Molecular mechanism and therapeutic modulation of high mobility group box 1 release and action: an updated review

High-Mobility Group Box 1 Is Dispensable for Autophagy, Mitochondrial Quality Control, and Organ Function In Vivo

(2014) Peter Huebener et al.   Cell Metabolism

Ghrelin Protects against Experimental Sepsis by Inhibiting High-Mobility Group Box 1 Release and by Killing Bacteria

(2014) A. Chorny et al.   JOURNAL OF IMMUNOLOGY

Systemic Release of High Mobility Group Box 1 Protein during Severe Murine Influenza

(2014) L. M. Alleva et al.   JOURNAL OF IMMUNOLOGY

High Mobility Group Protein-1 Inhibits Phagocytosis of Apoptotic Neutrophils through Binding to Phosphatidylserine

(2014) G. Liu et al.   JOURNAL OF IMMUNOLOGY

Calcium/Calmodulin-Dependent Protein Kinase (CaMK) IV Mediates Nucleocytoplasmic Shuttling and Release of HMGB1 during Lipopolysaccharide Stimulation of Macrophages

(2014) X. Zhang et al.   JOURNAL OF IMMUNOLOGY

Ultraviolet-radiation-induced inflammation promotes angiotropism and metastasis in melanoma

(2014) Tobias Bald et al.   NATURE

HMGB1 recruits hepatic stellate cells and liver endothelial cells to sites of ethanol-induced parenchymal cell injury

(2013) Yeon S. Seo et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

High Mobility Group Box–1 Mediates Hyperoxia-Induced Impairment ofPseudomonas aeruginosaClearance and Inflammatory Lung Injury in Mice

(2013) Vivek S. Patel et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

HMGB1 plays a critical role in vascular inflammation and lesion formation via toll-like receptor 9

(2013) Yoichiro Hirata et al.   ATHEROSCLEROSIS

Chloroquine inhibits HMGB1 inflammatory signaling and protects mice from lethal sepsis

(2013) Minghua Yang et al.   BIOCHEMICAL PHARMACOLOGY

The alarmin functions of high-mobility group box-1 and IL-33 in the pathogenesis of systemic lupus erythematosus

(2013) Shui-Lian Yu et al.   Expert Review of Clinical Immunology

Mechanistic biomarkers provide early and sensitive detection of acetaminophen-induced acute liver injury at first presentation to hospital

(2013) Daniel J. Antoine et al.   HEPATOLOGY

Effect of Eritoran, an Antagonist of MD2-TLR4, on Mortality in Patients With Severe Sepsis

(2013) Steven M. Opal et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Sepsis definitions: time for change

(2013) Jean-Louis Vincent et al.   LANCET

High mobility group box1 (HMGB1) in relation to cutaneous inflammation in systemic lupus erythematosus (SLE)

(2013) DA Abdulahad et al.   LUPUS

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(2013) Hogyoung Kim et al.   MOLECULAR MEDICINE

Vaccinia Virus Induces Programmed Necrosis in Ovarian Cancer Cells

(2013) Lynsey M Whilding et al.   MOLECULAR THERAPY

Acteoside improves survival in cecal ligation and puncture-induced septic mice via blocking of high mobility group box 1 release

(2013) Eun Sun Seo et al.   MOLECULES AND CELLS

Chemical genetics reveals a kinase-independent role for protein kinase R in pyroptosis

(2013) Erik C Hett et al.   Nature Chemical Biology

Cold-inducible RNA-binding protein (CIRP) triggers inflammatory responses in hemorrhagic shock and sepsis

(2013) Xiaoling Qiang et al.   NATURE MEDICINE

Protective Effect of Tanshinone IIA Against Infarct Size and Increased HMGB1, NFκB, GFAP and Apoptosis Consequent to Transient Middle Cerebral Artery Occlusion

(2013) Jian-Gang Wang et al.   NEUROCHEMICAL RESEARCH

(−)-Epigallocatechin-3-gallate (EGCG) attenuates peripheral nerve degeneration in rat sciatic nerve crush injury

(2013) Waleed M. Renno et al.   NEUROCHEMISTRY INTERNATIONAL

Ghrelin protects human pulmonary artery endothelial cells against hypoxia-induced injury via PI3-kinase/Akt

(2013) Dan Yang et al.   PEPTIDES

Pathway Analysis Reveals Common Pro-Survival Mechanisms of Metyrapone and Carbenoxolone after Traumatic Brain Injury

(2013) Helen L. Hellmich et al.   PLoS One

High-Mobility Group Box 1 Inhibits Gastric Ulcer Healing through Toll-Like Receptor 4 and Receptor for Advanced Glycation End Products

(2013) Yuji Nadatani et al.   PLoS One

Interferon-induced RIP1/RIP3-mediated necrosis requires PKR and is licensed by FADD and caspases

(2013) R. J. Thapa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Conditional ablation of HMGB1 in mice reveals its protective function against endotoxemia and bacterial infection

(2013) H. Yanai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tunable Signal Processing Through Modular Control of Transcription Factor Translocation

(2013) N. Hao et al.   SCIENCE

Noncanonical Inflammasome Activation by Intracellular LPS Independent of TLR4

(2013) N. Kayagaki et al.   SCIENCE

High-Mobility Group Box 1 Mediates Persistent Splenocyte Priming in Sepsis Survivors

(2013) Sergio I. Valdés-Ferrer et al.   SHOCK

Intravenous immunoglobulin suppresses NLRP1 and NLRP3 inflammasome-mediated neuronal death in ischemic stroke

(2013) D Yang-Wei Fann et al.   Cell Death & Disease

Dual role of chloroquine in liver ischemia reperfusion injury: reduction of liver damage in early phase, but aggravation in late phase

(2013) H Fang et al.   Cell Death & Disease

Glycyrrhizin protects rat heart against ischemia-reperfusion injury through blockade of HMGB1-dependent phospho-JNK/Bax pathway

(2012) Chang-lin Zhai et al.   ACTA PHARMACOLOGICA SINICA

High Mobility Group Box 1 Promotes Small Intestinal Damage Induced by Nonsteroidal Anti-Inflammatory Drugs through Toll-Like Receptor 4

(2012) Yuji Nadatani et al.   AMERICAN JOURNAL OF PATHOLOGY

Anti-high mobility group box-1 antibody therapy for traumatic brain injury

(2012) Yu Okuma et al.   ANNALS OF NEUROLOGY

Tanshinone IIA sodium sulfonate facilitates endocytic HMGB1 uptake

(2012) Yusong Zhang et al.   BIOCHEMICAL PHARMACOLOGY

Isorhamnetin-3-O-galactoside Protects against CCl4-Induced Hepatic Injury in Mice

(2012) Dong-Wook Kim et al.   Biomolecules & Therapeutics

High mobility group B1 impairs hepatocyte regeneration in acetaminophen hepatotoxicity

(2012) Runkuan Yang et al.   BMC GASTROENTEROLOGY

TLR activation regulates damage-associated molecular pattern isoforms released during pyroptosis

(2012) Sanna Nyström et al.   EMBO JOURNAL

High mobility group box chromosomal protein 1 in acute-on-chronic liver failure patients and mice with ConA-induced acute liver injury

(2012) Rong-Rong Zhou et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Emodin-6-O-β-d-glucoside inhibits HMGB1-induced inflammatory responses in vitro and in vivo

(2012) Wonhwa Lee et al.   FOOD AND CHEMICAL TOXICOLOGY

JAK and STAT Signaling Molecules in Immunoregulation and Immune-Mediated Disease

(2012) John J. O'Shea et al.   IMMUNITY

Chloroquine Improves Survival and Hematopoietic Recovery After Lethal Low-Dose-Rate Radiation

(2012) Yiting Lim et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Anti-inflammatory activities of isorhamnetin-3-O-galactoside against HMGB1-induced inflammatory responses in both HUVECs and CLP-induced septic mice

(2012) Tae Hoon Kim et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Persicarin is anti-inflammatory mediator against HMGB1-induced inflammatory responses in HUVECs and in CLP-induced sepsis mice

(2012) Tae Hoon Kim et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Barrier protective effects of rosmarinic acid on HMGB1-induced inflammatory responses in vitro and in vivo

(2012) Eun-Ju Yang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

HMGB1 promotes recruitment of inflammatory cells to damaged tissues by forming a complex with CXCL12 and signaling via CXCR4

(2012) Milena Schiraldi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Mutually exclusive redox forms of HMGB1 promote cell recruitment or proinflammatory cytokine release

(2012) Emilie Venereau et al.   JOURNAL OF EXPERIMENTAL MEDICINE

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(2012) Huan Yang et al.   MOLECULAR MEDICINE

Inflammasomes in health and disease

(2012) Till Strowig et al.   NATURE

Novel role of PKR in inflammasome activation and HMGB1 release

(2012) Ben Lu et al.   NATURE

HMGB1: A multifunctional alarmin driving autoimmune and inflammatory disease

(2012) Helena Erlandsson Harris et al.   Nature Reviews Rheumatology

Oxidation of HMGB1 Causes Attenuation of Its Pro-Inflammatory Activity and Occurs during Liver Ischemia and Reperfusion

(2012) Anding Liu et al.   PLoS One

Tanshinone IIA Attenuates the Inflammatory Response and Apoptosis after Traumatic Injury of the Spinal Cord in Adult Rats

(2012) Xin Yin et al.   PLoS One

Human macrophage and dendritic cell-specific silencing of high-mobility group protein B1 ameliorates sepsis in a humanized mouse model

(2012) C. Ye et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Systemic Involvement of High-Mobility Group Box 1 Protein and Therapeutic Effect of Anti–High-Mobility Group Box 1 Protein Antibody in a Rat Model of Crush Injury

(2012) Junya Shimazaki et al.   SHOCK

HMGB1 Is a Therapeutic Target for Sterile Inflammation and Infection

(2011) Ulf Andersson et al.   Annual Review of Immunology

EGCG stimulates autophagy and reduces cytoplasmic HMGB1 levels in endotoxin-stimulated macrophages

(2011) Wei Li et al.   BIOCHEMICAL PHARMACOLOGY

Ghrelin ameliorates bleomycin-induced acute lung injury by protecting alveolar epithelial cells and suppressing lung inflammation

(2011) Yoshifumi Imazu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Protective effects of chlorogenic acid against ischemia/reperfusion injury in rat liver: molecular evidence of its antioxidant and anti-inflammatory properties

(2011) Nari Yun et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

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(2011) Hanna Schierbeck et al.   MOLECULAR MEDICINE

Caspase-8 regulates TNF-α-induced epithelial necroptosis and terminal ileitis

(2011) Claudia Günther et al.   NATURE

Non-canonical inflammasome activation targets caspase-11

(2011) Nobuhiko Kayagaki et al.   NATURE

HMGB1 inhibitor glycyrrhizin attenuates intracerebral hemorrhage-induced injury in rats

(2011) Masatoshi Ohnishi et al.   NEUROPHARMACOLOGY

The effect of a gap-junction blocker, carbenoxolone, on ischemic brain injury and cortical spreading depression

(2011) K. Tamura et al.   NEUROSCIENCE

Forsythoside B Protects Against Experimental Sepsis by Modulating Inflammatory Factors

(2011) Wang-Lin Jiang et al.   PHYTOTHERAPY RESEARCH

Ethanol Extract of Prunella vulgaris var. lilacina Inhibits HMGB1 Release by Induction of Heme Oxygenase-1 in LPS-activated RAW 264.7 Cells and CLP-induced Septic Mice

(2011) Min Soo Jun et al.   PHYTOTHERAPY RESEARCH

A Hepatic Protein, Fetuin-A, Occupies a Protective Role in Lethal Systemic Inflammation

(2011) Wei Li et al.   PLoS One

Acetylcholine-Synthesizing T Cells Relay Neural Signals in a Vagus Nerve Circuit

(2011) M. Rosas-Ballina et al.   SCIENCE

Inhibition of Toll-like Receptor 4 With Vasoactive Intestinal Peptide Attenuates Liver Ischemia-Reperfusion Injury

(2011) W. Jiang et al.   TRANSPLANTATION PROCEEDINGS

Protective targeting of high mobility group box chromosomal protein 1 in a spontaneous arthritis model

(2010) Therese Östberg et al.   ARTHRITIS AND RHEUMATISM

HMGB1: A novel Beclin 1-binding protein active in autophagy

(2010) Rui Kang et al.   Autophagy

The role of HMGB1 in the pathogenesis of rheumatic disease

(2010) Ulf Andersson et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Neuroprotective efficacy and therapeutic window of Forsythoside B: In a rat model of cerebral ischemia and reperfusion injury

(2010) Wang-Lin Jiang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

High Mobility Group Box 1 Release from Hepatocytes during Ischemia and Reperfusion Injury Is Mediated by Decreased Histone Deacetylase Activity

(2010) John Evankovich et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Endogenous HMGB1 regulates autophagy

(2010) Daolin Tang et al.   JOURNAL OF CELL BIOLOGY

Inflammasome-Dependent Release of the Alarmin HMGB1 in Endotoxemia

(2010) M. Lamkanfi et al.   JOURNAL OF IMMUNOLOGY

HMGB1 Contributes to Kidney Ischemia Reperfusion Injury

(2010) H. Wu et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

A role for mitochondria in NLRP3 inflammasome activation

(2010) Rongbin Zhou et al.   NATURE

Circulating mitochondrial DAMPs cause inflammatory responses to injury

(2010) Qin Zhang et al.   NATURE

IL-1β-driven neutrophilia preserves antibacterial defense in the absence of the kinase IKKβ

(2010) Li-Chung Hsu et al.   NATURE IMMUNOLOGY

Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria

(2010) Edward A Miao et al.   NATURE IMMUNOLOGY

HMGB1 release and redox regulates autophagy and apoptosis in cancer cells

(2010) D Tang et al.   ONCOGENE

Anti-thrombin Therapy During Warm Ischemia and Cold Preservation Prevents Chronic Kidney Graft Fibrosis in a DCD Model

(2009) F. Favreau et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Phosphorylation-Driven Assembly of the RIP1-RIP3 Complex Regulates Programmed Necrosis and Virus-Induced Inflammation

(2009) YoungSik Cho et al.   CELL

Vasoactive intestinal peptide attenuates concanavalin A-mediated liver injury

(2009) Qingqiong Luo et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The NLRP3 Inflammasome Mediates In Vivo Innate Immunity to Influenza A Virus through Recognition of Viral RNA

(2009) Irving C. Allen et al.   IMMUNITY

Peripheral Administration of Fetuin-A Attenuates Early Cerebral Ischemic Injury in Rats

(2009) Haichao Wang et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Bacterial Endotoxin Induces the Release of High Mobility Group Box 1 via the IFN-  Signaling Pathway

(2009) J.-H. Kim et al.   JOURNAL OF IMMUNOLOGY

Docking and 3D QSAR studies of protoporphyrinogen oxidase inhibitor 3H-pyrazolo[3,4-d][1,2,3]triazin-4-one derivatives

(2009) Kunal Roy et al.   JOURNAL OF MOLECULAR MODELING

HMGB proteins function as universal sentinels for nucleic-acid-mediated innate immune responses

(2009) Hideyuki Yanai et al.   NATURE

CD24 and Siglec-10 Selectively Repress Tissue Damage-Induced Immune Responses

(2009) G.-Y. Chen et al.   SCIENCE

HMGB1 IS MARKEDLY ELEVATED WITHIN 6 HOURS OF MECHANICAL TRAUMA IN HUMANS

(2009) Erik D. Peltz et al.   SHOCK

Neuropeptides Rescue Mice from Lethal Sepsis by Down-regulating Secretion of the Late-Acting Inflammatory Mediator High Mobility Group Box 1

(2008) Alejo Chorny et al.   AMERICAN JOURNAL OF PATHOLOGY

Active Caspase-1 Is a Regulator of Unconventional Protein Secretion

(2008) Martin Keller et al.   CELL

Autophagy regulates selective HMGB1 release in tumor cells that are destined to die

(2008) J Thorburn et al.   CELL DEATH AND DIFFERENTIATION

High-Mobility Group Box-1 in Ischemia-Reperfusion Injury of the Heart

(2008) Martin Andrassy et al.   CIRCULATION

Therapeutic potential of HMGB1-targeting agents in sepsis

(2008) Haichao Wang et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

Rosmarinic acid, a photo-protective agent against UV and other ionizing radiations

(2008) M. Sánchez-Campillo et al.   FOOD AND CHEMICAL TOXICOLOGY

Induction of Immunological Tolerance by Apoptotic Cells Requires Caspase-Dependent Oxidation of High-Mobility Group Box-1 Protein

(2008) Hirotaka Kazama et al.   IMMUNITY

High-dose intravenous immunoglobulin G improves systemic inflammation in a rat model of CLP-induced sepsis

(2008) Satoshi Hagiwara et al.   INTENSIVE CARE MEDICINE

Induction of inflammatory and immune responses by HMGB1–nucleosome complexes: implications for the pathogenesis of SLE

(2008) Vilma Urbonaviciute et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Dengue virus infection induces passive release of high mobility group box 1 protein by epithelial cells

(2008) Lien-Cheng Chen et al.   JOURNAL OF INFECTION

Fetuin-A: A Major Fetal Serum Protein that Promotes “Wound Closure” and Scarless Healing

(2007) Xue-Qing Wang et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY