The Mitochondrial Permeability Transition Pore and Cancer: Molecular Mechanisms Involved in Cell Death

Molecular identity of the mitochondrial permeability transition pore and its role in ischemia-reperfusion injury

(2015) Giampaolo Morciano et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

mTOR-targeted therapy: Differential perturbation to mitochondrial membrane potential and permeability transition pore plays a role in therapeutic response

(2014) Jae Eun Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The mitochondrial permeability transition pore is a dispensable element for mitochondrial calcium efflux

(2014) Elena De Marchi et al.   CELL CALCIUM

Mitochondrial metabolism directs stemness and differentiation in P19 embryonal carcinoma stem cells

(2014) I Vega-Naredo et al.   CELL DEATH AND DIFFERENTIATION

Genetic deletion of the mitochondrial phosphate carrier desensitizes the mitochondrial permeability transition pore and causes cardiomyopathy

(2014) J Q Kwong et al.   CELL DEATH AND DIFFERENTIATION

Genetic manipulation of the cardiac mitochondrial phosphate carrier does not affect permeability transition

(2014) Manuel Gutiérrez-Aguilar et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Grape seed proanthocyanidins inhibit H2O2-induced osteoblastic MC3T3-E1 cell apoptosis via ameliorating H2O2-induced mitochondrial dysfunction

(2014) Zhifeng Zhang et al.   JOURNAL OF TOXICOLOGICAL SCIENCES

Molecular mechanisms of cell death: central implication of ATP synthase in mitochondrial permeability transition

(2014) M Bonora et al.   ONCOGENE

An uncoupling channel within the c-subunit ring of the F1FO ATP synthase is the mitochondrial permeability transition pore

(2014) K. N. Alavian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Unified Nomenclature and Amino Acid Numbering for Human PTEN

(2014) R. Pulido et al.   Science Signaling

Chaperoning mitochondrial permeability transition: regulation of transition pore complex by a J-protein, DnaJC15

(2014) D Sinha et al.   Cell Death & Disease

A Dialog on the First 20 Years of PML Research and the Next 20 Ahead

(2014) Rosa Bernardi et al.   Frontiers in Oncology

Perturbed mitochondrial Ca2+signals as causes or consequences of mitophagy induction

(2013) Alessandro Rimessi et al.   Autophagy

The endoplasmic reticulum–mitochondria connection: One touch, multiple functions

(2013) Saverio Marchi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Crosstalk between apoptosis, necrosis and autophagy

(2013) Vassiliki Nikoletopoulou et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

PI3K/Akt/mTOR pathway inhibitors in the therapy of pancreatic neuroendocrine tumors

(2013) Edward M. Wolin   CANCER LETTERS

Potential role of subunit c of F0F1-ATPase and subunit c of storage body in the mitochondrial permeability transition. Effect of the phosphorylation status of subunit c on pore opening

(2013) Tamara Azarashvili et al.   CELL CALCIUM

Role of the c subunit of the FOATP synthase in mitochondrial permeability transition

(2013) Massimo Bonora et al.   CELL CYCLE

Identification of PTEN at the ER and MAMs and its regulation of Ca2+ signaling and apoptosis in a protein phosphatase-dependent manner

(2013) A Bononi et al.   CELL DEATH AND DIFFERENTIATION

Reactive Oxygen Species in Cancer Biology and Anticancer Therapy

(2013) Y. Yang et al.   CURRENT MEDICINAL CHEMISTRY

Loss of MCL-1 leads to impaired autophagy and rapid development of heart failure

(2013) R. L. Thomas et al.   GENES & DEVELOPMENT

Mitochondrial complex I activity and NAD+/NADH balance regulate breast cancer progression

(2013) Antonio F. Santidrian et al.   JOURNAL OF CLINICAL INVESTIGATION

The mitochondrial calcium uniporter complex: molecular components, structure and physiopathological implications

(2013) Saverio Marchi et al.   JOURNAL OF PHYSIOLOGY-LONDON

H-Ras-driven tumoral maintenance is sustained through caveolin-1-dependent alterations in calcium signaling

(2013) A Rimessi et al.   ONCOGENE

Dimers of mitochondrial ATP synthase form the permeability transition pore

(2013) V. Giorgio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bax and Bak function as the outer membrane component of the mitochondrial permeability pore in regulating necrotic cell death in mice

(2013) Jason Karch et al.   eLife

Mitochondrial permeability transition pore as a selective target for anti-cancer therapy

(2013) Dong H. Suh et al.   Frontiers in Oncology

Crosstalk between Bcl-2 family and Ras family small GTPases: potential cell fate regulation?

