Journal
JOURNAL OF CELL BIOLOGY
Volume 218, Issue 1, Pages 55-69Publisher
ROCKEFELLER UNIV PRESS
DOI: 10.1083/jcb.201808028
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Funding
- Spanish Ministry of Economy, Industry, and Competitiveness [BFU2016-75008-P]
- European Regional Development Fund (FED ER)
- Fundacion Vencer El Cancer
- Agencia de Gestio d'Ajuts Universitaris i de Recerca
- ImPuLSe Marie Curie Postdoctoral Fellowship of the European Union Seventh Framework Program [608959]
- FPI fellowship
- Spanish Ministry of Economy, Industry, and Competitiveness through the Instituto de Salud Carlos III
- Centro de Excelencia Severo Ochoa
- Centres de Recerca de Catalunya Program/Generalitat de Catalunya
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Epigenetic mechanisms are crucial for sustaining cell type-specific transcription programs. Among the distinct factors, Polycomb group (PcG) proteins are major negative regulators of gene expression in mammals. These proteins play key roles in regulating the proliferation, self-renewal, and differentiation of stem cells. During hematopoietic differentiation, many PcG proteins are fundamental for proper lineage commitment, as highlighted by the fact that a lack of distinct PcG proteins results in embryonic lethality accompanied by differentiation biases. Correspondingly, proteins of these complexes are frequently dysregulated in hematological diseases. In this review, we present an overview of the role of PcG proteins in normal and malignant hematopoiesis, focusing on the compositional complexity of PcG complexes, and we briefly discuss the ongoing clinical trials for drugs targeting these factors.
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