Biosynthesis, total syntheses, and antitumor activity of tanshinones and their analogs as potential therapeutic agents

Antitumor agents 278. 4-Amino-2H-benzo[h]chromen-2-one (ABO) analogs as potent in vitro anti-cancer agents

(2010) Yizhou Dong et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Characterization, expression profiling, and functional identification of a gene encoding geranylgeranyl diphosphate synthase from Salvia miltiorrhiza

(2010) Guoyin Kai et al.   BIOTECHNOLOGY AND BIOPROCESS ENGINEERING

Down-Regulation of Telomerase Activity and Activation of Caspase-3 Are Responsible for Tanshinone I-Induced Apoptosis in Monocyte Leukemia Cells in Vitro

(2010) Xiao-Dan Liu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Antitumor Agents. 272. Structure−Activity Relationships and In Vivo Selective Anti-Breast Cancer Activity of Novel Neo-tanshinlactone Analogues

(2010) Yizhou Dong et al.   JOURNAL OF MEDICINAL CHEMISTRY

Cytotoxic Effects of Tanshinones fromSalvia miltiorrhizaon Doxorubicin-Resistant Human Liver Cancer Cells

(2010) Wayne Y. W. Lee et al.   JOURNAL OF NATURAL PRODUCTS

Tanshinone IIA inhibits constitutive STAT3 activation, suppresses proliferation, and induces apoptosis in rat C6 glioma cells

(2010) Chao Tang et al.   NEUROSCIENCE LETTERS

Inhibitory effects of tanshinone II-A on invasion and metastasis of human colon carcinoma cells

(2009) Yun-feng Shan et al.   ACTA PHARMACOLOGICA SINICA

Tanshinone IIA triggers p53 responses and apoptosis by RNA polymerase II upon DNA minor groove binding

(2009) Zhichao Zhang et al.   BIOCHEMICAL PHARMACOLOGY

Antitumor agents 270. Novel substituted 6-phenyl-4H-furo[3,2-c]pyran-4-one derivatives as potent and highly selective anti-breast cancer agents

(2009) Yizhou Dong et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Antitumor agents 269. Non-aromatic ring-A neotanshinlactone analog, TNO, as a new class of potent antitumor agents

(2009) Yizhou Dong et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Reactive oxygen species-mediated kinase activation by dihydrotanshinone in tanshinones-induced apoptosis in HepG2 cells

(2009) Wayne Y.W. Lee et al.   CANCER LETTERS

Tanshinone IIA: a potent, natural anti-carcinogenic agent for the management of systemic malignancies

(2009) Shailendra Kapoor   Chinese Journal of Integrative Medicine

Experimental study of the anti-cancer mechanism of tanshinone IIA against human breast cancer

(2009) Lu   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Unravelling the regulatory mechanisms that modulate the MEP pathway in higher plants

(2009) E. Cordoba et al.   JOURNAL OF EXPERIMENTAL BOTANY

Antitumor Agents. 266. Design, Synthesis, and Biological Evaluation of Novel 2-(Furan-2-yl)naphthalen-1-ol Derivatives as Potent and Selective Antibreast Cancer Agents

(2009) Yizhou Dong et al.   JOURNAL OF MEDICINAL CHEMISTRY

Emodin sensitizes paclitaxel-resistant human ovarian cancer cells to paclitaxel-induced apoptosis in vitro

(2009) Liu   ONCOLOGY REPORTS

A Functional Genomics Approach to Tanshinone Biosynthesis Provides Stereochemical Insights

(2009) Wei Gao et al.   ORGANIC LETTERS

Tanshinone IIA Interacts with DNA by Minor Groove-Binding

(2008) Zhichao Zhang et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Cloning and characterization of the 1-deoxy-D-xylulose 5-phosphate reductoisomerase gene for diterpenoid tanshinone biosynthesis in Salvia miltiorrhiza (Chinese sage) hairy roots

(2008) Shu Jing Wu et al.   BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY

Cryptotanshinone Inhibits Constitutive Signal Transducer and Activator of Transcription 3 Function through Blocking the Dimerization in DU145 Prostate Cancer Cells

(2008) D.-S. Shin et al.   CANCER RESEARCH

Tanshinone I suppresses growth and invasion of human breast cancer cells, MDA-MB-231, through regulation of adhesion molecules

(2008) I. T. Nizamutdinova et al.   CARCINOGENESIS

Tanshinone IIA, an isolated compound from Salvia miltiorrhiza Bunge, induces apoptosis in HeLa cells through mitotic arrest

(2008) Lingli Zhou et al.   LIFE SCIENCES

Anticancer effects of tanshinone I in human non-small cell lung cancer

(2008) C.-Y. Lee et al.   MOLECULAR CANCER THERAPEUTICS

Cytotoxicity of major tanshinones isolated from Danshen (Salvia miltiorrhiza) on HepG2 cells in relation to glutathione perturbation

(2007) W.Y.W. Lee et al.   FOOD AND CHEMICAL TOXICOLOGY

Silencing Geranylgeranyl Diphosphate Synthase in Nicotiana attenuata Dramatically Impairs Resistance to Tobacco Hornworm

(2007) A. R. Jassbi et al.   PLANT PHYSIOLOGY