(2013) Jia Kang et al.   Frontiers in Oncology

Mitochondrial Dysfunction in Cancer

(2013) Michelle L. Boland et al.   Frontiers in Oncology

GSK-3 and mitochondria in cancer cells

(2013) Federica Chiara et al.   Frontiers in Oncology

Inhibition of complex I regulates the mitochondrial permeability transition through a phosphate-sensitive inhibitory site masked by cyclophilin D

(2012) Bo Li et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Mitochondrial Ca2+ and apoptosis

(2012) Carlotta Giorgi et al.   CELL CALCIUM

The PI3K/AKT/mTOR Pathway as a Therapeutic Target in Endometrial Cancer

(2012) B. M. Slomovitz et al.   CLINICAL CANCER RESEARCH

Downregulation of the Mitochondrial Calcium Uniporter by Cancer-Related miR-25

(2012) Saverio Marchi et al.   CURRENT BIOLOGY

Targeting Mitochondria in Fighting Cancer

(2012) Vladimir Gogvadze   CURRENT PHARMACEUTICAL DESIGN

Mediation of the Antiapoptotic Activity of Bcl-xL Protein upon Interaction with VDAC1 Protein

(2012) Nir Arbel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MicroRNA-145 Protects Cardiomyocytes against Hydrogen Peroxide (H2O2)-Induced Apoptosis through Targeting the Mitochondria Apoptotic Pathway

(2012) Ruotian Li et al.   PLoS One

Reperfusion Promotes Mitochondrial Dysfunction following Focal Cerebral Ischemia in Rats

(2012) Jun Li et al.   PLoS One

ATP synthesis and storage

(2012) Massimo Bonora et al.   Purinergic Signalling

VDAC1: from structure to cancer therapy

(2012) Varda Shoshan-Barmatz et al.   Frontiers in Oncology

Upsides and Downsides of Reactive Oxygen Species for Cancer: The Roles of Reactive Oxygen Species in Tumorigenesis, Prevention, and Therapy

(2011) Subash C. Gupta et al.   ANTIOXIDANTS & REDOX SIGNALING

Cyclosporin A and cardioprotection: from investigative tool to therapeutic agent

(2011) DJ Hausenloy et al.   BRITISH JOURNAL OF PHARMACOLOGY

Mitochondrial Subversion in Cancer

(2011) A. Chatterjee et al.   Cancer Prevention Research

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Calcium signaling around Mitochondria Associated Membranes (MAMs)

(2011) Simone Patergnani et al.   Cell Communication and Signaling

Targeting Mcl-1 for the therapy of cancer

(2011) Bridget A Quinn et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Modulation of F0F1-ATP synthase activity by cyclophilin D regulates matrix adenine nucleotide levels

(2011) Christos Chinopoulos et al.   FEBS Journal

The roles of phosphate and the phosphate carrier in the mitochondrial permeability transition pore

(2011) Pinadda Varanyuwatana et al.   MITOCHONDRION

Bcl-xL regulates metabolic efficiency of neurons through interaction with the mitochondrial F1FO ATP synthase

(2011) Kambiz N. Alavian et al.   NATURE CELL BIOLOGY

Cyclosporine-A as a neuroprotective agent against stroke: Its translation from laboratory research to clinical application

(2011) Mohamed M. Osman et al.   NEUROPEPTIDES

Autophagy in health and disease. 5. Mitophagy as a way of life

(2010) Roberta A. Gottlieb et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Heat Shock Protein 60 Regulation of the Mitochondrial Permeability Transition Pore in Tumor Cells

(2010) J. C. Ghosh et al.   CANCER RESEARCH

Ghrelin protects H9c2 cells from hydrogen peroxide-induced apoptosis through NF-κB and mitochondria-mediated signaling

(2010) Qin Zhang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Cancer metabolism: The Warburg effect today

(2010) Leonardo M.R. Ferreira   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Generation of trans-mitochondrial mito-mice by the introduction of a pathogenic G13997A mtDNA from highly metastatic lung carcinoma cells

(2010) Mutsumi Yokota et al.   FEBS LETTERS

The causes of cancer revisited: “Mitochondrial malignancy” and ROS-induced oncogenic transformation – Why mitochondria are targets for cancer therapy

(2010) Stephen J. Ralph et al.   MOLECULAR ASPECTS OF MEDICINE

Heteroplasmic mitochondrial DNA mutations in normal and tumour cells

(2010) Yiping He et al.   NATURE

Targeting mitochondria for cancer therapy

(2010) Simone Fulda et al.   NATURE REVIEWS DRUG DISCOVERY

PML Regulates Apoptosis at Endoplasmic Reticulum by Modulating Calcium Release

(2010) C. Giorgi et al.   SCIENCE

A heteroplasmic, not homoplasmic, mitochondrial DNA mutation promotes tumorigenesis via alteration in reactive oxygen species generation and apoptosis

(2009) J. S. Park et al.   HUMAN MOLECULAR GENETICS

Structural and functional link between the mitochondrial network and the endoplasmic reticulum

(2009) Carlotta Giorgi et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Cyclophilin D Modulates Mitochondrial F0F1-ATP Synthase by Interacting with the Lateral Stalk of the Complex

(2009) Valentina Giorgio et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Calcium Elevation in Mitochondria Is the Main Ca2+Requirement for Mitochondrial Permeability Transition Pore (mPTP) Opening

(2009) Heidi K. Baumgartner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial gateways to cancer

(2009) Lorenzo Galluzzi et al.   MOLECULAR ASPECTS OF MEDICINE

Compartmentalized cancer drug discovery targeting mitochondrial Hsp90 chaperones

(2009) B H Kang et al.   ONCOGENE

Activation of mitochondrial ERK protects cancer cells from death through inhibition of the permeability transition

(2009) A. Rasola et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Akt kinase reducing endoplasmic reticulum Ca2+ release protects cells from Ca2+-dependent apoptotic stimuli

(2008) Saverio Marchi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Glycogen synthase kinase 3β (GSK3β) in tumorigenesis and cancer chemotherapy

(2008) Jia Luo   CANCER LETTERS

Ca2+ Signaling, Mitochondria and Cell Death

(2008) Paolo Pinton et al.   CURRENT MOLECULAR MEDICINE

Intermittent hypoxia is a key regulator of cancer cell and endothelial cell interplay in tumours

(2008) S. Toffoli et al.   FEBS Journal

Frameshift mutation of UVRAG, an autophagy-related gene, in gastric carcinomas with microsatellite instability

(2008) Min Sung Kim et al.   HUMAN PATHOLOGY

The Mitochondrial Phosphate Carrier Interacts with Cyclophilin D and May Play a Key Role in the Permeability Transition

(2008) Anna W. C. Leung et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Frameshift mutations of autophagy-related genesATG2B, ATG5, ATG9BandATG12in gastric and colorectal cancers with microsatellite instability

(2008) Mi Ran Kang et al.   JOURNAL OF PATHOLOGY

Bcl-2 family proteins and cancer

(2008) K W Yip et al.   ONCOGENE

Hexokinase II Detachment from Mitochondria Triggers Apoptosis through the Permeability Transition Pore Independent of Voltage-Dependent Anion Channels

(2008) Federica Chiara et al.   PLoS One

ROS-Generating Mitochondrial DNA Mutations Can Regulate Tumor Cell Metastasis

(2008) K. Ishikawa et al.   SCIENCE

Mitochondrial dynamics and cancer

(2008) Stéphanie Grandemange et al.   SEMINARS IN CANCER BIOLOGY

Mitochondria in cancer cells: what is so special about them?

(2008) Vladimir Gogvadze et al.   TRENDS IN CELL BIOLOGY