Strategies to enhance drug delivery to solid tumors by harnessing the EPR effects and alternative targeting mechanisms

EPR Effect-Based Tumor Targeted Nanomedicine: A Promising Approach for Controlling Cancer

(2022) Jun Fang   Journal of Personalized Medicine

CC Chemokine Receptor 2-Targeting Copper Nanoparticles for Positron Emission Tomography-Guided Delivery of Gemcitabine for Pancreatic Ductal Adenocarcinoma

(2021) Xiaohui Zhang et al.   ACS Nano

The Use of Alternative Strategies for Enhanced Nanoparticle Delivery to Solid Tumors

(2021) Mukaddes Izci et al.   CHEMICAL REVIEWS

Tumor Microenvironment Remodeling-Based Penetration Strategies to Amplify Nanodrug Accessibility to Tumor Parenchyma

(2021) Yanhong Liu et al.   ADVANCED DRUG DELIVERY REVIEWS

Morphology/Interstitial Fluid Pressure-Tunable Nanopomegranate Designed by Alteration of Membrane Fluidity under Tumor Enzyme and PEGylation

(2021) Chenchen Wu et al.   MOLECULAR PHARMACEUTICS

Reappraisal of anticancer nanomedicine design criteria in three types of preclinical cancer models for better clinical translation

(2021) Xin Luan et al.   BIOMATERIALS

Perspectives on Hypoxia Signaling in Tumor Stroma

(2021) Yuqing Zhang et al.   Cancers

A Critical Review of Radiation Therapy: From Particle Beam Therapy (Proton, Carbon, and BNCT) to Beyond

(2021) Yoshitaka Matsumoto et al.   Journal of Personalized Medicine

Improved In Vivo Delivery of Small RNA Based on the Calcium Phosphate Method

(2021) Xin Wu et al.   Journal of Personalized Medicine

Nano-puerarin regulates tumor microenvironment and facilitates chemo- and immunotherapy in murine triple negative breast cancer model

(2020) Huan Xu et al.   BIOMATERIALS

Applications of patient-derived tumor xenograft models and tumor organoids

(2020) Go J. Yoshida   Journal of Hematology & Oncology

Charge Conversional Biomimetic Nanocomplexes as a Multifunctional Platform for Boosting Orthotopic Glioblastoma RNAi Therapy

(2020) Yanjie Liu et al.   NANO LETTERS

The entry of nanoparticles into solid tumours

(2020) Shrey Sindhwani et al.   NATURE MATERIALS

Peptide-Based Nanoparticles Mimic Fibrillogenesis of Laminin in Tumor Vessels for Precise Embolization

(2020) Kuo Zhang et al.   ACS Nano

Size-adaptable and ligand (biotin)-sheddable nanocarriers equipped with avidin scavenging technology for deep tumor penetration and reduced toxicity

(2020) Ya Jin et al.   JOURNAL OF CONTROLLED RELEASE

A nanoparticle’s pathway into tumours

(2020) Irene de Lázaro et al.   NATURE MATERIALS

Active transcytosis and new opportunities for cancer nanomedicine

(2020) Subehndu Pandit et al.   NATURE MATERIALS

Exploiting the dynamics of the EPR effect and strategies to improve the therapeutic effects of nanomedicines by using EPR effect enhancers

(2020) Jun Fang et al.   ADVANCED DRUG DELIVERY REVIEWS

The roles of tumor-associated macrophages in tumor angiogenesis and metastasis

(2020) Luo-Qin Fu et al.   CELLULAR IMMUNOLOGY

Modeling of the early stage of atherosclerosis with emphasis on the regulation of the endothelial permeability

(2020) Telma Silva et al.   JOURNAL OF THEORETICAL BIOLOGY

pH-sensitive bromelain nanoparticles by ortho ester crosslinkage for enhanced doxorubicin penetration in solid tumor

(2020) Xin Wang et al.   Materials Science & Engineering C-Materials for Biological Applications

Delivering the power of nanomedicine to patients today

(2020) Matthieu Germain et al.   JOURNAL OF CONTROLLED RELEASE

GSH-responsive SN38 dimer-loaded shape-transformable nanoparticles with iRGD for enhancing chemo-photodynamic therapy

(2020) Congcong Lin et al.   Acta Pharmaceutica Sinica B

Polymeric Nitric Oxide Delivery Nanoplatforms for Treating Cancer, Cardiovascular Diseases, and Infection

(2020) Guorui Jin et al.   Advanced Healthcare Materials

Employment of enhanced permeability and retention effect (EPR): Nanoparticle-based precision tools for targeting of therapeutic and diagnostic agent in cancer

(2019) Dnyaneshwar Kalyane et al.   Materials Science & Engineering C-Materials for Biological Applications

Losartan treatment enhances chemotherapy efficacy and reduces ascites in ovarian cancer models by normalizing the tumor stroma

(2019) Yanxia Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Depletion of collagen by losartan to improve tumor accumulation and therapeutic efficacy of photodynamic nanoplatforms

(2019) Yuxia Tang et al.   Drug Delivery and Translational Research

Therapeutic Remodeling of the Tumor Microenvironment Enhances Nanoparticle Delivery

(2019) Yuanxin Chen et al.   Advanced Science

Enhanced Drug Delivery by Nanoscale Integration of a Nitric Oxide Donor To Induce Tumor Collagen Depletion

(2019) Xiao Dong et al.   NANO LETTERS

An Oxygen Self-sufficient Fluorinated Nanoplatform for Relieved Tumor Hypoxia and Enhanced Photodynamic Therapy of Cancers

(2019) Shengnan Ma et al.   ACS Applied Materials & Interfaces

Can intracellular drug delivery using hyaluronic acid functionalised pH-sensitive liposomes overcome gemcitabine resistance in pancreatic cancer?

(2019) Mingtan Tang et al.   JOURNAL OF CONTROLLED RELEASE

Transcellular transfer of nanomedicine

(2019) Hae Lin Jang et al.   Nature Nanotechnology

Enzyme-activatable polymer–drug conjugate augments tumour penetration and treatment efficacy

(2019) Quan Zhou et al.   Nature Nanotechnology

Collagenase Nanoparticles Enhance the Penetration of Drugs into Pancreatic Tumors

(2019) Assaf Zinger et al.   ACS Nano

Latest Advances in Targeting the Tumor Microenvironment for Tumor Suppression

(2019) Chloé Laplagne et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

4-Methylumbelliferone Inhibits Cancer Stem Cell Activation and Overcomes Chemoresistance in Ovarian Cancer

(2019) Noor A. Lokman et al.   Cancers

Trends and Challenges in Tumor Anti-Angiogenic Therapies

(2019) József Jászai et al.   Cells

Nanomedicine: From where are we coming and where are we going?

(2019) Patrick Couvreur   JOURNAL OF CONTROLLED RELEASE

Transcytosis of Nanomedicine for Tumor Penetration

(2019) Yan Liu et al.   NANO LETTERS

Smart cancer nanomedicine

(2019) Roy van der Meel et al.   Nature Nanotechnology

Oxygen-Self-Supplying and HIF-1α-Inhibiting Core–Shell Nanosystem for Hypoxia-Resistant Photodynamic Therapy

(2019) Peng Liu et al.   ACS Applied Materials & Interfaces

Tumor targeting via EPR: Strategies to enhance patient responses

(2018) Susanne K. Golombek et al.   ADVANCED DRUG DELIVERY REVIEWS

Size/Charge Changeable Acidity-Responsive Micelleplex for Photodynamic-Improved PD-L1 Immunotherapy with Enhanced Tumor Penetration

(2018) Liangliang Dai et al.   ADVANCED FUNCTIONAL MATERIALS

Establishment of a Patient-Derived Tumor Xenograft Model and Application for Precision Cancer Medicine

(2018) Seiji Okada et al.   CHEMICAL & PHARMACEUTICAL BULLETIN

Charge reversible and biodegradable nanocarriers showing dual pH-/reduction-sensitive disintegration for rapid site-specific drug delivery

(2018) Yalei Miao et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

iRGD-Mediated and Enzyme-Induced Precise Targeting and Retention of Gold Nanoparticles for the Enhanced Imaging and Treatment of Breast Cancer

(2018) Yuanyuan Yang et al.   Journal of Biomedical Nanotechnology

Histidine-rich glycoprotein-induced vascular normalization improves EPR-mediated drug targeting to and into tumors

(2018) Benjamin Theek et al.   JOURNAL OF CONTROLLED RELEASE

Analytical and functional similarity of Amgen biosimilar ABP 215 to bevacizumab

(2018) Neungseon Seo et al.   mAbs

Optimization of Weight Ratio for DSPE-PEG/TPGS Hybrid Micelles to Improve Drug Retention and Tumor Penetration

(2018) Ya Jin et al.   PHARMACEUTICAL RESEARCH

Multifunctional Theranostic Nanoparticles Derived from Fruit-Extracted Anthocyanins with Dynamic Disassembly and Elimination Abilities

(2018) Caina Xu et al.   ACS Nano

Hypoxic tumor therapy by hemoglobin-mediated drug delivery and reversal of hypoxia-induced chemoresistance

(2018) Jie Yang et al.   BIOMATERIALS

Augmentation of the Enhanced Permeability and Retention Effect with Nitric Oxide-Generating Agents Improves the Therapeutic Effects of Nanomedicines

(2018) Waliul Islam et al.   MOLECULAR CANCER THERAPEUTICS

A size switchable nanoplatform for targeting the tumor microenvironment and deep tumor penetration

(2018) Xingli Cun et al.   Nanoscale

Collagenase-Encapsulated pH-Responsive Nanoscale Coordination Polymers for Tumor Microenvironment Modulation and Enhanced Photodynamic Nanomedicine

(2018) Jingjing Liu et al.   ACS Applied Materials & Interfaces

4-Methylumbelliferone Decreases the Hyaluronan-rich Extracellular Matrix and Increases the Effectiveness of 5-Fluorouracil

(2018) ERI YOSHIDA et al.   ANTICANCER RESEARCH

Overcoming tumor hypoxia as a barrier to radiotherapy, chemotherapy and immunotherapy in cancer treatment

(2018) Kaitlin Graham et al.   International Journal of Nanomedicine

Turning foes to friends: targeting cancer-associated fibroblasts

(2018) Xueman Chen et al.   NATURE REVIEWS DRUG DISCOVERY

Perfluorocarbon Nanoparticles Mediated Platelet Blocking Disrupt Vascular Barriers to Improve the Efficacy of Oxygen-Sensitive Antitumor Drugs

(2018) Zaigang Zhou et al.   Small

Intratumoral injection of gels containing losartan microspheres and (PLG-g-mPEG)-cisplatin nanoparticles improves drug penetration, retention and anti-tumor activity

(2018) Meiling Yu et al.   CANCER LETTERS

Particle morphology: an important factor affecting drug delivery by nanocarriers into solid tumors

(2017) Zhen Wang et al.   Expert Opinion on Drug Delivery

Neutrophils promote hepatic metastasis growth through fibroblast growth factor 2-dependent angiogenesis in mice

(2017) Alex N. Gordon-Weeks et al.   HEPATOLOGY

High drug-loading nanomedicines: progress, current status, and prospects

(2017) Shihong Shen et al.   International Journal of Nanomedicine

Tumor-penetrating peptide enhances transcytosis of silicasome-based chemotherapy for pancreatic cancer

(2017) Xiangsheng Liu et al.   JOURNAL OF CLINICAL INVESTIGATION

Overcoming key biological barriers to cancer drug delivery and efficacy

(2017) Susy M. Kim et al.   JOURNAL OF CONTROLLED RELEASE

Extracellular matrix remodeling in vivo for enhancing tumor-targeting efficiency of nanoparticle drug carriers using the pulsed high intensity focused ultrasound

(2017) Sangmin Lee et al.   JOURNAL OF CONTROLLED RELEASE

Sonic-hedgehog pathway inhibition normalizes desmoplastic tumor microenvironment to improve chemo- and nanotherapy

(2017) Fotios Mpekris et al.   JOURNAL OF CONTROLLED RELEASE

Parameters Affecting the Enhanced Permeability and Retention Effect: The Need for Patient Selection

(2017) Az Alddien Natfji et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Neutrophil-mediated anticancer drug delivery for suppression of postoperative malignant glioma recurrence

(2017) Jingwei Xue et al.   Nature Nanotechnology

Inhibition of colony stimulating factor-1 receptor abrogates microenvironment-mediated therapeutic resistance in gliomas

(2017) D Yan et al.   ONCOGENE

Muscone Induces CYP1A2 and CYP3A4 Enzyme Expression in L02 Human Liver Cells and CYP1A2 and CYP3A11 Enzyme Expression in Kunming Mice

(2017) Sha Liu et al.   PHARMACOLOGY

Dual-Stage Light Amplified Photodynamic Therapy against Hypoxic Tumor Based on an O2 Self-Sufficient Nanoplatform

(2017) Li-Han Liu et al.   Small

Targeting the Tumor Stroma: the Biology and Clinical Development of Pegylated Recombinant Human Hyaluronidase (PEGPH20)

(2017) Kit Man Wong et al.   Current Oncology Reports

Cell-Based Drug Delivery and Use of Nano-and Microcarriers for Cell Functionalization

(2017) Alexander S. Timin et al.   Advanced Healthcare Materials

Nanoparticle-mediated local depletion of tumour-associated platelets disrupts vascular barriers and augments drug accumulation in tumours

(2017) Suping Li et al.   Nature Biomedical Engineering

Tumor-associated macrophages: Potential therapeutic targets for anti-cancer therapy

(2016) Yoshihiro Komohara et al.   ADVANCED DRUG DELIVERY REVIEWS

Extracellular matrix structure

(2016) Achilleas D. Theocharis et al.   ADVANCED DRUG DELIVERY REVIEWS

Hierarchical Targeting Strategy for Enhanced Tumor Tissue Accumulation/Retention and Cellular Internalization

(2016) Sheng Wang et al.   ADVANCED MATERIALS

Cyclopamine disrupts tumor extracellular matrix and improves the distribution and efficacy of nanotherapeutics in pancreatic cancer

(2016) Bo Zhang et al.   BIOMATERIALS

Development of a multi-target peptide for potentiating chemotherapy by modulating tumor microenvironment

(2016) Xu Song et al.   BIOMATERIALS

Patient-derived xenograft (PDX) models in basic and translational breast cancer research

(2016) Lacey E. Dobrolecki et al.   CANCER AND METASTASIS REVIEWS

Normalization of Tumor Vessels by Tie2 Activation and Ang2 Inhibition Enhances Drug Delivery and Produces a Favorable Tumor Microenvironment

(2016) Jin-Sung Park et al.   CANCER CELL

Genetically engineered mouse models in oncology research and cancer medicine

(2016) Kelly Kersten et al.   EMBO Molecular Medicine

To exploit the tumor microenvironment: Since the EPR effect fails in the clinic, what is the future of nanomedicine?

(2016) F. Danhier   JOURNAL OF CONTROLLED RELEASE

Targeting tumour-associated macrophages with CCR2 inhibition in combination with FOLFIRINOX in patients with borderline resectable and locally advanced pancreatic cancer: a single-centre, open-label, dose-finding, non-randomised, phase 1b trial

(2016) Timothy M Nywening et al.   LANCET ONCOLOGY

A Retrospective 30 Years After Discovery of the Enhanced Permeability and Retention Effect of Solid Tumors: Next-Generation Chemotherapeutics and Photodynamic Therapy-Problems, Solutions, and Prospects

(2016) Hiroshi Maeda et al.   MICROCIRCULATION

An Integrative Approach to Precision Cancer Medicine Using Patient-Derived Xenografts

(2016)   MOLECULES AND CELLS

Bacteria-Mediated Hypoxia-Specific Delivery of Nanoparticles for Tumors Imaging and Therapy

(2016) Cheng-Hung Luo et al.   NANO LETTERS

Hyaluronidase Embedded in Nanocarrier PEG Shell for Enhanced Tumor Penetration and Highly Efficient Antitumor Efficacy

(2016) Hao Zhou et al.   NANO LETTERS

Nanomedicine and tumor heterogeneity: Concept and complex reality

(2016) Sandra N. Ekdawi et al.   Nano Today

Magneto-aerotactic bacteria deliver drug-containing nanoliposomes to tumour hypoxic regions

(2016) Ouajdi Felfoul et al.   Nature Nanotechnology

Bisphosphonates for cancer treatment: Mechanisms of action and lessons from clinical trials

(2016) Heleen H. Van Acker et al.   PHARMACOLOGY & THERAPEUTICS

ATRA mechanically reprograms pancreatic stellate cells to suppress matrix remodelling and inhibit cancer cell invasion

(2016) Antonios Chronopoulos et al.   Nature Communications

Nanoreporter PET predicts the efficacy of anti-cancer nanotherapy

(2016) Carlos Pérez-Medina et al.   Nature Communications

Biodistribution, migration and homing of systemically applied mesenchymal stem/stromal cells

(2016) Johannes Leibacher et al.   Stem Cell Research & Therapy

Clearance Pathways and Tumor Targeting of Imaging Nanoparticles

(2015) Mengxiao Yu et al.   ACS Nano

Toward a full understanding of the EPR effect in primary and metastatic tumors as well as issues related to its heterogeneity

(2015) Hiroshi Maeda   ADVANCED DRUG DELIVERY REVIEWS

Peptide Assembly Integration of Fibroblast-Targeting and Cell-Penetration Features for Enhanced Antitumor Drug Delivery

(2015) Tianjiao Ji et al.   ADVANCED MATERIALS

Albumin-bound nanoparticle (nab) paclitaxel exhibits enhanced paclitaxel tissue distribution and tumor penetration

(2015) Nianhang Chen et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Hypoxia and hypoxia inducible factors in tumor metabolism

(2015) Wen Zeng et al.   CANCER LETTERS

Macrophage Blockade Using CSF1R Inhibitors Reverses the Vascular Leakage Underlying Malignant Ascites in Late-Stage Epithelial Ovarian Cancer

(2015) D. L. Moughon et al.   CANCER RESEARCH

Targeting Tumor Hypoxia With Hypoxia-Activated Prodrugs

(2015) Jen Jen Yeh et al.   JOURNAL OF CLINICAL ONCOLOGY

Cell penetrating peptides improve tumor delivery of cargos through neuropilin-1-dependent extravasation

(2015) Tetsuya Kadonosono et al.   JOURNAL OF CONTROLLED RELEASE

Nanocarriers for cancer-targeted drug delivery

(2015) Preeti Kumari et al.   JOURNAL OF DRUG TARGETING

Tumor-Priming Smoothened Inhibitor Enhances Deposition and Efficacy of Cytotoxic Nanoparticles in a Pancreatic Cancer Model

(2015) T. Roy Chaudhuri et al.   MOLECULAR CANCER THERAPEUTICS

Tumor stage, tumor site and HPV dependent correlation of perfusion CT parameters and [18F]-FDG uptake in head and neck squamous cell carcinoma

(2015) Marta Nesteruk et al.   RADIOTHERAPY AND ONCOLOGY

Tumors: Wounds That Do Not Heal--Redux

(2015) H. F. Dvorak   Cancer Immunology Research

Neuropilin-1 and heparan sulfate proteoglycans cooperate in cellular uptake of nanoparticles functionalized by cationic cell-penetrating peptides

(2015) H.-B. Pang et al.   Science Advances

Inflammation and the Blood Microvascular System

(2015) Jordan S. Pober et al.   Cold Spring Harbor Perspectives in Biology

Development of next-generation macromolecular drugs based on the EPR effect: challenges and pitfalls

(2014) Hideaki Nakamura et al.   Expert Opinion on Drug Delivery

EPR: Evidence and fallacy

(2014) Joseph W. Nichols et al.   JOURNAL OF CONTROLLED RELEASE

Intracellular delivery of nanomaterials: How to catch endosomal escape in the act

(2014) Thomas F. Martens et al.   Nano Today

Development of High-Content Gemcitabine PEGylated Liposomes and Their Cytotoxicity on Drug-Resistant Pancreatic Tumour Cells

(2014) Hongtao Xu et al.   PHARMACEUTICAL RESEARCH

Patient-Derived Xenograft Models: An Emerging Platform for Translational Cancer Research

(2014) M. Hidalgo et al.   Cancer Discovery

Exocytosis of nanoparticles from cells: Role in cellular retention and toxicity

(2013) Ramin Sakhtianchi et al.   ADVANCES IN COLLOID AND INTERFACE SCIENCE

Role of Macrophage Targeting in the Antitumor Activity of Trabectedin

(2013) Giovanni Germano et al.   CANCER CELL

Serum biomarkers for personalization of nanotherapeutics-based therapy in different tumor and organ microenvironments

(2013) Kenji Yokoi et al.   CANCER LETTERS

Neutrophils Recruited to Sites of Infection Protect from Virus Challenge by Releasing Neutrophil Extracellular Traps

(2013) Craig N. Jenne et al.   Cell Host & Microbe

Sirtuin-7 Inhibits the Activity of Hypoxia-inducible Factors

(2013) Maimon E. Hubbi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Questions on the role of the EPR effect in tumor targeting

(2013) Kinam Park   JOURNAL OF CONTROLLED RELEASE

Development of drug loaded nanoparticles for tumor targeting. Part 2: Enhancement of tumor penetration through receptor mediated transcytosis in 3D tumor models

(2013) Mohammad H. El-Dakdouki et al.   Nanoscale

Histological Advantages of the Tumor Graft

(2013) Yoshimasa Akashi et al.   PANCREAS

Development of macromolecular prodrug for rheumatoid arthritis

(2012) Fang Yuan et al.   ADVANCED DRUG DELIVERY REVIEWS

Cancer nanomedicines: So many papers and so few drugs!

(2012) Vincent J. Venditto et al.   ADVANCED DRUG DELIVERY REVIEWS

Peptides as Targeting Elements and Tissue Penetration Devices for Nanoparticles

(2012) Erkki Ruoslahti   ADVANCED MATERIALS

Bacteria-mediated in vivo delivery of quantum dots into solid tumor

(2012) Ying Liu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Intratumor Heterogeneity: Evolution through Space and Time

(2012) C. Swanton   CANCER RESEARCH

Hyaluronan impairs vascular function and drug delivery in a mouse model of pancreatic cancer

(2012) Michael A Jacobetz et al.   GUT

The enhanced permeability retention effect: a new paradigm for drug targeting in infection

(2012) E. A. Azzopardi et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Endocytic pathway rapidly delivers internalized molecules to lysosomes: An analysis of vesicle trafficking, clustering and mass transfer

(2012) Chinmay Pangarkar et al.   JOURNAL OF CONTROLLED RELEASE

Doxil® — The first FDA-approved nano-drug: Lessons learned

(2012) Yechezkel (Chezy) Barenholz   JOURNAL OF CONTROLLED RELEASE

Role of surface charge in cytotoxicity of charged manganese ferrite nanoparticles towards macrophages

(2012) Seung-Hyun Yang et al.   NANOTECHNOLOGY

The tumor microenvironment controls drug sensitivity

(2012) Arne Östman   NATURE MEDICINE

Normalization of tumour blood vessels improves the delivery of nanomedicines in a size-dependent manner

(2012) Vikash P. Chauhan et al.   Nature Nanotechnology

Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing

(2012) Marco Gerlinger et al.   NEW ENGLAND JOURNAL OF MEDICINE

Macrophages as Cell-Based Delivery Systems for Nanoshells in Photothermal Therapy

(2011) Steen J. Madsen et al.   ANNALS OF BIOMEDICAL ENGINEERING

Use of Macrophages to Target Therapeutic Adenovirus to Human Prostate Tumors

(2011) M. Muthana et al.   CANCER RESEARCH

Genetically engineered mouse models of pancreatic cancer: unravelling tumour biology and progressing translational oncology

(2011) Pawel K Mazur et al.   GUT

Targeted drug delivery to tumors: Myths, reality and possibility

(2011) You Han Bae et al.   JOURNAL OF CONTROLLED RELEASE

Lyn is a redox sensor that mediates leukocyte wound attraction in vivo

(2011) Sa Kan Yoo et al.   NATURE

The EPR effect: Unique features of tumor blood vessels for drug delivery, factors involved, and limitations and augmentation of the effect

(2010) Jun Fang et al.   ADVANCED DRUG DELIVERY REVIEWS

Tumor-Selective Delivery of Macromolecular Drugs via the EPR Effect: Background and Future Prospects

(2010) Hiroshi Maeda   BIOCONJUGATE CHEMISTRY

Effects of particle size and surface charge on cellular uptake and biodistribution of polymeric nanoparticles

(2010) Chunbai He et al.   BIOMATERIALS

Dynamic interplay between the collagen scaffold and tumor evolution

(2010) Mikala Egeblad et al.   CURRENT OPINION IN CELL BIOLOGY

Tumors as Organs: Complex Tissues that Interface with the Entire Organism

(2010) Mikala Egeblad et al.   DEVELOPMENTAL CELL

Lung Vascular Targeting Using Antibody to Aminopeptidase P: CT-SPECT Imaging, Biodistribution and Pharmacokinetic Analysis

(2010) A. Chrastina et al.   JOURNAL OF VASCULAR RESEARCH

Genome remodelling in a basal-like breast cancer metastasis and xenograft

(2010) Li Ding et al.   NATURE

Delivering nanomedicine to solid tumors

(2010) Rakesh K. Jain et al.   Nature Reviews Clinical Oncology

Development of a macromolecular prodrug for the treatment of inflammatory arthritis: mechanisms involved in arthrotropism and sustained therapeutic efficacy

(2010) Ling-dong Quan et al.   ARTHRITIS RESEARCH & THERAPY

Twenty years of cell-penetrating peptides: from molecular mechanisms to therapeutics

(2009) Frederic Heitz et al.   BRITISH JOURNAL OF PHARMACOLOGY

Elevating Blood Pressure as a Strategy to Increase Tumor-targeted Delivery of Macromolecular Drug SMANCS: Cases of Advanced Solid Tumors

(2009) Akinori Nagamitsu et al.   JAPANESE JOURNAL OF CLINICAL ONCOLOGY

Hedgehog signaling is restricted to the stromal compartment during pancreatic carcinogenesis

(2009) H. Tian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Direct Imaging of Immune Rejection and Memory Induction by Allogeneic Mesenchymal Stromal Cells

(2009) Lior Zangi et al.   STEM CELLS

Mesenchymal Stem Cell Homing Capacity

(2009) Valeria Sordi   TRANSPLANTATION

Cell-penetrating peptides: from molecular mechanisms to therapeutics

(2008) May C. Morris et al.   BIOLOGY OF THE CELL

Comparison of the effects of the kinase inhibitors imatinib, sorafenib, and transforming growth factor-β receptor inhibitor on extravasation of nanoparticles from neovasculature

(2008) Mitsunobu R. Kano et al.   CANCER SCIENCE

Regulatory T Cells and Immune Tolerance

(2008) Shimon Sakaguchi et al.   CELL

The effect of particle design on cellular internalization pathways

(2008) S. E. A. Gratton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA