Gene expression parallels synaptic excitability and plasticity changes in Alzheimer’s disease

Prediction of Mild Cognitive Impairment that Evolves into Alzheimer's Disease Dementia within Two Years using a Gene Expression Signature in Blood: A Pilot Study

(2018) Line Roed et al.   JOURNAL OF ALZHEIMERS DISEASE

Blood Genome-Wide Transcriptional Profiles Reflect Broad Molecular Impairments and Strong Blood-Brain Links in Alzheimer's Disease

(2018) Bartholomew J. Naughton et al.   JOURNAL OF ALZHEIMERS DISEASE

Regional Selectivity of rab5 and rab7 Protein Upregulation in Mild Cognitive Impairment and Alzheimer's Disease

(2017) Stephen D. Ginsberg et al.   JOURNAL OF ALZHEIMERS DISEASE

The case for rejecting the amyloid cascade hypothesis

(2015) Karl Herrup   NATURE NEUROSCIENCE

Alzheimer's disease is associated with altered expression of genes involved in immune response and mitochondrial processes in astrocytes

(2015) Shobana Sekar et al.   NEUROBIOLOGY OF AGING

Pyruvate prevents the development of age-dependent cognitive deficits in a mouse model of Alzheimer's disease without reducing amyloid and tau pathology

(2015) Elisa Isopi et al.   NEUROBIOLOGY OF DISEASE

A Genome-wide Gene-Expression Analysis and Database in Transgenic Mice during Development of Amyloid or Tau Pathology

(2015) Mar Matarin et al.   Cell Reports

Valproate Improves Memory Deficits in an Alzheimer’s disease Mouse Model: Investigation of Possible Mechanisms of Action

(2014) Zhi-Gang Yao et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Disrupted Intrinsic Networks Link Amyloid-β Pathology and Impaired Cognition in Prodromal Alzheimer's Disease

(2014) Kathrin Koch et al.   CEREBRAL CORTEX

Crtc1 Activates a Transcriptional Program Deregulated at Early Alzheimer's Disease-Related Stages

(2014) A. Parra-Damas et al.   JOURNAL OF NEUROSCIENCE

Alzheimer's Disease-Like Pathology Induced by Amyloid-β Oligomers in Nonhuman Primates

(2014) Leticia Forny-Germano et al.   JOURNAL OF NEUROSCIENCE

SNAP-25 is a promising novel cerebrospinal fluid biomarker for synapse degeneration in Alzheimer’s disease

(2014) Ann Brinkmalm et al.   Molecular Neurodegeneration

Temporal gene profiling of the 5XFAD transgenic mouse model highlights the importance of microglial activation in Alzheimer’s disease

(2014) Véréna Landel et al.   Molecular Neurodegeneration

Alzheimer's disease: early alterations in brain DNA methylation at ANK1, BIN1, RHBDF2 and other loci

(2014) Philip L De Jager et al.   NATURE NEUROSCIENCE

Brain gene expression patterns differentiate mild cognitive impairment from normal aged and Alzheimer's disease

(2014) Nicole C. Berchtold et al.   NEUROBIOLOGY OF AGING

The Evolution of Preclinical Alzheimer’s Disease: Implications for Prevention Trials

(2014) Reisa Sperling et al.   NEURON

The Intersection of Amyloid Beta and Tau at Synapses in Alzheimer’s Disease

(2014) Tara L. Spires-Jones et al.   NEURON

Two Phase 3 Trials of Bapineuzumab in Mild-to-Moderate Alzheimer's Disease

(2014) Stephen Salloway et al.   NEW ENGLAND JOURNAL OF MEDICINE

Phase 3 Trials of Solanezumab for Mild-to-Moderate Alzheimer's Disease

(2014) Rachelle S. Doody et al.   NEW ENGLAND JOURNAL OF MEDICINE

Increased Hippocampal Excitability in the 3xTgAD Mouse Model for Alzheimer's Disease In Vivo

(2014) Katherine E. Davis et al.   PLoS One

Specific Disruption of Hippocampal Mossy Fiber Synapses in a Mouse Model of Familial Alzheimer's Disease

