Applications of patient-derived tumor xenograft models and tumor organoids
Published 2020 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Applications of patient-derived tumor xenograft models and tumor organoids
Authors
Keywords
-
Journal
Journal of Hematology & Oncology
Volume 13, Issue 1, Pages -
Publisher
Springer Science and Business Media LLC
Online
2020-02-03
DOI
10.1186/s13045-019-0829-z
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Organoids — Preclinical Models of Human Disease
- (2019) Mo Li et al. NEW ENGLAND JOURNAL OF MEDICINE
- Protective autophagy elicited by RAF→MEK→ERK inhibition suggests a treatment strategy for RAS-driven cancers
- (2019) Conan G. Kinsey et al. NATURE MEDICINE
- Transforming Growth Factor-β Signaling in Immunity and Cancer
- (2019) Eduard Batlle et al. IMMUNITY
- Activated Fibroblast Program Orchestrates Tumor Initiation and Progression; Molecular Mechanisms and the Associated Therapeutic Strategies
- (2019) Go J. Yoshida et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Matrix stiffening and EGFR cooperate to promote the collective invasion of cancer cells.
- (2018) Eloise M Grasset et al. CANCER RESEARCH
- Tumor Evolution and Drug Response in Patient-Derived Organoid Models of Bladder Cancer
- (2018) Suk Hyung Lee et al. CELL
- A peek into cancer-associated fibroblasts: origins, functions and translational impact
- (2018) Valerie S. LeBleu et al. Disease Models & Mechanisms
- Involvement of partial EMT in cancer progression
- (2018) Masao Saitoh JOURNAL OF BIOCHEMISTRY
- TNF-driven adaptive response mediates resistance to EGFR inhibition in lung cancer
- (2018) Ke Gong et al. JOURNAL OF CLINICAL INVESTIGATION
- DNA methyltransferase expression in triple-negative breast cancer predicts sensitivity to decitabine
- (2018) Jia Yu et al. JOURNAL OF CLINICAL INVESTIGATION
- Estrogen-regulated feedback loop limits the efficacy of estrogen receptor–targeted breast cancer therapy
- (2018) Tengfei Xiao et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Patient-derived organoids model treatment response of metastatic gastrointestinal cancers
- (2018) Georgios Vlachogiannis et al. SCIENCE
- Sustained SREBP-1-dependent lipogenesis as a key mediator of resistance to BRAF-targeted therapy
- (2018) Ali Talebi et al. Nature Communications
- Genomic and Functional Fidelity of Small Cell Lung Cancer Patient-Derived Xenografts
- (2018) Benjamin J. Drapkin et al. Cancer Discovery
- FTY720 Decreases Tumorigenesis in Group 3 Medulloblastoma Patient-Derived Xenografts
- (2018) Evan F. Garner et al. Scientific Reports
- High-sensitivity Detection of Micrometastases Generated by GFP Lentivirus-transduced Organoids Cultured from a Patient-derived Colon Tumor
- (2018) Yu Okazawa et al. Jove-Journal of Visualized Experiments
- Emerging roles of Myc in stem cell biology and novel tumor therapies
- (2018) Go J. Yoshida JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- A patient-derived xenograft pre-clinical trial reveals treatment responses and a resistance mechanism to karonudib in metastatic melanoma
- (2018) Berglind O. Einarsdottir et al. Cell Death & Disease
- Methylation of all BRCA1 copies predicts response to the PARP inhibitor rucaparib in ovarian carcinoma
- (2018) Olga Kondrashova et al. Nature Communications
- The WNT10B network is associated with survival and metastases in chemoresistant triple-negative breast cancer
- (2018) Ikbale El Ayachi et al. CANCER RESEARCH
- Constructing and Deconstructing Cancers using Human Pluripotent Stem Cells and Organoids
- (2018) Ryan C. Smith et al. Cell Stem Cell
- Cancer-associated fibroblasts suppress SOX2-induced dysplasia in a lung squamous cancer coculture
- (2018) Shuang Chen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Therapeutic strategies of drug repositioning targeting autophagy to induce cancer cell death: from pathophysiology to treatment
- (2017) Go J. Yoshida Journal of Hematology & Oncology
- Cisplatin Increases Sensitivity to FGFR Inhibition in Patient-Derived Xenograft Models of Lung Squamous Cell Carcinoma
- (2017) Clare E. Weeden et al. MOLECULAR CANCER THERAPEUTICS
- JQ1 Induces DNA Damage and Apoptosis, and Inhibits Tumor Growth in a Patient-Derived Xenograft Model of Cholangiocarcinoma
- (2017) Patrick L. Garcia et al. MOLECULAR CANCER THERAPEUTICS
- Patient-derived xenografts undergo mouse-specific tumor evolution
- (2017) Uri Ben-David et al. NATURE GENETICS
- Single-cell functional and chemosensitive profiling of combinatorial colorectal therapy in zebrafish xenografts
- (2017) Rita Fior et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Personalized In Vitro and In Vivo Cancer Models to Guide Precision Medicine
- (2017) Chantal Pauli et al. Cancer Discovery
- The anti-cancer effects of itraconazole in epithelial ovarian cancer
- (2017) Chel Hun Choi et al. Scientific Reports
- A Comprehensive Patient-Derived Xenograft Collection Representing the Heterogeneity of Melanoma
- (2017) Clemens Krepler et al. Cell Reports
- Oncogenes Activate an Autonomous Transcriptional Regulatory Circuit That Drives Glioblastoma
- (2017) Dinesh K. Singh et al. Cell Reports
- Validation and development of MTH1 inhibitors for treatment of cancer
- (2016) U. Warpman Berglund et al. ANNALS OF ONCOLOGY
- SOX2 Determines Lineage Restriction: Modeling Lung Squamous Cell Carcinoma in the Mouse
- (2016) Nicole R. Murray et al. CANCER CELL
- SOX2 Is the Determining Oncogenic Switch in Promoting Lung Squamous Cell Carcinoma from Different Cells of Origin
- (2016) Giustina Ferone et al. CANCER CELL
- Modeling Development and Disease with Organoids
- (2016) Hans Clevers CELL
- A Colorectal Tumor Organoid Library Demonstrates Progressive Loss of Niche Factor Requirements during Tumorigenesis
- (2016) Masayuki Fujii et al. Cell Stem Cell
- Establishment of Patient-Derived Tumor Xenograft Models of Epithelial Ovarian Cancer for Preclinical Evaluation of Novel Therapeutics
- (2016) Joyce F. Liu et al. CLINICAL CANCER RESEARCH
- Targeting the ATR/CHK1 Axis with PARP Inhibition Results in Tumor Regression in BRCA -Mutant Ovarian Cancer Models
- (2016) Hyoung Kim et al. CLINICAL CANCER RESEARCH
- Patient-derived xenografts: a relevant preclinical model for drug development
- (2016) Luca Pompili et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Dedifferentiation of Glioma Cells to Glioma Stem-like Cells By Therapeutic Stress-induced HIF Signaling in the Recurrent GBM Model
- (2016) Gina Lee et al. MOLECULAR CANCER THERAPEUTICS
- Collective invasion of cancer: Perspectives from pathology and development
- (2016) Xiaoze Wang et al. PATHOLOGY INTERNATIONAL
- Inhibition of SP1 by the mithramycin analog EC-8042 efficiently targets tumor initiating cells in sarcoma
- (2016) Juan Tornin et al. Oncotarget
- Integrated Patient-Derived Models Delineate Individualized Therapeutic Vulnerabilities of Pancreatic Cancer
- (2016) Agnieszka K. Witkiewicz et al. Cell Reports
- IGF1 Receptor Targeted Theranostic Nanoparticles for Targeted and Image-Guided Therapy of Pancreatic Cancer
- (2015) Hongyu Zhou et al. ACS Nano
- Intravital Imaging Reveals How BRAF Inhibition Generates Drug-Tolerant Microenvironments with High Integrin β1/FAK Signaling
- (2015) Eishu Hirata et al. CANCER CELL
- Genetic Events That Limit the Efficacy of MEK and RTK Inhibitor Therapies in a Mouse Model of KRAS-Driven Pancreatic Cancer
- (2015) P. Pettazzoni et al. CANCER RESEARCH
- Microenvironment-Modulated Metastatic CD133+/CXCR4+/EpCAM- Lung Cancer-Initiating Cells Sustain Tumor Dissemination and Correlate with Poor Prognosis
- (2015) G. Bertolini et al. CANCER RESEARCH
- Evaluating Patient-Derived Colorectal Cancer Xenografts as Preclinical Models by Comparison with Patient Clinical Data
- (2015) M. Nunes et al. CANCER RESEARCH
- Prospective Derivation of a Living Organoid Biobank of Colorectal Cancer Patients
- (2015) Marc van de Wetering et al. CELL
- Organoid Models of Human and Mouse Ductal Pancreatic Cancer
- (2015) Sylvia F. Boj et al. CELL
- Antisense oligonucleotide–mediated MDM4 exon 6 skipping impairs tumor growth
- (2015) Michael Dewaele et al. JOURNAL OF CLINICAL INVESTIGATION
- Metabolic reprogramming: the emerging concept and associated therapeutic strategies
- (2015) Go J. Yoshida JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Single-cell analysis reveals a stem-cell program in human metastatic breast cancer cells
- (2015) Devon A. Lawson et al. NATURE
- Mouse hospital and co-clinical trial project—from bench to bedside
- (2015) John G. Clohessy et al. Nature Reviews Clinical Oncology
- Preserved genetic diversity in organoids cultured from biopsies of human colorectal cancer metastases
- (2015) Fleur Weeber et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Vertical suppression of the EGFR pathway prevents onset of resistance in colorectal cancers
- (2015) Sandra Misale et al. Nature Communications
- Quiescent Sox2+ Cells Drive Hierarchical Growth and Relapse in Sonic Hedgehog Subgroup Medulloblastoma
- (2014) Robert J. Vanner et al. CANCER CELL
- Snail1-Expressing Fibroblasts in the Tumor Microenvironment Display Mechanical Properties That Support Metastasis
- (2014) J. Stanisavljevic et al. CANCER RESEARCH
- Organoid Cultures Derived from Patients with Advanced Prostate Cancer
- (2014) Dong Gao et al. CELL
- SOX2 and p63 colocalize at genetic loci in squamous cell carcinomas
- (2014) Hideo Watanabe et al. JOURNAL OF CLINICAL INVESTIGATION
- Molecular correlates of platinum response in human high-grade serous ovarian cancer patient-derived xenografts
- (2014) Monique D. Topp et al. Molecular Oncology
- A time- and matrix-dependent TGFBR3–JUND–KRT5 regulatory circuit in single breast epithelial cells and basal-like premalignancies
- (2014) Chun-Chao Wang et al. NATURE CELL BIOLOGY
- Acquired resistance to TKIs in solid tumours: learning from lung cancer
- (2014) D. Ross Camidge et al. Nature Reviews Clinical Oncology
- Organogenesis in a dish: Modeling development and disease using organoid technologies
- (2014) M. A. Lancaster et al. SCIENCE
- Mutational landscape of intrahepatic cholangiocarcinoma
- (2014) Shanshan Zou et al. Nature Communications
- Patient-Derived Xenograft Models: An Emerging Platform for Translational Cancer Research
- (2014) M. Hidalgo et al. Cancer Discovery
- Influence of tumour micro-environment heterogeneity on therapeutic response
- (2013) Melissa R. Junttila et al. NATURE
- Endocrine-Therapy-Resistant ESR1 Variants Revealed by Genomic Characterization of Breast-Cancer-Derived Xenografts
- (2013) Shunqiang Li et al. Cell Reports
- Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration
- (2012) Valbona Luga et al. CELL
- MYC pathway activation in triple-negative breast cancer is synthetic lethal with CDK inhibition
- (2012) Dai Horiuchi et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Patient-derived tumour xenografts as models for oncology drug development
- (2012) John J. Tentler et al. Nature Reviews Clinical Oncology
- Global gene expression profiling confirms the molecular fidelity of primary tumor-based orthotopic xenograft mouse models of medulloblastoma
- (2012) Xiumei Zhao et al. NEURO-ONCOLOGY
- A Validated Tumorgraft Model Reveals Activity of Dovitinib Against Renal Cell Carcinoma
- (2012) S. Sivanand et al. Science Translational Medicine
- Long-term Expansion of Epithelial Organoids From Human Colon, Adenoma, Adenocarcinoma, and Barrett's Epithelium
- (2011) Toshiro Sato et al. GASTROENTEROLOGY
- Integrated genomic analyses of ovarian carcinoma
- (2011) D. Bell et al. NATURE
- Tumor grafts derived from women with breast cancer authentically reflect tumor pathology, growth, metastasis and disease outcomes
- (2011) Yoko S DeRose et al. NATURE MEDICINE
- High drug attrition rates—where are we going wrong?
- (2011) Lisa Hutchinson et al. Nature Reviews Clinical Oncology
- Extracellular Matrix Degradation and Remodeling in Development and Disease
- (2011) P. Lu et al. Cold Spring Harbor Perspectives in Biology
- A Molecularly Annotated Platform of Patient-Derived Xenografts ("Xenopatients") Identifies HER2 as an Effective Therapeutic Target in Cetuximab-Resistant Colorectal Cancer
- (2011) A. Bertotti et al. Cancer Discovery
- Itraconazole, a Commonly Used Antifungal that Inhibits Hedgehog Pathway Activity and Cancer Growth
- (2010) James Kim et al. CANCER CELL
- Mechanism of Action of Oral Fingolimod (FTY720) in Multiple Sclerosis
- (2010) Jerold Chun et al. CLINICAL NEUROPHARMACOLOGY
- Contributions of extracellular matrix signaling and tissue architecture to nuclear mechanisms and spatial organization of gene expression control
- (2009) Sophie A. Lelièvre BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
- The basics of epithelial-mesenchymal transition
- (2009) Raghu Kalluri et al. JOURNAL OF CLINICAL INVESTIGATION
- Cancer and the tumor microenvironment: a review of an essential relationship
- (2008) Flaubert Mbeunkui et al. CANCER CHEMOTHERAPY AND PHARMACOLOGY
- IL-15 trans-presentation promotes human NK cell development and differentiation in vivo
- (2008) Nicholas D. Huntington et al. JOURNAL OF EXPERIMENTAL MEDICINE
Create your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create NowBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started