Role of HMGB1/TLR4 and IL-1β/IL-1R1 Signaling Pathways in Epilepsy

Extracellular HMGB1 blockade inhibits tumor growth through profoundly remodeling immune microenvironment and enhances checkpoint inhibitor-based immunotherapy

(2021) Pascale Hubert et al.   Journal for ImmunoTherapy of Cancer

A Literature Overview on Epilepsy and Inflammasome Activation

(2021) Parvaneh Mohseni-Moghaddam et al.   BRAIN RESEARCH BULLETIN

Pentoxifylline prevents epileptic seizure via modulating HMGB1/RAGE/TLR4 signalling pathway and improves memory in pentylenetetrazol kindling rats

(2021) Ghada A. Badawi et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Neuroprotective Effect of Fisetin Through Suppression of IL-1R/TLR Axis and Apoptosis in Pentylenetetrazole-Induced Kindling in Mice

(2021) Saima Khatoon et al.   Frontiers in Neurology

Post-Translational Modification of HMGB1 Disulfide Bonds in Stimulating and Inhibiting Inflammation

(2021) Ulf Andersson et al.   Cells

Serum α-synuclein and IL-1β are increased and correlated with measures of disease severity in children with epilepsy: potential prognostic biomarkers?

(2020) Jieun Choi et al.   BMC Neurology

Toll-like Receptors and the Control of Immunity

(2020) Katherine A. Fitzgerald et al.   CELL

Long-term efficacy and cognitive effects of bilateral hippocampal deep brain stimulation in patients with drug-resistant temporal lobe epilepsy

(2020) Shu Wang et al.   NEUROLOGICAL SCIENCES

Myeloid Differentiation Primary Response Protein 88 (MyD88): The Central Hub of TLR/IL-1R Signaling

(2020) Lingfeng Chen et al.   JOURNAL OF MEDICINAL CHEMISTRY

Role of Innate Immune Receptor TLR4 and its endogenous ligands in epileptogenesis

(2020) Yam Nath Paudel et al.   PHARMACOLOGICAL RESEARCH

NLRP3 and NLRP1 inflammasomes are up-regulated in patients with mesial temporal lobe epilepsy and may contribute to overexpression of caspase-1 and IL-β in sclerotic hippocampi

(2020) Eliana Cristina de Brito Toscano et al.   BRAIN RESEARCH

High mobility group box 1 (HMGB1) as a novel frontier in epileptogenesis: From pathogenesis to therapeutic approaches

(2019) Yam Nath Paudel et al.   JOURNAL OF NEUROCHEMISTRY

(–)-Epigallocatechin-3-Gallate Protects Against Lithium-Pilocarpine-Induced Epilepsy by Inhibiting the Toll-Like Receptor 4 (TLR4)/Nuclear Factor-κB (NF-κB) Signaling Pathway

(2019) Zhenzhen Qu et al.   MEDICAL SCIENCE MONITOR

Epilepsy in adults

(2019) Roland D Thijs et al.   LANCET

The release and activity of HMGB1 in ferroptosis

(2019) Qirong Wen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Inflammasomes in neuroinflammatory and neurodegenerative diseases

(2019) Sofie Voet et al.   EMBO Molecular Medicine

Molecular isoforms of high-mobility group box 1 are mechanistic biomarkers for epilepsy

(2019) Lauren Elizabeth Walker et al.   JOURNAL OF CLINICAL INVESTIGATION

Evaluation of IL-1β levels in epilepsy and traumatic brain injury in dogs

(2019) Draginja Kostic et al.   BMC NEUROSCIENCE

Targeting oxidative stress improves disease outcomes in a rat model of acquired epilepsy

(2019) Alberto Pauletti et al.   BRAIN

Preconditioning with toll-like receptor agonists attenuates seizure activity and neuronal hyperexcitability in the pilocarpine rat model of epilepsy

(2019) Mahshid Hosseinzadeh et al.   NEUROSCIENCE

Inflammation and reactive oxygen species as disease modifiers in epilepsy

(2019) Gaetano Terrone et al.   NEUROPHARMACOLOGY

MicroRNA-542-3p regulates P-glycoprotein expression in rat epilepsy via the toll-like receptor 4/Nuclear factor-kappa B signaling pathway

(2019) YuKui Yan et al.   CURRENT NEUROVASCULAR RESEARCH

Original ArticleIL-1β-31/IL1-RA genetic markers association with idiopathic generalized epilepsy and treatment response in a cohort of Egyptian population

(2019) Naglaa Fathy Barseem et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

Review on Cross Talk between Neurotransmitters and Neuroinflammation in Striatum and Cerebellum in the Mediation of Motor Behaviour

(2019) Dayang Yasmin Abg Abd Wahab et al.   Biomed Research International

Critical roles of NLRP3 inflammasome in IL-1β secretion induced by Corynebacterium pseudotuberculosis in vitro

(2019) Zuoyong Zhou et al.   MOLECULAR IMMUNOLOGY

Functional morphology of the blood–brain barrier in health and disease

(2018) Stefan Liebner et al.   ACTA NEUROPATHOLOGICA

High Mobility Group Box 1 is a novel pathogenic factor and a mechanistic biomarker for epilepsy

(2018) Teresa Ravizza et al.   BRAIN BEHAVIOR AND IMMUNITY

HMGB1 a-Box Reverses Brain Edema and Deterioration of Neurological Function in a Traumatic Brain Injury Mouse Model

(2018) Lijun Yang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Epilepsy in Asia: Disease burden, management barriers, and challenges

(2018) Eugen Trinka et al.   EPILEPSIA

Toll-like receptors in immunity and inflammatory diseases: Past, present, and future

(2018) Kumar Vijay   INTERNATIONAL IMMUNOPHARMACOLOGY

Upregulation of HMGB1-TLR4 inflammatory pathway in focal cortical dysplasia type II

(2018) Zhongbin Zhang et al.   Journal of Neuroinflammation

Systemic autoinflammation with intractable epilepsy managed with interleukin-1 blockade

(2018) Allen D. DeSena et al.   Journal of Neuroinflammation

HMGB1 mediates microglia activation via the TLR4/NF-κB pathway in coriaria lactone induced epilepsy

(2018) Yunbo Shi et al.   Molecular Medicine Reports

Neuroinflammation Alters Integrative Properties of Rat Hippocampal Pyramidal Cells

(2018) Federica Frigerio et al.   MOLECULAR NEUROBIOLOGY

Review: Neuroinflammatory pathways as treatment targets and biomarker candidates in epilepsy: emerging evidence from preclinical and clinical studies

(2018) E. A. van Vliet et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Glycyrrhizin Protects Mice Against Experimental Autoimmune Encephalomyelitis by Inhibiting High-Mobility Group Box 1 (HMGB1) Expression and Neuronal HMGB1 Release

(2018) Yan Sun et al.   Frontiers in Immunology

Expression analysis of GRIN2B, BDNF, and IL-1β genes in the whole blood of epileptic patients

(2018) Anoushe Zhand et al.   NEUROLOGICAL SCIENCES

The green tea polyphenolic catechin epigallocatechin gallate and neuroprotection

(2018) Ali Reza Khalatbary et al.   NUTRITIONAL NEUROSCIENCE

HMGB1: A Common Biomarker and Potential Target for TBI, Neuroinflammation, Epilepsy, and Cognitive Dysfunction

(2018) Yam Nath Paudel et al.   Frontiers in Neuroscience

High Mobility Group Protein B1 (HMGB1) and Interleukin-1β as Prognostic Biomarkers of Epilepsy in Children

(2018) Min Zhu et al.   JOURNAL OF CHILD NEUROLOGY

Glycyrrhizin, an HMGB1 inhibitor, exhibits neuroprotective effects in rats after lithium-pilocarpine-induced status epilepticus

(2018) Ya-jun Li et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Pattern Recognition Receptors and the Host Cell Death Molecular Machinery

(2018) Gustavo P. Amarante-Mendes et al.   Frontiers in Immunology

Prospective clinical trials to investigate clinical and molecular biomarkers

(2017) Stéphane Auvin et al.   EPILEPSIA

The family of the interleukin-1 receptors

(2017) Diana Boraschi et al.   IMMUNOLOGICAL REVIEWS

Inflammation in epileptogenesis after traumatic brain injury

(2017) Kyria M. Webster et al.   Journal of Neuroinflammation

Interleukin-1 Receptor in Seizure Susceptibility after Traumatic Injury to the Pediatric Brain

(2017) Bridgette D. Semple et al.   JOURNAL OF NEUROSCIENCE

Modulators of microglial activation and polarization after intracerebral haemorrhage

(2017) Xi Lan et al.   Nature Reviews Neurology

HMGB1-TLR4 Axis Plays a Regulatory Role in the Pathogenesis of Mesial Temporal Lobe Epilepsy in Immature Rat Model and Children via the p38MAPK Signaling Pathway

(2017) Weihong Yang et al.   NEUROCHEMICAL RESEARCH

The effect of IL-1β on synaptophysin expression and electrophysiology of hippocampal neurons through the PI3K/Akt/mTOR signaling pathway in a rat model of mesial temporal lobe epilepsy

(2017) Zhaohua Xiao et al.   NEUROLOGICAL RESEARCH

The Immune System in Pediatric Seizures and Epilepsies

(2017) Christian M. Korff et al.   PEDIATRICS

TGFβ signaling is associated with changes in inflammatory gene expression and perineuronal net degradation around inhibitory neurons following various neurological insults

(2017) Soo Young Kim et al.   Scientific Reports

Understanding the mechanism of IL-1β secretion

(2011) Gloria Lopez-Castejon et al.   CYTOKINE & GROWTH FACTOR REVIEWS

IL-1, IL-18, and IL-33 families of cytokines

(2008) William P. Arend et al.   IMMUNOLOGICAL REVIEWS