Mitochondrial targeting theranostic nanomedicine and molecular biomarkers for efficient cancer diagnosis and therapy

Recent Advancements in Mitochondria-Targeted Nanoparticle Drug Delivery for Cancer Therapy

(2022) Jiangsheng Xu et al.   Nanomaterials

Multifunctional Programmable DNA Nanotrain for Activatable Hypoxia Imaging and Mitochondrion-Targeted Enhanced Photodynamic Therapy

(2021) Jin Liu et al.   ACS Applied Materials & Interfaces

Krebs cycle: activators, inhibitors and their roles in the modulation of carcinogenesis

(2021) Amin Gasmi et al.   ARCHIVES OF TOXICOLOGY

Biodegradable Polymeric Nanoparticles for Drug Delivery to Solid Tumors

(2021) Agnese Gagliardi et al.   Frontiers in Pharmacology

Therapeutic Mechanism and Effect of Camptothecin on Dextran Sodium Sulfate-Induced Ulcerative Colitis in Mice

(2021) Yizhuo Wang et al.   Journal of Immunology Research

Alternative Animal Models of Aging Research

(2021) Susanne Holtze et al.   Frontiers in Molecular Biosciences

Lipid Nanoparticles—From Liposomes to mRNA Vaccine Delivery, a Landscape of Research Diversity and Advancement

(2021) Rumiana Tenchov et al.   ACS Nano

Subcellular localization of biomolecules and drug distribution by high-definition ion beam imaging

(2021) Xavier Rovira-Clavé et al.   Nature Communications

Interactions of multidomain pro-apoptotic and anti-apoptotic proteins in cancer cell death

(2021) Alexander Chota et al.   Oncotarget

Increased mitochondrial protein import and cardiolipin remodelling upon early mtUPR

(2021) Daniel Poveda-Huertes et al.   PLoS Genetics

Biomedical Relevance of Novel Anticancer Peptides in the Sensitive Treatment of Cancer

(2021) Olalekan Olanrewaju Bakare et al.   Biomolecules

Metabolic regulation in the immune response to cancer

(2021) Qi Wu et al.   Cancer Communications

Emerging treatment modalities for systemic therapy in hepatocellular carcinoma

(2021) Xin Qing et al.   Biomarker Research

Development of D-melittin polymeric nanoparticles for anti-cancer treatment

(2021) Shixian Lv et al.   BIOMATERIALS

Engineered Cell‐Penetrating Peptides for Mitochondrion‐Targeted Drug Delivery in Cancer Therapy

(2021) Qicai Xiao et al.   CHEMISTRY-A EUROPEAN JOURNAL

BCL‐2‐family protein tBID can act as a BAX‐like effector of apoptosis

(2021) Hector Flores‐Romero et al.   EMBO JOURNAL

Synergism of a novel MCL‑1 downregulator, acriflavine, with navitoclax (ABT‑263) in triple‑negative breast cancer, lung adenocarcinoma and glioblastoma multiforme

(2021) Anbok Lee et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Insights on functionalized carbon nanotubes for cancer theranostics

(2021) Lu Tang et al.   JOURNAL OF NANOBIOTECHNOLOGY

The potassium channel Kv1.3 as a therapeutic target for immunocytoprotection after reperfusion

(2021) Yi‐Je Chen et al.   Annals of Clinical and Translational Neurology

Multifunctional Mitochondria-Targeting Nanosystems for Enhanced Anticancer Efficacy

(2021) Tingting Hu et al.   Frontiers in Bioengineering and Biotechnology

ROS in cancer therapy: the bright side of the moon

(2020) Bruno Perillo et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Nanocarrier-Based Therapeutics and Theranostics Drug Delivery Systems for Next Generation of Liver Cancer Nanodrug Modalities

(2020) Umme Ruman et al.   International Journal of Nanomedicine

Overcoming multidrug resistance in cancer: Recent progress in nanotechnology and new horizons

(2020) Maryam Majidinia et al.   IUBMB LIFE

Tumor- and mitochondria-targeted nanoparticles eradicate drug resistant lung cancer through mitochondrial pathway of apoptosis

(2020) He Wang et al.   JOURNAL OF NANOBIOTECHNOLOGY

The Application of Arsenic Trioxide in Ameliorating ABT-737 Target Therapy on Uterine Cervical Cancer Cells through Unique Pathways in Cell Death

(2020) I-Lun Hsin et al.   Cancers

Mitochondrial lactate metabolism: history and implications for exercise and disease

(2020) Brian Glancy et al.   JOURNAL OF PHYSIOLOGY-LONDON

Therapeutic Nanoparticles and Their Targeted Delivery Applications

(2020) Abuzer Alp Yetisgin et al.   MOLECULES

Mitochondrion- and nucleus-acting polymeric nanoagents for chemo-photothermal combination therapy

(2020) Xiaoyang Liu et al.   Science China-Materials

Rotenone restrains colon cancer cell viability, motility and epithelial‑mesenchymal transition and tumorigenesis in nude mice via the PI3K/AKT pathway

(2020) Wenbo Xiao et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Tumor Targeted Nanoparticles Improve Therapeutic Index of BCL2 and MCL1 dual inhibition

(2020) Neeta Bala Tannan et al.   BLOOD

Clinical trials in mitochondrial disorders, an update

(2020) Mohammed Almannai et al.   MOLECULAR GENETICS AND METABOLISM

Inhibition of Tumor Growth against Chemoresistant Cholangiocarcinoma by a Proapoptotic Peptide Targeting Interleukin-4 Receptor

(2020) Uttapol Permpoon et al.   MOLECULAR PHARMACEUTICS

Potential anticancer activity of a new pro-apoptotic peptide–thioctic acid gold nanoparticle platform

(2020) Mohammad Akrami et al.   NANOTECHNOLOGY

Engineering precision nanoparticles for drug delivery

(2020) Michael J. Mitchell et al.   NATURE REVIEWS DRUG DISCOVERY

Targeting the Opening of Mitochondrial Permeability Transition Pores Potentiates Nanoparticle Drug Delivery and Mitigates Cancer Metastasis

(2020) Xi Lin et al.   Advanced Science

Targeting mitochondrial ion channels for cancer therapy

(2020) Ildiko Szabo et al.   Redox Biology

Progress of Cancer Nanotechnology as Diagnostics, Therapeutics, and Theranostics Nanomedicine: Preclinical Promise and Translational Challenges

(2020) Sultan Alshehri et al.   Pharmaceutics

Obatoclax, a BH3 Mimetic, Enhances Cisplatin-Induced Apoptosis and Decreases the Clonogenicity of Muscle Invasive Bladder Cancer Cells via Mechanisms That Involve the Inhibition of Pro-Survival Molecules as Well as Cell Cycle Regulators

(2019) Thomas Steele et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Sequential Delivery and Cascade Targeting of Peptide Therapeutics for Triplexed Synergistic Therapy with Real-Time Monitoring Shuttled by Magnetic Gold Nanostars

(2019) Rong Wu et al.   ANALYTICAL CHEMISTRY

Mitochondria-Targeted and Ultrasound-Activated Nanodroplets for Enhanced Deep-Penetration Sonodynamic Cancer Therapy

(2019) Liang Zhang et al.   ACS Applied Materials & Interfaces

BCL2 Amplicon Loss and Transcriptional Remodeling Drives ABT-199 Resistance in B Cell Lymphoma Models

(2019) Xiaohong Zhao et al.   CANCER CELL

Intelligent polymeric micelles for multidrug co-delivery and cancer therapy

(2019) Guangping Yu et al.   Artificial Cells Nanomedicine and Biotechnology

Eradication of unresectable liver metastasis through induction of tumour specific energy depletion

