Mitochondrial Dysfunction and Cardiovascular Disease: Pathophysiology and Emerging Therapies

The role of nutrition in inflammaging

(2022) Paolo Di Giosia et al.   AGEING RESEARCH REVIEWS

Editorial: Mitochondrial Dysfunction and Cardiovascular Diseases

(2021) Junichi Sadoshima et al.   Frontiers in Cardiovascular Medicine

Implications on the Therapeutic Potential of Statins via Modulation of Autophagy

(2021) Armita Mahdavi Gorabi et al.   Oxidative Medicine and Cellular Longevity

Does Empagliflozin Modulate Leukocyte–Endothelium Interactions, Oxidative Stress, and Inflammation in Type 2 Diabetes?

(2021) Francisco Canet et al.   Antioxidants

The cardioprotective actions of statins in targeting mitochondrial dysfunction associated with myocardial ischaemia-reperfusion injury

(2021) Abigail R. Bland et al.   PHARMACOLOGICAL RESEARCH

Autophagy-dependent and -independent modulation of oxidative and organellar stress in the diabetic heart by glucose-lowering drugs

(2020) Milton Packer   Cardiovascular Diabetology

Empagliflozin improves endothelial and cardiomyocyte function in human heart failure with preserved ejection fraction via reduced pro-inflammatory-oxidative pathways and protein kinase Gα oxidation

(2020) Detmar Kolijn et al.   CARDIOVASCULAR RESEARCH

Is MCU dispensable for normal heart function?

(2020) Julia C. Liu   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

The debate continues – What is the role of MCU and mitochondrial calcium uptake in the heart?

(2020) Joanne F. Garbincius et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Effects of Plant and Animal Natural Products on Mitophagy

(2020) Farzaneh Shakeri et al.   Oxidative Medicine and Cellular Longevity

MitoTEMPO provides an antiarrhythmic effect in aged-rats through attenuation of mitochondrial reactive oxygen species

(2020) Yusuf Olgar et al.   EXPERIMENTAL GERONTOLOGY

Mitochondrial ion channels as targets for cardioprotection

(2020) Derek J. Hausenloy et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Molecular nature and regulation of the mitochondrial permeability transition pore(s), drug target(s) in cardioprotection

(2020) Michela Carraro et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Pathophysiological mechanisms of statin‐associated myopathies: possible role of the ubiquitin‐proteasome system

(2020) Amirhossein Sahebkar et al.   Journal of Cachexia Sarcopenia and Muscle

Boosting the autophagy-lysosomal pathway by phytochemicals: A potential therapeutic strategy against Alzheimer's disease

(2020) Fahimeh Nourbakhsh et al.   IUBMB LIFE

The effect of fasting or calorie restriction on mitophagy induction: a literature review

(2020) Sanaz Mehrabani et al.   Journal of Cachexia Sarcopenia and Muscle

Statin therapy and sex hormones

(2020) Cosimo Andrea Stamerra et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Cardioprotective Effect of the Mitochondrial Unfolded Protein Response During Chronic Pressure Overload

(2019) Ioannis Smyrnias et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Identification of an ATP-sensitive potassium channel in mitochondria

(2019) Angela Paggio et al.   NATURE

Oxidative stress and inflammation in the evolution of heart failure: From pathophysiology to therapeutic strategies

(2019) Alberto Aimo et al.   European Journal of Preventive Cardiology

Emerging role of mitophagy in cardiovascular physiology and pathology

(2019) Pablo E. Morales et al.   MOLECULAR ASPECTS OF MEDICINE

Mitochondrial dysfunction and oxidative stress in heart disease

(2019) Jessica N. Peoples et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Neuroprotective effects of curcumin through autophagy modulation

(2019) Fatemeh Forouzanfar et al.   IUBMB LIFE

The Mitochondrial Acylome Emerges: Proteomics, Regulation by Sirtuins, and Metabolic and Disease Implications

(2018) Chris Carrico et al.   Cell Metabolism

MicroRNA-195 Regulates Metabolism in Failing Myocardium Via Alterations in Sirtuin 3 Expression and Mitochondrial Protein Acetylation

(2018) Xiaokan Zhang et al.   CIRCULATION

Gender Differences in Epidemiology, Pathophysiology, and Treatment of Hypertension

(2018) Paolo Di Giosia et al.   Current Atherosclerosis Reports

MitoQ improves mitochondrial dysfunction in heart failure induced by pressure overload

(2018) Rogério Faustino Ribeiro Junior et al.   FREE RADICAL BIOLOGY AND MEDICINE

Chronic Supplementation With a Mitochondrial Antioxidant (MitoQ) Improves Vascular Function in Healthy Older AdultsNovelty and Significance

(2018) Matthew J. Rossman et al.   HYPERTENSION

The Role of Nutraceuticals in Statin Intolerant Patients

(2018) Maciej Banach et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Aspirin Recapitulates Features of Caloric Restriction

(2018) Federico Pietrocola et al.   Cell Reports

The effect of fasting or calorie restriction on autophagy induction: A review of the literature

(2018) Mohammad Bagherniya et al.   AGEING RESEARCH REVIEWS

Impact of curcumin on sirtuins: A review

(2018) Elham Zendedel et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Curcumin: A naturally occurring autophagy modulator

(2018) Abolfazl Shakeri et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Targeting mitochondria for cardiovascular disorders: therapeutic potential and obstacles

(2018) Massimo Bonora et al.   Nature Reviews Cardiology

Uncoupling proteins as a therapeutic target to protect the diabetic heart

(2018) Phiwayinkosi V. Dludla et al.   PHARMACOLOGICAL RESEARCH

NLRP3 inflammasome activation in inflammaging

(2018) Eicke Latz et al.   SEMINARS IN IMMUNOLOGY

Effects of Coenzyme Q10 on Statin‐Induced Myopathy: An Updated Meta‐Analysis of Randomized Controlled Trials

(2018) Hua Qu et al.   Journal of the American Heart Association

A novel antioxidant Mito-Tempol inhibits ox-LDL-induced foam cell formation through restoration of autophagy flux

(2018) Ying Ma et al.   FREE RADICAL BIOLOGY AND MEDICINE

Pharmacologic inhibition of the mitochondrial Na + /Ca 2+ exchanger protects against ventricular arrhythmias in a porcine model of ischemia-reperfusion

(2017) Stefania Sventzouri et al.   Hellenic Journal of Cardiology

Omecamtiv Mecarbil Enhances the Duty Ratio of Human β-Cardiac Myosin Resulting in Increased Calcium Sensitivity and Slowed Force Development in Cardiac Muscle

(2017) Anja M. Swenson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial cardiomyopathies feature increased uptake and diminished efflux of mitochondrial calcium

(2017) Salah Sommakia et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

The mitochondrial Na+/Ca2+ exchanger is essential for Ca2+ homeostasis and viability

(2017) Timothy S. Luongo et al.   NATURE

Regulation of PCSK9 by nutraceuticals

(2017) Amir Abbas Momtazi et al.   PHARMACOLOGICAL RESEARCH

Gender differences in cardiovascular prophylaxis: Focus on antiplatelet treatment

(2017) Paolo Di Giosia et al.   PHARMACOLOGICAL RESEARCH

Attenuated Superoxide Dismutase 2 Activity Induces Atherosclerotic Plaque Instability During Aging in Hyperlipidemic Mice

(2017) Aleksandr E. Vendrov et al.   Journal of the American Heart Association

Nicotinamide Riboside Preserves Cardiac Function in a Mouse Model of Dilated Cardiomyopathy

(2017) Nicolas Diguet et al.   CIRCULATION

What do we not know about mitochondrial potassium channels?

(2016) Michał Laskowski et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Antioxidant effects of resveratrol in the cardiovascular system

(2016) Ning Xia et al.   BRITISH JOURNAL OF PHARMACOLOGY

Normalization of NAD+Redox Balance as a Therapy for Heart FailureClinical Perspective

(2016) Chi Fung Lee et al.   CIRCULATION

Mitochondrial Function, Biology, and Role in Disease

(2016) Elizabeth Murphy et al.   CIRCULATION RESEARCH

Acute Treatment With Omecamtiv Mecarbil to Increase Contractility in Acute Heart Failure

(2016) John R. Teerlink et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Chronic Oral Study of Myosin Activation to Increase Contractility in Heart Failure (COSMIC-HF): a phase 2, pharmacokinetic, randomised, placebo-controlled trial

(2016) John R Teerlink et al.   LANCET

Cardioprotection and lifespan extension by the natural polyamine spermidine

(2016) Tobias Eisenberg et al.   NATURE MEDICINE

Mitochondrial function as a therapeutic target in heart failure

(2016) David A. Brown et al.   Nature Reviews Cardiology

Regulation of the mPTP by SIRT3-mediated deacetylation of CypD at lysine 166 suppresses age-related cardiac hypertrophy

(2016) Angela V. Hafner et al.   Aging-US

Distinct mPTP activation mechanisms in ischaemia–reperfusion: contributions of Ca2+, ROS, pH, and inorganic polyphosphate

(2015) Lea K. Seidlmayer et al.   CARDIOVASCULAR RESEARCH

Interdependence of Parkin-Mediated Mitophagy and Mitochondrial Fission in Adult Mouse HeartsNovelty and Significance

(2015) Moshi Song et al.   CIRCULATION RESEARCH

Epigenetics and Metabolism

(2015) S. T. Keating et al.   CIRCULATION RESEARCH

EMBRACE STEMI study: a Phase 2a trial to evaluate the safety, tolerability, and efficacy of intravenous MTP-131 on reperfusion injury in patients undergoing primary percutaneous coronary intervention

(2015) C. Michael Gibson et al.   EUROPEAN HEART JOURNAL

Mitochondrial calcium and the regulation of metabolism in the heart

(2015) George S.B. Williams et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

The mitochondrial permeability transition pore: Molecular nature and role as a target in cardioprotection

(2015) Paolo Bernardi et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Bendavia restores mitochondrial energy metabolism gene expression and suppresses cardiac fibrosis in the border zone of the infarcted heart

(2015) Jianru Shi et al.   LIFE SCIENCES

Cyclosporine before PCI in Patients with Acute Myocardial Infarction

(2015) Thien-Tri Cung et al.   NEW ENGLAND JOURNAL OF MEDICINE

Statin therapy and plasma coenzyme Q10 concentrations—A systematic review and meta-analysis of placebo-controlled trials

(2015) Maciej Banach et al.   PHARMACOLOGICAL RESEARCH

Mitochondrial calcium overload is a key determinant in heart failure

(2015) Gaetano Santulli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Physiology and relevance of human adaptive thermogenesis response

(2015) Francesco S. Celi et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Mitochondrial uncoupling proteins and energy metabolism

(2015) Rosa A. Busiello et al.   Frontiers in Physiology

Altered proteome turnover and remodeling by short-term caloric restriction or rapamycin rejuvenate the aging heart

(2014) Dao-Fu Dai et al.   AGING CELL

Spermidine induces autophagy by inhibiting the acetyltransferase EP300

(2014) F Pietrocola et al.   CELL DEATH AND DIFFERENTIATION

Myocardial Contractile Dysfunction Is Associated With Impaired Mitochondrial Function and Dynamics in Type 2 Diabetic but Not in Obese Patients

(2014) David Montaigne et al.   CIRCULATION

Histone Deacetylase Inhibition Blunts Ischemia/Reperfusion Injury by Inducing Cardiomyocyte Autophagy

(2014) Min Xie et al.   CIRCULATION

Energy Metabolic Reprogramming in the Hypertrophied and Early Stage Failing Heart

(2014) Ling Lai et al.   Circulation-Heart Failure

Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS

(2014) Edward T. Chouchani et al.   NATURE

Mitochondrial dynamics and inheritance during cell division, development and disease

(2014) Prashant Mishra et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mitochondrial Channels: Ion Fluxes and More

(2014) Ildiko Szabo et al.   PHYSIOLOGICAL REVIEWS

Mitochondrial Reactive Oxygen Species (ROS) and ROS-Induced ROS Release

(2014) Dmitry B. Zorov et al.   PHYSIOLOGICAL REVIEWS

Impaired Autophagy Contributes to Adverse Cardiac Remodeling in Acute Myocardial Infarction

(2014) Xiaoqian Wu et al.   PLoS One

The Effect of Coenzyme Q 10 on Morbidity and Mortality in Chronic Heart Failure

(2014) Svend A. Mortensen et al.   JACC-Heart Failure

Effect of Calcium on the Oxidative Phosphorylation Cascade in Skeletal Muscle Mitochondria

(2013) Brian Glancy et al.   BIOCHEMISTRY

First-in-class cardiolipin-protective compound as a therapeutic agent to restore mitochondrial bioenergetics

(2013) Hazel H Szeto   BRITISH JOURNAL OF PHARMACOLOGY

Role of the c subunit of the FOATP synthase in mitochondrial permeability transition

(2013) Massimo Bonora et al.   CELL CYCLE

Mitochondrial Complex I Deficiency Increases Protein Acetylation and Accelerates Heart Failure

(2013) Georgios Karamanlidis et al.   Cell Metabolism

Reduction of Early Reperfusion Injury With the Mitochondria-Targeting Peptide Bendavia

(2013) David A. Brown et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS

Interactions between sarco-endoplasmic reticulum and mitochondria in cardiac and skeletal muscle - pivotal roles in Ca2+ and reactive oxygen species signaling

(2013) V. Eisner et al.   JOURNAL OF CELL SCIENCE

Mito-Tempol and Dexrazoxane Exhibit Cardioprotective and Chemotherapeutic Effects through Specific Protein Oxidation and Autophagy in a Syngeneic Breast Tumor Preclinical Model

(2013) Jennifer S. Dickey et al.   PLoS One

Dimers of mitochondrial ATP synthase form the permeability transition pore

(2013) V. Giorgio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of mitochondria in steroidogenesis

(2012) Vassilios Papadopoulos et al.   BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM

Structure, function, and assembly of heme centers in mitochondrial respiratory complexes

(2012) Hyung J. Kim et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Cardiac involvement in mitochondrial DNA disease: clinical spectrum, diagnosis, and management

(2012) M. G. D. Bates et al.   EUROPEAN HEART JOURNAL

Mitochondria take center stage

(2012) Shey-Shing Sheu et al.   JOURNAL OF GENERAL PHYSIOLOGY

Mitochondrial superoxide flashes: From discovery to new controversies

(2012) Lan Wei et al.   JOURNAL OF GENERAL PHYSIOLOGY

Molecular identities of mitochondrial Ca2+influx mechanism: Updated passwords for accessing mitochondrial Ca2+-linked health and disease

(2012) Jin O-Uchi et al.   JOURNAL OF GENERAL PHYSIOLOGY

The renaissance of mitochondrial pH

(2012) Jaime Santo-Domingo et al.   JOURNAL OF GENERAL PHYSIOLOGY

Sirtuins as regulators of metabolism and healthspan

(2012) Riekelt H. Houtkooper et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Autophagy limits acute myocardial infarction induced by permanent coronary artery occlusion

(2011) Hiromitsu Kanamori et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Non-histone lysine acetylated proteins in heart failure

(2011) Jean Michel Grillon et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Mitochondrial Targeted Antioxidant Peptide Ameliorates Hypertensive Cardiomyopathy

(2011) Dao-Fu Dai et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter

(2011) Joshua M. Baughman et al.   NATURE

Succinate Dehydrogenase Is a Direct Target of Sirtuin 3 Deacetylase Activity

(2011) Lydia W. S. Finley et al.   PLoS One

PTEN-inducible kinase 1 (PINK1)/Park6 is indispensable for normal heart function

(2011) F. Billia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Expression of mitochondrial fusion–fission proteins during post-infarction remodeling: the effect of NHE-1 inhibition

(2010) Sabzali Javadov et al.   BASIC RESEARCH IN CARDIOLOGY

Sirt1 acts in association with PPAR  to protect the heart from hypertrophy, metabolic dysregulation, and inflammation

(2010) A. Planavila et al.   CARDIOVASCULAR RESEARCH

Mitochondrial fission and fusion

(2010) Iain Scott et al.   Essays in Biochemistry

Prevalence and natural history of heart disease in adults with primary mitochondrial respiratory chain disease

(2010) Giuseppe Limongelli et al.   EUROPEAN JOURNAL OF HEART FAILURE

Therapeutic use of coenzyme Q10and coenzyme Q10-related compounds and formulations

(2010) Jose M Villalba et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

In vivo hyperoxic preconditioning protects against rat-heart ischemia/reperfusion injury by inhibiting mitochondrial permeability transition pore opening and cytochrome c release

(2010) G. Petrosillo et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mitochondrial fission and fusion and their roles in the heart

(2010) Lesley A. Kane et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Myocardial Fatty Acid Metabolism in Health and Disease

(2010) Gary D. Lopaschuk et al.   PHYSIOLOGICAL REVIEWS

Melatonin protects against heart ischemia-reperfusion injury by inhibiting mitochondrial permeability transition pore opening

(2009) Giuseppe Petrosillo et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Mitochondrial OPA1, apoptosis, and heart failure

(2009) Le Chen et al.   CARDIOVASCULAR RESEARCH

Mitochondria-Targeted Antioxidant MitoQ 10 Improves Endothelial Function and Attenuates Cardiac Hypertrophy

(2009) Delyth Graham et al.   HYPERTENSION

Lack of Glutathione Peroxidase 1 Accelerates Cardiac-Specific Hypertrophy and Dysfunction in Angiotensin II Hypertension

(2009) Noelia Ardanaz et al.   HYPERTENSION

A CaPful of mechanisms regulating the mitochondrial permeability transition

(2009) Fabio Di Lisa et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Effect of metoprolol and ivabradine on left ventricular remodelling and Ca2+ handling in the post-infarction rat heart

(2008) M. Maczewski et al.   CARDIOVASCULAR RESEARCH

Is there a role for supplemented antioxidants in the prevention of atherosclerosis?

(2008) Niki Katsiki et al.   CLINICAL NUTRITION

N-acetylcysteine for the prevention of postoperative atrial fibrillation: a prospective, randomized, placebo-controlled pilot study

(2008) M. Ozaydin et al.   EUROPEAN HEART JOURNAL

Antioxidant properties of MitoTEMPOL and its hydroxylamine

(2008) Jan Trnka et al.   FREE RADICAL RESEARCH

Vitamins E and C in the Prevention of Cardiovascular Disease in Men

(2008) Howard D. Sesso   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Effect of Cyclosporine on Reperfusion Injury in Acute Myocardial Infarction

(2008) Christophe Piot et al.   NEW ENGLAND JOURNAL OF MEDICINE