The Fatal Circle of NETs and NET-Associated DAMPs Contributing to Organ Dysfunction

HMGB1-Mediated Neutrophil Extracellular Trap Formation Exacerbates Intestinal Ischemia/Reperfusion-Induced Acute Lung Injury

(2022) YaQing Zhan et al.   JOURNAL OF IMMUNOLOGY

The mechanism of HMGB1 secretion and release

(2022) Ruochan Chen et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Selectin-Mediated Signaling—Shedding Light on the Regulation of Integrin Activity in Neutrophils

(2022) Anika Cappenberg et al.   Cells

The cytosolic DNA sensor cGAS recognizes neutrophil extracellular traps

(2021) Falko Apel et al.   Science Signaling

Circulating Free DNA and Its Emerging Role in Autoimmune Diseases

(2021) Patricia Mondelo-Macía et al.   Journal of Personalized Medicine

Platelets orchestrate the resolution of pulmonary inflammation in mice by T reg cell repositioning and macrophage education

(2021) Jan Rossaint et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A Fragile Balance: Does Neutrophil Extracellular Trap Formation Drive Pulmonary Disease Progression?

(2021) Helena Block et al.   Cells

Secondary Immunodeficiency Related to Kidney Disease (SIDKD)—Definition, Unmet Need, and Mechanisms

(2021) Stefanie Steiger et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Receptor-Mediated NETosis on Neutrophils

(2021) Tao Chen et al.   Frontiers in Immunology

Non-Randomized Trial of Dornase Alfa for Acute Respiratory Distress Syndrome Secondary to Covid-19

(2021) Zachary M. Holliday et al.   Frontiers in Immunology

Neutrophil extracellular trap-associated RNA and LL37 enable self-amplifying inflammation in psoriasis

(2020) Franziska Herster et al.   Nature Communications

Citrullinated Histone H3 as a Therapeutic Target for Endotoxic Shock in Mice

(2020) Qiufang Deng et al.   Frontiers in Immunology

COVID-19 Autopsies, Oklahoma, USA

(2020) Lisa M Barton et al.   AMERICAN JOURNAL OF CLINICAL PATHOLOGY

COVID-19 and its implications for thrombosis and anticoagulation

(2020) Jean Marie Connors et al.   BLOOD

Therapeutic ACPA inhibits NET formation: a potential therapy for neutrophil-mediated inflammatory diseases

(2020) Renato G. S. Chirivi et al.   Cellular & Molecular Immunology

Targeting potential drivers of COVID-19: Neutrophil extracellular traps

(2020) Betsy J. Barnes et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The procoagulant pattern of patients with COVID‐19 acute respiratory distress syndrome

(2020) Marco Ranucci et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Pulmonary Vascular Endothelialitis, Thrombosis, and Angiogenesis in Covid-19

(2020) Maximilian Ackermann et al.   NEW ENGLAND JOURNAL OF MEDICINE

Risk Factors Associated With Acute Respiratory Distress Syndrome and Death in Patients With Coronavirus Disease 2019 Pneumonia in Wuhan, China

(2020) Chaomin Wu et al.   JAMA Internal Medicine

Neutrophil Extracellular Traps (NETs) Contribute to Immunothrombosis in COVID-19 Acute Respiratory Distress Syndrome

(2020) Elizabeth A Middleton et al.   BLOOD

Platelet Gene Expression and Function in COVID-19 Patients

(2020) Bhanu Kanth Manne et al.   BLOOD

Immunothrombotic Dysregulation in COVID-19 Pneumonia is Associated with Respiratory Failure and Coagulopathy

(2020) Leo Nicolai et al.   CIRCULATION

Thrombosis risk associated with COVID-19 infection. A scoping review

(2020) Fatimah Al-Ani et al.   THROMBOSIS RESEARCH

Fibrinogen protects neutrophils from the cytotoxic effects of histones and delays neutrophil extracellular trap formation induced by ionomycin

(2020) Matthew Locke et al.   Scientific Reports

Beyond Anti-viral Effects of Chloroquine/Hydroxychloroquine

(2020) Vincent Gies et al.   Frontiers in Immunology

Histopathologic Changes and SARS-CoV-2 Immunostaining in the Lung of a Patient With COVID-19

(2020) Huilan Zhang et al.   ANNALS OF INTERNAL MEDICINE

Neutrophil extracellular traps infiltrate the lung airway, interstitial, and vascular compartments in severe COVID-19

(2020) Coraline Radermecker et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Effect of aspirin on deaths associated with sepsis in healthy older people (ANTISEPSIS): a randomised, double-blind, placebo-controlled primary prevention trial

(2020) Damon P Eisen et al.   Lancet Respiratory Medicine

Extracellular DNA—A Danger Signal Triggering Immunothrombosis

(2020) Chongxu Shi et al.   Frontiers in Immunology

Inhibition of Efferocytosis by Extracellular CIRP–Induced Neutrophil Extracellular Traps

(2020) Kehong Chen et al.   JOURNAL OF IMMUNOLOGY

Inhibition of Peptidyl Arginine Deiminase-4 Prevents Renal Ischemia-Reperfusion-Induced Remote Lung Injury

(2020) Mingjun Du et al.   MEDIATORS OF INFLAMMATION

Organ crosstalk: the potent roles of inflammation and fibrotic changes in the course of organ interactions

(2019) Ferah Armutcu   INFLAMMATION RESEARCH

Cold-inducible RNA-binding Protein Induces Neutrophil Extracellular Traps in the Lungs during Sepsis

(2019) Yasumasa Ode et al.   Scientific Reports

Intra- and Extracellular Degradation of Neutrophil Extracellular Traps by Macrophages and Dendritic Cells

(2019) Beatrice Lazzaretto et al.   JOURNAL OF IMMUNOLOGY

Aggregated NETs Sequester and Detoxify Extracellular Histones

(2019) Jasmin Knopf et al.   Frontiers in Immunology

DAMPs, PAMPs, and LAMPs in Immunity and Sterile Inflammation

(2019) Joel Zindel et al.   Annual Review of Pathology-Mechanisms of Disease

Neutrophil extracellular traps are a source of extracellular HMGB1 in lupus nephritis: associations with clinical and histopathological features

(2019) L P Whittall-García et al.   LUPUS

Citrullination Licenses Calpain to Decondense Nuclei in Neutrophil Extracellular Trap Formation

(2019) Stefanie Gößwein et al.   Frontiers in Immunology

Does cell-free DNA promote coagulation and inhibit fibrinolysis in patients with unprovoked venous thromboembolism?

(2019) Sarah K. Medeiros et al.   THROMBOSIS RESEARCH

The antidiabetic drug metformin blunts NETosis in vitro and reduces circulating NETosis biomarkers in vivo

(2018) Lisa Menegazzo et al.   ACTA DIABETOLOGICA

Chloroquine reduces hypercoagulability in pancreatic cancer through inhibition of neutrophil extracellular traps

(2018) Brian A. Boone et al.   BMC CANCER

Impaired efferocytosis and neutrophil extracellular traps clearance by macrophages in ARDS

(2018) Murielle Grégoire et al.   EUROPEAN RESPIRATORY JOURNAL

CIRP increases ICAM-1+ phenotype of neutrophils exhibiting elevated iNOS and NETs in sepsis

(2018) Yasumasa Ode et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Neutrophil peptidyl arginine deiminase-4 has a pivotal role in ischemia/reperfusion-induced acute kidney injury

(2018) Wesley M. Raup-Konsavage et al.   KIDNEY INTERNATIONAL

Innate immune responses to trauma

(2018) Markus Huber-Lang et al.   NATURE IMMUNOLOGY

High-mobility group box 1 protein (HMGB1) operates as an alarmin outside as well as inside cells

(2018) Ulf Andersson et al.   SEMINARS IN IMMUNOLOGY

A ligand-specific blockade of the integrin Mac-1 selectively targets pathologic inflammation while maintaining protective host-defense

(2018) Dennis Wolf et al.   Nature Communications

Deep vein thrombosis in mice is regulated by platelet HMGB1 through release of neutrophil-extracellular traps and DNA

(2018) Mitchell R. Dyer et al.   Scientific Reports

Entamoeba histolytica Trophozoites Induce a Rapid Non-classical NETosis Mechanism Independent of NOX2-Derived Reactive Oxygen Species and PAD4 Activity

(2018) César Díaz-Godínez et al.   Frontiers in Cellular and Infection Microbiology

LPS-Challenged Macrophages Release Microvesicles Coated With Histones

(2018) Rohini Ravindran Nair et al.   Frontiers in Immunology

Aggregated neutrophil extracellular traps resolve inflammation by proteolysis of cytokines and chemokines and protection from antiproteases

(2018) Jonas Hahn et al.   FASEB JOURNAL

Biology, role and therapeutic potential of circulating histones in acute inflammatory disorders

(2018) Peter Szatmary et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Extracellular traps in kidney disease

(2018) Daigo Nakazawa et al.   KIDNEY INTERNATIONAL

Pattern Recognition Receptors and the Host Cell Death Molecular Machinery

(2018) Gustavo P. Amarante-Mendes et al.   Frontiers in Immunology

The self-association of HMGB1 and its possible role in the binding to DNA and cell membrane receptors

(2017) Wresti L. Anggayasti et al.   FEBS LETTERS

Macrophage Extracellular Traps: A Scoping Review

(2017) Ryan S. Doster et al.   Journal of Innate Immunity

Histones and Neutrophil Extracellular Traps Enhance Tubular Necrosis and Remote Organ Injury in Ischemic AKI

(2017) Daigo Nakazawa et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Release of extracellular DNA influences renal ischemia reperfusion injury by platelet activation and formation of neutrophil extracellular traps

(2017) Marcel P.B. Jansen et al.   KIDNEY INTERNATIONAL

An emerging role for neutrophil extracellular traps in noninfectious disease

(2017) Selina K Jorch et al.   NATURE MEDICINE

Low Molecular Weight Heparins—A new tool to disetangle from the NETs

(2017) Javier Sanchez   PHARMACOLOGICAL RESEARCH

Low molecular weight heparins prevent the induction of autophagy of activated neutrophils and the formation of neutrophil extracellular traps

(2017) Angelo A. Manfredi et al.   PHARMACOLOGICAL RESEARCH

Neutrophil Extracellular Traps Are Pathogenic in Ventilator-Induced Lung Injury and Partially Dependent on TLR4

(2017) Haosi Li et al.   Biomed Research International

Mineral particles stimulate innate immunity through neutrophil extracellular traps containing HMGB1

(2017) Hsin-Hsin Peng et al.   Scientific Reports

Regulation of Posttranslational Modifications of HMGB1 During Immune Responses

(2016) Yiting Tang et al.   ANTIOXIDANTS & REDOX SIGNALING

DAMP and DIC: The role of extracellular DNA and DNA-binding proteins in the pathogenesis of DIC

(2016) Patricia C. Liaw et al.   BLOOD REVIEWS

Cold-inducible proteins CIRP and RBM3, a unique couple with activities far beyond the cold

(2016) Xinzhou Zhu et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The Alarmin Properties of DNA and DNA-associated Nuclear Proteins

(2016) Melinda Magna et al.   CLINICAL THERAPEUTICS

Cold-inducible RBM3 inhibits PERK phosphorylation through cooperation with NF90 to protect cells from endoplasmic reticulum stress

(2016) Xinzhou Zhu et al.   FASEB JOURNAL

The responses of macrophages in interaction with neutrophils that undergo NETosis

(2016) Daigo Nakazawa et al.   JOURNAL OF AUTOIMMUNITY

Neonatal NET-inhibitory factor and related peptides inhibit neutrophil extracellular trap formation

(2016) Christian C. Yost et al.   JOURNAL OF CLINICAL INVESTIGATION

Neutrophil elastase-deficient mice form neutrophil extracellular traps in an experimental model of deep vein thrombosis

(2016) K. Martinod et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Superoxide Induces Neutrophil Extracellular Trap Formation in a TLR-4 and NOX-Dependent Mechanism

(2016) Ahmed B Al-Khafaji et al.   MOLECULAR MEDICINE

Directed transport of neutrophil-derived extracellular vesicles enables platelet-mediated innate immune response

