Pentoxifylline prevents epileptic seizure via modulating HMGB1/RAGE/TLR4 signalling pathway and improves memory in pentylenetetrazol kindling rats

Probiotics and Nigella sativa extract supplementation improved behavioral and electrophysiological effects of PTZ-induced chemical kindling in rats

(2020) Saeed Tahmasebi et al.   EPILEPSY & BEHAVIOR

Anti-Inflammation Associated Protective Mechanism of Berberine and its Derivatives on Attenuating Pentylenetetrazole-Induced Seizures in Zebrafish

(2020) Baoyue Zhang et al.   Journal of Neuroimmune Pharmacology

Sitagliptin and Liraglutide Modulate L-dopa Effect and Attenuate Dyskinetic Movements in Rotenone-Lesioned Rats

(2019) Ghada A. Badawi et al.   NEUROTOXICITY RESEARCH

Differential Effects of Pentoxifylline on Learning and Memory Impairment Induced by Hypoxic-ischemic Brain Injury in Rats

(2019) Hülya Halis et al.   Clinical Psychopharmacology and Neuroscience

Effect of adenovirus-mediated overexpression of PTEN on brain oxidative damage and neuroinflammation in a rat kindling model of epilepsy

(2019) Zhi-Sheng Wu et al.   CHINESE MEDICAL JOURNAL

Tau deletion reduces plaque‐associated BACE 1 accumulation and decelerates plaque formation in a mouse model of Alzheimer's disease

(2019) Finn Peters et al.   EMBO JOURNAL

The potential effects of anticonvulsant drugs on neuropeptides and neurotrophins in pentylenetetrazol kindled seizures in the rat

(2019) Hasan Tekgul et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

Mild foot electrical stimulation is comparable with phenytoin in inhibiting pentylenetetrazol-induced kindling in rats

(2019) Arefe Ghasemi-Dehno et al.   Journal of Physiological Sciences

High Mobility Group Box 1 is a novel pathogenic factor and a mechanistic biomarker for epilepsy

(2018) Teresa Ravizza et al.   BRAIN BEHAVIOR AND IMMUNITY

Improving effect of mild foot electrical stimulation on pentylenetetrazole-induced impairment of learning and memory

(2018) Monir Abasi-Moghadam et al.   EPILEPSY & BEHAVIOR

The role of inflammation in the development of epilepsy

(2018) Amna Rana et al.   Journal of Neuroinflammation

Targeting Keap-1/Nrf-2 pathway and cytoglobin as a potential protective mechanism of diosmin and pentoxifylline against cholestatic liver cirrhosis

(2018) Fares E.M. Ali et al.   LIFE SCIENCES

Chronic oral application of a periodontal pathogen results in brain inflammation, neurodegeneration and amyloid beta production in wild type mice

(2018) Vladimir Ilievski et al.   PLoS One

HMGB1: A Common Biomarker and Potential Target for TBI, Neuroinflammation, Epilepsy, and Cognitive Dysfunction

(2018) Yam Nath Paudel et al.   Frontiers in Neuroscience

Naringin in a combined therapy with phenytoin on pentylenetetrazole-induced kindling in rats

(2018) Phani Kumar Kola et al.   EPILEPSY & BEHAVIOR

Molecular isoforms of high-mobility group box 1 are mechanistic biomarkers for epilepsy

(2017) Lauren Elizabeth Walker et al.   JOURNAL OF CLINICAL INVESTIGATION

Oxidative Stress Contributes to Status Epilepticus Associated Mortality

(2017) Jennifer N. Pearson-Smith et al.   NEUROCHEMICAL RESEARCH

Alleviation of Oxidative Damage and Involvement of Nrf2-ARE Pathway in Mesodopaminergic System and Hippocampus of Status Epilepticus Rats Pretreated by Intranasal Pentoxifylline

(2017) Yunxiao Kang et al.   Oxidative Medicine and Cellular Longevity

Curcumin-loaded chitosan-alginate-STPP nanoparticles ameliorate memory deficits and reduce glial activation in pentylenetetrazol-induced kindling model of epilepsy

(2017) Mona Hashemian et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Roles of Caspases in Necrotic Cell Death

(2016) Junying Yuan et al.   CELL

Pentoxifylline Alleviates Early Brain Injury After Experimental Subarachnoid Hemorrhage in Rats: Possibly via Inhibiting TLR 4/NF-κB Signaling Pathway

