Integrin αvβ6–TGFβ–SOX4 Pathway Drives Immune Evasion in Triple-Negative Breast Cancer
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Title
Integrin αvβ6–TGFβ–SOX4 Pathway Drives Immune Evasion in Triple-Negative Breast Cancer
Authors
Keywords
cancer immunotherapy, therapy resistance, cytotoxic T cells, SOX4 transcription factor, integrin αvβ6, TGFβ
Journal
CANCER CELL
Volume 39, Issue 1, Pages 54-67.e9
Publisher
Elsevier BV
Online
2021-01-01
DOI
10.1016/j.ccell.2020.12.001
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- (2018) Carsten Denkert et al. LANCET ONCOLOGY
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- (2018) Deng Pan et al. SCIENCE
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- Atezolizumab and Nab-Paclitaxel in Advanced Triple-Negative Breast Cancer
- (2018) Peter Schmid et al. NEW ENGLAND JOURNAL OF MEDICINE
- Molecular alterations in triple-negative breast cancer—the road to new treatment strategies
- (2017) Carsten Denkert et al. LANCET
- Identification of essential genes for cancer immunotherapy
- (2017) Shashank J. Patel et al. NATURE
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- (2017) Robert T. Manguso et al. NATURE
- Force interacts with macromolecular structure in activation of TGF-β
- (2017) Xianchi Dong et al. NATURE
- Integrins as Therapeutic Targets: Successes and Cancers
- (2017) Sabine Raab-Westphal et al. Cancers
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- (2016) Rivka C. Stone et al. CELL AND TISSUE RESEARCH
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- (2016) Peter J. Chockley et al. JOURNAL OF IMMUNOLOGY
- Mutations Associated with Acquired Resistance to PD-1 Blockade in Melanoma
- (2016) Jesse M. Zaretsky et al. NEW ENGLAND JOURNAL OF MEDICINE
- TGF-β and the TGF-β Family: Context-Dependent Roles in Cell and Tissue Physiology
- (2016) Masato Morikawa et al. Cold Spring Harbor Perspectives in Biology
- High expression of integrinβ6 in association with the Rho-Rac pathway identifies a poor prognostic subgroup within HER2 amplified breast cancers
- (2016) Krisha Desai et al. Cancer Medicine
- Tumor Budding: The Name is EMT. Partial EMT.
- (2016) Alexandru Grigore et al. Journal of Clinical Medicine
- SOX4 is a potential prognostic factor in human cancers: a systematic review and meta-analysis
- (2015) J. Chen et al. Clinical & Translational Oncology
- Integrin αvβ8-Mediated TGF-β Activation by Effector Regulatory T Cells Is Essential for Suppression of T-Cell-Mediated Inflammation
- (2015) John J. Worthington et al. IMMUNITY
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- (2015) Stefani Spranger et al. NATURE
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- (2015) Guo-Dong Song et al. TUMOR BIOLOGY
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- (2015) W. Peng et al. Cancer Discovery
- Abituzumab combined with cetuximab plus irinotecan versus cetuximab plus irinotecan alone for patients withKRASwild-type metastatic colorectal cancer: the randomised phase I/II POSEIDON trial
- (2014) E. Élez et al. ANNALS OF ONCOLOGY
- Prognostic Value of Tumor-Infiltrating Lymphocytes in Triple-Negative Breast Cancers From Two Phase III Randomized Adjuvant Breast Cancer Trials: ECOG 2197 and ECOG 1199
- (2014) Sylvia Adams et al. JOURNAL OF CLINICAL ONCOLOGY
- IgG Subclasses and Allotypes: From Structure to Effector Functions
- (2014) Gestur Vidarsson et al. Frontiers in Immunology
- Sox4 Is a Master Regulator of Epithelial-Mesenchymal Transition by Controlling Ezh2 Expression and Epigenetic Reprogramming
- (2013) Neha Tiwari et al. CANCER CELL
- Safety, tolerability, and pharmacokinetics of the novel αv-integrin antibody EMD 525797 (DI17E6) in healthy subjects after ascending single intravenous doses
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- SOX4 Mediates TGF-β-Induced Expression of Mesenchymal Markers during Mammary Cell Epithelial to Mesenchymal Transition
- (2013) Stephin J. Vervoort et al. PLoS One
- Integrin-mediated regulation of TGFβ in fibrosis
- (2012) Neil C. Henderson et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- SOX4 Induces Epithelial-Mesenchymal Transition and Contributes to Breast Cancer Progression
- (2012) J. Zhang et al. CANCER RESEARCH
- Defining the Role of Integrin αvβ6 in Cancer
- (2012) A. Bandyopadhyay et al. CURRENT DRUG TARGETS
- Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and Cufflinks
- (2012) Cole Trapnell et al. Nature Protocols
- A human monoclonal antibody 264RAD targeting αvβ6 integrin reduces tumour growth and metastasis and modulates key biomarkers in vivo
- (2012) C Eberlein et al. ONCOGENE
- The role of SRY-related HMG box transcription factor 4 (SOX4) in tumorigenesis and metastasis: friend or foe?
- (2012) S J Vervoort et al. ONCOGENE
- Preferential Expression of Integrin αvβ8 Promotes Generation of Regulatory T Cells by Mouse CD103+ Dendritic Cells
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- (2008) Sohail F. Tavazoie et al. NATURE
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