Prospective clinical trials to investigate clinical and molecular biomarkers

Promoter-Specific Hypomethylation Correlates with IL-1β Overexpression in Tuberous Sclerosis Complex (TSC)

(2016) A. Fuso et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Specific pattern of maturation and differentiation in the formation of cortical tubers in tuberous sclerosis complex (TSC): evidence from layer-specific marker expression

(2016) Angelika Mühlebner et al.   Journal of Neurodevelopmental Disorders

HMGB1 as biomarker and drug target

(2016) Emilie Venereau et al.   PHARMACOLOGICAL RESEARCH

Oxidative stress-mediated HMGB1 biology

(2015) Yan Yu et al.   Frontiers in Physiology

Tuberous sclerosis complex neuropathology requires glutamate-cysteine ligase

(2015) Anna R. Malik et al.   Acta Neuropathologica Communications

Inflammation and Epilepsy in the Developing Brain: Clinical and Experimental Evidence

(2014) Nina Dupuis et al.   CNS Neuroscience & Therapeutics

Hippocampal sclerosis after febrile status epilepticus: The FEBSTAT study

(2013) Darrell V. Lewis et al.   ANNALS OF NEUROLOGY

Disulfide-Containing High Mobility Group Box-1 Promotes N-Methyl-d-Aspartate Receptor Function and Excitotoxicity by Activating Toll-Like Receptor 4-Dependent Signaling in Hippocampal Neurons

(2013) Silvia Balosso et al.   ANTIOXIDANTS & REDOX SIGNALING

Epilepsy biomarkers

(2013) Jerome Engel et al.   EPILEPSIA

Inflammation and iron metabolism in adult patients with epilepsy: Does a link exist?

(2013) M. Tombini et al.   EPILEPSY RESEARCH

A genome-wide association study and biological pathway analysis of epilepsy prognosis in a prospective cohort of newly treated epilepsy

(2013) D. Speed et al.   HUMAN MOLECULAR GENETICS

The many faces of HMGB1: molecular structure-functional activity in inflammation, apoptosis, and chemotaxis

(2013) Huan Yang et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Receptor for Advanced Glycation Endproducts is upregulated in temporal lobe epilepsy and contributes to experimental seizures

(2013) Valentina Iori et al.   NEUROBIOLOGY OF DISEASE

Fetal Brain Lesions in Tuberous Sclerosis Complex: TORC1 Activation and Inflammation

(2012) Avanita S. Prabowo et al.   BRAIN PATHOLOGY

Design and phenomenology of the FEBSTAT study

(2012) Dale C. Hesdorffer et al.   EPILEPSIA

HMGB1 promotes recruitment of inflammatory cells to damaged tissues by forming a complex with CXCL12 and signaling via CXCR4

(2012) Milena Schiraldi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Prognostic factors for time to treatment failure and time to 12 months of remission for patients with focal epilepsy: post-hoc, subgroup analyses of data from the SANAD trial

(2012) Laura Bonnett et al.   LANCET NEUROLOGY

Unknown

(2012) Huan Yang et al.   MOLECULAR MEDICINE

MRI abnormalities following febrile status epilepticus in children: The FEBSTAT study

(2012) S. Shinnar et al.   NEUROLOGY

Acute EEG findings in children with febrile status epilepticus: Results of the FEBSTAT study

(2012) D. R. Nordli et al.   NEUROLOGY

The role of inflammation in epileptogenesis

(2012) Annamaria Vezzani et al.   NEUROPHARMACOLOGY

Activation of toll-like receptor, RAGE and HMGB1 signalling in malformations of cortical development

(2011) E. Zurolo et al.   BRAIN

Antiepileptic treatment before the onset of seizures reduces epilepsy severity and risk of mental retardation in infants with tuberous sclerosis complex

(2011) Sergiusz Jóźwiak et al.   EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY

Loss of the tuberous sclerosis complex protein tuberin causes Purkinje cell degeneration

(2011) R. Michelle Reith et al.   NEUROBIOLOGY OF DISEASE

Inflammasome-Dependent Release of the Alarmin HMGB1 in Endotoxemia

(2010) M. Lamkanfi et al.   JOURNAL OF IMMUNOLOGY

Toll-like receptor 4 and high-mobility group box-1 are involved in ictogenesis and can be targeted to reduce seizures

(2010) Mattia Maroso et al.   NATURE MEDICINE

The role of inflammation in epilepsy

(2010) Annamaria Vezzani et al.   Nature Reviews Neurology

Tuberous Sclerosis Complex Activity Is Required to Control Neuronal Stress Responses in an mTOR-Dependent Manner

(2009) A. Di Nardo et al.   JOURNAL OF NEUROSCIENCE

The role of iron dysregulation in the pathogenesis of multiple sclerosis: an Egyptian study

(2008) N Abo-Krysha et al.   Multiple Sclerosis Journal

Inflammatory processes in cortical tubers and subependymal giant cell tumors of tuberous sclerosis complex

(2007) K. Boer et al.   EPILEPSY RESEARCH