdifferentiate into Osteoblasts in Endochondral Bone during Development, Postnatal Growth and Fracture Healing in Mice

(2014) Xin Zhou et al.   PLoS Genetics

The Osteocyte: An Endocrine Cell … and More

(2013) Sarah L. Dallas et al.   ENDOCRINE REVIEWS

Osteoclast-secreted CTHRC1 in the coupling of bone resorption to formation

(2013) Sunao Takeshita et al.   JOURNAL OF CLINICAL INVESTIGATION

Microglia emerge from erythromyeloid precursors via Pu.1- and Irf8-dependent pathways

(2013) Katrin Kierdorf et al.   NATURE NEUROSCIENCE

Inflammatory monocytes and Fc  receptor IV on osteoclasts are critical for bone destruction during inflammatory arthritis in mice

(2013) M. Seeling et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Osteoclast Fusion and Fission

(2012) Ineke D. C. Jansen et al.   CALCIFIED TISSUE INTERNATIONAL

Osteoclast stimulatory transmembrane protein and dendritic cell-specific transmembrane protein cooperatively modulate cell-cell fusion to form osteoclasts and foreign body giant cells

(2012) Hiroya Miyamoto et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Identification, characterization, and isolation of a common progenitor for osteoclasts, macrophages, and dendritic cells from murine bone marrow and periphery

(2012) Christian E Jacome-Galarza et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Inflammatory arthritis increases mouse osteoclast precursors with myeloid suppressor function

(2012) Julia F. Charles et al.   JOURNAL OF CLINICAL INVESTIGATION

Systemic Circulation and Bone Recruitment of Osteoclast Precursors Tracked by Using Fluorescent Imaging Techniques

(2012) M. Kotani et al.   JOURNAL OF IMMUNOLOGY

Osteoprotection by semaphorin 3A

(2012) Mikihito Hayashi et al.   NATURE

Wnt5a-Ror2 signaling between osteoblast-lineage cells and osteoclast precursors enhances osteoclastogenesis

(2012) Kazuhiro Maeda et al.   NATURE MEDICINE

Fracture healing under healthy and inflammatory conditions

(2012) Lutz Claes et al.   Nature Reviews Rheumatology

A Lineage of Myeloid Cells Independent of Myb and Hematopoietic Stem Cells

(2012) C. Schulz et al.   SCIENCE

Effects of Interleukin-6 Ablation on Fracture Healing in Mice

(2011) Aaron Wallace et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Matrix-embedded cells control osteoclast formation

(2011) Jinhu Xiong et al.   NATURE MEDICINE

Evidence for osteocyte regulation of bone homeostasis through RANKL expression

(2011) Tomoki Nakashima et al.   NATURE MEDICINE

Suppression of bone formation by osteoclastic expression of semaphorin 4D

(2011) Takako Negishi-Koga et al.   NATURE MEDICINE

Dynamics of the transition from osteoblast to osteocyte

(2010) Sarah L. Dallas et al.   Annals of the New York Academy of Sciences

Cross talk between the bone and immune systems: osteoclasts function as antigen-presenting cells and activate CD4+ and CD8+ T cells

(2010) H. Li et al.   BLOOD

Involvement of human endogenous retroviral syncytin-1 in human osteoclast fusion

(2010) Kent Søe et al.   BONE

Multiple roles for CCR2 during fracture healing

(2010) Z. Xing et al.   Disease Models & Mechanisms

A map for lineage restriction of progenitors during hematopoiesis: the essence of the myeloid-based model

(2010) Hiroshi Kawamoto et al.   IMMUNOLOGICAL REVIEWS

Effects of human recombinant CSF-GM and highly purified CSF-1 on the formation of multinucleated cells with osteoclast characteristics in long-term bone marrow cultures

(2010) B. R. MacDonald et al.   JOURNAL OF BONE AND MINERAL RESEARCH

T cell suppression by osteoclasts in vitro

(2010) Francesco Grassi et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Regulatory T Cells Protect from Local and Systemic Bone Destruction in Arthritis

(2010) M. M. Zaiss et al.   JOURNAL OF IMMUNOLOGY

The role of PU.1 and GATA-1 transcription factors during normal and leukemogenic hematopoiesis

(2010) P Burda et al.   LEUKEMIA

Circulating mitochondrial DAMPs cause inflammatory responses to injury

(2010) Qin Zhang et al.   NATURE

Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages

(2010) F. Ginhoux et al.   SCIENCE

Hematopoietic stem cell: self-renewal versus differentiation

(2010) Jun Seita et al.   Wiley Interdisciplinary Reviews-Systems Biology and Medicine

Stromal cell-derived factor 1/CXCR4 signaling is critical for the recruitment of mesenchymal stem cells to the fracture site during skeletal repair in a mouse model

(2009) Toshiyuki Kitaori et al.   ARTHRITIS AND RHEUMATISM

Prospective identification, isolation, and systemic transplantation of multipotent mesenchymal stem cells in murine bone marrow

(2009) Satoru Morikawa et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Regenerative Effects of Transplanted Mesenchymal Stem Cells in Fracture Healing

(2009) Froilán Granero-Moltó et al.   STEM CELLS

The Osteoclast: Friend or Foe?

(2008) Deborah V. Novack et al.   Annual Review of Pathology-Mechanisms of Disease

Blood monocytes: distinct subsets, how they relate to dendritic cells, and their possible roles in the regulation of T-cell responses

(2008) Frederic Geissmann et al.   IMMUNOLOGY AND CELL BIOLOGY

Cardiotrophin-1 Is an Osteoclast-Derived Stimulus of Bone Formation Required for Normal Bone Remodeling

(2008) Emma C Walker et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Regulation of bone formation by osteoclasts involves Wnt/BMP signaling and the chemokine sphingosine-1-phosphate

(2008) L. Pederson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA