Targeted nanoparticles in mitochondrial medicine

Mito-DCA: A Mitochondria Targeted Molecular Scaffold for Efficacious Delivery of Metabolic Modulator Dichloroacetate

(2014) Rakesh K. Pathak et al.   ACS Chemical Biology

Molecular Vehicles for Mitochondrial Chemical Biology and Drug Delivery

(2014) Sae Rin Jean et al.   ACS Chemical Biology

Detouring of cisplatin to access mitochondrial genome for overcoming resistance

(2014) S. Marrache et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The synthesis and functional evaluation of a mitochondria-targeted hydrogen sulfide donor, (10-oxo-10-(4-(3-thioxo-3H-1,2-dithiol-5-yl)phenoxy)decyl)triphenylphosphonium bromide (AP39)

(2014) Sophie Le Trionnaire et al.   MedChemComm

Targeted Delivery of Doxorubicin to Mitochondria

(2013) Graham R. Chamberlain et al.   ACS Chemical Biology

Ex Vivo Programming of Dendritic Cells by Mitochondria-Targeted Nanoparticles to Produce Interferon-Gamma for Cancer Immunotherapy

(2013) Sean Marrache et al.   ACS Nano

Tuning the Intracellular Bacterial Targeting of Peptidic Vectors

(2013) Eric K. Lei et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Multifunctional Nanoparticles for Drug Delivery and Molecular Imaging

(2013) Gang Bao et al.   Annual Review of Biomedical Engineering

Oxidative stress and mitochondrial dysfunction in Alzheimer's disease

(2013) Xinglong Wang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Cellular Uptake and Cytotoxicity of Drug–Peptide Conjugates Regulated by Conjugation Site

(2013) Pengcheng Zhang et al.   BIOCONJUGATE CHEMISTRY

The anticancer efficacy of paclitaxel liposomes modified with mitochondrial targeting conjugate in resistant lung cancer

(2013) Jia Zhou et al.   BIOMATERIALS

Enhanced cytotoxicity to cancer cells by mitochondria-targeting MWCNTs containing platinum(IV) prodrug of cisplatin

(2013) Sia Lee Yoong et al.   BIOMATERIALS

Mitochondria-targeted vitamin E analogs inhibit breast cancer cell energy metabolism and promote cell death

(2013) Gang Cheng et al.   BMC CANCER

Targeting mitochondrial cardiolipin and the cytochromec/cardiolipin complex to promote electron transport and optimize mitochondrial ATP synthesis

(2013) A V Birk et al.   BRITISH JOURNAL OF PHARMACOLOGY

Targeting Mitochondrial DNA with a Platinum-Based Anticancer Agent

(2013) Simon P. Wisnovsky et al.   CHEMISTRY & BIOLOGY

Nanocarriers for Tracking and Treating Diseases

(2013) Sean Marrache et al.   CURRENT MEDICINAL CHEMISTRY

A Selective Mitochondrial-Targeted Chlorambucil with Remarkable Cytotoxicity in Breast and Pancreatic Cancers

(2013) Melissa Millard et al.   JOURNAL OF MEDICINAL CHEMISTRY

Peptide-based carbon nanotubes for mitochondrial targeting

(2013) Alessia Battigelli et al.   Nanoscale

Mitochondrial Delivery of Doxorubicin by Triphenylphosphonium-Functionalized Hyperbranched Nanocarriers Results in Rapid and Severe Cytotoxicity

(2013) Theodossis A. Theodossiou et al.   PHARMACEUTICAL RESEARCH

Myc-induced AMPK-phospho p53 pathway activates Bak to sensitize mitochondrial apoptosis

(2013) A. I. Nieminen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial targeting dendrimer allows efficient and safe gene delivery

(2013) Xinyu Wang et al.   Journal of Materials Chemistry B

Late administration of Mn porphyrin-based SOD mimic enhances diabetic complications

(2013) Dana K. Ali et al.   Redox Biology

Mitochondrial Dysfunction in Cancer

(2013) Michelle L. Boland et al.   Frontiers in Oncology

Mitochondria in Vascular Health and Disease

(2012) Peter Dromparis et al.   Annual Review of Physiology

Surface conjugation of triphenylphosphonium to target poly(amidoamine) dendrimers to mitochondria

(2012) Swati Biswas et al.   BIOMATERIALS

Targeted polymeric therapeutic nanoparticles: design, development and clinical translation

(2012) Nazila Kamaly et al.   CHEMICAL SOCIETY REVIEWS

A Mitochondria-Targeted Macrocyclic Mn(II) Superoxide Dismutase Mimetic

(2012) Geoffrey F. Kelso et al.   CHEMISTRY & BIOLOGY

Immune stimulating photoactive hybrid nanoparticles for metastatic breast cancer

(2012) Sean Marrache et al.   Integrative Biology

Intracellular delivery of redox cycler-doxorubicin to the mitochondria of cancer cell by folate receptor targeted mitocancerotropic liposomes

(2012) Sarandeep Singh Malhi et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Mitochondrial dysfunction and cancer metastasis

(2012) Emily I. Chen   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Liposomes loaded with paclitaxel and modified with novel triphenylphosphonium-PEG-PE conjugate possess low toxicity, target mitochondria and demonstrate enhanced antitumor effects in vitro and in vivo

(2012) Swati Biswas et al.   JOURNAL OF CONTROLLED RELEASE

In Vitro assessment of the utility of stearyl triphenyl phosphonium modified liposomes in overcoming the resistance of ovarian carcinoma Ovcar-3 cells to paclitaxel

(2012) Melani A. Solomon et al.   MITOCHONDRION

Engineering of blended nanoparticle platform for delivery of mitochondria-acting therapeutics

(2012) S. Marrache et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial Evolution

(2012) M. W. Gray   Cold Spring Harbor Perspectives in Biology

Mitochondria-Targeted Small Molecule Therapeutics and Probes

(2011) Robin A.J. Smith et al.   ANTIOXIDANTS & REDOX SIGNALING

Manganese superoxide dismutase, MnSOD and its mimics

(2011) Sumitra Miriyala et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Design and Evaluation of Multifunctional Nanocarriers for Selective Delivery of Coenzyme Q10 to Mitochondria

(2011) Anjali Sharma et al.   BIOMACROMOLECULES

The use of mitochondrial targeting resveratrol liposomes modified with a dequalinium polyethylene glycol-distearoylphosphatidyl ethanolamine conjugate to induce apoptosis in resistant lung cancer cells

(2011) Xiao-Xing Wang et al.   BIOMATERIALS

Rerouting Chlorambucil to Mitochondria Combats Drug Deactivation and Resistance in Cancer Cells

(2011) Sonali B. Fonseca et al.   CHEMISTRY & BIOLOGY

Neuroprotective Efficacy from a Lipophilic Redox-Modulating Mn(III) N-Hexylpyridylporphyrin, MnTnHex-2-PyP: Rodent Models of Ischemic Stroke and Subarachnoid Hemorrhage

(2011) H. Sheng et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Maximizing the Therapeutic Window of an Antimicrobial Drug by Imparting Mitochondrial Sequestration in Human Cells

(2011) Mark P. Pereira et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Selective Uncoupling of Individual Mitochondria within a Cell Using a Mitochondria-Targeted Photoactivated Protonophore

(2011) Susan Chalmers et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A novel mitotropic oligolysine nanocarrier: Targeted delivery of covalently bound D-Luciferin to cell mitochondria

(2011) Theodossis A. Theodossiou et al.   MITOCHONDRION

From Serendipity to Mitochondria-Targeted Nanocarriers

(2011) Volkmar Weissig   PHARMACEUTICAL RESEARCH

Mitochondria-targeted penetrating cations as carriers of hydrophobic anions through lipid membranes

(2010) Tatyana I. Rokitskaya et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

DNA Damage Links Mitochondrial Dysfunction to Atherosclerosis and the Metabolic Syndrome

(2010) John R. Mercer et al.   CIRCULATION RESEARCH

Stimulation of anti-tumor immunity by photodynamic therapy

(2010) Pawel Mroz et al.   Expert Review of Clinical Immunology

ApoE3 Mediated Poly(butyl) Cyanoacrylate Nanoparticles Containing Curcumin: Study of Enhanced Activity of Curcumin against Beta Amyloid Induced Cytotoxicity UsingIn VitroCell Culture Model

(2010) Rohit S. Mulik et al.   MOLECULAR PHARMACEUTICS

Nanotechnology in Drug Delivery and Tissue Engineering: From Discovery to Applications

(2010) Jinjun Shi et al.   NANO LETTERS

Engineering of self-assembled nanoparticle platform for precisely controlled combination drug therapy

(2010) N. Kolishetti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evidence for an Alternative Glycolytic Pathway in Rapidly Proliferating Cells

(2010) M. G. Vander Heiden et al.   SCIENCE

Impact of Nanotechnology on Drug Delivery

(2009) Omid C. Farokhzad et al.   ACS Nano

Targeting mitochondrial biogenesis for preventing and treating insulin resistance in diabetes and obesity: Hope from natural mitochondrial nutrients☆

(2009) Jiankang Liu et al.   ADVANCED DRUG DELIVERY REVIEWS

Immunocompatibility properties of lipid–polymer hybrid nanoparticles with heterogeneous surface functional groups

(2009) Carolina Salvador-Morales et al.   BIOMATERIALS

Mitochondria-targeted (2-hydroxyamino-vinyl)-triphenyl-phosphonium releases NO and protects mouse embryonic cells against irradiation-induced apoptosis

(2009) Natalia A. Belikova et al.   FEBS LETTERS

Engineered Apoptosis-Inducing Peptides with Enhanced Mitochondrial Localization and Potency

(2009) Kristin L. Horton et al.   JOURNAL OF MEDICINAL CHEMISTRY

Small mitochondria-targeting molecules as anti-cancer agents

(2009) Feng Wang et al.   MOLECULAR ASPECTS OF MEDICINE

Mitochondria-Penetrating Peptides

(2008) Kristin L. Horton et al.   CHEMISTRY & BIOLOGY

Activation of NO donors in mitochondria: Peroxidase metabolism of (2-hydroxyamino-vinyl)-triphenyl-phosphonium by cytochromecreleases NO and protects cells against apoptosis

(2008) Detcho A. Stoyanovsky et al.   FEBS LETTERS

Organelle-Targeted Nanocarriers: Specific Delivery of Liposomal Ceramide to Mitochondria Enhances Its Cytotoxicity in Vitro and in Vivo

(2008) Sarathi V. Boddapati et al.   NANO LETTERS

MITO-Porter: A liposome-based carrier system for delivery of macromolecules into mitochondria via membrane fusion

(2007) Yuma Yamada et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES