Pharmacological manipulation of Ezh2 with salvianolic acid B results in tumor vascular normalization and synergizes with cisplatin and T cell-mediated immunotherapy

Hallmarks of Cancer: New Dimensions

(2022) Douglas Hanahan   Cancer Discovery

Integrin αvβ6–TGFβ–SOX4 Pathway Drives Immune Evasion in Triple-Negative Breast Cancer

(2021) Archis Bagati et al.   CANCER CELL

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2021) Hyuna Sung et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Therapeutic Targeting of the Tumor Microenvironment

(2021) Leire Bejarano et al.   Cancer Discovery

Control of PD-L1 expression in CLL-cells by stromal triggering of the Notch-c-Myc-EZH2 oncogenic signaling axis

(2021) Martin Böttcher et al.   Journal for ImmunoTherapy of Cancer

Targeting the Ang2/Tie2 Axis with Tanshinone IIA Elicits Vascular Normalization in Ischemic Injury and Colon Cancer

(2021) Wei Zou et al.   Oxidative Medicine and Cellular Longevity

Endothelial deletion of SHP2 suppresses tumor angiogenesis and promotes vascular normalization

(2021) Zhiyong Xu et al.   Nature Communications

Tazemetostat: First Approval

(2020) Sheridan M. Hoy   DRUGS

EZH2: a novel target for cancer treatment

(2020) Ran Duan et al.   Journal of Hematology & Oncology

Methylation of EZH2 by PRMT1 regulates its stability and promotes breast cancer metastasis

(2020) Zhongwei Li et al.   CELL DEATH AND DIFFERENTIATION

Tazemetostat for patients with relapsed or refractory follicular lymphoma: an open-label, single-arm, multicentre, phase 2 trial

(2020) Franck Morschhauser et al.   LANCET ONCOLOGY

Tumoural activation of TLR3–SLIT2 axis in endothelium drives metastasis

(2020) Bernardo Tavora et al.   NATURE

Manipulation of immune‒vascular crosstalk: new strategies towards cancer treatment

(2020) Yang Zhao et al.   Acta Pharmaceutica Sinica B

The VE-Cadherin/β-catenin signalling axis regulates immune cell infiltration into tumours

(2020) Yang Zhao et al.   CANCER LETTERS

Fat1 deletion promotes hybrid EMT state, tumour stemness and metastasis

(2020) Ievgenia Pastushenko et al.   NATURE

Interaction of EZH2 and P65 is involved in the arsenic trioxide-induced anti-angiogenesis in human triple-negative breast cancer cells

(2019) Fei Jiang et al.   CELL BIOLOGY AND TOXICOLOGY

Tumor‐Targeted Drug and CpG Delivery System for Phototherapy and Docetaxel‐Enhanced Immunotherapy with Polarization toward M1‐Type Macrophages on Triple Negative Breast Cancers

(2019) Lv Chen et al.   ADVANCED MATERIALS

Salvianolic Acid B Slows the Progression of Breast Cancer Cell Growth via Enhancement of Apoptosis and Reduction of Oxidative Stress, Inflammation, and Angiogenesis

(2019) Mohamed A. Katary et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mild photothermal therapy potentiates anti-PD-L1 treatment for immunologically cold tumors via an all-in-one and all-in-control strategy

(2019) Liping Huang et al.   Nature Communications

EZH2 negatively regulates PD-L1 expression in hepatocellular carcinoma

(2019) Gang Xiao et al.   Journal for ImmunoTherapy of Cancer

Beyond Angiogenesis: Exploiting Angiocrine Factors to Restrict Tumor Progression and Metastasis

(2019) Mahak Singhal et al.   CANCER RESEARCH

Identification of bioactive anti-angiogenic components targeting tumor endothelial cells in Shenmai injection using multidimensional pharmacokinetics

(2019) Chongjin Zhong et al.   Acta Pharmaceutica Sinica B

Salvia miltiorrhizaBurge (Danshen): a golden herbal medicine in cardiovascular therapeutics

(2018) Zhuo-ming Li et al.   ACTA PHARMACOLOGICA SINICA

Salvanic acid B inhibits glycolysis in oral squamous cell carcinoma via targeting PI3K/AKT/HIF-1α signaling pathway

(2018) Jie Wei et al.   Cell Death & Disease

Salvianolic acid B renders glioma cells more sensitive to radiation via Fis-1-mediated mitochondrial dysfunction

(2018) Wei Chen et al.   BIOMEDICINE & PHARMACOTHERAPY

Polypharmacological Profiles Underlying the Antitumor Property of Salvia miltiorrhiza Root (Danshen) Interfering with NOX-Dependent Neutrophil Extracellular Traps

(2018) Li Tao et al.   Oxidative Medicine and Cellular Longevity

Molecular alterations in triple-negative breast cancer—the road to new treatment strategies

(2017) Carsten Denkert et al.   LANCET

Dual angiopoietin-2 and VEGFA inhibition elicits antitumor immunity that is enhanced by PD-1 checkpoint blockade

(2017) Martina Schmittnaegel et al.   Science Translational Medicine

Normalization of Tumor Vessels by Tie2 Activation and Ang2 Inhibition Enhances Drug Delivery and Produces a Favorable Tumor Microenvironment

(2016) Jin-Sung Park et al.   CANCER CELL

Inhibition of the Glycolytic Activator PFKFB3 in Endothelium Induces Tumor Vessel Normalization, Impairs Metastasis, and Improves Chemotherapy

(2016) Anna Rita Cantelmo et al.   CANCER CELL

LDHA-Associated Lactic Acid Production Blunts Tumor Immunosurveillance by T and NK Cells

(2016) Almut Brand et al.   Cell Metabolism

Cellular uptake and anticancer activity of salvianolic acid B phospholipid complex loaded nanoparticles in head and neck cancer and precancer cells

(2016) Hongquan Li et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Angiocrine functions of organ-specific endothelial cells

(2016) Shahin Rafii et al.   NATURE

Tumour-cell-induced endothelial cell necroptosis via death receptor 6 promotes metastasis

(2016) Boris Strilic et al.   NATURE

Targeting EZH2 in cancer

(2016) Kimberly H Kim et al.   NATURE MEDICINE

Changing Treatment Paradigms in Metastatic Breast Cancer

(2015) Cesar A. Santa-Maria et al.   JAMA Oncology

Tumor Vessel Normalization by Chloroquine Independent of Autophagy

(2014) Hannelore Maes et al.   CANCER CELL

Antiangiogenesis Strategies Revisited: From Starving Tumors to Alleviating Hypoxia

(2014) Rakesh K. Jain   CANCER CELL

Phenolcarboxylic acids from medicinal herbs exert anticancer effects through disruption of COX-2 activity

(2014) Li Tao et al.   PHYTOMEDICINE

Sox4 Is a Master Regulator of Epithelial-Mesenchymal Transition by Controlling Ezh2 Expression and Epigenetic Reprogramming

(2013) Neha Tiwari et al.   CANCER CELL

VE-Cadherin and Endothelial Adherens Junctions: Active Guardians of Vascular Integrity

(2013) Monica Giannotta et al.   DEVELOPMENTAL CELL

Durable tumor regression in genetically altered malignant rhabdoid tumors by inhibition of methyltransferase EZH2

(2013) S. K. Knutson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

EZH2 inhibition: targeting the crossroad of tumor invasion and angiogenesis

(2012) Francesco Crea et al.   CANCER AND METASTASIS REVIEWS

VEGFA-VEGFR Pathway Blockade Inhibits Tumor-Induced Regulatory T-cell Proliferation in Colorectal Cancer

(2012) M. Terme et al.   CANCER RESEARCH

Convergent Multi-miRNA Targeting of ApoE Drives LRP1/LRP8-Dependent Melanoma Metastasis and Angiogenesis

(2012) Nora Pencheva et al.   CELL

EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations

(2012) Michael T. McCabe et al.   NATURE

Endothelial-Derived Angiocrine Signals Induce and Sustain Regenerative Lung Alveolarization

(2011) Bi-Sen Ding et al.   CELL

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Biosynthesis, total syntheses, and antitumor activity of tanshinones and their analogs as potential therapeutic agents

(2011) Yizhou Dong et al.   NATURAL PRODUCT REPORTS

A microRNA regulon that mediates endothelial recruitment and metastasis by cancer cells

(2011) Kim J. Png et al.   NATURE

Principles and mechanisms of vessel normalization for cancer and other angiogenic diseases

(2011) Peter Carmeliet et al.   NATURE REVIEWS DRUG DISCOVERY

Cisplatin as an Anti-Tumor Drug: Cellular Mechanisms of Activity, Drug Resistance and Induced Side Effects

(2011) Ana-Maria Florea et al.   Cancers

Inductive angiocrine signals from sinusoidal endothelium are required for liver regeneration

(2010) Bi-Sen Ding et al.   NATURE