How cells fuse

OC-STAMP promotes osteoclast fusion for pathogenic bone resorption in periodontitis via up-regulation of permissive fusogen CD9

(2018) Takenobu Ishii et al.   FASEB JOURNAL

Lipid-dependence of target membrane stability during influenza viral fusion

(2018) Sourav Haldar et al.   JOURNAL OF CELL SCIENCE

EFF-1 fusogen promotes phagosome sealing during cell process clearance in Caenorhabditis elegans

(2018) Piya Ghose et al.   NATURE CELL BIOLOGY

Spectrin is a mechanoresponsive protein shaping fusogenic synapse architecture during myoblast fusion

(2018) Rui Duan et al.   NATURE CELL BIOLOGY

The AFF-1 exoplasmic fusogen is required for endocytic scission and seamless tube elongation

(2018) Fabien Soulavie et al.   Nature Communications

Cardiomyocyte differentiation of mesenchymal stem cells from bone marrow: new regulators and its implications

(2018) Xiaofei Guo et al.   Stem Cell Research & Therapy

Myoblast fusion confusion: the resolution begins

(2018) Srihari C. Sampath et al.   Skeletal Muscle

Myomaker and Myomerger Work Independently to Control Distinct Steps of Membrane Remodeling during Myoblast Fusion

(2018) Evgenia Leikina et al.   DEVELOPMENTAL CELL

Dedifferentiation, transdifferentiation and cell fusion: in vivo reprogramming strategies for regenerative medicine

(2018) Martina Pesaresi et al.   FEBS Journal

Anoctamin 5/TMEM16E facilitates muscle precursor cell fusion

(2018) Jarred M. Whitlock et al.   JOURNAL OF GENERAL PHYSIOLOGY

The Ly6/uPAR protein Bouncer is necessary and sufficient for species-specific fertilization

(2018) Sarah Herberg et al.   SCIENCE

Impact of cell fusion in myeloma marrow microenvironment on tumor progression

(2018) Ziyan Wang et al.   Oncotarget

Evolutionary diversification of the HAP2 membrane insertion motifs to drive gamete fusion across eukaryotes

(2018) Juliette Fedry et al.   PLOS BIOLOGY

Cell fusion potentiates tumor heterogeneity and reveals circulating hybrid cells that correlate with stage and survival

(2018) Charles E. Gast et al.   Science Advances

Interactions with Muscle Cells Boost Fusion, Stemness, and Drug Resistance of Prostate Cancer Cells

(2018) Berna Uygur et al.   MOLECULAR CANCER RESEARCH

Spatiotemporal regulation of the GPCR activity of BAI3 by C1qL4 and Stabilin-2 controls myoblast fusion

(2018) Noumeira Hamoud et al.   Nature Communications

Fusion surface structure, function, and dynamics of gamete fusogen HAP2

(2018) Juan Feng et al.   eLife

Extrinsic Repair of Injured Dendrites as a Paradigm for Regeneration by Fusion inCaenorhabditis elegans

(2017) Meital Oren-Suissa et al.   GENETICS

Mutational analysis of IZUMO1R in women with fertilization failure and polyspermy after in vitro fertilization

(2017) Mengru Yu et al.   JOURNAL OF ASSISTED REPRODUCTION AND GENETICS

Cell-surface phosphatidylserine regulates osteoclast precursor fusion

(2017) Santosh K. Verma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Insights into the localization and function of myomaker during myoblast fusion

(2017) Dilani G. Gamage et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ArabidopsisHAP2/GCS1 is a gamete fusion protein homologous to somatic and viral fusogens

(2017) Clari Valansi et al.   JOURNAL OF CELL BIOLOGY

A pharmacological study ofArabidopsiscell fusion between the persistent synergid and endosperm

(2017) Kazuki Motomura et al.   JOURNAL OF CELL SCIENCE

Dynein and EFF-1 control dendrite morphology by regulating the localization pattern of SAX-7 in epidermal cells

(2017) Ting Zhu et al.   JOURNAL OF CELL SCIENCE

Fusion pores and their control of neurotransmitter and hormone release

(2017) Che-Wei Chang et al.   JOURNAL OF GENERAL PHYSIOLOGY

Male infertility-related molecules involved in sperm-oocyte fusion

(2017) Lisha MOU et al.   JOURNAL OF REPRODUCTION AND DEVELOPMENT

let-7miRNA controls CED-7 homotypic adhesion and EFF-1–mediated axonal self-fusion to restore touch sensation following injury

(2017) Atrayee Basu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phosphatidylserine save-me signals drive functional recovery of severed axons inCaenorhabditis elegans

(2017) Zehra C. Abay et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Control of muscle formation by the fusogenic micropeptide myomixer

(2017) Pengpeng Bi et al.   SCIENCE

Phosphatidylserine: A cancer cell targeting biomarker

(2017) Bhupender Sharma et al.   SEMINARS IN CANCER BIOLOGY

Time to make the doughnuts: Building and shaping seamless tubes

(2017) Meera V. Sundaram et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

The microprotein Minion controls cell fusion and muscle formation

(2017) Qiao Zhang et al.   Nature Communications

A defect in myoblast fusion underlies Carey-Fineman-Ziter syndrome

(2017) Silvio Alessandro Di Gioia et al.   Nature Communications

Myomerger induces fusion of non-fusogenic cells and is required for skeletal muscle development

(2017) Malgorzata E. Quinn et al.   Nature Communications

They Might Be Giants: Does Syncytium Formation Sink or Spread HIV Infection?

(2017) Alex A. Compton et al.   PLoS Pathogens

Extrinsic Repair of Injured Dendrites as a Paradigm for Regeneration by Fusion inCaenorhabditis elegans

(2017) Meital Oren-Suissa et al.   GENETICS

WASP-Arp2/3-dependent actin polymerization influences fusogen localization during cell-cell fusion inCaenorhabditiselegansembryos

(2017) Yan Zhang et al.   Biology Open

Annexin-A5 organized in 2D-network at the plasmalemma eases human trophoblast fusion

(2017) Severine A. Degrelle et al.   Scientific Reports

Novel function of stabilin-2 in myoblast fusion: the recognition of extracellular phosphatidylserine as a "fuse-me" signal

(2016) Go-Woon Kim et al.   BMB Reports

Two HAP2-GCS1 homologs responsible for gamete interactions in the cellular slime mold with multiple mating types: Implication for common mechanisms of sexual reproduction shared by plants and protozoa and for male-female differentiation

(2016) Marina Okamoto et al.   DEVELOPMENTAL BIOLOGY

Structure of IZUMO1–JUNO reveals sperm–oocyte recognition during mammalian fertilization

(2016) Umeharu Ohto et al.   NATURE

Molecular architecture of the human sperm IZUMO1 and egg JUNO fertilization complex

(2016) Halil Aydin et al.   NATURE

Myoblast fusion: Experimental systems and cellular mechanisms

(2016) Eyal D. Schejter   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Auto-fusion and the shaping of neurons and tubes

(2016) Fabien Soulavie et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Cell-cell fusion in the nervous system: Alternative mechanisms of development, injury, and repair

(2016) Rosina Giordano-Santini et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Cell fusion and nuclear fusion in plants

(2016) Daisuke Maruyama et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Fusion of the endoplasmic reticulum by membrane-bound GTPases

(2016) Junjie Hu et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Structural and functional insights into IZUMO1 recognition by JUNO in mammalian fertilization

(2016) Kazuki Kato et al.   Nature Communications

Mesenchymal stem cells generate distinct functional hybrids in vitro via cell fusion or entosis

(2016) Francesco Sottile et al.   Scientific Reports

RAB-5- and DYNAMIN-1-Mediated Endocytosis of EFF-1 Fusogen Controls Cell-Cell Fusion

(2016) Ksenia Smurova et al.   Cell Reports

The EFF-1A Cytoplasmic Domain Influences Hypodermal Cell Fusions in C. elegans But Is Not Dependent on 14-3-3 Proteins

(2016) Jessica H. Shinn-Thomas et al.   PLoS One

Cell Fusion Connects Oncogenesis with Tumor Evolution

(2015) Xiaofeng Zhou et al.   AMERICAN JOURNAL OF PATHOLOGY

Osteoclast fusion is initiated by a small subset of RANKL-stimulated monocyte progenitors, which can fuse to RANKL-unstimulated progenitors

(2015) Noam Levaot et al.   BONE

Rapid Elimination of the Persistent Synergid through a Cell Fusion Mechanism

(2015) Daisuke Maruyama et al.   CELL

The challenges involved in elucidating the molecular basis of sperm–egg recognition in mammals and approaches to overcome them

(2015) Gavin J. Wright et al.   CELL AND TISSUE RESEARCH

Mechanisms of myoblast fusion during muscle development

(2015) Ji Hoon Kim et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

The cytoplasmic domain of the gamete membrane fusion protein HAP2 targets the protein to the fusion site in Chlamydomonas and regulates the fusion reaction

(2015) Y. Liu et al.   DEVELOPMENT

The Atlastin C-terminal Tail Is an Amphipathic Helix That Perturbs the Bilayer Structure during Endoplasmic Reticulum Homotypic Fusion

(2015) Joseph E. Faust et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Surface apposition and multiple cell contacts promote myoblast fusion inDrosophilaflight muscles

(2015) Nagaraju Dhanyasi et al.   JOURNAL OF CELL BIOLOGY

Targeting ASCT2-mediated glutamine uptake blocks prostate cancer growth and tumour development

(2015) Qian Wang et al.   JOURNAL OF PATHOLOGY

EFF-1-mediated regenerative axonal fusion requires components of the apoptotic pathway

(2015) Brent Neumann et al.   NATURE

Cis and trans interactions between atlastin molecules during membrane fusion

(2015) Tina Y. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sex is a ubiquitous, ancient, and inherent attribute of eukaryotic life

(2015) Dave Speijer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HIV-1-Induced Small T Cell Syncytia Can Transfer Virus Particles to Target Cells through Transient Contacts

(2015) Menelaos Symeonides et al.   Viruses-Basel

Oocyte-triggered dimerization of sperm IZUMO1 promotes sperm–egg fusion in mice

(2015) Naokazu Inoue et al.   Nature Communications

Endothelial Cell Self-fusion during Vascular Pruning

(2015) Anna Lenard et al.   PLOS BIOLOGY

Virus and Cell Fusion Mechanisms

(2014) Benjamin Podbilewicz   Annual Review of Cell and Developmental Biology

Late stages of the synchronized macrophage fusion in osteoclast formation depend on dynamin

(2014) Santosh K. Verma et al.   BIOCHEMICAL JOURNAL

Live Cell Imaging of In Vitro Human Trophoblast Syncytialization1

(2014) Rui Wang et al.   BIOLOGY OF REPRODUCTION

Structural Basis of Eukaryotic Cell-Cell Fusion

(2014) Jimena Pérez-Vargas et al.   CELL

PI(4,5)P2 regulates myoblast fusion through Arp2/3 regulator localization at the fusion site

(2014) I. Bothe et al.   DEVELOPMENT

Binding of sperm protein Izumo1 and its egg receptor Juno drives Cd9 accumulation in the intercellular contact area prior to fusion during mammalian fertilization

(2014) M. Chalbi et al.   DEVELOPMENT

Dynamin and endocytosis are required for the fusion of osteoclasts and myoblasts

(2014) Nah-Young Shin et al.   JOURNAL OF CELL BIOLOGY

Efficient Reovirus- and Measles Virus-Mediated Pore Expansion during Syncytium Formation Is Dependent on Annexin A1 and Intracellular Calcium

(2014) M. Ciechonska et al.   JOURNAL OF VIROLOGY

Juno is the egg Izumo receptor and is essential for mammalian fertilization

(2014) Enrica Bianchi et al.   NATURE

Cross-species fertilization: the hamster egg receptor, Juno, binds the human sperm ligand, Izumo1

(2014) E. Bianchi et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Variable cooperativity in SNARE-mediated membrane fusion

(2014) J. M. Hernandez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Compact, Multifunctional Fusion Module Directs Cholesterol-Dependent Homomultimerization and Syncytiogenic Efficiency of Reovirus p10 FAST Proteins

(2014) Tim Key et al.   PLoS Pathogens

Molecular dissection of IZUMO1, a sperm protein essential for sperm-egg fusion

(2013) N. Inoue et al.   DEVELOPMENT

Extracellular annexins and dynamin are important for sequential steps in myoblast fusion

(2013) Evgenia Leikina et al.   JOURNAL OF CELL BIOLOGY

A transgenic insertion on mouse chromosome 17 inactivates a novel immunoglobulin superfamily gene potentially involved in sperm–egg fusion

(2013) Diego Lorenzetti et al.   MAMMALIAN GENOME

Phosphatidylserine receptor BAI1 and apoptotic cells as new promoters of myoblast fusion

(2013) Amelia E. Hochreiter-Hufford et al.   NATURE

Myomaker is a membrane activator of myoblast fusion and muscle formation

(2013) Douglas P. Millay et al.   NATURE

Actin-Propelled Invasive Membrane Protrusions Promote Fusogenic Protein Engagement During Cell-Cell Fusion

(2013) K. Shilagardi et al.   SCIENCE

Genetic basis of cell–cell fusion mechanisms

(2013) Pablo S. Aguilar et al.   TRENDS IN GENETICS

Presence and Incidence of Izumo Antibodies in Sera of Immunoinfertile Women and Men

(2012) Sydney Clark et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

The quest for the sea urchin egg receptor for sperm

(2012) Victor D. Vacquier   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Visualization of the moment of mouse sperm-egg fusion and dynamic localization of IZUMO1

(2012) Y. Satouh et al.   JOURNAL OF CELL SCIENCE

Axonal regeneration proceeds through specific axonal fusion in transected C. elegans neurons

(2011) Brent Neumann et al.   DEVELOPMENTAL DYNAMICS

A pair of co-opted retroviral envelope syncytin genes is required for formation of the two-layered murine placental syncytiotrophoblast

(2011) A. Dupressoir et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Conserved Eukaryotic Fusogens Can Fuse Viral Envelopes to Cells

(2011) O. Avinoam et al.   SCIENCE

Jamb and Jamc Are Essential for Vertebrate Myocyte Fusion

(2011) Gareth T. Powell et al.   PLOS BIOLOGY

The Caenorhabditis elegans GATA Factor ELT-1 Works through the Cell Proliferation Regulator BRO-1 and the Fusogen EFF-1 to Maintain the Seam Stem-Like Fate

(2011) Charles Brabin et al.   PLoS Genetics

Involvement of human endogenous retroviral syncytin-1 in human osteoclast fusion

(2010) Kent Søe et al.   BONE

Caenorhabditis elegans: A new model organism for studies of axon regeneration

(2010) Anindya Ghosh-Roy et al.   DEVELOPMENTAL DYNAMICS

Spermatogenesis-defective (spe) mutants of the nematodeCaenorhabditis elegansprovide clues to solve the puzzle of male germline functions during reproduction

(2010) Hitoshi Nishimura et al.   DEVELOPMENTAL DYNAMICS

Prm1 Targeting to Contact Sites Enhances Fusion during Mating in Saccharomyces cerevisiae

(2010) Valerie N. Olmo et al.   EUKARYOTIC CELL

An invasive podosome-like structure promotes fusion pore formation during myoblast fusion

(2010) Kristin L. Sens et al.   JOURNAL OF CELL BIOLOGY

The Fusogen EFF-1 Controls Sculpting of Mechanosensory Dendrites

(2010) M. Oren-Suissa et al.   SCIENCE

Lipocalin signaling controls unicellular tube development in the Caenorhabditis elegans excretory system

(2009) Craig E. Stone et al.   DEVELOPMENTAL BIOLOGY

The stratified syncytium of the vertebrate lens

(2009) Y. Shi et al.   JOURNAL OF CELL SCIENCE

How Does Synaptotagmin Trigger Neurotransmitter Release?

(2008) Edwin R. Chapman   Annual Review of Biochemistry

Lysosomal disorders: From storage to cellular damage

(2008) Andrea Ballabio et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Notch Signaling and Morphogenesis of Single-Cell Tubes in the C. elegans Digestive Tract

(2008) Jeffrey P. Rasmussen et al.   DEVELOPMENTAL CELL

Viral and Developmental Cell Fusion Mechanisms: Conservation and Divergence

(2008) Amir Sapir et al.   DEVELOPMENTAL CELL

The conserved plant sterility gene HAP2 functions after attachment of fusogenic membranes in Chlamydomonas and Plasmodium gametes

(2008) Y. Liu et al.   GENES & DEVELOPMENT

Mechanics of membrane fusion

(2008) Leonid V Chernomordik et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Comparative Transcriptomics of Arabidopsis Sperm Cells

(2008) F. Borges et al.   PLANT PHYSIOLOGY

Changing of the cell division axes drives vulva evolution in nematodes

(2007) Irina Kolotuev et al.   DEVELOPMENTAL BIOLOGY