Osteoclast Fusion: Physiological Regulation of Multinucleation through Heterogeneity—Potential Implications for Drug Sensitivity

miR-99a in bone homeostasis: Regulating osteogenic lineage commitment and osteoclast differentiation

(2020) Sara Reis Moura et al.   BONE

Treatment with zoledronate subsequent to denosumab in osteoporosis: a randomized trial

(2020) Anne Sophie Sølling et al.   JOURNAL OF BONE AND MINERAL RESEARCH

ATRAID regulates the action of nitrogen-containing bisphosphonates on bone

(2020) Lauren E. Surface et al.   Science Translational Medicine

Ostm1 from Mouse to Human: Insights into Osteoclast Maturation

(2020) Jean Vacher et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Osteoclast Multinucleation: Review of Current Literature

(2020) Joe Kodama et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Osteoclast formation at the bone marrow/bone surface interface: Importance of structural elements, matrix, and intercellular communication

(2020) Kent Søe et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

A trans-eQTL network regulates osteoclast multinucleation and bone mass

(2020) Marie Pereira et al.   eLife

Re-thinking the bone remodeling cycle mechanism and the origin of bone loss

(2020) Jean-Marie Delaisse et al.   BONE

Heterogeneity and Actin Cytoskeleton in Osteoclast and Macrophage Multinucleation

(2020) Jiro Takito et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Fusion Potential of Human Osteoclasts In Vitro Reflects Age, Menopause, and In Vivo Bone Resorption Levels of Their Donors—A Possible Involvement of DC-STAMP

(2020) Anaïs M. J. Møller et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Genetic regulatory mechanisms in human osteoclasts suggest a role for the STMP1 and DCSTAMP genes in Paget’s disease of bone

(2019) Benjamin H. Mullin et al.   Scientific Reports

Membrane trafficking in osteoclasts and implications for osteoporosis

(2019) Pei Ying Ng et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

A Genome-Wide Association Study of Bisphosphonate-Associated Atypical Femoral Fracture

(2019) Mohammad Kharazmi et al.   CALCIFIED TISSUE INTERNATIONAL

How cells fuse

(2019) Nicolas G. Brukman et al.   JOURNAL OF CELL BIOLOGY

Developmental origin, functional maintenance and genetic rescue of osteoclasts

(2019) Christian E. Jacome-Galarza et al.   NATURE

The bone marrow microenvironment at single-cell resolution

(2019) Anastasia N. Tikhonova et al.   NATURE

Pharmacogenomics of osteonecrosis of the jaw

(2019) Guang Yang et al.   BONE

Coordination of Fusion and Trafficking of Pre-osteoclasts at the Marrow–Bone Interface

(2019) Kent Søe et al.   CALCIFIED TISSUE INTERNATIONAL

Osteoclasts Provide Coupling Signals to Osteoblast Lineage Cells Through Multiple Mechanisms

(2019) Natalie A. Sims et al.   Annual Review of Physiology

EZH2 supports osteoclast differentiation and bone resorption via epigenetic and cytoplasmic targets

(2019) Juraj Adamik et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Zoledronate for the Prevention of Bone Loss in Women Discontinuing Denosumab Treatment. A Prospective 2‐year Clinical Trial

(2019) Athanasios D. Anastasilakis et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Combined single-cell and spatial transcriptomics reveal the molecular, cellular and spatial bone marrow niche organization

(2019) Chiara Baccin et al.   NATURE CELL BIOLOGY

Certainties and Uncertainties About Denosumab Discontinuation

(2018) Elena Tsourdi et al.   CALCIFIED TISSUE INTERNATIONAL

Ostm1 Bifunctional Roles in Osteoclast Maturation: Insights From a Mouse Model Mimicking a Human OSTM1 Mutation

(2018) Monica Pata et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Microgravity modulation of syncytin-A expression enhance osteoclast formation

(2018) Purushoth Ethiraj et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Identification of a transporter complex responsible for the cytosolic entry of nitrogen-containing bisphosphonates

(2018) Zhou Yu et al.   eLife

The Osteoclast in Bone Metastasis: Player and Target

(2018) Antonio Maurizi et al.   Cancers

Increased osteoclastogenesis in patients with vertebral fractures following discontinuation of denosumab treatment

(2017) Athanasios D Anastasilakis et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Cell-surface phosphatidylserine regulates osteoclast precursor fusion

