Nickel‐Catalyzed Defluorinative Asymmetric Cyclization of Fluoroalkyl‐Substituted 1,6‐Enynes for the Synthesis of Seletracetam
Published 2022 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Nickel‐Catalyzed Defluorinative Asymmetric Cyclization of Fluoroalkyl‐Substituted 1,6‐Enynes for the Synthesis of Seletracetam
Authors
Keywords
-
Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume -, Issue -, Pages -
Publisher
Wiley
Online
2022-09-23
DOI
10.1002/anie.202212664
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Nickel‐Catalyzed Arylative Cyclizations of Alkyne‐ and Allene‐Tethered Electrophiles using Arylboron Reagents
- (2022) Simone M. Gillbard et al. CHEMISTRY-A EUROPEAN JOURNAL
- Ni-Catalyzed Reductive Coupling of Alkynes and Amides to Access Multi-Functionalized Indoles
- (2022) Kwan Hong Min et al. ORGANIC LETTERS
- Nickel‐Catalyzed Enantioselective Synthesis of 2,3,4‐Trisubstituted 3‐Pyrrolines
- (2022) Shrikant D. Tambe et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Ni‐Catalyzed Divergent Synthesis of 2‐Benzazepine Derivatives via Tunable Cyclization and 1,4‐Acyl Transfer Triggered by Amide N‐C Bond Cleavage
- (2022) Yuanyuan Ping et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Switchable 1,2-Rearrangement Enables Expedient Synthesis of Structurally Diverse Fluorine-Containing Scaffolds
- (2022) Yuanyuan Ping et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Synthesis of gem ‐Difluoroalkenes via Ni‐Catalyzed Three‐Component Defluorinative Reductive Cross‐Coupling of Organohalides, Alkenes and Trifluoromethyl Alkenes
- (2022) Teng Ma et al. CHINESE JOURNAL OF CHEMISTRY
- Asymmetric Cobalt‐Catalyzed Regioselective Hydrosilylation/Cyclization of 1,6‐Enynes
- (2021) Yang’en You et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Enantioselective Nickel‐Catalyzed anti ‐Arylmetallative Cyclizations onto Acyclic Ketones
- (2021) Harley Green et al. CHEMISTRY-A EUROPEAN JOURNAL
- Ni-Catalyzed Ligand-Controlled Regiodivergent Reductive Dicarbofunctionalization of Alkenes
- (2021) Qi Pan et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Transition-Metal-Catalyzed Functionalization of Alkynes with Organoboron Reagents: New Trends, Mechanistic Insights, and Applications
- (2021) Javier Corpas et al. ACS Catalysis
- Recent Progress in Metal-Catalyzed [2+2+2] Cycloaddition Reactions
- (2021) Virginie Ratovelomanana-Vidal et al. SYNTHESIS-STUTTGART
- NiH-Catalyzed Migratory Defluorinative Olefin Cross-Coupling: Trifluoromethyl-Substituted Alkenes as Acceptor Olefins to Form gem -Difluoroalkenes
- (2020) Fenglin Chen et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Catalyzing the Hydrodefluorination of CF3-Substituted Alkenes by PhSiH3. H• Transfer from a Nickel Hydride
- (2020) Chengbo Yao et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Enantioselective Assembly of Cycloenones with a Nitrile-Containing All-Carbon Quaternary Center from Malononitriles Enabled by Ni Catalysis
- (2020) Zhiwu Lu et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Cobalt-Catalyzed Enantioselective Hydroarylation of 1,6-Enynes
- (2020) Andrew Whyte et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Synthesis of bridged tricyclo[5.2.1.01,5]decanes via nickel-catalyzed asymmetric domino cyclization of enynones
- (2020) Jiachang Chen et al. Nature Communications
- Enantioselective Cobalt‐Catalyzed Intermolecular Hydroacylation of 1,6‐Enynes
- (2020) Andrew Whyte et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Mechanistic Studies of Transition-Metal-Catalyzed [2 + 2 + 2] Cycloaddition Reactions
- (2020) Anna Roglans et al. CHEMICAL REVIEWS
- Nickel-Catalyzed anti-Selective Alkyne Functionalization Reactions
- (2020) Dale J. Wilger et al. SYNTHESIS-STUTTGART
- Ni-Catalyzed Reductive Antiarylative Cyclization of Alkynones
- (2020) Zhijun Zhou et al. ORGANIC LETTERS
- Migratory functionalization of unactivated alkyl bromides for construction of all-carbon quaternary centers via transposed tert-C-radicals
- (2020) Chuan Zhu et al. Nature Communications
- Synthesis of Indanones and Spiroindanones by Diastereoselective Annulation Based on a Hydrogen Autotransfer Strategy
- (2020) Yate Chen et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Catalytic Enantioselective Allylic C–F Bond Functionalization
- (2020) Minyan Wang et al. CHEMISTRY LETTERS
- Diastereo- and Enantioselective Construction of Spirocycles by Nickel-Catalyzed Cascade Borrowing Hydrogen Cyclization
- (2020) Zhengtian Ding et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Catalytic Enantioselective Synthesis of Allylic Boronates Bearing a Trisubstituted Alkenyl Fluoride and Related Derivatives
- (2019) Sota Akiyama et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Transition‐Metal‐Free Defluorosilylation of Fluoroalkenes with Silylboronates
- (2019) Pan Gao et al. CHINESE JOURNAL OF CHEMISTRY
- Rhodium(III)-Catalyzed Asymmetric Borylative Cyclization of Cyclohexadienone-Containing 1,6-Dienes: An Experimental and DFT Study
- (2019) Yun-Xuan Tan et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Defluorosilylation of Industrially Relevant Fluoroolefins Using Nucleophilic Silicon Reagents
- (2019) Greg Coates et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Access to Multifunctionalized Benzofurans by Aryl Nickelation of Alkynes: Efficient Synthesis of the Anti-Arrhythmic Drug Amiodarone
- (2019) Naeem Iqbal et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Asymmetric Synthesis of a Fused tricyclic Hydronaphthofuran Scaffold by Desymmetric [2+2+2] Cycloaddition
- (2019) Qi Teng et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Catalytic Enantioselective Boryl and Silyl Substitution with Trifluoromethyl Alkenes: Scope, Utility, and Mechanistic Nuances of Cu–F β-Elimination
- (2019) Paulo H. S. Paioti et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Enantioselective Synthesis of Chiral Cyclopent-2-enones by Nickel-Catalyzed Desymmetrization of Malonate Esters
- (2018) Somnath Narayan Karad et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- A Copper(I)-Catalyzed Enantioselective γ-Boryl Substitution of Trifluoromethyl-Substituted Alkenes: Synthesis of Enantioenriched γ,γ-gem -Difluoroallylboronates
- (2018) Ryoto Kojima et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Transition Metal-Mediated and -Catalyzed C-F Bond Activation via Fluorine Elimination
- (2018) Takeshi Fujita et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Asymmetric Synthesis of Spirocyclic β-Lactams through Copper-Catalyzed Kinugasa/Michael Domino Reactions
- (2018) Tao Shu et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- A nickel-catalyzed anti-carbometallative cyclization of alkyne–azides with organoboronic acids: synthesis of 2,3-diarylquinolines
- (2018) Gadi Ranjith Kumar et al. CHEMICAL COMMUNICATIONS
- Metal-Free Iodine-Mediated Deoxygenation of Alcohols in the Position α to Electron-Withdrawing Groups
- (2018) Maëva M. Pichon et al. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
- Enantioselective Copper-Catalyzed Defluoroalkylation Using Arylboronate-Activated Alkyl Grignard Reagents
- (2018) Minyan Wang et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Highly Enantioselective Nickel-Catalyzed Intramolecular Hydroalkenylation of N- and O-Tethered 1,6-Dienes To Form Six-Membered Heterocycles
- (2018) Ke Li et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Highly Diastereoselective Palladium-Catalyzed Oxidative Carbocyclization of Enallenes Assisted by a Weakly Coordinating Hydroxyl Group
- (2018) Daniels Posevins et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Synthesis of Monofluoroalkenes: A Leap Forward
- (2018) Jean-François Paquin et al. SYNTHESIS-STUTTGART
- Rhodium-Catalyzed Highly Regio- and Enantioselective Reductive Cyclization of Alkyne-Tethered Cyclohexadienones
- (2018) Krishna Kumar Gollapelli et al. ACS Catalysis
- Chiral Induction in [2+2+2] Cycloaddition Reactions
- (2018) Anna Pla-Quintana et al. Asian Journal of Organic Chemistry
- Recent advances in the synthesis of functionalised monofluorinated compounds
- (2018) Santos Fustero et al. CHEMICAL COMMUNICATIONS
- Activation of C–F bonds α to C–C multiple bonds
- (2018) Jean-Denys Hamel et al. CHEMICAL COMMUNICATIONS
- Synthesis of multisubstituted pyrroles by nickel-catalyzed arylative cyclizations of N-tosyl alkynamides
- (2018) Simone M Gillbard et al. CHEMICAL COMMUNICATIONS
- Versatile Cobalt-Catalyzed Enantioselective Entry to Boryl-Functionalized All-Carbon Quaternary Stereogenic Centers
- (2018) Chao Wang et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- sp3 C–H Arylation and Alkylation Enabled by the Synergy of Triplet Excited Ketones and Nickel Catalysts
- (2018) Yangyang Shen et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Synthesis of gem-Difluoroalkenes via Nickel-Catalyzed Allylic Defluorinative Reductive Cross-Coupling
- (2018) Yun Lan et al. ACS Catalysis
- Copper-Catalyzed Asymmetric Defluoroborylation of 1-(Trifluoromethyl)Alkenes
- (2018) Pan Gao et al. Chem
- Rhodium-Catalyzed Enantioselective Defluorinative α-Arylation of Secondary Amides
- (2018) Young Jin Jang et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Synthesis of gem-Difluoroalkenes via Nickel-Catalyzed Reductive C–F and C–O Bond Cleavage
- (2018) Zhiyang Lin et al. ACS Catalysis
- Nickel-Catalyzed Reductive Cycloisomerization of Enynes with CO2
- (2017) Justin B. Diccianni et al. JOURNAL OF ORGANIC CHEMISTRY
- Copper-Catalyzed Regioselective Monodefluoroborylation of Polyfluoroalkenes en Route to Diverse Fluoroalkenes
- (2017) Hironobu Sakaguchi et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Cobalt-Catalyzed Asymmetric Hydroboration/Cyclization of 1,6-Enynes with Pinacolborane
- (2017) Songjie Yu et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Nickel-Catalyzed Defluorinative Reductive Cross-Coupling of gem-Difluoroalkenes with Unactivated Secondary and Tertiary Alkyl Halides
- (2017) Xi Lu et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Palladium-catalyzed synthesis of monofluoroalkenes from 3,3-difluoropropenes using dimethylmalonate and derivatives as nucleophiles
- (2017) Myriam Drouin et al. ORGANIC & BIOMOLECULAR CHEMISTRY
- Synthesis of gem-Difluoroallylboronates via FeCl2-Catalyzed Boration/β-Fluorine Elimination of Trifluoromethyl Alkenes
- (2017) Yang Liu et al. ORGANIC LETTERS
- Cu-Catalyzed Stereoselective Borylation of gem-Difluoroalkenes with B2pin2
- (2017) Juan Zhang et al. ORGANIC LETTERS
- Nickel-Catalyzed Hydroalkenylation of Alkynes through C–F Bond Activation: Synthesis of 2-Fluoro-1,3-dienes
- (2017) Junji Ichikawa et al. SYNTHESIS-STUTTGART
- Cationic Pd(II)-catalyzed arylative cyclization of 1,6-enynes with arylboronic acids
- (2017) Kun Shen et al. TETRAHEDRON LETTERS
- Recent advances in the synthesis and CF functionalization of gem-difluoroalkenes
- (2017) Xuxue Zhang et al. TETRAHEDRON LETTERS
- Two-step synthesis of chiral fused tricyclic scaffolds from phenols via desymmetrization on nickel
- (2017) Ravindra Kumar et al. Nature Communications
- Nickel-catalyzed highly chemo- and stereoselective borylative cyclization of 1,6-enynes with bis(pinacolato)diboron
- (2017) Jen-Chieh Hsieh et al. Organic Chemistry Frontiers
- Palladium-Catalyzed Defluorinative Coupling of 1-Aryl-2,2-Difluoroalkenes and Boronic Acids: Stereoselective Synthesis of Monofluorostilbenes
- (2016) Richard T. Thornbury et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Cobalt-Catalyzed Hydrosilylation/Cyclization of 1,6-Enynes
- (2016) Tuo Xi et al. JOURNAL OF ORGANIC CHEMISTRY
- Rhodium-Catalyzed Asymmetric Arylation/Defluorination of 1-(Trifluoromethyl)alkenes Forming Enantioenriched 1,1-Difluoroalkenes
- (2016) Yinhua Huang et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Enantioselective Nickel-Catalyzed anti-Carbometallative Cyclizations of Alkynyl Electrophiles Enabled by Reversible Alkenylnickel E/Z Isomerization
- (2016) Christopher Clarke et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Nickel-catalyzed cyclization of alkyne-nitriles with organoboronic acids involving anti-carbometalation of alkynes
- (2016) Xingjie Zhang et al. Chemical Science
- Monofluorination of Organic Compounds: 10 Years of Innovation
- (2015) Pier Alexandre Champagne et al. CHEMICAL REVIEWS
