Histone Mono-Ubiquitination in Transcriptional Regulation and Its Mark on Life: Emerging Roles in Tissue Development and Disease

Context-specific Polycomb mechanisms in development

(2022) Jongmin J. Kim et al.   NATURE REVIEWS GENETICS

Histone Ubiquitination: An Integrative Signaling Platform in Genome Stability

(2021) Francesca Mattiroli et al.   TRENDS IN GENETICS

Polycomb complexes redundantly maintain epidermal stem cell identity during development

(2021) Idan Cohen et al.   GENES & DEVELOPMENT

Ubiquitin‐dependent regulation of transcription in development and disease

(2021) Kevin G Mark et al.   EMBO REPORTS

BAP1 constrains pervasive H2AK119ub1 to control the transcriptional potential of the genome

(2021) Nadezda A. Fursova et al.   GENES & DEVELOPMENT

H2AK119ub1 guides maternal inheritance and zygotic deposition of H3K27me3 in mouse embryos

(2021) Hailiang Mei et al.   NATURE GENETICS

Distinct dynamics and functions of H2AK119ub1 and H3K27me3 in mouse preimplantation embryos

(2021) Zhiyuan Chen et al.   NATURE GENETICS

Ring finger 20/ring finger 40/WW domain‑containing adaptor with coiled‑coil complex interacts with p53 to regulate gene transcription in DNA damage response

(2021) Danni Meng et al.   Oncology Letters

RNF20 and RNF40 regulate vitamin D receptor-dependent signaling in inflammatory bowel disease

(2021) Robyn Laura Kosinsky et al.   CELL DEATH AND DIFFERENTIATION

Histone H2B ubiquitination mediated chromatin relaxation is essential for the induction of somatic cell reprogramming

(2021) Liying Wang et al.   CELL PROLIFERATION

UV-induced reduction in Polycomb repression promotes epidermal pigmentation

(2021) Meng-Yen Li et al.   DEVELOPMENTAL CELL

Epigenetic regulation and signalling pathways in Merkel cell development

(2021) Liat Oss‐Ronen et al.   EXPERIMENTAL DERMATOLOGY

BAP1 enhances Polycomb repression by counteracting widespread H2AK119ub1 deposition and chromatin condensation

(2021) Eric Conway et al.   MOLECULAR CELL

Revealing protein-protein interactions at the transcriptome scale by sequencing

(2021) Kara L. Johnson et al.   MOLECULAR CELL

BARD1 reads H2A lysine 15 ubiquitination to direct homologous recombination

(2021) Jordan R. Becker et al.   NATURE

The molecular principles of gene regulation by Polycomb repressive complexes

(2021) Neil P. Blackledge et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Polycomb protein RING1B enables estrogen-mediated gene expression by promoting enhancer–promoter interaction and R-loop formation

(2021) Yusheng Zhang et al.   NUCLEIC ACIDS RESEARCH

Loss of polycomb repressive complex 1 activity and chromosomal instability drive uveal melanoma progression

(2021) Mathieu F. Bakhoum et al.   Nature Communications

E2F6 initiates stable epigenetic silencing of germline genes during embryonic development

(2021) Thomas Dahlet et al.   Nature Communications

Massively parallel in vivo CRISPR screening identifies RNF20/40 as epigenetic regulators of cardiomyocyte maturation

(2021) Nathan J. VanDusen et al.   Nature Communications

PRC1 drives Polycomb-mediated gene repression by controlling transcription initiation and burst frequency

(2021) Paula Dobrinić et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Polycomb Repressive Complex(es) and Their Role in Adult Stem Cells

(2021) Pooja Flora et al.   Genes

Structural basis for COMPASS recognition of an H2B-ubiquitinated nucleosome

(2020) Evan J Worden et al.   eLife

Widespread activation of developmental gene expression characterized by PRC1-dependent chromatin looping

(2020) V. Loubiere et al.   Science Advances

Activity of PRC1 and Histone H2AK119 Monoubiquitination: Revising Popular Misconceptions

