PTPRJ promotes osteoclast maturation and activity by inhibiting Cbl‐mediated ubiquitination of NFATc1 in late osteoclastogenesis

Massive osteopetrosis caused by non-functional osteoclasts in R51Q SNX10 mutant mice

(2020) Merle Stein et al.   BONE

Phosphorylation of the phosphatase PTPROt at Tyr399 is a molecular switch that controls osteoclast activity and bone mass in vivo

(2019) Lee Roth et al.   Science Signaling

Osteoporosis

(2019) Juliet E Compston et al.   LANCET

Osteoclasts Provide Coupling Signals to Osteoblast Lineage Cells Through Multiple Mechanisms

(2019) Natalie A. Sims et al.   Annual Review of Physiology

The protein tyrosine phosphatase PTPRJ/DEP-1 contributes to the regulation of the Notch-signaling pathway and sprouting angiogenesis

(2019) Patrick Fournier et al.   ANGIOGENESIS

The roles of protein tyrosine phosphatases in bone-resorbing osteoclasts

(2018) Moran Shalev et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The Sealing Zone in Osteoclasts: A Self-Organized Structure on the Bone

(2018) et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Genetics of Osteopetrosis

(2018) Eleonora Palagano et al.   Current Osteoporosis Reports

PTPRJ Inhibits Leptin Signaling, and Induction of PTPRJ in the Hypothalamus Is a Cause of the Development of Leptin Resistance

(2017) Takafumi Shintani et al.   Scientific Reports

Tyrosine Phosphatase PTPRJ/DEP-1 Is an Essential Promoter of Vascular Permeability, Angiogenesis, and Tumor Progression

(2016) P. Fournier et al.   CANCER RESEARCH

Feel the force: Podosomes in mechanosensing

(2016) Stefan Linder et al.   EXPERIMENTAL CELL RESEARCH

Positive Regulation of Lyn Kinase by CD148 Is Required for B Cell Receptor Signaling in B1 but Not B2 B Cells

(2016) Katarzyna M. Skrzypczynska et al.   IMMUNITY

Osteoclast fusion is initiated by a small subset of RANKL-stimulated monocyte progenitors, which can fuse to RANKL-unstimulated progenitors

(2015) Noam Levaot et al.   BONE

The elementary fusion modalities of osteoclasts

(2015) Kent Søe et al.   BONE

The R3 receptor-like protein tyrosine phosphatase subfamily inhibits insulin signalling by dephosphorylating the insulin receptor at specific sites

(2015) Takafumi Shintani et al.   JOURNAL OF BIOCHEMISTRY

Unraveling CRISPR-Cas9 genome engineering parameters via a library-on-library approach

(2015) Raj Chari et al.   NATURE METHODS

Enhanced insulin signaling in density-enhanced phosphatase-1 (DEP-1) knockout mice

(2015) Janine Krüger et al.   Molecular Metabolism

Phosphorylation of DEP-1/PTPRJ on threonine 1318 regulates Src activation and endothelial cell permeability induced by vascular endothelial growth factor

(2014) Kathleen Spring et al.   CELLULAR SIGNALLING

Thrombospondin-1 Regulates Bone Homeostasis Through Effects on Bone Matrix Integrity and Nitric Oxide Signaling in Osteoclasts

(2014) Sarah R Amend et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Podosome organization drives osteoclast-mediated bone resorption

(2014) Dan Georgess et al.   Cell Adhesion & Migration

Macrophage Fusion Is Controlled by the Cytoplasmic Protein Tyrosine Phosphatase PTP-PEST/PTPN12

(2013) I. Rhee et al.   MOLECULAR AND CELLULAR BIOLOGY

Osteoclasts: New Insights

(2013) Feng Xu et al.   Bone Research

Osteoclast Fusion and Fission

(2012) Ineke D. C. Jansen et al.   CALCIFIED TISSUE INTERNATIONAL

c-Src Links a RANK/ v 3 Integrin Complex to the Osteoclast Cytoskeleton

(2012) T. Izawa et al.   MOLECULAR AND CELLULAR BIOLOGY

Primer3—new capabilities and interfaces

(2012) Andreas Untergasser et al.   NUCLEIC ACIDS RESEARCH

Thrombospondin-1 acts as a ligand for CD148 tyrosine phosphatase

(2012) K. Takahashi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The osteoclast and its unique cytoskeleton

(2011) Steven L. Teitelbaum   Annals of the New York Academy of Sciences

Inhibition of T-cell activation by syndecan-4 is mediated by CD148 through protein tyrosine phosphatase activity

(2011) Jin-Sung Chung et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Regulation of Src Family Kinases Involved in T Cell Receptor Signaling by Protein-tyrosine Phosphatase CD148

(2011) Ondrej Stepanek et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Syndecan-2 is a novel ligand for the protein tyrosine phosphatase receptor CD148

(2011) James R. Whiteford et al.   MOLECULAR BIOLOGY OF THE CELL

Integrins, growth factors, and the osteoclast cytoskeleton

(2010) Wei Zou et al.   Annals of the New York Academy of Sciences

The Loss of Cbl-Phosphatidylinositol 3-Kinase Interaction Perturbs RANKL-mediated Signaling, Inhibiting Bone Resorption and Promoting Osteoclast Survival

(2010) Naga Suresh Adapala et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Negative Regulation of EGFR-Vav2 Signaling Axis by Cbl Ubiquitin Ligase Controls EGF Receptor-mediated Epithelial Cell Adherens Junction Dynamics and Cell Migration

(2010) Lei Duan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CD148 enhances platelet responsiveness to collagen by maintaining a pool of active Src family kinases

(2010) S. ELLISON et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

The tyrosine phosphatase CD148 is an essential positive regulator of platelet activation and thrombosis

(2009) Y. A. Senis et al.   BLOOD

CD148/DEP-1 association with areas of cytoskeletal organisation in macrophages

(2009) Richa K. Dave et al.   EXPERIMENTAL CELL RESEARCH

CD45, CD148, and Lyp/Pep: critical phosphatases regulating Src family kinase signaling networks in immune cells

(2009) Michelle L. Hermiston et al.   IMMUNOLOGICAL REVIEWS

Negative Feedback Control of Osteoclast Formation through Ubiquitin-mediated Down-regulation of NFATc1

(2009) Jung Ha Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activation of Src kinase by protein-tyrosine phosphatase-PEST in osteoclasts: Comparative analysis of the effects of bisphosphonate and protein-tyrosine phosphatase inhibitor on Src activation in vitro

(2009) Meenakshi A. Chellaiah et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Osteopetrosis with micro-lacunar resorption because of defective integrin organization

(2009) Harry C Blair et al.   LABORATORY INVESTIGATION

Protein Tyrosine Phosphatase Epsilon Regulates Integrin-mediated Podosome Stability in Osteoclasts by Activating Src

(2009) Shira Granot-Attas et al.   MOLECULAR BIOLOGY OF THE CELL

Src-dependent repression of ARF6 is required to maintain podosome-rich sealing zones in bone-digesting osteoclasts

(2009) T. Heckel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structurally Distinct Phosphatases CD45 and CD148 Both Regulate B Cell and Macrophage Immunoreceptor Signaling

(2008) Jing W. Zhu et al.   IMMUNITY

CD45 regulates retention, motility, and numbers of hematopoietic progenitors, and affects osteoclast remodeling of metaphyseal trabecules

(2008) Shoham Shivtiel et al.   JOURNAL OF EXPERIMENTAL MEDICINE

New Role for the Protein Tyrosine Phosphatase DEP-1 in Akt Activation and Endothelial Cell Survival

(2008) C. Chabot et al.   MOLECULAR AND CELLULAR BIOLOGY

Osteoclast stimulatory transmembrane protein (OC-STAMP), a novel protein induced by RANKL that promotes osteoclast differentiation

(2007) Meiheng Yang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

NFATc1 Induces Osteoclast Fusion Via Up-Regulation of Atp6v0d2 and the Dendritic Cell-Specific Transmembrane Protein (DC-STAMP)

(2007) Kabsun Kim et al.   MOLECULAR ENDOCRINOLOGY