(2014) Scott A. Wilke et al.   PLoS One

Early and sustained altered expression of aging-related genes in young 3xTg-AD mice

(2014) V Gatta et al.   Cell Death & Disease

APP Homodimers Transduce an Amyloid-β-Mediated Increase in Release Probability at Excitatory Synapses

(2014) Hilla Fogel et al.   Cell Reports

Age-Dependent Modifications of AMPA Receptor Subunit Expression Levels and Related Cognitive Effects in 3xTg-AD Mice

(2014) Pamela Cantanelli et al.   Frontiers in Aging Neuroscience

MicroRNA in Alzheimer’s disease: an exploratory study in brain, cerebrospinal fluid and plasma

(2013) Lynn M. Bekris et al.   BIOMARKERS

The influence of phospho-tau on dendritic spines of cortical pyramidal neurons in patients with Alzheimer’s disease

(2013) Paula Merino-Serrais et al.   BRAIN

DNA methylation map of mouse and human brain identifies target genes in Alzheimer’s disease

(2013) Jose V. Sanchez-Mut et al.   BRAIN

Alteration of the microRNA network during the progression of Alzheimer's disease

(2013) Pierre Lau et al.   EMBO Molecular Medicine

 -Amyloid Disrupts Activity-Dependent Gene Transcription Required for Memory through the CREB Coactivator CRTC1

(2013) J. Espana et al.   JOURNAL OF NEUROSCIENCE

Consistent decrease in global DNA methylation and hydroxymethylation in the hippocampus of Alzheimer's disease patients

(2013) Leonidas Chouliaras et al.   NEUROBIOLOGY OF AGING

Impaired default network functional connectivity in autosomal dominant Alzheimer disease

(2013) J. P. Chhatwal et al.   NEUROLOGY

Synaptic gene dysregulation within hippocampal CA1 pyramidal neurons in mild cognitive impairment

(2013) Scott E. Counts et al.   NEUROPHARMACOLOGY

A  induces astrocytic glutamate release, extrasynaptic NMDA receptor activation, and synaptic loss

(2013) M. Talantova et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Brain homogenates from human tauopathies induce tau inclusions in mouse brain

(2013) Florence Clavaguera et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neuronal dark matter: the emerging role of microRNAs in neurodegeneration

(2013) Emily F. Goodall et al.   Frontiers in Cellular Neuroscience

Circulating microRNAs in Alzheimer’s disease: the search for novel biomarkers

(2013) Véronique Dorval et al.   Frontiers in Molecular Neuroscience

Hippocampal subfield volumetry in mild cognitive impairment, Alzheimer's disease and semantic dementia

(2013) Renaud La Joie et al.   NeuroImage-Clinical

Inhibitory Interneuron Deficit Links Altered Network Activity and Cognitive Dysfunction in Alzheimer Model

(2012) Laure Verret et al.   CELL

Increased Cortical and Thalamic Excitability in Freely Moving APPswe/PS1dE9 Mice Modeling Epileptic Activity Associated with Alzheimer's Disease

(2012) Kestutis Gurevicius et al.   CEREBRAL CORTEX

Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study

(2012) David H Cribbs et al.   Journal of Neuroinflammation

Correlation of Alzheimer Disease Neuropathologic Changes With Cognitive Status: A Review of the Literature

(2012) Peter T. Nelson et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Brain imaging and fluid biomarker analysis in young adults at genetic risk for autosomal dominant Alzheimer's disease in the presenilin 1 E280A kindred: a case-control study

(2012) Eric M Reiman et al.   LANCET NEUROLOGY

Orchestrated experience-driven Arc responses are disrupted in a mouse model of Alzheimer's disease

(2012) Nikita Rudinskiy et al.   NATURE NEUROSCIENCE

Age-associated changes in gene expression in human brain and isolated neurons

(2012) Azad Kumar et al.   NEUROBIOLOGY OF AGING

Synaptic genes are extensively downregulated across multiple brain regions in normal human aging and Alzheimer's disease

(2012) Nicole C. Berchtold et al.   NEUROBIOLOGY OF AGING

Reduction of Hippocampal Hyperactivity Improves Cognition in Amnestic Mild Cognitive Impairment

(2012) Arnold Bakker et al.   NEURON

Transcriptional Alterations Related to Neuropathology and Clinical Manifestation of Alzheimer’s Disease

(2012) Aderbal R. T. Silva et al.   PLoS One

Levetiracetam suppresses neuronal network dysfunction and reverses synaptic and cognitive deficits in an Alzheimer's disease model

(2012) P. E. Sanchez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Soluble Oligomers of Amyloid-β Peptide Disrupt Membrane Trafficking of α-Amino-3-hydroxy-5-methylisoxazole-4-propionic Acid Receptor Contributing to Early Synapse Dysfunction

(2011) Alfredo J. Miñano-Molina et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Reduced Spine Density in Specific Regions of CA1 Pyramidal Neurons in Two Transgenic Mouse Models of Alzheimer's Disease

(2011) C. Perez-Cruz et al.   JOURNAL OF NEUROSCIENCE

Neuronal activity regulates the regional vulnerability to amyloid-β deposition

(2011) Adam W Bero et al.   NATURE NEUROSCIENCE

Microarray analysis of the astrocyte transcriptome in the aging brain: relationship to Alzheimer's pathology and APOE genotype

(2011) Julie E. Simpson et al.   NEUROBIOLOGY OF AGING

Structural MRI changes detectable up to ten years before clinical Alzheimer's disease

(2011) Manuela Tondelli et al.   NEUROBIOLOGY OF AGING

Gene expression profiling of peripheral blood leukocytes identifies and validates ABCB1 as a novel biomarker for Alzheimer's disease

(2011) Kuang-Den Chen et al.   NEUROBIOLOGY OF DISEASE

Microarray analysis of CA1 pyramidal neurons in a mouse model of tauopathy reveals progressive synaptic dysfunction

(2011) Melissa J. Alldred et al.   NEUROBIOLOGY OF DISEASE

Gene expression levels assessed by CA1 pyramidal neuron and regional hippocampal dissections in Alzheimer's disease

(2011) Stephen D. Ginsberg et al.   NEUROBIOLOGY OF DISEASE

Chronic divalproex sodium use and brain atrophy in Alzheimer disease

(2011) A. S. Fleisher et al.   NEUROLOGY

Increasing CREB Function in the CA1 Region of Dorsal Hippocampus Rescues the Spatial Memory Deficits in a Mouse Model of Alzheimer's Disease

(2011) Adelaide P Yiu et al.   NEUROPSYCHOPHARMACOLOGY

Mild Cognitive Impairment

(2011) Ronald C. Petersen   NEW ENGLAND JOURNAL OF MEDICINE

Identification and Validation of Novel Cerebrospinal Fluid Biomarkers for Staging Early Alzheimer's Disease

(2011) Richard J. Perrin et al.   PLoS One

Molecular Insights into the Pathogenesis of Alzheimer's Disease and Its Relationship to Normal Aging

(2011) Alexei A. Podtelezhnikov et al.   PLoS One

The role of CREB signaling in Alzheimer’s disease and other cognitive disorders

(2011) Carlos A. Saura et al.   REVIEWS IN THE NEUROSCIENCES

Neuronal Activity-Regulated Gene Transcription in Synapse Development and Cognitive Function

(2011) A. E. West et al.   Cold Spring Harbor Perspectives in Biology

Concerted changes in transcripts in the prefrontal cortex precede neuropathology in Alzheimer's disease

(2010) Koen Bossers et al.   BRAIN

Phenylbutyrate rescues dendritic spine loss associated with memory deficits in a mouse model of Alzheimer disease

(2010) Ana Ricobaraza et al.   HIPPOCAMPUS

Caspase-3 triggers early synaptic dysfunction in a mouse model of Alzheimer's disease

(2010) Marcello D'Amelio et al.   NATURE NEUROSCIENCE

Longitudinal fMRI in elderly reveals loss of hippocampal activation with clinical decline

(2010) J. L. O'Brien et al.   NEUROLOGY

Functional Alterations in Memory Networks in Early Alzheimer’s Disease

(2010) Reisa A. Sperling et al.   NEUROMOLECULAR MEDICINE

Uncovering Molecular Biomarkers That Correlate Cognitive Decline with the Changes of Hippocampus' Gene Expression Profiles in Alzheimer's Disease

(2010) Martín Gómez Ravetti et al.   PLoS One

Intraneuronal β-Amyloid Accumulation in the Amygdala Enhances Fear and Anxiety in Alzheimer's Disease Transgenic Mice

(2009) Judit España et al.   BIOLOGICAL PSYCHIATRY

Amyloid Plaques Disrupt Resting State Default Mode Network Connectivity in Cognitively Normal Elderly

(2009) Yvette I. Sheline et al.   BIOLOGICAL PSYCHIATRY

Epigenetic dysregulation in cognitive disorders

(2009) Johannes Gräff et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Disruption of Functional Connectivity in Clinically Normal Older Adults Harboring Amyloid Burden

(2009) T. Hedden et al.   JOURNAL OF NEUROSCIENCE

A Role for Synaptic Zinc in Activity-Dependent A  Oligomer Formation and Accumulation at Excitatory Synapses

(2009) A. Deshpande et al.   JOURNAL OF NEUROSCIENCE

Amyloid  -Induced Neuronal Hyperexcitability Triggers Progressive Epilepsy

(2009) R. Minkeviciene et al.   JOURNAL OF NEUROSCIENCE

Genome wide profiling of altered gene expression in the neocortex of Alzheimer's disease

(2009) Michelle G. Tan et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Amyloid-β as a positive endogenous regulator of release probability at hippocampal synapses

(2009) Efrat Abramov et al.   NATURE NEUROSCIENCE

Cerebrospinal Fluid Concentration of Brain-Derived Neurotrophic Factor and Cognitive Function in Non-Demented Subjects

(2009) Ge Li et al.   PLoS One

Reversal of long-term dendritic spine alterations in Alzheimer disease models

(2009) D. L. Smith et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Brain's Default Network

(2008) Randy L. Buckner et al.   Annals of the New York Academy of Sciences

Abnormal Functional Connectivity of Hippocampus During Episodic Memory Retrieval Processing Network in Amnestic Mild Cognitive Impairment

(2008) Feng Bai et al.   BIOLOGICAL PSYCHIATRY

A Systems Level Analysis of Transcriptional Changes in Alzheimer's Disease and Normal Aging

(2008) J. A. Miller et al.   JOURNAL OF NEUROSCIENCE

Neuronal gene expression in non-demented individuals with intermediate Alzheimer's Disease neuropathology

(2008) Winnie S. Liang et al.   NEUROBIOLOGY OF AGING

Significant structural but not physiological changes in cortical neurons of 12-month-old Tg2576 mice

(2008) Anne B. Rocher et al.   NEUROBIOLOGY OF DISEASE

Aged wild-type and APP, PS1, and APP+PS1 mice present similar deficits in associative learning and synaptic plasticity independent of amyloid load

(2008) A. Gruart et al.   NEUROBIOLOGY OF DISEASE

Altered fMRI activation during mental rotation in those at genetic risk for Alzheimer disease

(2008) M. A. Yassa et al.   NEUROLOGY

Gene expression changes in the course of normal brain aging are sexually dimorphic

(2008) N. C. Berchtold et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alzheimer's disease is associated with reduced expression of energy metabolism genes in posterior cingulate neurons

(2008) W. S. Liang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Clusters of Hyperactive Neurons Near Amyloid Plaques in a Mouse Model of Alzheimer's Disease

(2008) M. A. Busche et al.   SCIENCE

Identification of a novel panel of cerebrospinal fluid biomarkers for Alzheimer's disease

(2007) A.H. Simonsen et al.   NEUROBIOLOGY OF AGING

Deregulation of NMDA-receptor function and down-stream signaling in APP[V717I] transgenic mice

(2007) I. Dewachter et al.   NEUROBIOLOGY OF AGING