(2016) Jan Rossaint et al.   Nature Communications

Low ADAMTS13 activity is associated with an increased risk of ischemic stroke

(2015) M. A. H. Sonneveld et al.   BLOOD

Circulating Histones Are Major Mediators of Cardiac Injury in Patients With Sepsis*

(2015) Yasir Alhamdi et al.   CRITICAL CARE MEDICINE

Damage-associated molecular pattern-activated neutrophil extracellular trap exacerbates sterile inflammatory liver injury

(2015) Hai Huang et al.   HEPATOLOGY

Platelet-derived HMGB1 is a critical mediator of thrombosis

(2015) Sebastian Vogel et al.   JOURNAL OF CLINICAL INVESTIGATION

Cutting Edge: Antimalarial Drugs Inhibit IFN-β Production through Blockade of Cyclic GMP-AMP Synthase–DNA Interaction

(2015) Jie An et al.   JOURNAL OF IMMUNOLOGY

HMGB1 Binds to Lipoteichoic Acid and Enhances TNF-a and IL-6 Production through HMGB1-Mediated Transfer of Lipoteichoic Acid to CD14 and TLR2

(2015) Man Sup Kwak et al.   Journal of Innate Immunity

Mediators and molecular pathways involved in the regulation of neutrophil extracellular trap formation mediated by activated platelets

(2015) Agostina Carestia et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Histone exchange, chromatin structure and the regulation of transcription

(2015) Swaminathan Venkatesh et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Comparison of the Proinflammatory and Procoagulant Properties of Nuclear, Mitochondrial, and Bacterial DNA

(2015) Vinai C. Bhagirath et al.   SHOCK

Molecular mechanisms of NET formation and degradation revealed by intravital imaging in the liver vasculature

(2015) Elzbieta Kolaczkowska et al.   Nature Communications

Targeting HMGB1 in the treatment of sepsis

(2014) Haichao Wang et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Molecular mechanism and therapeutic modulation of high mobility group box 1 release and action: an updated review

(2014) Ben Lu et al.   Expert Review of Clinical Immunology

Activated Platelets Interfere with Recruitment of Mesenchymal Stem Cells to Apoptotic Cardiac Cells via High Mobility Group Box 1/Toll-like Receptor 4-mediated Down-regulation of Hepatocyte Growth Factor Receptor MET

(2014) Sebastian Vogel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

High Mobility Group Box 1 Protein Binding to Lipopolysaccharide Facilitates Transfer of Lipopolysaccharide to CD14 and Enhances Lipopolysaccharide-Mediated TNF-  Production in Human Monocytes

(2014) J. H. Youn et al.   JOURNAL OF IMMUNOLOGY

Novel Role of the Antimicrobial Peptide LL-37 in the Protection of Neutrophil Extracellular Traps against Degradation by Bacterial Nucleases

(2014) Ariane Neumann et al.   Journal of Innate Immunity

Cystic Fibrosis Sputum DNA Has NETosis Characteristics and Neutrophil Extracellular Trap Release Is Regulated by Macrophage Migration-Inhibitory Factor

(2014) Markryan Dwyer et al.   Journal of Innate Immunity

Activated platelets present high mobility group box 1 to neutrophils, inducing autophagy and promoting the extrusion of neutrophil extracellular traps

(2014) N. Maugeri et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

The high-mobility group protein B1–Toll-like receptor 4 pathway contributes to the acute lung injury induced by bilateral nephrectomy

(2014) Kent Doi et al.   KIDNEY INTERNATIONAL

Aggregated neutrophil extracellular traps limit inflammation by degrading cytokines and chemokines

(2014) Christine Schauer et al.   NATURE MEDICINE

Efficient Neutrophil Extracellular Trap Induction Requires Mobilization of Both Intracellular and Extracellular Calcium Pools and Is Modulated by Cyclosporine A

(2014) Anurag Kumar Gupta et al.   PLoS One

Presence of Neutrophil Extracellular Traps and Citrullinated Histone H3 in the Bloodstream of Critically Ill Patients

(2014) Tomoya Hirose et al.   PLoS One

A Myeloperoxidase-Containing Complex Regulates Neutrophil Elastase Release and Actin Dynamics during NETosis

(2014) Kathleen D. Metzler et al.   Cell Reports

HMGB1 promotes neutrophil extracellular trap formation through interactions with Toll-like receptor 4

(2013) Jean-Marc Tadie et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Tissue factor expression in neutrophil extracellular traps and neutrophil derived microparticles in antineutrophil cytoplasmic antibody associated vasculitis may promote thromboinflammation and the thrombophilic state associated with the disease

(2013) Konstantinos Kambas et al.   ANNALS OF THE RHEUMATIC DISEASES

Redox Modulation of HMGB1-Related Signaling

(2013) Christina Janko et al.   ANTIOXIDANTS & REDOX SIGNALING

Human antimicrobial peptide LL-37 modulates proinflammatory responses induced by cytokine milieus and double-stranded RNA in human keratinocytes

(2013) Xue Chen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Nonanticoagulant heparin prevents histone-mediated cytotoxicity in vitro and improves survival in sepsis

(2013) K. C. A. A. Wildhagen et al.   BLOOD

Synchronized integrin engagement and chemokine activation is crucial in neutrophil extracellular trap-mediated sterile inflammation

(2013) J. Rossaint et al.   BLOOD

NETosis: how vital is it?

(2013) B. G. Yipp et al.   BLOOD

Extracellular histones are essential effectors of C5aR- and C5L2-mediated tissue damage and inflammation in acute lung injury

(2013) Markus Bosmann et al.   FASEB JOURNAL

Intracellular Hmgb1 Inhibits Inflammatory Nucleosome Release and Limits Acute Pancreatitis in Mice

(2013) Rui Kang et al.   GASTROENTEROLOGY

Mechanical Stability and Fibrinolytic Resistance of Clots Containing Fibrin, DNA, and Histones

(2013) Colin Longstaff et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Macrophage Clearance of Neutrophil Extracellular Traps Is a Silent Process

(2013) C. Farrera et al.   JOURNAL OF IMMUNOLOGY

An Extracellular Matrix-Based Mechanism of Rapid Neutrophil Extracellular Trap Formation in Response to Candida albicans

(2013) A. S. Byrd et al.   JOURNAL OF IMMUNOLOGY

The many faces of HMGB1: molecular structure-functional activity in inflammation, apoptosis, and chemotaxis

(2013) Huan Yang et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Lung-Derived Mediators Induce Cytokine Production in Downstream Organs via anNF-κB-Dependent Mechanism

(2013) E. K. Patterson et al.   MEDIATORS OF INFLAMMATION

Nucleation of platelets with blood-borne pathogens on Kupffer cells precedes other innate immunity and contributes to bacterial clearance

(2013) Connie H Y Wong et al.   NATURE IMMUNOLOGY

An endogenous factor mediates shock-induced injury

(2013) Peter A Ward   NATURE MEDICINE

Cold-inducible RNA-binding protein (CIRP) triggers inflammatory responses in hemorrhagic shock and sepsis

(2013) Xiaoling Qiang et al.   NATURE MEDICINE

Inhibition of LPS-induced airway neutrophilic inflammation in healthy volunteers with an oral CXCR2 antagonist

(2013) Brian R Leaker et al.   RESPIRATORY RESEARCH

NETs Are a Source of Citrullinated Autoantigens and Stimulate Inflammatory Responses in Rheumatoid Arthritis

(2013) R. Khandpur et al.   Science Translational Medicine

Physiologically-Relevant Modes of Membrane Interactions by the Human Antimicrobial Peptide, LL-37, Revealed by SFG Experiments

(2013) Bei Ding et al.   Scientific Reports

Neutrophil extracellular traps mediate transfer of cytoplasmic neutrophil antigens to myeloid dendritic cells toward ANCA induction and associated autoimmunity

(2012) S. Sangaletti et al.   BLOOD

The Proinflammatory Myeloid Cell Receptor TREM-1 Controls Kupffer Cell Activation and Development of Hepatocellular Carcinoma

(2012) Juan Wu et al.   CANCER RESEARCH

Intravascular Neutrophil Extracellular Traps Capture Bacteria from the Bloodstream during Sepsis

(2012) Braedon McDonald et al.   Cell Host & Microbe

A comprehensive summary of LL-37, the factotum human cathelicidin peptide

(2012) Dieter Vandamme et al.   CELLULAR IMMUNOLOGY

How anti-neutrophil cytoplasmic autoantibodies activate neutrophils

(2012) R. Kettritz   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Sterile Inflammation in the Liver

(2012) Paul Kubes et al.   GASTROENTEROLOGY

The antimicrobial peptide cathelicidin modulatesClostridium difficile-associated colitis and toxin A-mediated enteritis in mice

(2012) Tressia C Hing et al.   GUT

Platelets induce neutrophil extracellular traps in transfusion-related acute lung injury

(2012) Axelle Caudrillier et al.   JOURNAL OF CLINICAL INVESTIGATION

HMGB1 promotes recruitment of inflammatory cells to damaged tissues by forming a complex with CXCL12 and signaling via CXCR4

(2012) Milena Schiraldi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Mutually exclusive redox forms of HMGB1 promote cell recruitment or proinflammatory cytokine release

(2012) Emilie Venereau et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Requirements for NADPH oxidase and myeloperoxidase in neutrophil extracellular trap formation differ depending on the stimulus

(2012) Heather Parker et al.   JOURNAL OF LEUKOCYTE BIOLOGY

HMGB1 and leukocyte migration during trauma and sterile inflammation

(2012) Emilie Venereau et al.   MOLECULAR IMMUNOLOGY

Infection-induced NETosis is a dynamic process involving neutrophil multitasking in vivo

(2012) Bryan G Yipp et al.   NATURE MEDICINE

The renaissance of granulomatous inflammation in AAV

(2012) Stephan D. Gadola et al.   Nature Reviews Rheumatology

Anti-Proteinase 3 Anti-Neutrophil Cytoplasm Autoantibodies Recapitulate Systemic Vasculitis in Mice with a Humanized Immune System

(2012) Mark A. Little et al.   PLoS One

Neutrophil Extracellular Traps Directly Induce Epithelial and Endothelial Cell Death: A Predominant Role of Histones

(2012) Mona Saffarzadeh et al.   PLoS One

Hepatic Fibrosis in a Long-term Murine Model of Sepsis

(2012) Falk A. Gonnert et al.   SHOCK

Abundant neutrophil extracellular traps in thrombus of patient with microscopic polyangiitis

(2012) Daigo Nakazawa et al.   Frontiers in Immunology

Glucan phosphate attenuates myocardial HMGB1 translocation in severe sepsis through inhibiting NF-κB activation

(2011) Tuanzhu Ha et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Granulomatosis with Polyangiitis (Wegener's): An alternative name for Wegener's Granulomatosis

(2011) Ronald J. Falk et al.   ARTHRITIS AND RHEUMATISM

Transmembrane Pores Formed by Human Antimicrobial Peptide LL-37

(2011) Chang-Chun Lee et al.   BIOPHYSICAL JOURNAL

C1-esterase inhibitor infusion increases survival rates for patients with sepsis*

(2011) Anton A. Igonin et al.   CRITICAL CARE MEDICINE

Endogenous histones function as alarmins in sterile inflammatory liver injury through Toll-like receptor 9 in mice

(2011) Hai Huang et al.   HEPATOLOGY

Hemorrhagic Shock Activation of NLRP3 Inflammasome in Lung Endothelial Cells

(2011) M. Xiang et al.   JOURNAL OF IMMUNOLOGY

Host Defense Peptide LL-37 Selectively Reduces Proinflammatory Macrophage Responses

(2011) K. L. Brown et al.   JOURNAL OF IMMUNOLOGY

Extracellular Histones Are Mediators of Death through TLR2 and TLR4 in Mouse Fatal Liver Injury

(2011) J. Xu et al.   JOURNAL OF IMMUNOLOGY

Mechanism of Endosomal TLR Inhibition by Antimalarial Drugs and Imidazoquinolines

(2011) A. Kuznik et al.   JOURNAL OF IMMUNOLOGY

Extracellular histones increase plasma thrombin generation by impairing thrombomodulin-dependent protein C activation

(2011) C. T. AMMOLLO et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Antiviral Activity and Increased Host Defense against Influenza Infection Elicited by the Human Cathelicidin LL-37

(2011) Peter G. Barlow et al.   PLoS One

LL37 and Cationic Peptides Enhance TLR3 Signaling by Viral Double-stranded RNAs

(2011) Yvonne Lai et al.   PLoS One

High tidal volume mechanical ventilation-induced lung injury in rats is greater after acid instillation than after sepsis-induced acute lung injury, but does not increase systemic inflammation: an experimental study

(2011) Jan Willem Kuiper et al.   BMC Anesthesiology

High Mobility Group Box 1 Release from Hepatocytes during Ischemia and Reperfusion Injury Is Mediated by Decreased Histone Deacetylase Activity

(2010) John Evankovich et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neutrophil elastase and myeloperoxidase regulate the formation of neutrophil extracellular traps

(2010) Venizelos Papayannopoulos et al.   JOURNAL OF CELL BIOLOGY

PAD4 is essential for antibacterial innate immunity mediated by neutrophil extracellular traps

(2010) Pingxin Li et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A Novel Mechanism of Rapid Nuclear Neutrophil Extracellular Trap Formation in Response to Staphylococcus aureus

(2010) F. H. Pilsczek et al.   JOURNAL OF IMMUNOLOGY

Activation of the Raf-MEK-ERK pathway is required for neutrophil extracellular trap formation

(2010) Abdul Hakkim et al.   Nature Chemical Biology

Extracellular DNA traps promote thrombosis

(2010) T. A. Fuchs et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MITOCHONDRIAL DNA IS RELEASED BY SHOCK AND ACTIVATES NEUTROPHILS VIA P38 MAP KINASE

(2010) Qin Zhang et al.   SHOCK

Molecular Biology of Liver Ischemia/Reperfusion Injury: Established Mechanisms and Recent Advancements

(2010) John R. Klune et al.   SURGICAL CLINICS OF NORTH AMERICA

Blood Monocytes: Development, Heterogeneity, and Relationship with Dendritic Cells

(2009) Cedric Auffray et al.   Annual Review of Immunology

Dual functions of the human antimicrobial peptide LL-37—Target membrane perturbation and host cell cargo delivery

(2009) Xuan Zhang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Increased PADI4 expression in blood and tissues of patients with malignant tumors

(2009) Xiaotian Chang et al.   BMC CANCER

Viable neutrophils release mitochondrial DNA to form neutrophil extracellular traps

(2009) S Yousefi et al.   CELL DEATH AND DIFFERENTIATION

Lung Dysfunction Following Cardiopulmonary Bypass

(2009) Efstratios Apostolakis et al.   JOURNAL OF CARDIAC SURGERY

Self-RNA–antimicrobial peptide complexes activate human dendritic cells through TLR7 and TLR8

(2009) Dipyaman Ganguly et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Extracellular histones are major mediators of death in sepsis

(2009) Jun Xu et al.   NATURE MEDICINE

Netting neutrophils in autoimmune small-vessel vasculitis

(2009) Kai Kessenbrock et al.   NATURE MEDICINE

Toll-like receptors (TLRs) and Nod-like receptors (NLRs) in inflammatory disorders

(2009) Masayuki Fukata et al.   SEMINARS IN IMMUNOLOGY

High frequency of venous thromboembolic events in Churg-Strauss syndrome, Wegener's granulomatosis and microscopic polyangiitis but not polyarteritis nodosa: a systematic retrospective study on 1130 patients

(2008) Y Allenbach et al.   ANNALS OF THE RHEUMATIC DISEASES

The story of the discovery of heparin and warfarin

(2008) Douglas Wardrop et al.   BRITISH JOURNAL OF HAEMATOLOGY

C5a Receptor Mediates Neutrophil Activation and ANCA-Induced Glomerulonephritis

(2008) A. Schreiber et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Catapult-like release of mitochondrial DNA by eosinophils contributes to antibacterial defense

(2008) Shida Yousefi et al.   NATURE MEDICINE