(2016) Da-yong Xia et al.   NEUROCHEMICAL RESEARCH

Role of ROS and RNS Sources in Physiological and Pathological Conditions

(2016) Sergio Di Meo et al.   Oxidative Medicine and Cellular Longevity

Osmotin attenuates LPS-induced neuroinflammation and memory impairments via the TLR4/NFκB signaling pathway

(2016) Haroon Badshah et al.   Scientific Reports

Fluvoxamine alleviates seizure activity and downregulates hippocampal GAP-43 expression in pentylenetetrazole-kindled mice

(2015) Momen W. Alhaj et al.   BEHAVIOURAL PHARMACOLOGY

Effects of a lyophilized aqueous extract of Feretia apodanthera Del. (Rubiaceae) on pentylenetetrazole-induced kindling, oxidative stress, and cognitive impairment in mice

(2015) G.S. Taiwe et al.   EPILEPSY & BEHAVIOR

Lipoic acid and pentoxifylline mitigate nandrolone decanoate-induced neurobehavioral perturbations in rats via re-balance of brain neurotransmitters, up-regulation of Nrf2/HO-1 pathway, and down-regulation of TNFR1 expression

(2015) Maha A.E. Ahmed et al.   HORMONES AND BEHAVIOR

Comparative behavioral and neurochemical analysis of phenytoin and valproate treatment on epilepsy induced learning and memory deficit: Search for add on therapy

(2015) Awanish Mishra et al.   METABOLIC BRAIN DISEASE

Brain redox imaging in the pentylenetetrazole (PTZ)-induced kindling model of epilepsy by using in vivo electron paramagnetic resonance and a nitroxide imaging probe

(2015) Miho C. Emoto et al.   NEUROSCIENCE LETTERS

Can pentylenetetrazole and maximal electroshock rodent seizure models quantitatively predict antiepileptic efficacy in humans?

(2015) Eunice S.M. Yuen et al.   SEIZURE-EUROPEAN JOURNAL OF EPILEPSY

Pentoxifylline attenuates nitrogen mustard-induced acute lung injury, oxidative stress and inflammation

(2014) Vasanthi R. Sunil et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

The Effects of Quinacrine, Proglumide, and Pentoxifylline on Seizure Activity, Cognitive Deficit, and Oxidative Stress in Rat Lithium-Pilocarpine Model of Status Epilepticus

(2014) Mohammad Ahmad et al.   Oxidative Medicine and Cellular Longevity

Evening primrose oil and celecoxib inhibited pathological angiogenesis, inflammation, and oxidative stress in adjuvant-induced arthritis: novel role of angiopoietin-1

(2014) R. M. El-Sayed et al.   INFLAMMOPHARMACOLOGY

Ascorbic acid ameliorates seizures and brain damage in rats through inhibiting autophagy

(2013) Yan Dong et al.   BRAIN RESEARCH

Ameliorative effect of Curcumin on seizure severity, depression like behavior, learning and memory deficit in post-pentylenetetrazole-kindled mice

(2013) Kailash M. Choudhary et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Mitochondrial involvement and oxidative stress in temporal lobe epilepsy

(2013) Shane Rowley et al.   FREE RADICAL BIOLOGY AND MEDICINE

Role of Redox Signaling in Neuroinflammation and Neurodegenerative Diseases

(2013) Hsi-Lung Hsieh et al.   Biomed Research International

The Role of Reactive Species in Epileptogenesis and Influence of Antiepileptic Drug Therapy on Oxidative Stress

(2012) Bostjan Martinc et al.   Current Neuropharmacology

The effect of pentoxifylline and its metabolite-1 on inflammation and fibrosis in the TNBS model of colitis

(2011) Theresa C. Peterson et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

HMGB1 Acts on Microglia Mac1 to Mediate Chronic Neuroinflammation That Drives Progressive Neurodegeneration

(2011) H.-M. Gao et al.   JOURNAL OF NEUROSCIENCE

High-Mobility Group Box 1, Oxidative Stress, and Disease

(2010) Daolin Tang et al.   ANTIOXIDANTS & REDOX SIGNALING

The role of inflammation in epilepsy

(2010) Annamaria Vezzani et al.   Nature Reviews Neurology

Pentylenetetrazole-induced seizures affect binding site densities for GABA, glutamate and adenosine receptors in the rat brain

(2009) C.M. Cremer et al.   NEUROSCIENCE

Pentoxifylline ameliorates lithium-pilocarpine induced status epilepticus in young rats

(2008) Mohammad Tariq et al.   EPILEPSY & BEHAVIOR