- Seletracetam enhances short term depression in vitro
- (2015) Xiaofeng Yang et al. EPILEPSY RESEARCH
- Ligand-Controlled Divergent C—H Functionalization of Aldehydes with Enynes by Cobalt Catalysts
- (2015) Rajagopal Santhoshkumar et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Visible light-induced selective hydrobromodifluoromethylation of alkenes with dibromodifluoromethane
- (2015) Qing-Yu Lin et al. ORGANIC & BIOMOLECULAR CHEMISTRY
- Nickel-Catalyzed Allylic C(sp3)–F Bond Activation of Trifluoromethyl Groups via β-Fluorine Elimination: Synthesis of Difluoro-1,4-dienes
- (2015) Tomohiro Ichitsuka et al. ACS Catalysis
- Double CF Bond Activation through β-Fluorine Elimination: Nickel-Mediated [3+2] Cycloaddition of 2-Trifluoromethyl-1-alkenes with Alkynes
- (2014) Tomohiro Ichitsuka et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Advances in Catalytic Enantioselective Fluorination, Mono-, Di-, and Trifluoromethylation, and Trifluoromethylthiolation Reactions
- (2014) Xiaoyu Yang et al. CHEMICAL REVIEWS
- Enzymatic Fluorination and Biotechnological Developments of the Fluorinase
- (2014) David O’Hagan et al. CHEMICAL REVIEWS
- Recent Advances in Stereoselective [2+2+2] Cycloadditions
- (2014) Muriel Amatore et al. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
- Enantioselective Cycloisomerization of 1,6-Enynes to Bicyclo[3.1.0]hexanes Catalyzed by Rhodium and Benzoic Acid
- (2014) Koji Masutomi et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Oxidative Debenzylation of N-Benzyl Amides and O-Benzyl Ethers Using Alkali Metal Bromide
- (2014) Katsuhiko Moriyama et al. ORGANIC LETTERS
- Rhodium-Catalyzed Asymmetric Arylative Cyclization ofmeso-1,6-Dienynes Leading to Enantioenrichedcis-Hydrobenzofurans
- (2013) Zhi-Tao He et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Introduction of Fluorine and Fluorine-Containing Functional Groups
- (2013) Theresa Liang et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Nickel-Catalyzed Chemo- and Stereoselective Alkenylative Cyclization of 1,6-Enynes with Alkenyl Boronic Acids
- (2013) Chun-Ming Yang et al. CHEMISTRY-A EUROPEAN JOURNAL
- Cu-Catalyzed Asymmetric Borylative Cyclization of Cyclohexadienone-Containing 1,6-Enynes
- (2013) Ping Liu et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Nickel-Catalyzed Amination of Aryl Sulfamates and Carbamates Using an Air-Stable Precatalyst
- (2012) Liana Hie et al. ORGANIC LETTERS
- SN2′ Reaction of Allylic Difluorides with Lithium Amides and Thiolates
- (2012) Maxime Bergeron et al. ORGANIC LETTERS
- NHC-Cu-Catalyzed Enantioselective Hydroboration of Acyclic and Exocyclic 1,1-Disubstituted Aryl Alkenes
- (2011) Rosa Corberán et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Synthetic approaches to monofluoroalkenes
- (2011) Grégory Landelle et al. CHEMICAL SOCIETY REVIEWS
- Nickel-Catalyzed Cyclization of Difluoro-Substituted 1,6-Enynes with Organozinc Reagents through the Stereoselective Activation of CF Bonds: Synthesis of Bicyclo[3.2.0]heptene Derivatives
- (2010) Manabu Takachi et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Activation of Allylic CF bonds: Palladium-Catalyzed Allylic Amination of 3,3-Difluoropropenes
- (2009) Xavier Pigeon et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Profile of the new pyrrolidone derivative seletracetam (ucb 44212) in animal models of epilepsy
- (2009) Alain Matagne et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Rhodium-Catalyzed Cyclization Reaction of 1,6-Enynes with Arylboronic Acids through β-Hydride Elimination/Hydrorhodation Sequence
- (2008) Masahiko Shimada et al. Chemistry-An Asian Journal
- Seletracetam (ucb 44212) inhibits high-voltage-activated Ca2+currents and intracellular Ca2+increase in rat cortical neurons in vitro
- (2008) Giuseppina Martella et al. EPILEPSIA
- The Many Roles for Fluorine in Medicinal Chemistry
- (2008) William K. Hagmann JOURNAL OF MEDICINAL CHEMISTRY
- Fluorine in medicinal chemistry
- (2007) Sophie Purser et al. CHEMICAL SOCIETY REVIEWS
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started