Recent Advances in Stereoselective [2+2+2] Cycloadditions

Highly Chemo-, Regio-, and Enantioselective Rhodium-Catalyzed Cross-Cyclotrimerization of Two Different Alkynes with Alkenes

(2014) Jun Hara et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Electron-Deficient Diphosphines: The Impact of DIFLUORPHOS in Asymmetric Catalysis

(2014) Jean-Pierre Genet et al.   CHEMICAL REVIEWS

Rhodium-Catalyzed [2+2+2] Cycloaddition of Diynes with Carbodiimides and Carbon Dioxide under Ambient Conditions

(2014) Masahiro Ishii et al.   CHEMISTRY-A EUROPEAN JOURNAL

The Design and Synthesis of Planar Chiral Ligands and Their Application to Asymmetric Catalysis

(2014) Wanbin Zhang et al.   SYNLETT

Enantioselective Synthesis of Planar-Chiral Carba-Paracyclophanes: Rhodium-Catalyzed [2+2+2] Cycloaddition of Cyclic Diynes with Terminal Monoynes

(2013) Tatsuya Araki et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Catalytic Asymmetric Synthesis of Polysubstituted Piperidines Using a Rhodium(I)-Catalyzed [2+2+2] Cycloaddition Employing a Cleavable Tether

(2013) Timothy J. Martin et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Rapid Access to Dibenzohelicenes and their Functionalized Derivatives

(2013) Andrej Jančařík et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Atroposelective [2+2+2] cycloadditions catalyzed by a rhodium(i)–chiral phosphate system

(2013) Mylène Augé et al.   CHEMICAL COMMUNICATIONS

A [2+2+2] cyclization strategy for the synthesis of phosphorus embedding [6]helicene-like structures

(2013) Paul Aillard et al.   CHEMICAL COMMUNICATIONS

Chiroptical Properties of Carbo[6]Helicene Derivatives Bearing Extended π-Conjugated Cyano Substituents

(2013) Mehdi El Sayed Moussa et al.   CHIRALITY

Asymmetric Synthesis ofC2-Symmetric Axially Chiral Biaryls through Rhodium-Catalyzed and Alkyne-Controlled Diastereoselective Double [2+2+2] Cycloaddition

(2013) Ayaka Mori et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Helical-Chiral Small Molecules in Asymmetric Catalysis

(2013) Maurice J. Narcis et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Highly Enantioselective Rhodium-Catalyzed [2+2+2] Cycloaddition of Diynes to Sulfonimines

(2013) Muriel Amatore et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Catalytic, Asymmetric Indolizidinone Aza-Quaternary Stereocenter Synthesis: Expedient Synthesis of the Cylindricine Alkaloid Core

(2013) Derek M. Dalton et al.   ORGANIC LETTERS

From the Development of Catalysts for Alkyne and Alkyne-Nitrile [2+2+2] Cycloaddition Reactions to Their Use in Polymerization Reactions

(2013) Sentaro Okamoto et al.   SYNLETT

Enantioselective Synthesis of the Tricyclic Core of FR901483 Featuring a Rhodium-Catalyzed [2+2+2] Cycloaddition

(2013) Tomislav Rovis et al.   SYNTHESIS-STUTTGART

Rhodium-Catalyzed Regio-, Diastereo-, and Enantioselective [2+2+2] Cycloaddition of 1,6-Enynes with Acrylamides

(2012) Koji Masutomi et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A General Approach to Optically Pure [5]-, [6]-, and [7]Heterohelicenes

(2012) Jaroslav Žádný et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Dendritic phosphoramidite ligands for Rh-catalyzed [2+2+2] cycloaddition reactions: unprecedented enhancement of enantiodiscrimination

(2012) Lídia Garcia et al.   CHEMICAL COMMUNICATIONS

Asymmetric catalysis based on tropos ligands

(2012) Kohsuke Aikawa et al.   CHEMICAL COMMUNICATIONS

Transfer of chirality from ligands to metal centers: recent examples

(2012) Jeanne Crassous   CHEMICAL COMMUNICATIONS

Applications of Helical-Chiral Pyridines as Organocatalysts in Asymmetric Synthesis

(2012) Zhili Peng et al.   CHEMICAL RECORD

One hundred years of helicene chemistry. Part 3: applications and properties of carbohelicenes

(2012) Marc Gingras   CHEMICAL SOCIETY REVIEWS

One hundred years of helicene chemistry. Part 1: non-stereoselective syntheses of carbohelicenes

(2012) Marc Gingras   CHEMICAL SOCIETY REVIEWS

One hundred years of helicene chemistry. Part 2: stereoselective syntheses and chiral separations of carbohelicenes

(2012) Marc Gingras et al.   CHEMICAL SOCIETY REVIEWS

Rhodium-Catalyzed [2+2+2] Cycloaddition for the Synthesis of Substituted Pyridines, Pyridones, and Thiopyranimines

(2012) Ken Tanaka   HETEROCYCLES

C-H Arylation of 3-Substituted Thiophene with Regioselective Deprotonation by TMPMgCl·LiCl and Transition Metal Catalyzed Cross Coupling

(2012) Atsunori Mori et al.   HETEROCYCLES

The Role of Symmetry in Asymmetric Catalysis

(2012) Christina Moberg   ISRAEL JOURNAL OF CHEMISTRY

Chiral cobaltI and nickel0 complexes in the synthesis of nonracemic helicenes through the enantioselective [2 + 2 + 2] cyclotrimerisation of alkynes

(2012) Barbara Heller et al.   JOURNAL OF ORGANOMETALLIC CHEMISTRY

Iridium-Catalyzed [2 + 2 + 2] Cycloaddition of α,ω-Diynes with Nitriles

(2012) Gen Onodera et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Rhodium-Catalyzed Enantioselective Synthesis, Crystal Structures, and Photophysical Properties of Helically Chiral 1,1′-Bitriphenylenes

(2012) Yayoi Sawada et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The progression of chiral anions from concepts to applications in asymmetric catalysis

(2012) Robert J. Phipps et al.   Nature Chemistry

The power of pairing

(2012) Hajime Ito   Nature Chemistry

Enantioselective synthesis of helicenequinones and -bisquinones

(2012) Antonio Urbano et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Enantioselective Intermolecular [2 + 2 + 2] Cycloadditions of Ene–Allenes with Allenoates

(2012) Andrew T. Brusoe et al.   ORGANIC LETTERS

Rhodium-Catalyzed One-Pot Intermolecular [2 + 2 + 2] Trimerization/Asymmetric Intramolecular [4 + 2] Cycloaddition of Two Aryl Ethynyl Ethers and 5-Alkynals

(2012) Yuta Miyauchi et al.   ORGANIC LETTERS

Facile Synthesis of Cyclic Polyphenylenes by Consecutive Inter- and Intramolecular Cycloadditions of ortho-, meta-, and para-Phenylene-Tethered Triynes

(2012) Takanori Shibata et al.   SYNTHESIS-STUTTGART

Recent Advances in Transition-Metal-Catalyzed [2+2+2]-Cyclo(co)trimerization Reactions

(2012) Eelco Ruijter et al.   SYNTHESIS-STUTTGART

Enantioselective synthesis of tripodal cyclophanes and pyridinophanes by intramolecular [2+2+2] cycloaddition

(2012) Takanori Shibata et al.   TETRAHEDRON

Rhodium(I)-Catalyzed Ene-Allene-Allene [2+2+2] Cycloadditions: Stereoselective Synthesis of Complex trans-Fused Carbocycles

(2011) Andrew T. Brusoe et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Rhodium-Catalyzed Asymmetric Formal Olefination or Cycloaddition: 1,3-Dicarbonyl Compounds Reacting with 1,6-Diynes or 1,6-Enynes

(2011) Takeshi Suda et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Conjugated Macrocycles: Concepts and Applications

(2011) Masahiko Iyoda et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enantioselective Construction of Bridged Multicyclic Skeletons: Intermolecular [2+2+2] Cycloaddition/Intramolecular Diels-Alder Reaction Cascade

(2011) Masayuki Kobayashi et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enantioselective [2+2+2] cycloaddition of ketenes and carbon disulfide catalyzed by N-heterocyclic carbenes

(2011) Xiao-Na Wang et al.   CHEMICAL COMMUNICATIONS

Highly enantioselective synthesis of silahelicenes using Ir-catalyzed [2+2+2] cycloaddition

(2011) Takanori Shibata et al.   CHEMICAL COMMUNICATIONS

Helicenes: Synthesis and Applications

(2011) Yun Shen et al.   CHEMICAL REVIEWS

Recent advances in [2+2+2] cycloaddition reactions

(2011) Gema Domínguez et al.   CHEMICAL SOCIETY REVIEWS

Preparation and synthetic applications of alkene complexes of group 9 transition metals in [2+2+2] cycloaddition reactions

(2011) Nico Weding et al.   CHEMICAL SOCIETY REVIEWS

Enantioselective Synthesis of Axially Chiral 1-Arylisoquinolines by Rhodium-Catalyzed [2+2+2] Cycloaddition

(2011) Norifumi Sakiyama et al.   CHEMISTRY-A EUROPEAN JOURNAL

Asymmetric Catalysis with Helical Polymers

(2011) Rik P. Megens et al.   CHEMISTRY-A EUROPEAN JOURNAL

Enantioselective Synthesis of Axially Chiral Hydroxy Carboxylic Acid Derivatives by Rhodium-Catalyzed [2 + 2 + 2] Cycloaddition

(2011) Shuichiro Ogaki et al.   JOURNAL OF ORGANIC CHEMISTRY

Iridium-Catalyzed [2+2+2] Cycloaddition of α,ω-Diynes with Isocyanates

(2011) Gen Onodera et al.   JOURNAL OF ORGANIC CHEMISTRY

NHC-Catalyzed Enantioselective [2 + 2] and [2 + 2 + 2] Cycloadditions of Ketenes with Isothiocyanates

(2011) Xiao-Na Wang et al.   ORGANIC LETTERS

Enantioselective construction of new chiral cyclic scaffolds using [2 + 2 + 2] cycloaddition

(2011) Takanori Shibata et al.   PURE AND APPLIED CHEMISTRY

TADDOL-Derived Phosphonites, Phosphites, and Phosphoramidites in Asymmetric Catalysis

(2011) Hon Lam   SYNTHESIS-STUTTGART

Construction of fused heterocycles by metal-mediated [2+2+2] cyclotrimerization of alkynes and/or nitriles

(2011) Mohamed R. Shaaban et al.   TETRAHEDRON

Stereoselective transition metal-catalysed higher-order carbocyclisation reactions

(2010) Phillip A. Inglesby et al.   CHEMICAL SOCIETY REVIEWS

Racemic and Optically Pure Heptahelicene-2-carboxylic Acid: Its Synthesis and Self-Assembly into Nanowire-Like Aggregates

(2010) Jiří Rybáček et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Asymmetric Synthesis of Axially Chiral 1-Aryl-5,6,7,8-tetrahydroquinolines by Cobalt-Catalyzed [2 + 2 + 2] Cycloaddition Reaction of 1-Aryl-1,7-octadiynes and Nitriles

(2010) Marko Hapke et al.   JOURNAL OF ORGANIC CHEMISTRY

Enantioselective [2 + 2 + 2] Cycloaddition Reaction of Isocyanates and Allenes Catalyzed by Nickel

(2010) Tomoya Miura et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

[2+2+2] Cycloaddition Reactions of Macrocyclic Systems Catalyzed by Transition Metals. A Review

(2010) Anna Pla-Quintana et al.   MOLECULES

Asymmetric Synthesis and Photophysical Properties of Benzopyrano- or Naphthopyrano-Fused Helical Phosphafluorenes

(2010) Naohiro Fukawa et al.   ORGANIC LETTERS

Asymmetric Synthesis of Axially Chiral Biaryl Diphosphine Ligands by Rhodium-Catalyzed Enantioselective Intramolecular Double [2 + 2 + 2] Cycloaddition

(2010) Fumiya Mori et al.   ORGANIC LETTERS

Phosphoramidite-rhodium complexes as catalysts for the asymmetric [2 + 2 + 2] cycloaddition of alkenyl isocyanates and alkynes

(2010) Rebecca Keller Friedman et al.   PURE AND APPLIED CHEMISTRY

Enantioselective Intramolecular [2+2+2] Cycloaddition of Dienynes for the Construction of Adjacent Three Chiral Centers

(2010) Takanori Shibata et al.   SYNLETT

Catalytic Enantioselective Synthesis of Chiral Tetraphenylenes: Consecutive Inter- and Intramolecular Cycloadditions of Two Triynes

(2009) Takanori Shibata et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

One-Step Construction of Five Successive Rings by Rhodium-Catalyzed Intermolecular Double [2+2+2] Cycloaddition: Enantioenriched [9]Helicene-Like Molecules

(2009) Ken Tanaka et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Metallahelicenes: Easily Accessible Helicene Derivatives with Large and Tunable Chiroptical Properties

(2009) Lucie Norel et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Asymmetric Synthesis of Chiral Tetraphenylenes

(2009) Andrzej Rajca et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Beyond Reppe: Building Substituted Arenes by [2+2+2] Cycloadditions of Alkynes

(2009) Brandon R. Galan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The Challenge of Atropisomerism in Drug Discovery

(2009) Jonathan Clayden et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Chiral transfer in coordination complexes: towards molecular materials

(2009) Jeanne Crassous   CHEMICAL SOCIETY REVIEWS

Multi-component cycloaddition approaches in the catalytic asymmetric synthesis of alkaloid targets

(2009) Stéphane Perreault et al.   CHEMICAL SOCIETY REVIEWS

Enantioselective Rhodium-Catalyzed [2 + 2 + 2] Cycloadditions of Terminal Alkynes and Alkenyl Isocyanates: Mechanistic Insights Lead to a Unified Model that Rationalizes Product Selectivity

(2009) Derek M. Dalton et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Excess Substrate is a Spectator Ligand in a Rhodium-Catalyzed Asymmetric [2 + 2 + 2] Cycloaddition of Alkenyl Isocyanates with Tolanes

(2009) Mark Emil Oinen et al.   ORGANIC LETTERS

Enantioselective Synthesis of Chiral Tripodal Cage Compounds by [2 + 2 + 2] Cycloaddition of Branched Triynes

(2009) Takanori Shibata et al.   ORGANIC LETTERS

An organometallic route to long helicenes

(2009) P. Sehnal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transition-Metal-Catalyzed Enantioselective Synthesis of Compounds with Non-Centrochirality

(2009) Masamichi Ogasawara et al.   SYNTHESIS-STUTTGART

A rhodium(I)-xylyl-BINAP catalyzed asymmetric ynamide-[2+2+2] cycloaddition in the synthesis of optically enriched N,O-biaryls

(2009) Jossian Oppenheimer et al.   TETRAHEDRON

Highly Regio-, Diastereo-, and Enantioselective [2+2+2] Cycloaddition of 1,6-Enynes with Electron-Deficient Ketones Catalyzed by a Cationic RhI/H8-binap Complex

(2008) Ken Tanaka et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Straightforward Route to Helically Chiral N-Heteroaromatic Compounds: Practical Synthesis of Racemic 1,14-Diaza[5]helicene and Optically Pure 1- and 2-Aza[6]helicenes

(2008) Jiří Míšek et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enantioselective Synthesis of P-Stereogenic Alkynylphosphine Oxides by Rh-Catalyzed [2+2+2] Cycloaddition

(2008) Goushi Nishida et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Rhodium-catalyzed enantio- and diastereoselective intramolecular [2 + 2 + 2] cycloaddition of unsymmetrical dienynes

(2008) Hiromi Sagae et al.   CHEMICAL COMMUNICATIONS

Synthesis and structure of built-up organic macromolecules containing helicene

(2008) Ryo Amemiya et al.   CHEMICAL RECORD

Highly Enantioselective Synthesis ofN,N-Dialkylbenzamides with Aryl-Carbonyl Axial Chirality by Rhodium-Catalyzed [2+2+2] Cycloaddition

(2008) Takeshi Suda et al.   CHEMISTRY-A EUROPEAN JOURNAL

Transition-Metal-Catalyzed Enantioselective [2+2+2] Cycloadditions for the Synthesis of Axially Chiral Biaryls

(2008) Ken Tanaka   Chemistry-An Asian Journal

On the Origin of Diastereoselectivity in [2 + 2 + 2] Cycloisomerization of Chiral Triynes:  Controlling Helicity of Helicene-like Compounds by Thermodynamic Factors

(2008) Petr Sehnal et al.   JOURNAL OF ORGANIC CHEMISTRY

Asymmetric Synthesis of Bicyclic Amidines via Rhodium-Catalyzed [2+2+2] Cycloaddition of Carbodiimides

(2008) Robert T. Yu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Highly diastereo- and enantioselective construction of both central and axial chiralities by Rh-catalyzed [2 + 2 + 2] cycloaddition

(2008) Takanori Shibata et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Recent advances in enantioselective [2 + 2 + 2] cycloaddition

(2008) Takanori Shibata et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Practical Enantioselective Synthesis of Axially Chiral Biaryl Diphosphonates and Dicarboxylates by Cationic Rhodium(I)/Segphos-Catalyzed Double [2 + 2 + 2] Cycloaddition

(2008) Goushi Nishida et al.   ORGANIC LETTERS

Rhodium-Catalyzed Highly Enantio- and Diastereoselective Cotrimerization of Alkenes and Dialkyl Acetylenedicarboxylates Leading to Furylcyclopropanes

(2008) Yu Shibata et al.   ORGANIC LETTERS

Enantioselective Synthesis of Indolizidines Bearing Quaternary Substituted Stereocenters via Rhodium-Catalyzed [2 + 2 + 2] Cycloaddition of Alkenyl Isocyanates and Terminal Alkynes

(2008) Ernest E. Lee et al.   ORGANIC LETTERS

Highly Enantioselective Synthesis of Pseudo-C2-Symmetric Axially Chiral Biaryl Diphosphines via Rhodium-Catalyzed Double [2 + 2 + 2] Cycloaddition

(2008) Simon Doherty et al.   ORGANOMETALLICS

Synthesis of Enantioenriched N-Aryl-2-pyridones with Chiral C-N Axes by Rhodium-Catalyzed [2+2+2] Cycloaddition of Alkynes with Isocyanates

(2008) Ken Tanaka et al.   SYNLETT

Enantioselective synthesis of α,α-disubstituted α-amino acids by Rh-catalyzed [2+2+2] cycloaddition of 1,6-diynes with protected dehydroamino acid

(2008) Ken Tanaka et al.   TETRAHEDRON

Synchronized stereocontrol of planar chirality by crystallization-induced asymmetric transformation

(2008) Nobuhiro Kanomata et al.   TETRAHEDRON LETTERS

Iridium-catalyzed consecutive and enantioselective [2+2+2] cycloaddition of tetraynes and hexaynes for the construction of an axially chiral biaryl system

(2007) Takanori Shibata et al.   TETRAHEDRON

Enantioselective synthesis of planar-chiral metacyclophanes through cationic Rh(I)/modified-BINAP-catalyzed inter- and intramolecular alkyne cyclotrimerizations

(2007) Ken Tanaka et al.   TETRAHEDRON