CX3CL1/fractalkine regulates the differentiation of human peripheral blood monocytes and monocyte-derived dendritic cells into osteoclasts

The Macrophage-Osteoclast Axis in Osteoimmunity and Osteo-Related Diseases

(2021) Yao Yao et al.   Frontiers in Immunology

Human dendritic cell-derived osteoclasts with high bone resorption capacity and T cell stimulation ability

(2020) Manabu Narisawa et al.   BONE

Citrullination Controls Dendritic Cell Transdifferentiation into Osteoclasts

(2019) Akilan Krishnamurthy et al.   JOURNAL OF IMMUNOLOGY

Rheumatoid arthritis

(2018) Josef S. Smolen et al.   Nature Reviews Disease Primers

Anti-Fractalkine Antibody Suppresses Joint Destruction by Inhibiting Migration of Osteoclast Precursors to the Synovium in Experimental Arthritis

(2018) Kana Hoshino-Negishi et al.   Arthritis & Rheumatology

Involvement of CX3CL1 in the Migration of Osteoclast Precursors Across Osteoblast Layer Stimulated by Interleukin-1ß

(2017) Tsuyoshi Matsuura et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Safety, pharmacokinetics, and efficacy of E6011, an antifractalkine monoclonal antibody, in a first-in-patient phase 1/2 study on rheumatoid arthritis

(2017) Yoshiya Tanaka et al.   Modern Rheumatology

Vascular expression of the chemokine CX3CL1 promotes osteoclast recruitment and exacerbates bone resorption in an irradiated murine model

(2014) Ki Hoon Han et al.   BONE

Functional Phenotype of Synovial Monocytes Modulating Inflammatory T-Cell Responses in Rheumatoid Arthritis (RA)

(2014) Bo Ruem Yoon et al.   PLoS One

In vivo structure/function and expression analysis of the CX3C chemokine fractalkine

(2011) K.-W. Kim et al.   BLOOD

Fractalkine functions as a chemoattractant for osteoarthritis synovial fibroblasts and stimulates phosphorylation of mitogen-activated protein kinases and Akt

(2009) K. Klosowska et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Genome-wide expression analyses establish dendritic cells as a new osteoclast precursor able to generate bone-resorbing cells more efficiently than monocytes

(2009) A Gallois et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Role of CX3CL1/Fractalkine in Osteoclast Differentiation and Bone Resorption

(2009) K. Koizumi et al.   JOURNAL OF IMMUNOLOGY

Evidence that cytokines play a role in rheumatoid arthritis

(2008) Fionula M. Brennan et al.   JOURNAL OF CLINICAL INVESTIGATION