(2020) Idan Cohen et al.   BIOESSAYS

A central role for canonical PRC1 in shaping the 3D nuclear landscape

(2020) Shelagh Boyle et al.   GENES & DEVELOPMENT

RYBP/YAF2-PRC1 complexes and histone H1-dependent chromatin compaction mediate propagation of H2AK119ub1 during cell division

(2020) Jicheng Zhao et al.   NATURE CELL BIOLOGY

The H2B ubiquitin-protein ligase RNF40 is required for somatic cell reprogramming

(2020) Wanhua Xie et al.   Cell Death & Disease

Egr2-guided histone H2B monoubiquitination is required for peripheral nervous system myelination

(2020) Hannah M Wüst et al.   NUCLEIC ACIDS RESEARCH

RNF40 exerts stage-dependent functions in differentiating osteoblasts and is essential for bone cell crosstalk

(2020) Zeynab Najafova et al.   CELL DEATH AND DIFFERENTIATION

The histone H2B ubiquitin ligase RNF40 is required for HER2-driven mammary tumorigenesis

(2020) Florian Wegwitz et al.   Cell Death & Disease

The epigenetic basis of cellular heterogeneity

(2020) Benjamin Carter et al.   NATURE REVIEWS GENETICS

Epigenetic modification and a role for the E3 ligase RNF40 in cancer development and metastasis

(2020) Junjiang Fu et al.   ONCOGENE

Chromatin Regulation through Ubiquitin and Ubiquitin-like Histone Modifications

(2020) Robert M. Vaughan et al.   TRENDS IN BIOCHEMICAL SCIENCES

Polycomb group-mediated histone H2A monoubiquitination in epigenome regulation and nuclear processes

(2020) Haithem Barbour et al.   Nature Communications

Histone Monoubiquitination in Chromatin Remodelling: Focus on the Histone H2B Interactome and Cancer

(2020) Deborah J. Marsh et al.   Cancers

Epigenetic control in skin development, homeostasis and injury repair

(2019) Sangjo Kang et al.   EXPERIMENTAL DERMATOLOGY

Chromatin accessibility and the regulatory epigenome

(2019) Sandy L. Klemm et al.   NATURE REVIEWS GENETICS

Writing Histone Monoubiquitination in Human Malignancy—The Role of RING Finger E3 Ubiquitin Ligases

(2019) Deborah J. Marsh et al.   Genes

Schwann Cell Precursors; Multipotent Glial Cells in Embryonic Nerves

(2019) Kristjan R. Jessen et al.   Frontiers in Molecular Neuroscience

Post-translational modifications and chromatin dynamics

(2019) Thomas O. Tolsma et al.   Essays in Biochemistry

Epigenetic gene regulation, chromatin structure, and force-induced chromatin remodelling in epidermal development and homeostasis

(2019) Yekaterina A Miroshnikova et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Functional Landscape of PCGF Proteins Reveals Both RING1A/B-Dependent-and RING1A/B-Independent-Specific Activities

(2019) Andrea Scelfo et al.   MOLECULAR CELL

Synergy between Variant PRC1 Complexes Defines Polycomb-Mediated Gene Repression

(2019) Nadezda A. Fursova et al.   MOLECULAR CELL

Emerging Roles for Polycomb-Group Proteins in Stem Cells and Cancer

(2019) Ho Lam Chan et al.   TRENDS IN BIOCHEMICAL SCIENCES

Phase separation of Polycomb-repressive complex 1 is governed by a charged disordered region of CBX2

(2019) Aaron J. Plys et al.   GENES & DEVELOPMENT

Epigenetic reprogramming of immune cells in injury, repair, and resolution

(2019) Katarzyna Placek et al.   JOURNAL OF CLINICAL INVESTIGATION

Advances in epigenetics link genetics to the environment and disease

(2019) Giacomo Cavalli et al.   NATURE

Histone H2B monoubiquitination regulates heart development via epigenetic control of cilia motility

(2019) Andrew Robson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Unexpected Noncatalytic Roles of Histone Modifiers in Development and Disease

(2019) Yann Aubert et al.   TRENDS IN GENETICS

H3K14 ubiquitylation promotes H3K9 methylation for heterochromatin assembly

(2019) Eriko Oya et al.   EMBO REPORTS

PRC1 Catalytic Activity Is Central to Polycomb System Function

(2019) Neil P. Blackledge et al.   MOLECULAR CELL

Epigenetic Regulation of Mesenchymal Stem Cell Homeostasis

(2019) Bing-Dong Sui et al.   TRENDS IN CELL BIOLOGY

PRC1 Fine-tunes Gene Repression and Activation to Safeguard Skin Development and Stem Cell Specification

(2018) Idan Cohen et al.   Cell Stem Cell

Targeted in situ genome-wide profiling with high efficiency for low cell numbers

(2018) Peter J Skene et al.   Nature Protocols

Functional crosstalk between histone H2B ubiquitylation and H2A modifications and variants

(2018) Felix Wojcik et al.   Nature Communications

MGA, L3MBTL2 and E2F6 determine genomic binding of the non-canonical Polycomb repressive complex PRC1.6

(2018) Bastian Stielow et al.   PLoS Genetics

A Comprehensive Atlas of E3 Ubiquitin Ligase Mutations in Neurological Disorders

(2018) Arlene J. George et al.   Frontiers in Genetics

Polycomb complexes associate with enhancers and promote oncogenic transcriptional programs in cancer through multiple mechanisms

(2018) Ho Lam Chan et al.   Nature Communications

Loss of PRC1 induces higher-order opening of Hox loci independently of transcription during Drosophila embryogenesis

(2018) Thierry Cheutin et al.   Nature Communications

PRC1 preserves epidermal tissue integrity independently of PRC2

(2018) Idan Cohen et al.   GENES & DEVELOPMENT

Nuclear condensates of the Polycomb protein chromobox 2 (CBX2) assemble through phase separation

(2018) Roubina Tatavosian et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Polycomb complexes in normal and malignant hematopoiesis

(2018) Valerio Di Carlo et al.   JOURNAL OF CELL BIOLOGY

Loss of RNF40 Decreases NF-κB Activity in Colorectal Cancer Cells and Reduces Colitis Burden in Mice

(2018) Robyn Laura Kosinsky et al.   Journal of Crohns & Colitis

Polycomb complexes PRC1 and their function in hematopoiesis

(2017) Miguel Vidal et al.   EXPERIMENTAL HEMATOLOGY

Polycomb group RING finger proteins 3/5 activate transcription via an interaction with the pluripotency factor Tex10 in embryonic stem cells

(2017) Wukui Zhao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Polycomb Repressive Complex 1 Generates Discrete Compacted Domains that Change during Differentiation

(2017) Sharmistha Kundu et al.   MOLECULAR CELL

Contribution of rare inherited and de novo variants in 2,871 congenital heart disease probands

(2017) Sheng Chih Jin et al.   NATURE GENETICS

H3 ubiquitination by NEDD4 regulates H3 acetylation and tumorigenesis

(2017) Xian Zhang et al.   Nature Communications

PCGF6-PRC1 suppresses premature differentiation of mouse embryonic stem cells by regulating germ cell-related genes

(2017) Mitsuhiro Endoh et al.   eLife

Ubiquitin modifications

(2016) Kirby N Swatek et al.   CELL RESEARCH

Uveal melanoma: relatively rare but deadly cancer

(2016) S Kaliki et al.   EYE

Dissecting the Roles of Polycomb Repressive Complex 2 Subunits in the Control of Skin Development

(2016) Katherine L. Dauber et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Structure and Function of the RING Domains of RNF20 and RNF40, Dimeric E3 Ligases that Monoubiquitylate Histone H2B

(2016) Martina Foglizzo et al.   JOURNAL OF MOLECULAR BIOLOGY

ATXN7L3 and ENY2 Coordinate Activity of Multiple H2B Deubiquitinases Important for Cellular Proliferation and Tumor Growth

(2016) Boyko S. Atanassov et al.   MOLECULAR CELL

Structural insights into the catalysis and regulation of E3 ubiquitin ligases

(2016) Lori Buetow et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Human BRCA1–BARD1 ubiquitin ligase activity counteracts chromatin barriers to DNA resection

(2016) Ruth M Densham et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

H2B ubiquitination regulates meiotic recombination by promoting chromatin relaxation

(2016) Zhiliang Xu et al.   NUCLEIC ACIDS RESEARCH

Impact of the Circadian Clock on UV-Induced DNA Damage Response and Photocarcinogenesis

(2016) Panshak Dakup et al.   PHOTOCHEMISTRY AND PHOTOBIOLOGY

Structural mechanism for the recognition and ubiquitination of a single nucleosome residue by Rad6–Bre1

(2016) Laura D. Gallego et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural basis for histone H2B deubiquitination by the SAGA DUB module

(2016) M. T. Morgan et al.   SCIENCE

Lateral Thinking: How Histone Modifications Regulate Gene Expression

(2016) Moyra Lawrence et al.   TRENDS IN GENETICS

Jarid2 binds mono-ubiquitylated H2A lysine 119 to mediate crosstalk between Polycomb complexes PRC1 and PRC2

(2016) Sarah Cooper et al.   Nature Communications

BAP1/ASXL1 recruitment and activation for H2A deubiquitination

(2016) Danny D. Sahtoe et al.   Nature Communications

Ubiquitin ligase RNF20/40 facilitates spindle assembly and promotes breast carcinogenesis through stabilizing motor protein Eg5

(2016) Yang Duan et al.   Nature Communications

Chromatin topology is coupled to Polycomb group protein subnuclear organization

(2016) Ajazul H. Wani et al.   Nature Communications

Human BRCA1–BARD1 ubiquitin ligase activity counteracts chromatin barriers to DNA resection

(2016) Ruth M Densham et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

RNF20 Links Histone H2B Ubiquitylation with Inflammation and Inflammation-Associated Cancer

(2016) Ohad Tarcic et al.   Cell Reports

Polycomb-Mediated Repression and Sonic Hedgehog Signaling Interact to Regulate Merkel Cell Specification during Skin Development

(2016) Carolina N. Perdigoto et al.   PLoS Genetics

RYBP stimulates PRC1 to shape chromatin-based communication between Polycomb repressive complexes

(2016) Nathan R Rose et al.   eLife

DNA methylation requires a DNMT1 ubiquitin interacting motif (UIM) and histone ubiquitination

(2015) Weihua Qin et al.   CELL RESEARCH

The interplay of histone modifications - writers that read

(2015) T. Zhang et al.   EMBO REPORTS

The E3 ubiquitin ligase activity of RING1B is not essential for early mouse development

(2015) Robert S. Illingworth et al.   GENES & DEVELOPMENT

Transcriptional repression by PRC1 in the absence of H2A monoubiquitylation

(2015) Ana Raquel Pengelly et al.   GENES & DEVELOPMENT

Histone H1 couples initiation and amplification of ubiquitin signalling after DNA damage

(2015) Tina Thorslund et al.   NATURE

Polycomb repressive complex PRC1 spatially constrains the mouse embryonic stem cell genome

(2015) Stefan Schoenfelder et al.   NATURE GENETICS

Context-dependent actions of Polycomb repressors in cancer

(2015) M Koppens et al.   ONCOGENE

BMI1–RING1B is an autoinhibited RING E3 ubiquitin ligase

(2015) Asad M. Taherbhoy et al.   Nature Communications

Usp22 deficiency impairs intestinal epithelial lineage specification in vivo

(2015) Robyn L. Kosinsky et al.   Oncotarget

RNF168 Promotes Noncanonical K27 Ubiquitination to Signal DNA Damage

(2015) Marco Gatti et al.   Cell Reports

RNF20-SNF2H Pathway of Chromatin Relaxation in DNA Double-Strand Break Repair

(2015) Akihiro Kato et al.   Genes

Variant PRC1 Complex-Dependent H2A Ubiquitylation Drives PRC2 Recruitment and Polycomb Domain Formation

(2014) Neil P. Blackledge et al.   CELL

Histone H2B monoubiquitination: roles to play in human malignancy

(2014) Alexander J Cole et al.   ENDOCRINE-RELATED CANCER

The SAGA coactivator complex acts on the whole transcribed genome and is required for RNA polymerase II transcription

(2014) Jacques Bonnet et al.   GENES & DEVELOPMENT

H2B Ubiquitylation Promotes RNA Pol II Processivity via PAF1 and pTEFb

(2014) Lipeng Wu et al.   MOLECULAR CELL

An AUTS2–Polycomb complex activates gene expression in the CNS

(2014) Zhonghua Gao et al.   NATURE

Histone H2A monoubiquitination promotes histone H3 methylation in Polycomb repression

(2014) Reinhard Kalb et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The histone H2A deubiquitinase Usp16 regulates embryonic stem cell gene expression and lineage commitment

(2014) Wei Yang et al.   Nature Communications

BRCA1 Is a Histone-H2A-Specific Ubiquitin Ligase

(2014) Reinhard Kalb et al.   Cell Reports

Targeting Polycomb to Pericentric Heterochromatin in Embryonic Stem Cells Reveals a Role for H2AK119u1 in PRC2 Recruitment

(2014) Sarah Cooper et al.   Cell Reports

RING-type E3 ligases: Master manipulators of E2 ubiquitin-conjugating enzymes and ubiquitination

(2013) Meredith B. Metzger et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Polycomb complexes in stem cells and embryonic development

(2013) L. Aloia et al.   DEVELOPMENT

SAM Domain Polymerization Links Subnuclear Clustering of PRC1 to Gene Silencing

(2013) Kyoichi Isono et al.   DEVELOPMENTAL CELL

The Aurora B Kinase and the Polycomb Protein Ring1B Combine to Regulate Active Promoters in Quiescent Lymphocytes

(2013) Alberto Frangini et al.   MOLECULAR CELL

Fbxl10/Kdm2b Recruits Polycomb Repressive Complex 1 to CpG Islands and Regulates H2A Ubiquitylation

(2013) Xudong Wu et al.   MOLECULAR CELL

Uhrf1-dependent H3K23 ubiquitylation couples maintenance DNA methylation and replication

(2013) Atsuya Nishiyama et al.   NATURE

Kdm2b maintains murine embryonic stem cell status by recruiting PRC1 complex to CpG islands of developmental genes

(2013) Jin He et al.   NATURE CELL BIOLOGY

Transcriptional regulation by Polycomb group proteins

(2013) Luciano Di Croce et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Histone H2B ubiquitin ligase RNF20 is required for MLL-rearranged leukemia

(2013) E. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The COMPASS Family of Histone H3K4 Methylases: Mechanisms of Regulation in Development and Disease Pathogenesis

(2012) Ali Shilatifard   Annual Review of Biochemistry

Deficiency in Mammalian Histone H2B Ubiquitin Ligase Bre1 (Rnf20/Rnf40) Leads to Replication Stress and Chromosomal Instability

(2012) S. B. Chernikova et al.   CANCER RESEARCH

RNF168 Ubiquitinates K13-15 on H2A/H2AX to Drive DNA Damage Signaling

(2012) Francesca Mattiroli et al.   CELL

RYBP-PRC1 Complexes Mediate H2A Ubiquitylation at Polycomb Target Sites Independently of PRC2 and H3K27me3

(2012) Lígia Tavares et al.   CELL

Histone H2B lysine 120 monoubiquitination is required for embryonic stem cell differentiation

(2012) Su Chen et al.   CELL RESEARCH

Polycomb Associates Genome-wide with a Specific RNA Polymerase II Variant, and Regulates Metabolic Genes in ESCs

(2012) Emily Brookes et al.   Cell Stem Cell

The enigmatic role of H2Bub1 in cancer

(2012) Steven A. Johnsen   FEBS LETTERS

H2B monoubiquitylation is a 5′-enriched active transcription mark and correlates with exon–intron structure in human cells

(2012) Inkyung Jung et al.   GENOME RESEARCH

The Growth-Suppressive Function of the Polycomb Group Protein Polyhomeotic Is Mediated by Polymerization of Its Sterile Alpha Motif (SAM) Domain

(2012) Angela K. Robinson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human Histone H3K79 Methyltransferase DOT1L Methyltransferase Binds Actively Transcribing RNA Polymerase II to Regulate Gene Expression

(2012) Seung-Kyoon Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Polycomb Repressive Complex 1 (PRC1) Disassembles RNA Polymerase II Preinitiation Complexes

(2012) Lynn Lehmann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dynamic Loss of H2B Ubiquitylation without Corresponding Changes in H3K4 Trimethylation during Myogenic Differentiation

(2012) V. Vethantham et al.   MOLECULAR AND CELLULAR BIOLOGY

The Histone H2B Monoubiquitination Regulatory Pathway Is Required for Differentiation of Multipotent Stem Cells

(2012) Oleksandra Karpiuk et al.   MOLECULAR CELL

RNF20 and USP44 Regulate Stem Cell Differentiation by Modulating H2B Monoubiquitylation

(2012) Gilad Fuchs et al.   MOLECULAR CELL

PCGF Homologs, CBX Proteins, and RYBP Define Functionally Distinct PRC1 Family Complexes

(2012) Zhonghua Gao et al.   MOLECULAR CELL

Genome-wide analysis of EGR2/SOX10 binding in myelinating peripheral nerve

(2012) Rajini Srinivasan et al.   NUCLEIC ACIDS RESEARCH

KDM2B links the Polycomb Repressive Complex 1 (PRC1) to recognition of CpG islands

(2012) Anca M Farcas et al.   eLife

Histone Ubiquitination and Deubiquitination in Transcription, DNA Damage Response, and Cancer

(2012) Jian Cao et al.   Frontiers in Oncology

Estrogen-Dependent Gene Transcription in Human Breast Cancer Cells Relies upon Proteasome-Dependent Monoubiquitination of Histone H2B

(2011) T. Prenzel et al.   CANCER RESEARCH

The flip side of the coin: Role of ZRF1 and histone H2A ubiquitination in transcriptional activation

(2011) Holger Richly et al.   CELL CYCLE

The H2B ubiquitin ligase RNF40 cooperates with SUPT16H to induce dynamic changes in chromatin structure during DNA double-strand break repair

(2011) Vijayalakshmi Kari et al.   CELL CYCLE

RNF20-RNF40: A ubiquitin-driven link between gene expression and the DNA damage response

(2011) Yosef Shiloh et al.   FEBS LETTERS

Genome-wide function of H2B ubiquitylation in promoter and genic regions

(2011) K. Batta et al.   GENES & DEVELOPMENT

The tumor suppressor CDC73 interacts with the ring finger proteins RNF20 and RNF40 and is required for the maintenance of histone 2B monoubiquitination

(2011) Michael A. Hahn et al.   HUMAN MOLECULAR GENETICS

Monoubiquitination of H2AX Protein Regulates DNA Damage Response Signaling

(2011) Mei-Ren Pan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Tightly Controlled Deubiquitination Activity of the Human SAGA Complex Differentially Modifies Distinct Gene Regulatory Elements

(2011) G. Lang et al.   MOLECULAR AND CELLULAR BIOLOGY

Regulation of Homologous Recombination by RNF20-Dependent H2B Ubiquitination

(2011) Kyosuke Nakamura et al.   MOLECULAR CELL

RNF20 Inhibits TFIIS-Facilitated Transcriptional Elongation to Suppress Pro-oncogenic Gene Expression

(2011) Efrat Shema et al.   MOLECULAR CELL

WAC, a Functional Partner of RNF20/40, Regulates Histone H2B Ubiquitination and Gene Transcription

(2011) Feng Zhang et al.   MOLECULAR CELL

The RING Finger Protein MSL2 in the MOF Complex Is an E3 Ubiquitin Ligase for H2B K34 and Is Involved in Crosstalk with H3 K4 and K79 Methylation

(2011) Lipeng Wu et al.   MOLECULAR CELL

RINGs hold the key to ubiquitin transfer

(2011) Rhesa Budhidarmo et al.   TRENDS IN BIOCHEMICAL SCIENCES

Ring1B Compacts Chromatin Structure and Represses Gene Expression Independent of Histone Ubiquitination

(2010) Ragnhild Eskeland et al.   MOLECULAR CELL

CpG Islands Recruit a Histone H3 Lysine 36 Demethylase

(2010) Neil P. Blackledge et al.   MOLECULAR CELL

Histone H2A deubiquitinase activity of the Polycomb repressive complex PR-DUB

(2010) Johanna C. Scheuermann et al.   NATURE

Transcriptional activation of polycomb-repressed genes by ZRF1

(2010) Holger Richly et al.   NATURE

Regulation and Cellular Roles of Ubiquitin-Specific Deubiquitinating Enzymes

(2009) Francisca E. Reyes-Turcu et al.   Annual Review of Biochemistry

RAD6-Mediated Transcription-Coupled H2B Ubiquitylation Directly Stimulates H3K4 Methylation in Human Cells

(2009) Jaehoon Kim et al.   CELL

CDK9 directs H2B monoubiquitination and controls replication-dependent histone mRNA 3′-end processing

(2009) Judith Pirngruber et al.   EMBO REPORTS

Breaking the chains: structure and function of the deubiquitinases

(2009) David Komander et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The histone H2B-specific ubiquitin ligase RNF20/hBRE1 acts as a putative tumor suppressor through selective regulation of gene expression

(2008) E. Shema et al.   GENES & DEVELOPMENT

Deubiquitylation of histone H2A activates transcriptional initiation via trans-histone cross-talk with H3K4 di- and trimethylation

(2008) T. Nakagawa et al.   GENES & DEVELOPMENT

Histone H2B ubiquitination: the cancer connection

(2008) J. M. Espinosa   GENES & DEVELOPMENT

dKDM2 couples histone H2A ubiquitylation to histone H3 demethylation during Polycomb group silencing

(2008) A. Lagarou et al.   GENES & DEVELOPMENT

Polyubiquitylation of Histone H2B

(2008) Fuqiang Geng et al.   MOLECULAR BIOLOGY OF THE CELL

H2B Ubiquitylation Plays a Role in Nucleosome Dynamics during Transcription Elongation

(2008) Alastair B. Fleming et al.   MOLECULAR CELL

Histone H2A Monoubiquitination Represses Transcription by Inhibiting RNA Polymerase II Transcriptional Elongation

(2008) Wenlai Zhou et al.   MOLECULAR CELL

The Putative Cancer Stem Cell Marker USP22 Is a Subunit of the Human SAGA Complex Required for Activated Transcription and Cell-Cycle Progression

(2008) Xiao-Yong Zhang et al.   MOLECULAR CELL

Chemically ubiquitylated histone H2B stimulates hDot1L-mediated intranucleosomal methylation

(2008) Robert K. McGinty et al.   NATURE

Monoubiquitinated H2B is associated with the transcribed region of highly expressed genes in human cells

(2008) Neri Minsky et al.   NATURE CELL BIOLOGY

Genomewide Analysis of PRC1 and PRC2 Occupancy Identifies Two Classes of Bivalent Domains

(2008) Manching Ku et al.   PLoS Genetics