Tale of the Good and the Bad Cdk5: Remodeling of the Actin Cytoskeleton in the Brain
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Title
Tale of the Good and the Bad Cdk5: Remodeling of the Actin Cytoskeleton in the Brain
Authors
Keywords
Cdk5, p25, p35, β-Amyloid, Neuronal cytoskeleton, Actin, Microtubules, Remodeling, Cdk, Cyclins, Neurodegeneration, Alzheimer’s disease, Parkinson’s disease, Dendritic spines, Neurotransmitters, Synaptic plasticity, Learning and memory, Neuronal migration, Axonal growth, Neurotransmitters, Synaptogenesis, Drug addiction, Ephexin1, p25, Mst3, CaMKv, Kalirin-7, RasGRF2, Pak1, WAVE1, Neurabin-1, TrkB, 5-HT6R, Talin, Drebrin, Synapsin I, Synapsin III, CRMP1, GKAP, SPAR, PSD-95, LRRK2
Journal
MOLECULAR NEUROBIOLOGY
Volume 55, Issue 4, Pages 3426-3438
Publisher
Springer Nature
Online
2017-05-13
DOI
10.1007/s12035-017-0525-3
References
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Related references
Note: Only part of the references are listed.- Cdk5–Foxo3 axis: initially neuroprotective, eventually neurodegenerative in Alzheimer's disease models
- (2016) Chun Shi et al. JOURNAL OF CELL SCIENCE
- A Tale of the Good and Bad: Remodeling of the Microtubule Network in the Brain by Cdk5
- (2016) Kavita Shah et al. MOLECULAR NEUROBIOLOGY
- Parkinson-Related LRRK2 Mutation R1628P Enables Cdk5 Phosphorylation of LRRK2 and Upregulates Its Kinase Activity
- (2016) Yang Shu et al. PLoS One
- The pseudokinase CaMKv is required for the activity-dependent maintenance of dendritic spines
- (2016) Zhuoyi Liang et al. Nature Communications
- Functional characterization of CDK5 and CDK5R1 mutations identified in patients with non-syndromic intellectual disability
- (2015) Silvia Moncini et al. JOURNAL OF HUMAN GENETICS
- Phosphorylation by PKA and Cdk5 Mediates the Early Effects of Synapsin III in Neuronal Morphological Maturation
- (2015) A. Piccini et al. JOURNAL OF NEUROSCIENCE
- Synapsin III Acts Downstream of Semaphorin 3A/CDK5 Signaling to Regulate Radial Migration and Orientation of Pyramidal Neurons In Vivo
- (2015) Laura E. Perlini et al. Cell Reports
- Phosphorylation of Cyclin-dependent Kinase 5 (Cdk5) at Tyr-15 Is Inhibited by Cdk5 Activators and Does Not Contribute to the Activation of Cdk5
- (2014) Hiroyuki Kobayashi et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Cdk5 activity in the brain - multiple paths of regulation
- (2014) K. Shah et al. JOURNAL OF CELL SCIENCE
- Cdk5-Dependent Mst3 Phosphorylation and Activity Regulate Neuronal Migration through RhoA Inhibition
- (2014) J. Tang et al. JOURNAL OF NEUROSCIENCE
- Phosphorylation of Synapsin I by Cyclin-Dependent Kinase-5 Sets the Ratio between the Resting and Recycling Pools of Synaptic Vesicles at Hippocampal Synapses
- (2014) A. M. J. Verstegen et al. JOURNAL OF NEUROSCIENCE
- Ischemic Stroke Injury Is Mediated by Aberrant Cdk5
- (2014) D. A. Meyer et al. JOURNAL OF NEUROSCIENCE
- Preferential targeting of p39-activated Cdk5 to Rac1-induced lamellipodia
- (2014) Yuki Ito et al. MOLECULAR AND CELLULAR NEUROSCIENCE
- CRMP1 Interacted with Spy1 During the Collapse of Growth Cones Induced by Sema3A and Acted on Regeneration After Sciatic Nerve Crush
- (2014) Li Yao et al. MOLECULAR NEUROBIOLOGY
- Cdk5 induces constitutive activation of 5-HT6 receptors to promote neurite growth
- (2014) Fanny Duhr et al. Nature Chemical Biology
- Locomotor conditioning by amphetamine requires cyclin-dependent kinase 5 signaling in the nucleus accumbens
- (2014) Bryan F. Singer et al. NEUROPHARMACOLOGY
- Phosphorylation of Drebrin by Cyclin-Dependent Kinase 5 and Its Role in Neuronal Migration
- (2014) Kazuya Tanabe et al. PLoS One
- Axon growth inhibition by RhoA/ROCK in the central nervous system
- (2014) Yuki Fujita et al. Frontiers in Neuroscience
- Drebrin contains a cryptic F-actin–bundling activity regulated by Cdk5 phosphorylation
- (2013) Daniel C. Worth et al. JOURNAL OF CELL BIOLOGY
- Mice lacking collapsin response mediator protein 1 manifest hyperactivity, impaired learning and memory, and impaired prepulse inhibition
- (2013) Naoya Yamashita et al. Frontiers in Behavioral Neuroscience
- Major channels involved in neuropsychiatric disorders and therapeutic perspectives
- (2013) Paola Imbrici et al. Frontiers in Genetics
- Deregulated Cdk5 Activity Is Involved in Inducing Alzheimer’s Disease
- (2012) Varsha Shukla et al. ARCHIVES OF MEDICAL RESEARCH
- Deregulated Cdk5 triggers aberrant activation of cell cycle kinases and phosphatases inducing neuronal death
- (2012) K.-H. Chang et al. JOURNAL OF CELL SCIENCE
- Interplay between MEK-ERK signaling, cyclin D1, and cyclin-dependent kinase 5 regulates cell cycle reentry and apoptosis of neurons
- (2012) Prashant Kumar Modi et al. MOLECULAR BIOLOGY OF THE CELL
- Schizophrenia is associated with dysregulation of a Cdk5 activator that regulates synaptic protein expression and cognition
- (2011) Olivia Engmann et al. BRAIN
- Cyclin E Constrains Cdk5 Activity to Regulate Synaptic Plasticity and Memory Formation
- (2011) Junko Odajima et al. DEVELOPMENTAL CELL
- Glutathione-S-transferase P1 is a critical regulator of Cdk5 kinase activity
- (2011) Kai-Hui Sun et al. JOURNAL OF NEUROCHEMISTRY
- PSD-95 Is Required to Sustain the Molecular Organization of the Postsynaptic Density
- (2011) X. Chen et al. JOURNAL OF NEUROSCIENCE
- Nuclear envelope dispersion triggered by deregulated Cdk5 precedes neuronal death
- (2011) Kuei-Hua Chang et al. MOLECULAR BIOLOGY OF THE CELL
- CDK5 Is Essential for Soluble Amyloid β-Induced Degradation of GKAP and Remodeling of the Synaptic Actin Cytoskeleton
- (2011) Francesco Roselli et al. PLoS One
- Synapsin regulation of vesicle organization and functional pools
- (2011) Maria Bykhovskaia SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
- Kalirin-7 is a Key Player in the Formation of Excitatory Synapses in Hippocampal Neurons
- (2011) Xin-Ming Ma TheScientificWorldJOURNAL
- Cdk5: a multifaceted kinase in neurodegenerative diseases
- (2011) Zelda H. Cheung et al. TRENDS IN CELL BIOLOGY
- Dynamics of the Rho-family small GTPases in actin regulation and motility
- (2011) Désirée Spiering et al. Cell Adhesion & Migration
- Attention-Deficit/Hyperactivity Phenotype in Mice Lacking the Cyclin-Dependent Kinase 5 Cofactor p35
- (2010) Justin M. Drerup et al. BIOLOGICAL PSYCHIATRY
- Cyclin I-Cdk5 governs survival in post-mitotic cells
- (2010) Paul T. Brinkkoetter et al. CELL CYCLE
- The neuronal p35 activator of Cdk5 is a novel F-actin binding and bundling protein
- (2010) Lisheng He et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Actin in dendritic spines: connecting dynamics to function
- (2010) Pirta Hotulainen et al. JOURNAL OF CELL BIOLOGY
- Actin interaction and regulation of cyclin-dependent kinase 5/p35 complex activity
- (2010) Jiqing Xu et al. JOURNAL OF NEUROCHEMISTRY
- Cdk5 is a major regulator of p38 cascade: relevance to neurotoxicity in Alzheimer’s disease
- (2010) Kuei-Hua Chang et al. JOURNAL OF NEUROCHEMISTRY
- Regulation and role of cyclin-dependent kinase activity in neuronal survival and death
- (2010) Shin-ichi Hisanaga et al. JOURNAL OF NEUROCHEMISTRY
- Cell mechanics and the cytoskeleton
- (2010) Daniel A. Fletcher et al. NATURE
- The role of leucine-rich repeat kinase 2 (LRRK2) in Parkinson's disease
- (2010) Mark R. Cookson NATURE REVIEWS NEUROSCIENCE
- The synapsins: Key actors of synapse function and plasticity
- (2010) F. Cesca et al. PROGRESS IN NEUROBIOLOGY
- Dendritic spine formation and stabilization
- (2009) Yoshihiro Yoshihara et al. CURRENT OPINION IN NEUROBIOLOGY
- Phosphorylation of Ezrin/Radixin/Moesin Proteins by LRRK2 Promotes the Rearrangement of Actin Cytoskeleton in Neuronal Morphogenesis
- (2009) L. Parisiadou et al. JOURNAL OF NEUROSCIENCE
- Direct and Indirect Roles of Cyclin-dependent Kinase 5 as an Upstream Regulator in the c-Jun NH2-Terminal Kinase Cascade: Relevance to Neurotoxic Insults in Alzheimer's Disease
- (2009) Kai-Hui Sun et al. MOLECULAR BIOLOGY OF THE CELL
- Cyclin-dependent kinases: a family portrait
- (2009) Marcos Malumbres et al. NATURE CELL BIOLOGY
- Talin phosphorylation by Cdk5 regulates Smurf1-mediated talin head ubiquitylation and cell migration
- (2009) Cai Huang et al. NATURE CELL BIOLOGY
- Kalirin regulates cortical spine morphogenesis and disease-related behavioral phenotypes
- (2009) M. E. Cahill et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Gene expression analysis on anterior temporal neocortex of patients with intractable epilepsy
- (2009) Zhi-Qin Xi et al. SYNAPSE
- Balancing Structure and Function at Hippocampal Dendritic Spines
- (2008) Jennifer N Bourne et al. Annual Review of Neuroscience
- Molecular dynamics of postsynaptic receptors and scaffold proteins
- (2008) Marianne Renner et al. CURRENT OPINION IN NEUROBIOLOGY
- Regulation of Kalirin by Cdk5
- (2008) X. Xin et al. JOURNAL OF CELL SCIENCE
- Deregulated Cdk5 promotes oxidative stress and mitochondrial dysfunction
- (2008) Kai-Hui Sun et al. JOURNAL OF NEUROCHEMISTRY
- Novel Genetic Tools Reveal Cdk5's Major Role in Golgi Fragmentation in Alzheimer's Disease
- (2008) Kai-Hui Sun et al. MOLECULAR BIOLOGY OF THE CELL
- Mammalian Rho GTPases: new insights into their functions from in vivo studies
- (2008) Sarah J. Heasman et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Actin in action: the interplay between the actin cytoskeleton and synaptic efficacy
- (2008) Lorenzo A. Cingolani et al. NATURE REVIEWS NEUROSCIENCE
- Critical Role of CDK5 and Polo-like Kinase 2 in Homeostatic Synaptic Plasticity during Elevated Activity
- (2008) Daniel P. Seeburg et al. NEURON
- Striatal dysregulation of Cdk5 alters locomotor responses to cocaine, motor learning, and dendritic morphology
- (2008) D. A. Meyer et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- WAVE1 controls neuronal activity-induced mitochondrial distribution in dendritic spines
- (2008) J. Y. Sung et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Dendritic spine dynamics – a key role for kalirin-7
- (2008) Peter Penzes et al. TRENDS IN NEUROSCIENCES
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