Citrullinated Histone H3 as a Therapeutic Target for Endotoxic Shock in Mice

Histone H3 Mutations: An Updated View of Their Role in Chromatin Deregulation and Cancer

(2019) Brandon R. Lowe et al.   Cancers

Extracellular traps and PAD4 released by macrophages induce citrullination and auto-antibody production in autoimmune arthritis

(2019) Mohey Eldin M. El Shikh et al.   JOURNAL OF AUTOIMMUNITY

Citrullinated histone 3 causes endothelial barrier dysfunction

(2018) Jamie E. Meegan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Inhibition of peptidylarginine deiminase alleviates LPS-induced pulmonary dysfunction and improves survival in a mouse model of lethal endotoxemia

(2018) Yingjian Liang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Neutrophil dysregulation during sepsis: an overview and update

(2017) Xiao-Fei Shen et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

DEK-targeting DNA aptamers as therapeutics for inflammatory arthritis

(2017) Nirit Mor-Vaknin et al.   Nature Communications

CitH3: a reliable blood biomarker for diagnosis and treatment of endotoxic shock

(2017) Baihong Pan et al.   Scientific Reports

A novel method for high-throughput detection and quantification of neutrophil extracellular traps reveals ROS-independent NET release with immune complexes

(2016) Tineke Kraaij et al.   AUTOIMMUNITY REVIEWS

Histones as mediators of host defense, inflammation and thrombosis

(2016) Marloes Hoeksema et al.   Future Microbiology

The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)

(2016) Mervyn Singer et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Cl-Amidine Prevents Histone 3 Citrullination and Neutrophil Extracellular Trap Formation, and Improves Survival in a Murine Sepsis Model

(2016) Bethany M. Biron et al.   Journal of Innate Immunity

New Aspects of the Biology of Neutrophil Extracellular Traps

(2016) D. Dąbrowska et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

The Endothelium in Sepsis

(2016) Can Ince et al.   SHOCK

Current Murine Models of Sepsis

(2016) Anthony J. Lewis et al.   Surgical Infections

Current Challenges and Limitations in Antibody-Based Detection of Citrullinated Histones

(2016) Indira Neeli et al.   Frontiers in Immunology

Protective effect of Cl-amidine against CLP-induced lethal septic shock in mice

(2016) Ting Zhao et al.   Scientific Reports

Damage-associated molecular pattern-activated neutrophil extracellular trap exacerbates sterile inflammatory liver injury

(2015) Hai Huang et al.   HEPATOLOGY

Impaired DNase1-mediated degradation of neutrophil extracellular traps is associated with acute thrombotic microangiopathies

(2015) M. Jiménez-Alcázar et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Delayed but not Early Treatment with DNase Reduces Organ Damage and Improves Outcome in a Murine Model of Sepsis

(2015) Safiah H. C. Mai et al.   SHOCK

Circulating levels of DNA-histone complex and dsDNA are independent prognostic factors of disseminated intravascular coagulation

(2015) Ji-Eun Kim et al.   THROMBOSIS RESEARCH

DNA Is an Antimicrobial Component of Neutrophil Extracellular Traps

(2015) Tyler W.R. Halverson et al.   PLoS Pathogens

Histone Cleavage as a Mechanism for Epigenetic Regulation: Current Insights and Perspectives

(2014) P. Zhou et al.   CURRENT MOLECULAR MEDICINE

New Aspects on the Structure of Neutrophil Extracellular Traps from Chronic Obstructive Pulmonary Disease and In Vitro Generation

(2014) Astrid Obermayer et al.   PLoS One

Residual Endotoxin Contaminations in Recombinant Proteins Are Sufficient to Activate Human CD1c+ Dendritic Cells

(2014) Harald Schwarz et al.   PLoS One

Formation, Clearance, Deposition, Pathogenicity, and Identification of Biopharmaceutical-related Immune Complexes

(2014) Jennifer L. Rojko et al.   TOXICOLOGIC PATHOLOGY

Neutrophil histone modification by peptidylarginine deiminase 4 is critical for deep vein thrombosis in mice

(2013) K. Martinod et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neutrophil Extracellular Traps Mediate a Host Defense Response to Human Immunodeficiency Virus-1

(2012) Tatsuya Saitoh et al.   Cell Host & Microbe

Neutrophil Extracellular Traps: Double-Edged Swords of Innate Immunity

(2012) M. J. Kaplan et al.   JOURNAL OF IMMUNOLOGY

Role for Peptidylarginine Deiminase Enzymes in Disease and Female Reproduction

(2012) Sachi HORIBATA et al.   JOURNAL OF REPRODUCTION AND DEVELOPMENT

Neutrophil Extracellular Traps Directly Induce Epithelial and Endothelial Cell Death: A Predominant Role of Histones

(2012) Mona Saffarzadeh et al.   PLoS One

Peptidylarginine deiminase 2-catalyzed histone H3 arginine 26 citrullination facilitates estrogen receptor   target gene activation

(2012) X. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Excessive Neutrophils and Neutrophil Extracellular Traps Contribute to Acute Lung Injury of Influenza Pneumonitis

(2011) Teluguakula Narasaraju et al.   AMERICAN JOURNAL OF PATHOLOGY

Extracellular histones promote thrombin generation through platelet-dependent mechanisms: involvement of platelet TLR2 and TLR4

(2011) F. Semeraro et al.   BLOOD

Netting Neutrophils Induce Endothelial Damage, Infiltrate Tissues, and Expose Immunostimulatory Molecules in Systemic Lupus Erythematosus

(2011) E. Villanueva et al.   JOURNAL OF IMMUNOLOGY

Extracellular Histones Are Mediators of Death through TLR2 and TLR4 in Mouse Fatal Liver Injury

(2011) J. Xu et al.   JOURNAL OF IMMUNOLOGY

Extracellular histones increase plasma thrombin generation by impairing thrombomodulin-dependent protein C activation

(2011) C. T. AMMOLLO et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Neutrophil extracellular traps promote deep vein thrombosis in mice

(2011) A. BRILL et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Extracellular DNA traps promote thrombosis

(2010) T. A. Fuchs et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Histone hypercitrullination mediates chromatin decondensation and neutrophil extracellular trap formation

(2009) Yanming Wang et al.   JOURNAL OF CELL BIOLOGY

Extracellular histones are major mediators of death in sepsis

(2009) Jun Xu et al.   NATURE MEDICINE

Leishmania amazonensis promastigotes induce and are killed by neutrophil extracellular traps

(2009) A. B. Guimaraes-Costa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cytokine-associated neutrophil extracellular traps and antinuclear antibodies in Plasmodium falciparum infected children under six years of age

(2008) Virginia S Baker et al.   MALARIA JOURNAL