Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 59, Issue 6, Pages 2220-2224Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201911071
Keywords
asymmetric catalysis; cycloaddition; homogeneous catalysis; desymmetrization; rhodium
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Funding
- Natural Science Foundation of China [21572118, 21971149]
- Tang scholar award
- Fundamental Research Funds of Shandong University
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A rhodium(I)-BINAP-catalyzed highly enantioselective [2+2+2] cycloaddition of enynes with alkynes has been developed. Diverse fused tricyclic hydronaphthofuran scaffolds with three consecutive stereogenic centers were constructed in one step from easily available materials with excellent chemo-, regio-, diastereo-, and enantioselectivity. Notable features of these reactions include 100 % atom economy, very broad scope, and mild reaction conditions.
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