How anti-neutrophil cytoplasmic autoantibodies activate neutrophils

Anti-LAMP-2 Autoantibodies in ANCA-Associated Pauci-Immune Glomerulonephritis

(2012) S. M. Flint et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

High Prevalence of Autoantibodies to hLAMP-2 in Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis

(2012) R. Kain et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Neutrophil Serine Proteases Promote IL-1  Generation and Injury in Necrotizing Crescentic Glomerulonephritis

(2012) A. Schreiber et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

ANCA-associated vasculitis is linked to carriage of the Z allele of  1 antitrypsin and its polymers

(2011) H. Morris et al.   ANNALS OF THE RHEUMATIC DISEASES

Sialylation levels of anti-proteinase 3 antibodies are associated with the activity of granulomatosis with polyangiitis (Wegener's)

(2011) Cécile Espy et al.   ARTHRITIS AND RHEUMATISM

Immunoglobulin subclass determines ability of immunoglobulin (Ig)G to capture and activate neutrophils presented as normal human IgG or disease-associated anti-neutrophil cytoplasm antibody (ANCA)-IgG

(2011) T. Pankhurst et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Molecular analysis of the membrane insertion domain of proteinase 3, the Wegenerˈs autoantigen, in RBL cells: implication for its pathogenic activity

(2011) Chahrazade Kantari et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Anti-Neutrophil Cytoplasmic Antibodies Stimulate Release of Neutrophil Microparticles

(2011) Y. Hong et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Anti-LAMP-2 Antibodies Are Not Prevalent in Patients With Antineutrophil Cytoplasmic Autoantibody Glomerulonephritis

(2011) A. J. Roth et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

IgA and IgG antineutrophil cytoplasmic antibody engagement of Fc receptor genetic variants influences granulomatosis with polyangiitis

(2011) J. M. Kelley et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effects of p38 mitogen-activated protein kinase inhibition on anti-neutrophil cytoplasmic autoantibody pathogenicity in vitro and in vivo

(2010) B. S. van der Veen et al.   ANNALS OF THE RHEUMATIC DISEASES

Activation of normal neutrophils by anti-neutrophil cytoplasm antibodies

(2010) M. T. KEOGAN et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Neutrophil surface presentation of the anti-neutrophil cytoplasmic antibody-antigen proteinase 3 depends on N-terminal processing

(2010) S. Von Vietinghoff et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Activation of granulocytes by anti-neutrophil cytoplasmic antibodies (ANCA): a FcγRII-dependent process

(2010) A. H. L. MULDER et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Activated neutrophils express proteinase 3 on their plasma membrane in vitro and in vivo

(2010) E. CSERNOK et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Complement Receptor Mac-1 Is an Adaptor for NB1 (CD177)-mediated PR3-ANCA Neutrophil Activation

(2010) Uwe Jerke et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Epigenetic basis for aberrant upregulation of autoantigen genes in humans with ANCA vasculitis

(2010) Dominic J. Ciavatta et al.   JOURNAL OF CLINICAL INVESTIGATION

Mapping of Conformational Epitopes on Human Proteinase 3, the Autoantigen of Wegener's Granulomatosis

(2010) A. Kuhl et al.   JOURNAL OF IMMUNOLOGY

IgG Glycan Hydrolysis Attenuates ANCA-Mediated Glomerulonephritis

(2010) M. M. van Timmeren et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Intracellular Cytokine Production in ANCA-associated Vasculitis: Low Levels of Interleukin-10 in Remission Are Associated with a Higher Relapse Rate in the Long-term Follow-up

(2009) Zdenka Hruskova et al.   ARCHIVES OF MEDICAL RESEARCH

Coexpression of CD177 and membrane proteinase 3 on neutrophils in antineutrophil cytoplasmic autoantibody-associated systemic vasculitis: Anti-proteinase 3-mediated neutrophil activation is independent of the role of CD177-expressing neutrophils

(2009) N. Hu et al.   ARTHRITIS AND RHEUMATISM

Phosphoinositol 3-kinase-γ mediates antineutrophil cytoplasmic autoantibody-induced glomerulonephritis

(2009) Adrian Schreiber et al.   KIDNEY INTERNATIONAL

Netting neutrophils in autoimmune small-vessel vasculitis

(2009) Kai Kessenbrock et al.   NATURE MEDICINE

A Hydrophobic Patch on Proteinase 3, the Target of Autoantibodies in Wegener Granulomatosis, Mediates Membrane Binding via NB1 Receptors

(2008) Brice Korkmaz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

C5a Receptor Mediates Neutrophil Activation and ANCA-Induced Glomerulonephritis

(2008) A. Schreiber et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Molecular mimicry in pauci-immune focal necrotizing glomerulonephritis

(2008) Renate Kain et al.   NATURE MEDICINE