(2019) Da Huo et al.   Nature Communications

Exploiting Mitochondrial Vulnerabilities to Trigger Apoptosis Selectively in Cancer Cells

(2019) Christopher Nguyen et al.   Cancers

Hexokinase 2 Regulates Ovarian Cancer Cell Migration, Invasion and Stemness via FAK/ERK1/2/MMP9/NANOG/SOX9 Signaling Cascades

(2019) Michelle K. Y. Siu et al.   Cancers

Mitochondrial Uncoupling: A Key Controller of Biological Processes in Physiology and Diseases

(2019) Demine et al.   Cells

Tumor targeting peptides: novel therapeutic strategies in glioblastoma

(2019) Drazen Raucher   CURRENT OPINION IN PHARMACOLOGY

Identification of an ATP-sensitive potassium channel in mitochondria

(2019) Angela Paggio et al.   NATURE

A Kinetic Map of the Homomeric Voltage-Gated Potassium Channel (Kv) Family

(2019) Rajnish Ranjan et al.   Frontiers in Cellular Neuroscience

Aggregation determines the selectivity of membrane-active anticancer and antimicrobial peptides: The case of killerFLIP

(2019) Zahra Vaezi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Cationic Oligopeptide-Functionalized Mitochondria Targeting Sequence Show Mitochondria Targeting and Anticancer Activity

(2019) Yoonhee Bae et al.   MACROMOLECULAR RESEARCH

Mitochondria-acting nanomicelles for destruction of cancer cells via excessive mitophagy/autophagy-driven lethal energy depletion and phototherapy

(2019) Ya-Xuan Zhu et al.   BIOMATERIALS

Estimates of incidence and mortality of cervical cancer in 2018: a worldwide analysis

(2019) Marc Arbyn et al.   Lancet Global Health

“Triple-Punch” Anticancer Strategy Mediated by Near-Infrared Photosensitizer/CpG Oligonucleotides Dual-Dressed and Mitochondria-Targeted Nanographene

(2018) Chunhui Wu et al.   ACS Applied Materials & Interfaces

Overcoming Multidrug Resistance through the GLUT1-Mediated and Enzyme-Triggered Mitochondrial Targeting Conjugate with Redox-Sensitive Paclitaxel Release

(2018) Pengkai Ma et al.   ACS Applied Materials & Interfaces

Precisely Striking Tumors without Adjacent Normal Tissue Damage via Mitochondria-Templated Accumulation

(2018) Zhaoyu Ma et al.   ACS Nano

Cognitive Effects of Cancer and Cancer Treatments

(2018) Tim A. Ahles et al.   Annual Review of Clinical Psychology

Rational Design of Multifunctional Polymeric Nanoparticles Based on Poly(l-histidine) and d-α-Vitamin E Succinate for Reversing Tumor Multidrug Resistance

(2018) Zhen Li et al.   BIOMACROMOLECULES

Mitochondrial alkaline pH-responsive drug release mediated by Celastrol loaded glycolipid-like micelles for cancer therapy

(2018) Yanan Tan et al.   BIOMATERIALS

Mitochondrial Ca 2+ -activated K + channels and their role in cell life and death pathways

(2018) Inge E. Krabbendam et al.   CELL CALCIUM

New natural inhibitors of hexokinase 2 (HK2): Steroids from Ganoderma sinense

(2018) Fengyan Bao et al.   FITOTERAPIA

Targeting Mitochondrial Ion Channels to Fight Cancer

(2018) Magdalena Bachmann et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

BCL-2 as therapeutic target for hematological malignancies

(2018) Guilherme Fleury Perini et al.   Journal of Hematology & Oncology

Selective induction of cancer cell death by VDAC1-based peptides and their potential use in cancer therapy

(2018) Anna Shteinfer-Kuzmine et al.   Molecular Oncology

The expanding role of prodrugs in contemporary drug design and development

(2018) Jarkko Rautio et al.   NATURE REVIEWS DRUG DISCOVERY

Mechanisms of clathrin-mediated endocytosis

(2018) Marko Kaksonen et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The role of the mitochondrial calcium uniporter (MCU) complex in cancer

(2018) Adina Vultur et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Targeting BCL-2 regulated apoptosis in cancer

(2018) Kirsteen J. Campbell et al.   Open Biology

VDAC1 as Pharmacological Target in Cancer and Neurodegeneration: Focus on Its Role in Apoptosis

(2018) Andrea Magrì et al.   Frontiers in Chemistry

Nano based drug delivery systems: recent developments and future prospects

(2018) Jayanta Kumar Patra et al.   JOURNAL OF NANOBIOTECHNOLOGY

Mitochondrial-Targeting Anticancer Agent Conjugates and Nanocarrier Systems for Cancer Treatment

(2018) Gantumur Battogtokh et al.   Frontiers in Pharmacology

Improving the Phototherapeutic Efficiencies of Molecular and Nanoscale Materials by Targeting Mitochondria

(2018) Fengming Lin et al.   MOLECULES

Mitochondrial Permeability Transition: A Molecular Lesion with Multiple Drug Targets

(2018) Thomas Briston et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Programmed cell death protein-1/programmed death-ligand 1 blockade enhances the antitumor efficacy of adoptive cell therapy against non-small cell lung cancer

(2018) Jingyi Chen et al.   Journal of Thoracic Disease

iRGD as a tumor-penetrating peptide for cancer therapy

(2017) Hong Yin et al.   Molecular Medicine Reports

Mitochondria-targeting self-assembled nanoparticles derived from triphenylphosphonium-conjugated cyanostilbene enable site-specific imaging and anticancer drug delivery

(2017) Ka Young Kim et al.   Nano Research

Carbon quantum dots with intrinsic mitochondrial targeting ability for mitochondria-based theranostics

(2017) Xian-Wu Hua et al.   Nanoscale

Redox-triggered activation of nanocarriers for mitochondria-targeting cancer chemotherapy

(2017) Wei Zhou et al.   Nanoscale

Co-treatment of breast cancer cells with pharmacologic doses of 2-deoxy-D-glucose and metformin: Starving tumors

(2017) Ulrike Wokoun et al.   ONCOLOGY REPORTS

Non-glycanated Decorin Is a Drug Target on Human Adipose Stromal Cells

(2017) Alexes C. Daquinag et al.   Molecular Therapy-Oncolytics

Nanopreparations for mitochondria targeting drug delivery system: Current strategies and future prospective

(2017) Zhenjie Wang et al.   Asian Journal of Pharmaceutical Sciences

The Landscape of mtDNA Modifications in Cancer: A Tale of Two Cities

(2017) Kate L. Hertweck et al.   Frontiers in Oncology

Structure, Activity Regulation, and Role of the Mitochondrial Calcium Uniporter in Health and Disease

(2017) Cristina Mammucari et al.   Frontiers in Oncology

Origin of anti-tumor activity of the cysteine-containing GO peptides and further optimization of their cytotoxic properties

(2017) Irina I. Tyuryaeva et al.   Scientific Reports

Mitochondria-Targeted Hydroxyapatite Nanoparticles for Selective Growth Inhibition of Lung Cancer in Vitro and in Vivo

(2016) Yi Sun et al.   ACS Applied Materials & Interfaces

Mitochondria-Targeted Small-Molecule Fluorophores for Dual Modal Cancer Phototherapy

(2016) Shenglin Luo et al.   ADVANCED FUNCTIONAL MATERIALS

Epidemiology, Incidence and Mortality of Bladder Cancer and their Relationship with the Development Index in the World

(2016) Neda Mahdavifar et al.   Asian Pacific Journal of Cancer Prevention

Inhibition of MUC1-C Suppresses MYC Expression and Attenuates Malignant Growth in KRAS Mutant Lung Adenocarcinomas

(2016) Audrey Bouillez et al.   CANCER RESEARCH

Derivatisation of buforin IIb, a cationic henicosapeptide, to afford its complexation to platinum(ii) resulting in a novel platinum(ii)–buforin IIb conjugate with anti-cancer activity

(2016) J. P. Parker et al.   DALTON TRANSACTIONS

Anti-cancer activity of doxorubicin-loaded liposomes co-modified with transferrin and folic acid

(2016) Shravan Kumar Sriraman et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

VDAC-2: Mitochondrial outer membrane regulator masquerading as a channel?

(2016) Svetlana Rajkumar Maurya et al.   FEBS Journal

Delivery of drugs and macromolecules to the mitochondria for cancer therapy

(2016) Phong Lu et al.   JOURNAL OF CONTROLLED RELEASE

Targeted Proapoptotic Peptides Depleting Adipose Stromal Cells Inhibit Tumor Growth

(2016) Alexes C Daquinag et al.   MOLECULAR THERAPY

A tenascin C targeted nanoliposome with navitoclax for specifically eradicating of cancer-associated fibroblasts

(2016) Binlong Chen et al.   Nanomedicine-Nanotechnology Biology and Medicine

Targeting BCL2 with Venetoclax in Relapsed Chronic Lymphocytic Leukemia

(2016) Andrew W. Roberts et al.   NEW ENGLAND JOURNAL OF MEDICINE

iRGD-targeted delivery of a pro-apoptotic peptide activated by cathepsin B inhibits tumor growth and metastasis in mice

(2016) Wang Qifan et al.   TUMOR BIOLOGY

A Fhit-mimetic peptide suppresses annexin A4-mediated chemoresistance to paclitaxel in lung cancer cells

(2016) Eugenio Gaudio et al.   Oncotarget

A novel agent exerts antitumor activity in breast cancer cells by targeting mitochondrial complex II

(2016) Liang Wang et al.   Oncotarget

Tumor-reducing effect of the clinically used drug clofazimine in a SCID mouse model of pancreatic ductal adenocarcinoma

(2016) Angela Zaccagnino et al.   Oncotarget

Mitochondrial Thioredoxin System as a Modulator of Cyclophilin D Redox State

(2016) Alessandra Folda et al.   Scientific Reports

Mitochondria-Targeting Nanoplatform with Fluorescent Carbon Dots for Long Time Imaging and Magnetic Field-Enhanced Cellular Uptake

(2015) Ye Zhang et al.   ACS Applied Materials & Interfaces

Noncovalent Ruthenium(II) Complexes–Single-Walled Carbon Nanotube Composites for Bimodal Photothermal and Photodynamic Therapy with Near-Infrared Irradiation

(2015) Pingyu Zhang et al.   ACS Applied Materials & Interfaces

Self-Targeting Fluorescent Carbon Dots for Diagnosis of Brain Cancer Cells

(2015) Min Zheng et al.   ACS Nano

Understanding nanoparticle cellular entry: A physicochemical perspective

(2015) Charlotte M. Beddoes et al.   ADVANCES IN COLLOID AND INTERFACE SCIENCE

Expression and function of Kv7.4 channels in rat cardiac mitochondria: possible targets for cardioprotection

(2015) Lara Testai et al.   CARDIOVASCULAR RESEARCH

Microenvironmental hCAP-18/LL-37 promotes pancreatic ductal adenocarcinoma by activating its cancer stem cell compartment

(2015) Bruno Sainz et al.   GUT

Magnetic nanoparticles enhance the anticancer activity of cathelicidin LL-37 peptide against colon cancer cells

(2015) Katarzyna Niemirowicz et al.   International Journal of Nanomedicine

Cell-penetrating peptides transport therapeutics into cells

(2015) Joshua D. Ramsey et al.   PHARMACOLOGY & THERAPEUTICS

Mitochondrial targeted peptides for cancer therapy

(2015) Sadaf Farsinejad et al.   TUMOR BIOLOGY

Image-guided combination chemotherapy and photodynamic therapy using a mitochondria-targeted molecular probe with aggregation-induced emission characteristics

(2015) Chong-Jing Zhang et al.   Chemical Science

Core–Shell Nanoparticle-Based Peptide Therapeutics and Combined Hyperthermia for Enhanced Cancer Cell Apoptosis

(2014) Birju P. Shah et al.   ACS Nano

Granzyme B–Activated p53 Interacts with Bcl-2 To Promote Cytotoxic Lymphocyte–Mediated Apoptosis

(2014) Thouraya Ben Safta et al.   JOURNAL OF IMMUNOLOGY

Mitochondrial ion channels as oncological targets

(2014) L Leanza et al.   ONCOGENE

Mitochondrial Reactive Oxygen Species (ROS) and ROS-Induced ROS Release

(2014) Dmitry B. Zorov et al.   PHYSIOLOGICAL REVIEWS

Targeted nanoparticles in mitochondrial medicine

(2014) Rakesh K. Pathak et al.   Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology

The Mitochondrial Permeability Transition Pore and Cancer: Molecular Mechanisms Involved in Cell Death

(2014) Massimo Bonora et al.   Frontiers in Oncology

A specific cell-penetrating peptide induces apoptosis in SKOV3 cells by down-regulation of Bcl-2

(2013) Chuying Ma et al.   BIOTECHNOLOGY LETTERS

Targeting the Mitochondrial Electron Transport Chain Complexes for the Induction of Apoptosis and Cancer Treatment

(2013) Jakub Rohlena et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Cancer Development, Progression, and Therapy: An Epigenetic Overview

(2013) Sibaji Sarkar et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

VDAC1-based peptides: novel pro-apoptotic agents and potential therapeutics for B-cell chronic lymphocytic leukemia

(2013) T Prezma et al.   Cell Death & Disease

Surface conjugation of triphenylphosphonium to target poly(amidoamine) dendrimers to mitochondria

(2012) Swati Biswas et al.   BIOMATERIALS

Mitochondrial metabolism in cancer metastasis

(2012) Federica Sotgia et al.   CELL CYCLE

Targeting the Bcl-2 family for cancer therapy

(2012) Shibu Thomas et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Liposomes loaded with paclitaxel and modified with novel triphenylphosphonium-PEG-PE conjugate possess low toxicity, target mitochondria and demonstrate enhanced antitumor effects in vitro and in vivo

(2012) Swati Biswas et al.   JOURNAL OF CONTROLLED RELEASE

Preliminary evidences on mitochondrial injury and impaired oxidative metabolism in breast cancer

(2012) Lorenza Putignani et al.   MITOCHONDRION

Cancer biomarkers

(2012) N. Lynn Henry et al.   Molecular Oncology

Mitochondrial targeting topotecan-loaded liposomes for treating drug-resistant breast cancer and inhibiting invasive metastases of melanoma

(2011) Yang Yu et al.   BIOMATERIALS

Mitochondrial-targeted Signal Transducer and Activator of Transcription 3 (STAT3) Protects against Ischemia-induced Changes in the Electron Transport Chain and the Generation of Reactive Oxygen Species

(2011) Karol Szczepanek et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oxidative stress and apoptosis induced by hydroxyapatite nanoparticles in C6 cells

(2011) Jing Xu et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Upconversion nanoparticles in biological labeling, imaging, and therapy

(2010) Feng Wang et al.   ANALYST

Quantitative proteomics study of breast cancer cell lines isolated from a single patient: Discovery of TIMM17A as a marker for breast cancer

(2010) Xiaoen Xu et al.   PROTEOMICS

Mitochondrial potassium channel Kv1.3 mediates Bax-induced apoptosis in lymphocytes

(2008) I. Szabo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA