Pridopidine Induces Functional Neurorestoration Via the Sigma-1 Receptor in a Mouse Model of Parkinson’s Disease
Published 2019 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Pridopidine Induces Functional Neurorestoration Via the Sigma-1 Receptor in a Mouse Model of Parkinson’s Disease
Authors
Keywords
MAM, endoplasmic reticulum, disease modification, neuroprotection, neuroinflammation, plasticity
Journal
Neurotherapeutics
Volume -, Issue -, Pages -
Publisher
Springer Nature
Online
2019-02-13
DOI
10.1007/s13311-018-00699-9
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Relationship between Sigma-1 receptor and BDNF in the visual system
- (2018) Barbara A. Mysona et al. EXPERIMENTAL EYE RESEARCH
- Disease Modification in Parkinson's Disease: Current Approaches, Challenges, and Future Considerations
- (2018) Anthony E. Lang et al. MOVEMENT DISORDERS
- Striatal Reinnervation Process after Acute Methamphetamine-Induced Dopaminergic Degeneration in Mice
- (2018) Noelia Granado et al. NEUROTOXICITY RESEARCH
- Vitamin D protects dopaminergic neurons against neuroinflammation and oxidative stress in hemiparkinsonian rats
- (2018) Ludmila A R Lima et al. Journal of Neuroinflammation
- Neuroprotection and neurorestoration as experimental therapeutics for Parkinson's disease
- (2017) Veronica Francardo et al. EXPERIMENTAL NEUROLOGY
- Animal models of l-DOPA-induced dyskinesia: the 6-OHDA-lesioned rat and mouse
- (2017) Elisabetta Tronci et al. JOURNAL OF NEURAL TRANSMISSION
- Sigma-1 receptor knockout increases α-synuclein aggregation and phosphorylation with loss of dopaminergic neurons in substantia nigra
- (2017) Juan Hong et al. NEUROBIOLOGY OF AGING
- The sigma-1 receptor mediates the beneficial effects of pridopidine in a mouse model of Huntington disease
- (2017) Daniel Ryskamp et al. NEUROBIOLOGY OF DISEASE
- Neuroprotective Activities of Spirulina platensis in the 6-OHDA Model of Parkinson’s Disease Are Related to Its Anti-Inflammatory Effects
- (2017) Francisco Arnaldo Viana Lima et al. NEUROCHEMICAL RESEARCH
- Pridopidine activates neuroprotective pathways impaired in Huntington Disease
- (2016) Michal Geva et al. HUMAN MOLECULAR GENETICS
- Anti-Inflammatory Modulation of Microglia via CD163-Targeted Glucocorticoids Protects Dopaminergic Neurons in the 6-OHDA Parkinson's Disease Model
- (2016) Noemie Tentillier et al. JOURNAL OF NEUROSCIENCE
- Pridopidine, a dopamine stabilizer, improves motor performance and shows neuroprotective effects in Huntington disease R6/2 mouse model
- (2015) Ferdinando Squitieri et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- Pridopidine selectively occupies sigma-1 rather than dopamine D2 receptors at behaviorally active doses
- (2015) Kristoffer Sahlholm et al. PSYCHOPHARMACOLOGY
- Sigma-1 receptor deficiency reduces MPTP-induced parkinsonism and death of dopaminergic neurons
- (2015) J Hong et al. Cell Death & Disease
- Pharmacological stimulation of sigma-1 receptors has neurorestorative effects in experimental parkinsonism
- (2014) Veronica Francardo et al. BRAIN
- Neuroprotection by 6-(methylsulfinyl)hexyl isothiocyanate in a 6-hydroxydopamine mouse model of Parkinson׳s disease
- (2014) Fabiana Morroni et al. BRAIN RESEARCH
- Disease duration and the integrity of the nigrostriatal system in Parkinson’s disease
- (2013) Jeffrey H. Kordower et al. BRAIN
- Doxycycline restrains glia and confers neuroprotection in a 6-OHDA Parkinson model
- (2013) Marcio Lazzarini et al. GLIA
- Altered localization, abnormal modification and loss of function of Sigma receptor-1 in amyotrophic lateral sclerosis
- (2013) J. Prause et al. HUMAN MOLECULAR GENETICS
- A randomized, double-blind, placebo-controlled trial of pridopidine in Huntington's disease
- (2013) MOVEMENT DISORDERS
- Neuroprotective effects of the Sigma-1 receptor (S1R) agonist PRE-084, in a mouse model of motor neuron disease not linked to SOD1 mutation
- (2013) Marco Peviani et al. NEUROBIOLOGY OF DISEASE
- Blockade of Tau Hyperphosphorylation and Aβ1–42 Generation by the Aminotetrahydrofuran Derivative ANAVEX2-73, a Mixed Muscarinic and σ1 Receptor Agonist, in a Nontransgenic Mouse Model of Alzheimer’s Disease
- (2013) Valentine Lahmy et al. NEUROPSYCHOPHARMACOLOGY
- Microglia and macrophages of the central nervous system: the contribution of microglia priming and systemic inflammation to chronic neurodegeneration
- (2013) V. Hugh Perry et al. Seminars in Immunopathology
- The dopamine stabilizers ACR16 and (−)-OSU6162 display nanomolar affinities at the σ-1 receptor
- (2012) K Sahlholm et al. MOLECULAR PSYCHIATRY
- Sigma-1R Agonist Improves Motor Function and Motoneuron Survival in ALS Mice
- (2012) Renzo Mancuso et al. Neurotherapeutics
- Effects of the Sigma-1 Receptor Agonist 1-(3,4-Dimethoxyphenethyl)-4-(3-Phenylpropyl)-Piperazine Dihydro-Chloride on Inflammation after Stroke
- (2012) Karsten Ruscher et al. PLoS One
- Sigma-1 receptor chaperones regulate the secretion of brain-derived neurotrophic factor
- (2012) Michiko Fujimoto et al. SYNAPSE
- The sigma-1 receptor enhances brain plasticity and functional recovery after experimental stroke
- (2011) Karsten Ruscher et al. BRAIN
- Regional Cerebral Glucose Metabolism After Pridopidine (ACR16) Treatment in Patients With Huntington Disease
- (2011) Mouna Esmaeilzadeh et al. CLINICAL NEUROPHARMACOLOGY
- Sigma Receptor Agonist 2-(4-Morpholinethyl)1 Phenylcyclohexanecarboxylate (Pre084) Increases GDNF and BiP Expression and Promotes Neuroprotection after Root Avulsion Injury
- (2011) Clara Penas et al. JOURNAL OF NEUROTRAUMA
- Pridopidine for the treatment of motor function in patients with Huntington's disease (MermaiHD): a phase 3, randomised, double-blind, placebo-controlled trial
- (2011) Justo Garcia de Yebenes et al. LANCET NEUROLOGY
- Impact of the lesion procedure on the profiles of motor impairment and molecular responsiveness to L-DOPA in the 6-hydroxydopamine mouse model of Parkinson's disease
- (2011) Veronica Francardo et al. NEUROBIOLOGY OF DISEASE
- Efficacy and Safety of the Dopaminergic Stabilizer Pridopidine (ACR16) in Patients With Huntington's Disease
- (2010) Anders Lundin et al. CLINICAL NEUROPHARMACOLOGY
- In vivo pharmacology of the dopaminergic stabilizer pridopidine
- (2010) Henrik Ponten et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Anti-amnesic and neuroprotective potentials of the mixed muscarinic receptor/sigma1 (σ1) ligand ANAVEX2-73, a novel aminotetrahydrofuran derivative
- (2010) Vanessa Villard et al. JOURNAL OF PSYCHOPHARMACOLOGY
- The dopaminergic stabilizers pridopidine (ACR16) and (−)-OSU6162 display dopamine D2 receptor antagonism and fast receptor dissociation properties
- (2009) Tino Dyhring et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Stepping test in mice: A reliable approach in determining forelimb akinesia in MPTP-induced Parkinsonism
- (2009) Shannon R. Blume et al. EXPERIMENTAL NEUROLOGY
- Neuroinflammation in Parkinson's disease: Its role in neuronal death and implications for therapeutic intervention
- (2009) Malú G. Tansey et al. NEUROBIOLOGY OF DISEASE
- The pharmacology of sigma-1 receptors
- (2009) Tangui Maurice et al. PHARMACOLOGY & THERAPEUTICS
- Effects of (−)-OSU6162 and ACR16 on motor activity in rats, indicating a unique mechanism of dopaminergic stabilization
- (2008) Johan P. Rung et al. JOURNAL OF NEURAL TRANSMISSION
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExplorePublish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn More