Omecamtiv Mecarbil Enhances the Duty Ratio of Human β-Cardiac Myosin Resulting in Increased Calcium Sensitivity and Slowed Force Development in Cardiac Muscle

Review: The ATPase mechanism of myosin and actomyosin

(2016) Michael A. Geeves   BIOPOLYMERS

Acute Treatment With Omecamtiv Mecarbil to Increase Contractility in Acute Heart Failure

(2016) John R. Teerlink et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Force-producing ADP state of myosin bound to actin

(2016) Sarah F. Wulf et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Omecamtiv Mecarbil Modulates the Kinetic and Motile Properties of Porcine β-Cardiac Myosin

(2015) Yingying Liu et al.   BIOCHEMISTRY

Myosin Activator Omecamtiv Mecarbil Increases Myocardial Oxygen Consumption and Impairs Cardiac Efficiency Mediated by Resting Myosin ATPase ActivityCLINICAL PERSPECTIVE

(2015) Jens Petter Bakkehaug et al.   Circulation-Heart Failure

Omecamtiv Mecarbil, a Cardiac Myosin Activator, Increases Ca2+ Sensitivity in Myofilaments With a Dilated Cardiomyopathy Mutant Tropomyosin E54K

(2015) Megan S. Utter et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Molecular effects of the myosin activator omecamtiv mecarbil on contractile properties of skinned myocardium lacking cardiac myosin binding protein-C

(2015) Ranganath Mamidi et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Direct real-time detection of the structural and biochemical events in the myosin power stroke

(2015) Joseph M. Muretta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Velocities of unloaded muscle filaments are not limited by drag forces imposed by myosin cross-bridges

(2015) Richard K. Brizendine et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Direct measurements of the coordination of lever arm swing and the catalytic cycle in myosin V

(2015) Darshan V. Trivedi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural basis for drug-induced allosteric changes to human β-cardiac myosin motor activity

(2015) Donald A. Winkelmann et al.   Nature Communications

Ensemble Force Changes that Result from Human Cardiac Myosin Mutations and a Small-Molecule Effector

(2015) Tural Aksel et al.   Cell Reports

Safety and Tolerability of Omecamtiv Mecarbil During Exercise in Patients With Ischemic Cardiomyopathy and Angina

(2015) Barry H. Greenberg et al.   JACC-Heart Failure

Contractility parameters of human  -cardiac myosin with the hypertrophic cardiomyopathy mutation R403Q show loss of motor function

(2015) S. Nag et al.   Science Advances

Analytical Comparison of Natural and Pharmaceutical Ventricular Myosin Activators

(2014) Yihua Wang et al.   BIOCHEMISTRY

The Kinetics Underlying the Velocity of Smooth Muscle Myosin Filament Sliding on Actin Filamentsin Vitro

(2014) Brian D. Haldeman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transmural heterogeneity of cellular level power output is reduced in human heart failure

(2014) Premi Haynes et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

To understand muscle you must take it apart

(2014) Christopher Batters et al.   Frontiers in Physiology

Research Advances in Heart Failure

(2013) Eugene Braunwald   CIRCULATION RESEARCH

Molecular consequences of the R453C hypertrophic cardiomyopathy mutation on human  -cardiac myosin motor function

(2013) R. F. Sommese et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Getting the skinny on thick filament regulation in cardiac muscle biology and disease

(2013) Farah Sheikh et al.   TRENDS IN CARDIOVASCULAR MEDICINE

Molecular Mechanics of Cardiac Myosin-Binding Protein C in Native Thick Filaments

(2012) M. J. Previs et al.   SCIENCE

Heart Disease and Stroke Statistics—2012 Update

(2011) et al.   CIRCULATION

The effects of the cardiac myosin activator, omecamtiv mecarbil, on cardiac function in systolic heart failure: a double-blind, placebo-controlled, crossover, dose-ranging phase 2 trial

(2011) John GF Cleland et al.   LANCET

Cardiac Myosin Activation: A Potential Therapeutic Approach for Systolic Heart Failure

(2011) F. I. Malik et al.   SCIENCE

Intermolecular Autophosphorylation Regulates Myosin IIIa Activity and Localization in Parallel Actin Bundles

(2010) Omar A. Quintero et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Emerging complex pathways of the actomyosin powerstroke

(2010) András Málnási-Csizmadia et al.   TRENDS IN BIOCHEMICAL SCIENCES

Inotropes in the management of acute heart failure

(2009) John W. Petersen et al.   CRITICAL CARE MEDICINE

Agents with inotropic properties for the management of acute heart failure syndromes. Traditional agents and beyond

(2009) John R. Teerlink et al.   HEART FAILURE REVIEWS

Drug Effect Unveils Inter-head Cooperativity and Strain-dependent ADP Release in Fast Skeletal Actomyosin

(2009) Nuria Albet-Torres et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Kinase Domain Alters the Kinetic Properties of the Myosin IIIA Motor†

(2008) Andréa C. Dosé et al.   BIOCHEMISTRY