Nickel‐Catalyzed Defluorinative Asymmetric Cyclization of Fluoroalkyl‐Substituted 1,6‐Enynes for the Synthesis of Seletracetam

Nickel‐Catalyzed Arylative Cyclizations of Alkyne‐ and Allene‐Tethered Electrophiles using Arylboron Reagents

(2022) Simone M. Gillbard et al.   CHEMISTRY-A EUROPEAN JOURNAL

Ni-Catalyzed Reductive Coupling of Alkynes and Amides to Access Multi-Functionalized Indoles

(2022) Kwan Hong Min et al.   ORGANIC LETTERS

Nickel‐Catalyzed Enantioselective Synthesis of 2,3,4‐Trisubstituted 3‐Pyrrolines

(2022) Shrikant D. Tambe et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Ni‐Catalyzed Divergent Synthesis of 2‐Benzazepine Derivatives via Tunable Cyclization and 1,4‐Acyl Transfer Triggered by Amide N‐C Bond Cleavage

(2022) Yuanyuan Ping et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Switchable 1,2-Rearrangement Enables Expedient Synthesis of Structurally Diverse Fluorine-Containing Scaffolds

(2022) Yuanyuan Ping et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthesis of gem ‐Difluoroalkenes via Ni‐Catalyzed Three‐Component Defluorinative Reductive Cross‐Coupling of Organohalides, Alkenes and Trifluoromethyl Alkenes

(2022) Teng Ma et al.   CHINESE JOURNAL OF CHEMISTRY

Asymmetric Cobalt‐Catalyzed Regioselective Hydrosilylation/Cyclization of 1,6‐Enynes

(2021) Yang’en You et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enantioselective Nickel‐Catalyzed anti ‐Arylmetallative Cyclizations onto Acyclic Ketones

(2021) Harley Green et al.   CHEMISTRY-A EUROPEAN JOURNAL

Ni-Catalyzed Ligand-Controlled Regiodivergent Reductive Dicarbofunctionalization of Alkenes

(2021) Qi Pan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Transition-Metal-Catalyzed Functionalization of Alkynes with Organoboron Reagents: New Trends, Mechanistic Insights, and Applications

(2021) Javier Corpas et al.   ACS Catalysis

Recent Progress in Metal-Catalyzed [2+2+2] Cycloaddition Reactions

(2021) Virginie Ratovelomanana-Vidal et al.   SYNTHESIS-STUTTGART

NiH-Catalyzed Migratory Defluorinative Olefin Cross-Coupling: Trifluoromethyl-Substituted Alkenes as Acceptor Olefins to Form gem -Difluoroalkenes

(2020) Fenglin Chen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Catalyzing the Hydrodefluorination of CF3-Substituted Alkenes by PhSiH3. H• Transfer from a Nickel Hydride

(2020) Chengbo Yao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enantioselective Assembly of Cycloenones with a Nitrile-Containing All-Carbon Quaternary Center from Malononitriles Enabled by Ni Catalysis

(2020) Zhiwu Lu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Cobalt-Catalyzed Enantioselective Hydroarylation of 1,6-Enynes

(2020) Andrew Whyte et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthesis of bridged tricyclo[5.2.1.01,5]decanes via nickel-catalyzed asymmetric domino cyclization of enynones

(2020) Jiachang Chen et al.   Nature Communications

Enantioselective Cobalt‐Catalyzed Intermolecular Hydroacylation of 1,6‐Enynes

(2020) Andrew Whyte et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Mechanistic Studies of Transition-Metal-Catalyzed [2 + 2 + 2] Cycloaddition Reactions

(2020) Anna Roglans et al.   CHEMICAL REVIEWS

Nickel-Catalyzed anti-Selective Alkyne Functionalization Reactions

(2020) Dale J. Wilger et al.   SYNTHESIS-STUTTGART

Ni-Catalyzed Reductive Antiarylative Cyclization of Alkynones

(2020) Zhijun Zhou et al.   ORGANIC LETTERS

Migratory functionalization of unactivated alkyl bromides for construction of all-carbon quaternary centers via transposed tert-C-radicals

(2020) Chuan Zhu et al.   Nature Communications

Synthesis of Indanones and Spiroindanones by Diastereoselective Annulation Based on a Hydrogen Autotransfer Strategy

(2020) Yate Chen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Catalytic Enantioselective Allylic C–F Bond Functionalization

(2020) Minyan Wang et al.   CHEMISTRY LETTERS

Diastereo- and Enantioselective Construction of Spirocycles by Nickel-Catalyzed Cascade Borrowing Hydrogen Cyclization

(2020) Zhengtian Ding et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Catalytic Enantioselective Synthesis of Allylic Boronates Bearing a Trisubstituted Alkenyl Fluoride and Related Derivatives

(2019) Sota Akiyama et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Transition‐Metal‐Free Defluorosilylation of Fluoroalkenes with Silylboronates

(2019) Pan Gao et al.   CHINESE JOURNAL OF CHEMISTRY

Rhodium(III)-Catalyzed Asymmetric Borylative Cyclization of Cyclohexadienone-Containing 1,6-Dienes: An Experimental and DFT Study

(2019) Yun-Xuan Tan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Defluorosilylation of Industrially Relevant Fluoroolefins Using Nucleophilic Silicon Reagents

(2019) Greg Coates et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Access to Multifunctionalized Benzofurans by Aryl Nickelation of Alkynes: Efficient Synthesis of the Anti-Arrhythmic Drug Amiodarone

(2019) Naeem Iqbal et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Asymmetric Synthesis of a Fused tricyclic Hydronaphthofuran Scaffold by Desymmetric [2+2+2] Cycloaddition

(2019) Qi Teng et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Catalytic Enantioselective Boryl and Silyl Substitution with Trifluoromethyl Alkenes: Scope, Utility, and Mechanistic Nuances of Cu–F β-Elimination

(2019) Paulo H. S. Paioti et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enantioselective Synthesis of Chiral Cyclopent-2-enones by Nickel-Catalyzed Desymmetrization of Malonate Esters

(2018) Somnath Narayan Karad et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Copper(I)-Catalyzed Enantioselective γ-Boryl Substitution of Trifluoromethyl-Substituted Alkenes: Synthesis of Enantioenriched γ,γ-gem -Difluoroallylboronates

(2018) Ryoto Kojima et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Transition Metal-Mediated and -Catalyzed C-F Bond Activation via Fluorine Elimination

(2018) Takeshi Fujita et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Asymmetric Synthesis of Spirocyclic β-Lactams through Copper-Catalyzed Kinugasa/Michael Domino Reactions

(2018) Tao Shu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A nickel-catalyzed anti-carbometallative cyclization of alkyne–azides with organoboronic acids: synthesis of 2,3-diarylquinolines

(2018) Gadi Ranjith Kumar et al.   CHEMICAL COMMUNICATIONS

Metal-Free Iodine-Mediated Deoxygenation of Alcohols in the Position α to Electron-Withdrawing Groups

(2018) Maëva M. Pichon et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Enantioselective Copper-Catalyzed Defluoroalkylation Using Arylboronate-Activated Alkyl Grignard Reagents

(2018) Minyan Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Highly Enantioselective Nickel-Catalyzed Intramolecular Hydroalkenylation of N- and O-Tethered 1,6-Dienes To Form Six-Membered Heterocycles

(2018) Ke Li et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Highly Diastereoselective Palladium-Catalyzed Oxidative Carbocyclization of Enallenes Assisted by a Weakly Coordinating Hydroxyl Group

(2018) Daniels Posevins et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthesis of Monofluoroalkenes: A Leap Forward

(2018) Jean-François Paquin et al.   SYNTHESIS-STUTTGART

Rhodium-Catalyzed Highly Regio- and Enantioselective Reductive Cyclization of Alkyne-Tethered Cyclohexadienones

(2018) Krishna Kumar Gollapelli et al.   ACS Catalysis

Chiral Induction in [2+2+2] Cycloaddition Reactions

(2018) Anna Pla-Quintana et al.   Asian Journal of Organic Chemistry

Recent advances in the synthesis of functionalised monofluorinated compounds

(2018) Santos Fustero et al.   CHEMICAL COMMUNICATIONS

Activation of C–F bonds α to C–C multiple bonds

(2018) Jean-Denys Hamel et al.   CHEMICAL COMMUNICATIONS

Synthesis of multisubstituted pyrroles by nickel-catalyzed arylative cyclizations of N-tosyl alkynamides

(2018) Simone M Gillbard et al.   CHEMICAL COMMUNICATIONS

Versatile Cobalt-Catalyzed Enantioselective Entry to Boryl-Functionalized All-Carbon Quaternary Stereogenic Centers

(2018) Chao Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

sp3 C–H Arylation and Alkylation Enabled by the Synergy of Triplet Excited Ketones and Nickel Catalysts

(2018) Yangyang Shen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthesis of gem-Difluoroalkenes via Nickel-Catalyzed Allylic Defluorinative Reductive Cross-Coupling

(2018) Yun Lan et al.   ACS Catalysis

Copper-Catalyzed Asymmetric Defluoroborylation of 1-(Trifluoromethyl)Alkenes

(2018) Pan Gao et al.   Chem

Rhodium-Catalyzed Enantioselective Defluorinative α-Arylation of Secondary Amides

(2018) Young Jin Jang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis of gem-Difluoroalkenes via Nickel-Catalyzed Reductive C–F and C–O Bond Cleavage

(2018) Zhiyang Lin et al.   ACS Catalysis

Nickel-Catalyzed Reductive Cycloisomerization of Enynes with CO2

(2017) Justin B. Diccianni et al.   JOURNAL OF ORGANIC CHEMISTRY

Copper-Catalyzed Regioselective Monodefluoroborylation of Polyfluoroalkenes en Route to Diverse Fluoroalkenes

(2017) Hironobu Sakaguchi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Cobalt-Catalyzed Asymmetric Hydroboration/Cyclization of 1,6-Enynes with Pinacolborane

(2017) Songjie Yu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Nickel-Catalyzed Defluorinative Reductive Cross-Coupling of gem-Difluoroalkenes with Unactivated Secondary and Tertiary Alkyl Halides

(2017) Xi Lu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Palladium-catalyzed synthesis of monofluoroalkenes from 3,3-difluoropropenes using dimethylmalonate and derivatives as nucleophiles

(2017) Myriam Drouin et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Synthesis of gem-Difluoroallylboronates via FeCl2-Catalyzed Boration/β-Fluorine Elimination of Trifluoromethyl Alkenes

(2017) Yang Liu et al.   ORGANIC LETTERS

Cu-Catalyzed Stereoselective Borylation of gem-Difluoroalkenes with B2pin2

(2017) Juan Zhang et al.   ORGANIC LETTERS

Nickel-Catalyzed Hydroalkenylation of Alkynes through C–F Bond Activation: Synthesis of 2-Fluoro-1,3-dienes

(2017) Junji Ichikawa et al.   SYNTHESIS-STUTTGART

Cationic Pd(II)-catalyzed arylative cyclization of 1,6-enynes with arylboronic acids

(2017) Kun Shen et al.   TETRAHEDRON LETTERS

Recent advances in the synthesis and CF functionalization of gem-difluoroalkenes

(2017) Xuxue Zhang et al.   TETRAHEDRON LETTERS

Two-step synthesis of chiral fused tricyclic scaffolds from phenols via desymmetrization on nickel

(2017) Ravindra Kumar et al.   Nature Communications

Nickel-catalyzed highly chemo- and stereoselective borylative cyclization of 1,6-enynes with bis(pinacolato)diboron

(2017) Jen-Chieh Hsieh et al.   Organic Chemistry Frontiers

Palladium-Catalyzed Defluorinative Coupling of 1-Aryl-2,2-Difluoroalkenes and Boronic Acids: Stereoselective Synthesis of Monofluorostilbenes

(2016) Richard T. Thornbury et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Cobalt-Catalyzed Hydrosilylation/Cyclization of 1,6-Enynes

(2016) Tuo Xi et al.   JOURNAL OF ORGANIC CHEMISTRY

Rhodium-Catalyzed Asymmetric Arylation/Defluorination of 1-(Trifluoromethyl)alkenes Forming Enantioenriched 1,1-Difluoroalkenes

(2016) Yinhua Huang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enantioselective Nickel-Catalyzed anti-Carbometallative Cyclizations of Alkynyl Electrophiles Enabled by Reversible Alkenylnickel E/Z Isomerization

(2016) Christopher Clarke et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Nickel-catalyzed cyclization of alkyne-nitriles with organoboronic acids involving anti-carbometalation of alkynes

(2016) Xingjie Zhang et al.   Chemical Science

Monofluorination of Organic Compounds: 10 Years of Innovation

(2015) Pier Alexandre Champagne et al.   CHEMICAL REVIEWS

Seletracetam enhances short term depression in vitro

(2015) Xiaofeng Yang et al.   EPILEPSY RESEARCH

Ligand-Controlled Divergent C—H Functionalization of Aldehydes with Enynes by Cobalt Catalysts

(2015) Rajagopal Santhoshkumar et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Visible light-induced selective hydrobromodifluoromethylation of alkenes with dibromodifluoromethane

(2015) Qing-Yu Lin et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Nickel-Catalyzed Allylic C(sp3)–F Bond Activation of Trifluoromethyl Groups via β-Fluorine Elimination: Synthesis of Difluoro-1,4-dienes

(2015) Tomohiro Ichitsuka et al.   ACS Catalysis

Double CF Bond Activation through β-Fluorine Elimination: Nickel-Mediated [3+2] Cycloaddition of 2-Trifluoromethyl-1-alkenes with Alkynes

(2014) Tomohiro Ichitsuka et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Advances in Catalytic Enantioselective Fluorination, Mono-, Di-, and Trifluoromethylation, and Trifluoromethylthiolation Reactions

(2014) Xiaoyu Yang et al.   CHEMICAL REVIEWS

Enzymatic Fluorination and Biotechnological Developments of the Fluorinase

(2014) David O’Hagan et al.   CHEMICAL REVIEWS

Recent Advances in Stereoselective [2+2+2] Cycloadditions

(2014) Muriel Amatore et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Enantioselective Cycloisomerization of 1,6-Enynes to Bicyclo[3.1.0]hexanes Catalyzed by Rhodium and Benzoic Acid

(2014) Koji Masutomi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Oxidative Debenzylation of N-Benzyl Amides and O-Benzyl Ethers Using Alkali Metal Bromide

(2014) Katsuhiko Moriyama et al.   ORGANIC LETTERS

Rhodium-Catalyzed Asymmetric Arylative Cyclization ofmeso-1,6-Dienynes Leading to Enantioenrichedcis-Hydrobenzofurans

(2013) Zhi-Tao He et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Introduction of Fluorine and Fluorine-Containing Functional Groups

(2013) Theresa Liang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Nickel-Catalyzed Chemo- and Stereoselective Alkenylative Cyclization of 1,6-Enynes with Alkenyl Boronic Acids

(2013) Chun-Ming Yang et al.   CHEMISTRY-A EUROPEAN JOURNAL

Cu-Catalyzed Asymmetric Borylative Cyclization of Cyclohexadienone-Containing 1,6-Enynes

(2013) Ping Liu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Nickel-Catalyzed Amination of Aryl Sulfamates and Carbamates Using an Air-Stable Precatalyst

(2012) Liana Hie et al.   ORGANIC LETTERS

SN2′ Reaction of Allylic Difluorides with Lithium Amides and Thiolates

(2012) Maxime Bergeron et al.   ORGANIC LETTERS

NHC-Cu-Catalyzed Enantioselective Hydroboration of Acyclic and Exocyclic 1,1-Disubstituted Aryl Alkenes

(2011) Rosa Corberán et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthetic approaches to monofluoroalkenes

(2011) Grégory Landelle et al.   CHEMICAL SOCIETY REVIEWS

Nickel-Catalyzed Cyclization of Difluoro-Substituted 1,6-Enynes with Organozinc Reagents through the Stereoselective Activation of CF Bonds: Synthesis of Bicyclo[3.2.0]heptene Derivatives

(2010) Manabu Takachi et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Activation of Allylic CF bonds: Palladium-Catalyzed Allylic Amination of 3,3-Difluoropropenes

(2009) Xavier Pigeon et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Profile of the new pyrrolidone derivative seletracetam (ucb 44212) in animal models of epilepsy

(2009) Alain Matagne et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Rhodium-Catalyzed Cyclization Reaction of 1,6-Enynes with Arylboronic Acids through β-Hydride Elimination/Hydrorhodation Sequence

(2008) Masahiko Shimada et al.   Chemistry-An Asian Journal

Seletracetam (ucb 44212) inhibits high-voltage-activated Ca2+currents and intracellular Ca2+increase in rat cortical neurons in vitro

(2008) Giuseppina Martella et al.   EPILEPSIA

The Many Roles for Fluorine in Medicinal Chemistry

(2008) William K. Hagmann   JOURNAL OF MEDICINAL CHEMISTRY

Fluorine in medicinal chemistry

(2007) Sophie Purser et al.   CHEMICAL SOCIETY REVIEWS