Review: Neuroinflammatory pathways as treatment targets and biomarker candidates in epilepsy: emerging evidence from preclinical and clinical studies

Toll-like receptor 3 deficiency decreases epileptogenesis in a pilocarpine model of SE-induced epilepsy in mice

(2017) Adi Gross et al.   EPILEPSIA

Neuroinflammatory targets and treatments for epilepsy validated in experimental models

(2017) Eleonora Aronica et al.   EPILEPSIA

Nonsteroidal anti-inflammatory drugs in clinical and experimental epilepsy

(2017) Beatrice Mihaela Radu et al.   EPILEPSY RESEARCH

Molecular isoforms of high-mobility group box 1 are mechanistic biomarkers for epilepsy

(2017) Lauren Elizabeth Walker et al.   JOURNAL OF CLINICAL INVESTIGATION

Blockade of the IL-1R1/TLR4 pathway mediates disease-modification therapeutic effects in a model of acquired epilepsy

(2017) Valentina Iori et al.   NEUROBIOLOGY OF DISEASE

Febrile infection-related epilepsy syndrome treated with anakinra

(2016) Daniel L. Kenney-Jung et al.   ANNALS OF NEUROLOGY

Anti-tumor necrosis factor alpha therapy (adalimumab) in Rasmussen's encephalitis: An open pilot study

(2016) Stanislas Lagarde et al.   EPILEPSIA

Upregulation of HMGB1, toll-like receptor and RAGE in human Rasmussen’s encephalitis

(2016) Guoming Luan et al.   EPILEPSY RESEARCH

Blocking GluN2B subunits reverses the enhanced seizure susceptibility after prolonged febrile seizures with a wide therapeutic time-window

(2016) Bin Chen et al.   EXPERIMENTAL NEUROLOGY

Promoter-Specific Hypomethylation Correlates with IL-1β Overexpression in Tuberous Sclerosis Complex (TSC)

(2016) A. Fuso et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Transient P2X7 Receptor Antagonism Produces Lasting Reductions in Spontaneous Seizures and Gliosis in Experimental Temporal Lobe Epilepsy

(2016) Alba Jimenez-Pacheco et al.   JOURNAL OF NEUROSCIENCE

The Chemokine CCL2 Mediates the Seizure-enhancing Effects of Systemic Inflammation

(2016) Chiara Cerri et al.   JOURNAL OF NEUROSCIENCE

Inhibition of the prostaglandin E2 receptor EP2 prevents status epilepticus-induced deficits in the novel object recognition task in rats

(2016) Asheebo Rojas et al.   NEUROPHARMACOLOGY

Inflammatory mediators in human epilepsy: A systematic review and meta-analysis

(2016) Evelien E. de Vries et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Preventing epileptogenesis: A realistic goal?

(2016) Gaetano Terrone et al.   PHARMACOLOGICAL RESEARCH

Immunity and inflammation in status epilepticus and its sequelae: possibilities for therapeutic application

(2015) Annamaria Vezzani et al.   Expert Review of Neurotherapeutics

NLRP1 inflammasome is activated in patients with medial temporal lobe epilepsy and contributes to neuronal pyroptosis in amygdala kindling-induced rat model

(2015) Chen-Chen Tan et al.   Journal of Neuroinflammation

Increased Expression and Cellular Localization of P2X7R in Cortical Lesions of Patients With Focal Cortical Dysplasia

(2015) Yu-Jia Wei et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

A novel anticonvulsant mechanism via inhibition of complement receptor C5ar1 in murine epilepsy models

(2015) Melissa J. Benson et al.   NEUROBIOLOGY OF DISEASE

Therapeutic window for cyclooxygenase-2 related anti-inflammatory therapy after status epilepticus

(2015) Jianxiong Jiang et al.   NEUROBIOLOGY OF DISEASE

GABA A currents are decreased by IL-1β in epileptogenic tissue of patients with temporal lobe epilepsy: implications for ictogenesis

(2015) Cristina Roseti et al.   NEUROBIOLOGY OF DISEASE

Inhibition of the prostaglandin EP2 receptor is neuroprotective and accelerates functional recovery in a rat model of organophosphorus induced status epilepticus

(2015) Asheebo Rojas et al.   NEUROPHARMACOLOGY

Neuromodulatory properties of inflammatory cytokines and their impact on neuronal excitability

(2015) Annamaria Vezzani et al.   NEUROPHARMACOLOGY

Immunity and inflammation in status epilepticus and its sequelae: possibilities for therapeutic application

(2015) Annamaria Vezzani et al.   Expert Review of Neurotherapeutics

IL-1β associations with posttraumatic epilepsy development: A genetics and biomarker cohort study

(2014) Matthew L. Diamond et al.   EPILEPSIA

Intrathecal overproduction of proinflammatory cytokines and chemokines in febrile infection-related refractory status epilepticus

(2014) Hiroshi Sakuma et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Epilepsy Related to Developmental Tumors and Malformations of Cortical Development

(2014) Eleonora Aronica et al.   Neurotherapeutics

Disulfide-Containing High Mobility Group Box-1 Promotes N-Methyl-d-Aspartate Receptor Function and Excitotoxicity by Activating Toll-Like Receptor 4-Dependent Signaling in Hippocampal Neurons

(2013) Silvia Balosso et al.   ANTIOXIDANTS & REDOX SIGNALING

Fractalkine/CX3CL1 modulates GABAAcurrents in human temporal lobe epilepsy

(2013) Cristina Roseti et al.   EPILEPSIA

Cyclooxygenase-2 in epilepsy

(2013) Asheebo Rojas et al.   EPILEPSIA

Does aspirin use make it harder to collect seizures during elective video-EEG telemetry?

(2013) Rachel M. Godfred et al.   EPILEPSY & BEHAVIOR

The dual role of TNF-α and its receptors in seizures

(2013) Silvia Balosso et al.   EXPERIMENTAL NEUROLOGY

Opposing actions of hippocampus TNFα receptors on limbic seizure susceptibility

(2013) Marc S. Weinberg et al.   EXPERIMENTAL NEUROLOGY

Inflammasome induction in Rasmussen’s encephalitis: cortical and associated white matter pathogenesis

(2013) Vijay Ramaswamy et al.   Journal of Neuroinflammation

Differential expression of major histocompatibility complex class I in developmental glioneuronal lesions

(2013) Avanita S Prabowo et al.   Journal of Neuroinflammation

Neurogenic neuroinflammation: inflammatory CNS reactions in response to neuronal activity

(2013) Dimitris N. Xanthos et al.   NATURE REVIEWS NEUROSCIENCE

Pharmacological blockade of IL-1β/IL-1 receptor type 1 axis during epileptogenesis provides neuroprotection in two rat models of temporal lobe epilepsy

(2013) F.M. Noe et al.   NEUROBIOLOGY OF DISEASE

Receptor for Advanced Glycation Endproducts is upregulated in temporal lobe epilepsy and contributes to experimental seizures

(2013) Valentina Iori et al.   NEUROBIOLOGY OF DISEASE

Tenidap, an agonist of the inwardly rectifying K+ channel Kir2·3, delays the onset of cortical epileptiform activity in a model of chronic temporal lobe epilepsy

(2013) Lan Xu et al.   NEUROLOGICAL RESEARCH

Inhibition of the prostaglandin receptor EP2 following status epilepticus reduces delayed mortality and brain inflammation

(2013) Jianxiong Jiang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TLR4, ATF-3 and IL8 inflammation mediator expression correlates with seizure frequency in human epileptic brain tissue

(2013) Katharina Pernhorst et al.   SEIZURE-EUROPEAN JOURNAL OF EPILEPSY

Glia and epilepsy: excitability and inflammation

(2013) Orrin Devinsky et al.   TRENDS IN NEUROSCIENCES

Regulation of HMGB1 release by inflammasomes

(2013) Ben Lu et al.   Protein & Cell

Aspirin attenuates spontaneous recurrent seizures and inhibits hippocampal neuronal loss, mossy fiber sprouting and aberrant neurogenesis following pilocarpine-induced status epilepticus in rats

(2012) Lei Ma et al.   BRAIN RESEARCH

Progress report on new antiepileptic drugs: A summary of the Eleventh Eilat Conference (EILAT XI)

(2012) Meir Bialer et al.   EPILEPSY RESEARCH

Aspirin Use in Sturge-Weber Syndrome

(2012) Eboni I. Lance et al.   JOURNAL OF CHILD NEUROLOGY

Mutually exclusive redox forms of HMGB1 promote cell recruitment or proinflammatory cytokine release

(2012) Emilie Venereau et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Novel role of PKR in inflammasome activation and HMGB1 release

(2012) Ben Lu et al.   NATURE

The role of inflammation in epileptogenesis

(2012) Annamaria Vezzani et al.   NEUROPHARMACOLOGY

Hippocampal tissue of patients with refractory temporal lobe epilepsy is associated with astrocyte activation, inflammation, and altered expression of channels and receptors

(2012) A. Das et al.   NEUROSCIENCE

MicroRNA-146a: A Key Regulator of Astrocyte-Mediated Inflammatory Response

(2012) Anand Iyer et al.   PLoS One

Small molecule antagonist reveals seizure-induced mediation of neuronal injury by prostaglandin E2 receptor subtype EP2

(2012) J. Jiang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Brain inflammation as a biomarker in epilepsy

(2011) Annamaria Vezzani et al.   Biomarkers in Medicine

Activation of toll-like receptor, RAGE and HMGB1 signalling in malformations of cortical development

(2011) E. Zurolo et al.   BRAIN

IL-1 receptor/Toll-like receptor signaling in infection, inflammation, stress and neurodegeneration couples hyperexcitability and seizures

(2011) Annamaria Vezzani et al.   BRAIN BEHAVIOR AND IMMUNITY

Towards developing new strategies to reduce the adverse side-effects of nonsteroidal anti-inflammatory drugs

(2011) Noritaka Kawada et al.   Clinical and Experimental Nephrology

Inflammatory changes during epileptogenesis and spontaneous seizures in a mouse model of mesiotemporal lobe epilepsy

(2011) Fabien Pernot et al.   EPILEPSIA

Inflammation in epilepsy: Clinical observations

(2011) Eleonora Aronica et al.   EPILEPSIA

Seizure suppression and neuroprotection by targeting the purinergic P2X7 receptor during status epilepticus in mice

(2011) Tobias Engel et al.   FASEB JOURNAL

Role of microglia in CNS inflammation

(2011) Manuel B. Graeber et al.   FEBS LETTERS

Survey of Aspirin Use in Sturge-Weber Syndrome

(2011) Mihee J. Bay et al.   JOURNAL OF CHILD NEUROLOGY

IL-1β is induced in reactive astrocytes in the somatosensory cortex of rats with genetic absence epilepsy at the onset of spike-and-wave discharges, and contributes to their occurrence

(2011) Demet Akin et al.   NEUROBIOLOGY OF DISEASE

Complement protein 6 deficiency in PVG/c rats does not lead to neuroprotection against seizure induced cell death

(2011) L. Holtman et al.   NEUROSCIENCE

Interleukin-1β Biosynthesis Inhibition Reduces Acute Seizures and Drug Resistant Chronic Epileptic Activity in Mice

(2011) Mattia Maroso et al.   Neurotherapeutics

Targeting the prostaglandin E2 EP1 receptor and cyclooxygenase-2 in the amygdala kindling model in mice

(2010) Sarah Verena Fischborn et al.   EPILEPSY RESEARCH

Cox-2 inhibition can lead to adverse effects in a rat model for temporal lobe epilepsy

(2010) Linda Holtman et al.   EPILEPSY RESEARCH

Expression pattern of miR-146a, an inflammation-associated microRNA, in experimental and human temporal lobe epilepsy

(2010) E. Aronica et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

The COX-2 inhibitor parecoxib is neuroprotective but not antiepileptogenic in the pilocarpine model of temporal lobe epilepsy

(2010) Nadine Polascheck et al.   EXPERIMENTAL NEUROLOGY

Role of CCR5 and its ligands in the control of vascular inflammation and leukocyte recruitment required for acute excitotoxic seizure induction and neural damage

(2010) Jean-Pierre Louboutin et al.   FASEB JOURNAL

The emerging role for chemokines in epilepsy

(2010) Paolo F. Fabene et al.   JOURNAL OF NEUROIMMUNOLOGY

Epileptogenesis Provoked by Prolonged Experimental Febrile Seizures: Mechanisms and Biomarkers

(2010) C. M. Dube et al.   JOURNAL OF NEUROSCIENCE

Role for Complement in the Development of Seizures following Acute Viral Infection

(2010) J. E. Libbey et al.   JOURNAL OF VIROLOGY

Toll-like receptor 4 and high-mobility group box-1 are involved in ictogenesis and can be targeted to reduce seizures

(2010) Mattia Maroso et al.   NATURE MEDICINE

The role of inflammation in epilepsy

(2010) Annamaria Vezzani et al.   Nature Reviews Neurology

Gene Expression Analysis of Tuberous Sclerosis Complex Cortical Tubers Reveals Increased Expression of Adhesion and Inflammatory Factors

(2009) Karin Boer et al.   BRAIN PATHOLOGY

Effects of SC58236, a selective COX-2 inhibitor, on epileptogenesis and spontaneous seizures in a rat model for temporal lobe epilepsy

(2009) L. Holtman et al.   EPILEPSY RESEARCH

COX-2 inhibition controls P-glycoprotein expression and promotes brain delivery of phenytoin in chronic epileptic rats

(2009) Erwin A. van Vliet et al.   NEUROPHARMACOLOGY

Molecular and functional interactions between tumor necrosis factor-alpha receptors and the glutamatergic system in the mouse hippocampus: Implications for seizure susceptibility

(2009) S. Balosso et al.   NEUROSCIENCE

The distinct roles of cyclooxygenase-1 and -2 in neuroinflammation: implications for translational research

(2009) Sang-Ho Choi et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

A novel non-transcriptional pathway mediates the proconvulsive effects of interleukin-1 

(2008) S. Balosso et al.   BRAIN

Involvement of endogenous prostaglandin F2α on kainic acid-induced seizure activity through FP receptor: The mechanism of proconvulsant effects of COX-2 inhibitors

(2008) Hee-Jae Kim et al.   BRAIN RESEARCH

Age-dependent cyclooxygenase-2 induction and neuronal damage after status epilepticus in the postnatal rat hippocampus

(2008) Juha T. Järvelä et al.   EPILEPSIA

Complex time-dependent alterations in the brain expression of different drug efflux transporter genes after status epilepticus

(2008) Konstantin Kuteykin-Teplyakov et al.   EPILEPSIA

Cyclooxygenase-2/PGE2 pathway facilitates pentylenetetrazol-induced seizures

(2008) Mauro Schneider Oliveira et al.   EPILEPSY RESEARCH

TNF-α receptor 1 deficiency enhances kainic acid–induced hippocampal injury in mice

(2008) Ming-Ou Lu et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Interleukin Converting Enzyme inhibition impairs kindling epileptogenesis in rats by blocking astrocytic IL-1β production

(2008) Teresa Ravizza et al.   NEUROBIOLOGY OF DISEASE

Rofecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor increases pentylenetetrazol seizure threshold in mice: Possible involvement of adenosinergic mechanism

(2007) Kiran Kumar Akula et al.   EPILEPSY RESEARCH

Innate and adaptive immunity during epileptogenesis and spontaneous seizures: Evidence from experimental models and human temporal lobe epilepsy

(2007) Teresa Ravizza et al.   NEUROBIOLOGY OF DISEASE

Gene expression profile analysis of epilepsy-associated gangliogliomas

(2007) E. Aronica et al.   NEUROSCIENCE