Journal
JOURNAL OF MEDICINAL CHEMISTRY
Volume 63, Issue 22, Pages 13316-13329Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jmedchem.0c00884
Keywords
-
Categories
Funding
- National Key Research Project of China [2017YFA0506000, 2019ZX09301148]
- National Natural Science Foundation of China [81770825]
- Natural Science Funding of Zhejiang Province [LYY19H310006]
- Zhejiang Provincial Key Research Project [2018C03068]
- Wenzhou Science and Technology Key Project [2018ZY009]
Ask authors/readers for more resources
Myeloid differentiation primary response protein 88 (MyD88) is a ubiquitously expressed cytoplasmic adaptor protein that plays a central role in the Toll-like receptor (TLR) and interleukin-1 receptor (IL-1R) signaling pathways. TLR/IL-1R pathways regulate the proliferation and differentiation of cells involved in the innate and adaptive immunity. Although the general TLR/IL-1R activation cascade is well understood, the molecular mechanisms involving MyD88 have only begun to surface in the past decade. In this review, we explore MyD88 structural biology, the role of posttranslational modifications (PTMs), and the recent developments in MyD88 inhibitor discovery and use. We also highlight the potential application of MyD88-targeted therapies in human diseases.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available