(2017) Santosh K. Verma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Coupling of Bone Resorption and Formation in Real Time: New Knowledge Gained From Human Haversian BMUs

(2017) Nicolai Ernlund Lassen et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Mesenchymal stem cells: key players in cancer progression

(2017) Sarah M. Ridge et al.   Molecular Cancer

Characterization of different osteoclast phenotypes in the progression of bone invasion by oral squamous cell carcinoma

(2017) Jingjing Quan et al.   ONCOLOGY REPORTS

Adult Paget’s disease of bone: a review

(2017) Stephen Paul Tuck et al.   RHEUMATOLOGY

Changes in Bone Turnover Marker Levels and Clinical Outcomes in Patients with Advanced Cancer and Bone Metastases Treated with Bone Antiresorptive Agents

(2016) A. Lipton et al.   CLINICAL CANCER RESEARCH

DC-STAMP: A Key Regulator in Osteoclast Differentiation

(2016) Ya-Hui Chiu et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Osteoclast Fusion: Time-Lapse Reveals Involvement of CD47 and Syncytin-1 at Different Stages of Nuclearity

(2016) Anaïs Marie Julie Møller et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Real-time intravital imaging of pH variation associated with osteoclast activity

(2016) Hiroki Maeda et al.   Nature Chemical Biology

Quiescent Bone Lining Cells Are a Major Source of Osteoblasts During Adulthood

(2016) Igor Matic et al.   STEM CELLS

Genetic Evidence That Captured Retroviral Envelope syncytins Contribute to Myoblast Fusion and Muscle Sexual Dimorphism in Mice

(2016) François Redelsperger et al.   PLoS Genetics

Bone Canopies in Pediatric Renal Osteodystrophy

(2016) Renata C. Pereira et al.   PLoS One

Osteoclast fusion is initiated by a small subset of RANKL-stimulated monocyte progenitors, which can fuse to RANKL-unstimulated progenitors

(2015) Noam Levaot et al.   BONE

The elementary fusion modalities of osteoclasts

(2015) Kent Søe et al.   BONE

Oxysterols and EBI2 promote osteoclast precursor migration to bone surfaces and regulate bone mass homeostasis

(2015) Erin Nevius et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Review: An overview of molecular events occurring in human trophoblast fusion

(2015) P. Gerbaud et al.   PLACENTA

MiR-7b directly targets DC-STAMP causing suppression of NFATc1 and c-Fos signaling during osteoclast fusion and differentiation

(2014) Ce Dou et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Osteoclast Fusion is Based on Heterogeneity Between Fusion Partners

(2014) Anne-Sofie Hobolt-Pedersen et al.   CALCIFIED TISSUE INTERNATIONAL

Syncytin-1 in differentiating human myoblasts: relationship to caveolin-3 and myogenin

(2014) Bolette Bjerregard et al.   CELL AND TISSUE RESEARCH

Syncytin-1 and its receptor is present in human gametes

(2014) B. Bjerregaard et al.   JOURNAL OF ASSISTED REPRODUCTION AND GENETICS

Secretion of a Truncated Osteopetrosis-associated Transmembrane Protein 1 (OSTM1) Mutant Inhibits Osteoclastogenesis through Down-regulation of the B Lymphocyte-induced Maturation Protein 1 (BLIMP1)-Nuclear Factor of Activated T Cells c1 (NFATc1) Axis

(2014) Bongjin Shin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DC-STAMP, the Key Fusion-Mediating Molecule in Osteoclastogenesis

(2014) Chengcheng Zhang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Periodontitis mainly increases osteoclast formation via enhancing the differentiation of quiescent osteoclast precursors into osteoclasts

(2014) D.-E. Lee et al.   JOURNAL OF PERIODONTAL RESEARCH

Kcnn4 Is a Regulator of Macrophage Multinucleation in Bone Homeostasis and Inflammatory Disease

(2014) Heeseog Kang et al.   Cell Reports

Understanding Coupling between Bone Resorption and Formation

(2013) Thomas L. Andersen et al.   AMERICAN JOURNAL OF PATHOLOGY

RANKL Synthesized by Both Stromal Cells and Cancer Cells Plays a Crucial Role in Osteoclastic Bone Resorption Induced by Oral Cancer

(2013) Kiyoshi Sato et al.   AMERICAN JOURNAL OF PATHOLOGY

Systematic Review: Comparative Effectiveness of Treatments to Prevent Fractures in Men and Women with Low Bone Density or Osteoporosis

(2013) Catherine MacLean et al.   ANNALS OF INTERNAL MEDICINE

Bisphosphonate-osteoclasts: Changes in osteoclast morphology and function induced by antiresorptive nitrogen-containing bisphosphonate treatment in osteoporosis patients

(2013) Björn Jobke et al.   BONE

Identification of rare genetic variants in novel loci associated with Paget’s disease of bone

(2013) Mariejka Beauregard et al.   HUMAN GENETICS

PU.1 target genes undergo Tet2-coupled demethylation and DNMT3b-mediated methylation in monocyte-to-osteoclast differentiation

(2013) Lorenzo de la Rica et al.   GENOME BIOLOGY

“Fusion and Fission” Unveils Remarkable Insights into Osteoclast Plasticity

(2012) Nathan John Pavlos et al.   CALCIFIED TISSUE INTERNATIONAL

Osteoclast Fusion and Fission

(2012) Ineke D. C. Jansen et al.   CALCIFIED TISSUE INTERNATIONAL

Pathogenesis of Paget Disease of Bone

(2012) Stuart H. Ralston et al.   CALCIFIED TISSUE INTERNATIONAL

Superiority of denosumab to zoledronic acid for prevention of skeletal-related events: A combined analysis of 3 pivotal, randomised, phase 3 trials

(2012) Allan Lipton et al.   EUROPEAN JOURNAL OF CANCER

Treatment failure in osteoporosis

(2012) A. Diez-Perez et al.   OSTEOPOROSIS INTERNATIONAL

p62/SQSTM1/A170: Physiology and pathology

(2012) Masaaki Komatsu et al.   PHARMACOLOGICAL RESEARCH

A Retrospective Study Evaluating Frequency and Risk Factors of Osteonecrosis of the Jaw in 576 Cancer Patients Receiving Intravenous Bisphosphonates

(2011) Vivek Thumbigere-Math et al.   AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS

Bisphosphonates: The first 40years

(2011) R. Graham G. Russell   BONE

Regulation of human osteoclast development by dendritic cell-specific transmembrane protein (DC-STAMP)

(2011) Ya-Hui Chiu et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Bone remodelling at a glance

(2011) J. C. Crockett et al.   JOURNAL OF CELL SCIENCE

Genome-wide association identifies three new susceptibility loci for Paget's disease of bone

(2011) Omar M E Albagha et al.   NATURE GENETICS

Matrix-embedded cells control osteoclast formation

(2011) Jinhu Xiong et al.   NATURE MEDICINE

Evidence for osteocyte regulation of bone homeostasis through RANKL expression

(2011) Tomoki Nakashima et al.   NATURE MEDICINE

Involvement of human endogenous retroviral syncytin-1 in human osteoclast fusion

(2010) Kent Søe et al.   BONE

Genome-wide association study identifies variants at CSF1, OPTN and TNFRSF11A as genetic risk factors for Paget's disease of bone

(2010) Omar M E Albagha et al.   NATURE GENETICS

Lysosomal Pathology and Osteopetrosis upon Loss of H+-Driven Lysosomal Cl- Accumulation

(2010) S. Weinert et al.   SCIENCE

Myeloma cell-induced disruption of bone remodelling compartments leads to osteolytic lesions and generation of osteoclast-myeloma hybrid cells

(2009) Thomas L. Andersen et al.   BRITISH JOURNAL OF HAEMATOLOGY

Identification of cell cycle–arrested quiescent osteoclast precursors in vivo

(2009) Toshihide Mizoguchi et al.   JOURNAL OF CELL BIOLOGY

Giant Osteoclast Formation and Long-Term Oral Bisphosphonate Therapy

(2009) Robert S. Weinstein et al.   NEW ENGLAND JOURNAL OF MEDICINE

Syncytin-A knockout mice demonstrate the critical role in placentation of a fusogenic, endogenous retrovirus-derived, envelope gene

(2009) A. Dupressoir et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Physical Mechanism for Coupling Bone Resorption and Formation in Adult Human Bone

(2008) Thomas Levin Andersen et al.   AMERICAN JOURNAL OF PATHOLOGY

Ion channels and transporters in osteoclasts

(2008) Chayarop Supanchart et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Large Osteoclasts in Pediatric Osteogenesis Imperfecta Patients Receiving Intravenous Pamidronate

(2008) Moira S Cheung et al.   JOURNAL OF BONE AND MINERAL RESEARCH